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PIAS2 Gene

protein-coding   GIFtS: 62
GCID: GC18M044392

Protein Inhibitor Of Activated STAT, 2

  See PIAS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Inhibitor Of Activated STAT, 21 2     MIZ12
Androgen Receptor-Interacting Protein 32 3     PIASX-ALPHA2
Msx-Interacting Zinc Finger Protein2 3     PIASX-BETA2
Protein Inhibitor Of Activated STAT X2 3     SIZ22
ARIP32 3     ZMIZ42
DIP2 3     E3 SUMO-Protein Ligase PIAS22
PIASX2 3     Zinc Finger, MIZ-Type Containing 42
DAB2-Interacting Protein2 3     EC 6.3.2.-3
MIZ-Type Containing 41     Miz13
Zinc Finger1     PIAS-NY Protein3
MIZ2     Protein Inhibitor Of Activated STAT23

External Ids:    HGNC: 173111   Entrez Gene: 90632   Ensembl: ENSG000000780437   OMIM: 6035675   UniProtKB: O759283   

Export aliases for PIAS2 gene to outside databases

Previous GC identifers: GC18M042645 GC18M042646 GC18M041249


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIAS2 Gene:
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as
SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target
proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor
suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of
chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on
chromosome 1. (provided by RefSeq, Aug 2011)

GeneCards Summary for PIAS2 Gene:
PIAS2 (protein inhibitor of activated STAT, 2) is a protein-coding gene. Diseases associated with PIAS2 include tinea capitis. GO annotations related to this gene include transcription coactivator activity and androgen receptor binding. An important paralog of this gene is PIAS3.

UniProtKB/Swiss-Prot: PIAS2_HUMAN, O75928
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between
UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in
various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.
The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the
biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing.
Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1,
thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform
PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta
promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML
at'Lys-65' and 'Lys-160'

Gene Wiki entry for PIAS2 (Protein inhibitor of activated STAT2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIAS2 gene promoter:
         AP-1   ATF-2   c-Jun   GATA-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIAS2 promoter sequence
   Search Chromatin IP Primers for PIAS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIAS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.1   Ensembl cytogenetic band:  18q21.1   HGNC cytogenetic band: 18q12.1-q12.3

PIAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIAS2 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M044392:  view genomic region     (about GC identifiers)

Start:
44,388,353 bp from pter      End:
44,500,123 bp from pter
Size:
111,771 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PIAS2_HUMAN, O75928 (See protein sequence)
Recommended Name: E3 SUMO-protein ligase PIAS2  
Size: 621 amino acids; 68240 Da
Subunit: Binds SUMO1 and UBE2I. Interacts with AXIN1, JUN, MDM2, PARK7, TP53 and TP73 isoform alpha, but not TP73
isoform beta. Interacts with STAT4 following IL12 and IFN-alpha stimulation of T-cells. Interacts also with
GTF2I, GTF2IRD1, IKFZ1, DAB2 and MSX2, as well as with several steroid receptors, including ESR1, ESR2, NR3C1,
PGR, AR, and with NCOA2 (By similarity). Sumoylation of a target protein seems to enhance the interaction. Binds
to sumoylated ELK1. Binds DNA, such as CDKN1A promoter, in a sequence-specific manner. Interacts with PLAG1.
Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and
of its cell cycle progression into G(1) phase. PIAS2-beta interacts with IFIH1/MDA5. Isoform PIAS2-alpha
interacts with PML (isoform PML-12)
Developmental stage: Isoform 3 expression in adult testis is 14.2-fold stronger than in embryonic testis
2 PDB 3D structures from and Proteopedia for PIAS2:
2ASQ (3D)        4FO9 (3D)    
Secondary accessions: O75927 Q96BT5 Q96KE3
Alternative splicing: 3 isoforms:  O75928-1   O75928-2   O75928-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIAS2: NX_O75928

Explore proteomics data for PIAS2 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys326, Lys452
  • Modification sites at PhosphoSitePlus

  • See PIAS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004662.2  NP_775298.1  

    ENSEMBL proteins: 
     ENSP00000465676   ENSP00000381648   ENSP00000443238   ENSP00000317163   ENSP00000465312  
     ENSP00000468166   ENSP00000466596   ENSP00000468017  

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    Cloud-Clone Corp. Proteins for PIAS2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMIZ: Zinc fingers, MIZ-type

