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Aliases for PIAS2 Gene

Aliases for PIAS2 Gene

  • Protein Inhibitor Of Activated STAT 2 2 3 5
  • Androgen Receptor-Interacting Protein 3 3 4
  • Protein Inhibitor Of Activated