    4 InterPro protein domains:
     IPR027228 PIAS2
     IPR004181 Znf_MIZ
     IPR003034 SAP_dom
     IPR023321 PINIT

    Graphical View of Domain Structure for InterPro Entry O75928

    ProtoNet protein and cluster: O75928

    2 Blocks protein domains:
    IPB003034 DNA-binding SAP
    IPB004181 Zn-finger


    UniProtKB/Swiss-Prot: PIAS2_HUMAN, O75928
    Domain: The LXXLL motif is a transcriptional coregulator signature
    Similarity: Belongs to the PIAS family
    Similarity: Contains 1 PINIT domain
    Similarity: Contains 1 SAP domain
    Similarity: Contains 1 SP-RING-type zinc finger


    Find genes that share domains with PIAS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIAS2_HUMAN, O75928
    Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between
    UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in
    various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.
    The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the
    biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing.
    Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1,
    thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform
    PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta
    promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML
    at'Lys-65' and 'Lys-160'
    Induction: Up-regulated transiently during myeloid differentiation in various cells lines, such as HL-60, U-937,
    K-562, induced by either phorbol ester (TPA) or retinoic acid

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity NAS15572661
    GO:0005515protein binding IPI11477070
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with PIAS2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PIAS2:
     Decreased viability with cispl 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pias2):
     normal  pigmentation  vision/eye 

    Find genes that share phenotypes with PIAS2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PIAS2

    miRNA
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    miRTarBase miRNAs that target PIAS2:
    hsa-mir-26b-5p (MIRT029164)

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    hsa-miR-124* hsa-miR-145* hsa-miR-137 hsa-miR-7-1* hsa-miR-7-2*
    SwitchGear 3'UTR luciferase reporter plasmidPIAS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIAS2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIAS2_HUMAN, O75928: Nucleus speckle. Nucleus, PML body. Note=Colocalizes at least partially with promyelocytic
    leukemia nuclear bodies (PML NBs)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11477070
    GO:0016604nuclear body ----
    GO:0016605colocalizes with PML body IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with PIAS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIAS2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Proteolysis Putative SUMO 1 pathway
    DNA damage Role of SUMO in p53 regulation0.33
    Proteolysis Putative SUMO 1 pathway0.33
    2Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    3Transcription P53 signaling pathway
    Transcription P53 signaling pathway
    4TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    5Sumoylation by RanBP2 regulates transcriptional repression
    Sumoylation by RanBP2 regulates transcriptional repression


    Find genes that share SuperPaths with PIAS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIAS2
        Molecular Mechanisms of Cancer
    JAK-STAT Pathway

    4 GeneGo (Thomson Reuters) Pathways for PIAS2
        Proteolysis Putative SUMO-1 pathway
    Immune response IL-12 signaling pathway
    Transcription P53 signaling pathway
    DNA damage Role of SUMO in p53 regulation

    3 BioSystems Pathways for PIAS2
        TGF-beta Receptor Signaling Pathway
    IL12 signaling mediated by STAT4
    Sumoylation by RanBP2 regulates transcriptional repression



    4 Kegg Pathways  (Kegg details for PIAS2):
        Ubiquitin mediated proteolysis
    Jak-STAT signaling pathway
    Pathways in cancer
    Small cell lung cancer

    UniProtKB/Swiss-Prot: PIAS2_HUMAN, O75928
    Pathway: Protein modification; protein sumoylation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIAS2: 

              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PIAS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIAS2 (O759281, 2, 3 ENSP000003816484) via UniProtKB, MINT, STRING, and/or I2D (see all 265)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632791, 3, ENSP000003248974EBI-348555,EBI-80168 I2D: score=6 STRING: ENSP00000324897
    MYCP011061, 3, ENSP000003672074EBI-348555,EBI-447544 I2D: score=2 STRING: ENSP00000367207
    PIAS1O759252, 3, ENSP000002496364MINT-6542674 I2D: score=2 STRING: ENSP00000249636
    TOPBP1Q925472, 3, ENSP000002608104MINT-3379366 I2D: score=1 STRING: ENSP00000260810
    YWHAHQ049172, 3MINT-6542674 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0016925protein sumoylation IEA--
    GO:0030521androgen receptor signaling pathway NAS15572661
    GO:0045667regulation of osteoblast differentiation IEA--

    Find genes that share ontologies with PIAS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for PIAS2

    4 Novoseek inferred chemical compound relationships for PIAS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 47.2 2 11477070 (1)
    arginine 33.1 2 11477070 (1)
    testosterone 29.5 5 11477070 (2), 11893729 (1), 12177000 (1)
    steroid 10.2 3 11893729 (1), 11117529 (1)



    Find genes that share compounds with PIAS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIAS2 gene (2 alternative transcripts): 
    NM_004671.3  NM_173206.3  

    Unigene Cluster for PIAS2:

    Protein inhibitor of activated STAT, 2
    Hs.657844  [show with all ESTs]
    Unigene Representative Sequence: CR749597
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585916 ENST00000398654(uc002lck.3 uc010dnp.3) ENST00000545673(uc010xda.2)
    ENST00000324794(uc002lcl.3 uc002lcm.3 uc002lcn.1) ENST00000592212
    ENST00000590127 ENST00000592011 ENST00000591865 ENST00000589819 ENST00000589917
    ENST00000586953 ENST00000592221 ENST00000587810 ENST00000586170 ENST00000586634
    ENST00000590944
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    Additional mRNA sequence: 

    AF077953.1 AF077954.1 AF361054.1 AK294801.1 AK308143.1 BC015190.1 BC111060.1 CR749597.1 

    13 DOTS entries:

    DT.442408  DT.100751140  DT.107895  DT.305701  DT.92427952  DT.97812758  DT.91839970  DT.121083852 
    DT.75101741  DT.95165823  DT.40111331  DT.434739  DT.92427953 

    Selected AceView cDNA sequences (see all 164):

    AA701927 NM_173206 H25373 CD678727 AI335650 BQ708645 AA905597 NM_004671 
    AI300507 AL700367 AI168038 AW028483 BU561576 BF434868 AF077953 BC015190 
    BG717031 AI912909 AI582206 AA912514 AL120954 AA682903 CB162566 BU616541 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIAS2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                    -     -     -     -                                                           -           -                             -               
    SP2:                                                                                                  -           -                             -               
    SP3:              -     -     -     -     -                                                           -           -                                             
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20
    SP1:                  
    SP2:        -         
    SP3:                  
    SP4:  -     -         
    SP5:                  


    ECgene alternative splicing isoforms for PIAS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIAS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCAGATT
    PIAS2 Expression
    About this image


    PIAS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Neural Crest (Gastrulation Derivatives)
             Cranial Neural Crest Cells Cranial Neural Crest
     
     Head Mesenchyme (Muscoskeletal System)
             Head Mesenchyme
     
     Thyroid (Endocrine System)
    PIAS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIAS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657844

    UniProtKB/Swiss-Prot: PIAS2_HUMAN, O75928
    Tissue specificity: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in
    pancreas, embryonic testis and sperm, and at very low levels in other organs

        Pathway & Disease-focused RT2 Profiler PCR Arrays including PIAS2: 
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIAS2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pias21 , 5 protein inhibitor of activated STAT 21, 5 93.61(n)1
    98.07(a)1
      18 (52.07 cM)5
    173441  NM_008602.41  NP_032628.31 
     770652085 
    chicken
    (Gallus gallus)
    Aves PIAS21 protein inhibitor of activated STAT, 2 81.21(n)
    91.79(a)
      416383  NM_001030626.1  NP_001025797.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIAS26
    protein inhibitor of activated STAT, 2
    87(a)
    1 ↔ 1
    1(34390879-34433998)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pias21 protein inhibitor of activated STAT, 2 72.13(n)
    79.27(a)
      779910  NM_001078987.1  NP_001072455.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pias21 protein inhibitor of activated STAT, 2 66.67(n)
    72.24(a)
      564149  XM_680612.5  XP_685704.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(var)2-106
    Suppressor of variegation 2-10
    35(a)
    1 → many
    2R(5003631-5009507)
    worm
    (Caenorhabditis elegans)
    Secernentea gei-176
    Protein GEI-17, isoform f (gei-17) mRNA, complete ...
    21(a)
    1 → many
    I(9100854-9107939) WBGene00001574
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NFI16
    SIZ16
    SUMO E3 ligase, catalyzes the covalent attachment ...
    SUMO/Smt3 ligase that promotes the attachment of s...
    14(a)
    12(a)
    many ↔ many
    many ↔ many
    XV(628360-630540) YOR156C
    IV(1289406-1292120) YDR409W


    ENSEMBL Gene Tree for PIAS2 (if available)
    TreeFam Gene Tree for PIAS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIAS2 gene
    PIAS32  ZMIZ22  PIAS12  ZMIZ12  PIAS42  
    5 SIMAP similar genes for PIAS2 using alignment to 7 protein entries:     PIAS2_HUMAN (see all proteins):
    DKFZp434O0617    PIAS3    PIAS1    DKFZp727A051    PIAS4

    Find genes that share paralogs with PIAS2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PIAS2
    PGOHUM00000259892


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIAS2 (see all 1870)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461748311,2
    Cuntested144422256(+) AAAAAA/C/TAAAAA 4 I F mis10--------
    rs765026641,2
    C--44367686(+) TACTCA/GGGAGG 1 -- ds50010--------
    rs1121446281,2
    C,F--44367734(+) GTTGCA/GGTGAG 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1506424381,2
    --44367759(+) TTGCAC/TTCCAT 1 -- ds50010--------
    rs570387001,2
    --44367984(+) TCTGGA/TTAAGA 1 -- ds50010--------
    rs1493746831,2
    --44368015(+) CTGACA/GGATTA 1 -- ds50010--------
    rs1474666001,2
    --44368071(+) CTCAAC/GACAGA 1 -- ds50010--------
    rs1454089451,2
    C--44368100(+) ATTTC-/AAGATGAT 1 -- cds10--------
    rs610418631,2
    C--44368101(+) TTTCA-/AGATGATA 1 -- cds10--------
    rs2021389101,2
    C--44368225(+) AAATAA/GAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIAS2 (44388353 - 44500123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for PIAS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717037CNV Deletion23290073
    esv2669583CNV Deletion23128226
    esv999328CNV Deletion20482838
    nsv522397CNV Loss19592680
    nsv833639CNV Loss17160897
    dgv3413n71CNV Gain21882294
    nsv428355CNV Gain18775914
    dgv3412n71CNV Gain21882294
    dgv3415n71CNV Gain21882294
    nsv9629CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIAS2
    DNA2.0 Custom Variant and Variant Library Synthesis for PIAS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603567    OMIM disorders: --

    1 disease for PIAS2:    
    About MalaCards
    tinea capitis

    1 disease from the University of Copenhagen DISEASES database for PIAS2:
    Tinea capitis

    Find genes that share disorders with PIAS2           About GenesLikeMe


    Export disorders for PIAS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIAS2 gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with PIAS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of Stat1-mediated gene activation by PIAS1. (PubMed id 9724754)1, 2, 3 Liu B....Shuai K. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. (PubMed id 11477070)1, 2, 9 Takahashi K....Ariga H. (J. Biol. Chem. 2001)
    3. Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. (PubMed id 12393906)1, 2, 9 Miyauchi Y.... Yasuda H. (J. Biol. Chem. 2002)
    4. Molecular cloning and characterization of a novel splicing variant of PIASx. (PubMed id 15301740)1, 2, 9 Zheng Y.... Sha J.-H. (Acta Pharmacol. Sin. 2004)
    5. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. (PubMed id 11867732)1, 2, 9 Schmidt D. and Mueller S. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. (PubMed id 16204249)1, 2, 9 Song J.... Chen Y. (J. Biol. Chem. 2005)
    7. The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. (PubMed id 22406621)1, 2 Rabellino A....Scaglioni P.P. (Cancer Res. 2012)
    8. MDA5 is SUMOylated by PIAS2? in the upregulation of type I interferon signaling. (PubMed id 21156324)1, 2 Fu J.... Tang H. (Mol. Immunol. 2011)
    9. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. (PubMed id 15976810)1, 2 Shinbo Y.... Ariga H. (Cell Death Differ. 2006)
    10. PIASx acts as an Elk-1 coactivator by facilitating derepression. (PubMed id 15920481)1, 2 Yang S.-H. and Sharrocks A.D. (EMBO J. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9063 HGNC: 17311 AceView: PIAS2 Ensembl:ENSG00000078043 euGenes: HUgn9063
    ECgene: PIAS2 Kegg: 9063 H-InvDB: PIAS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIAS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIAS2 gene:
    Search GeneIP for patents involving PIAS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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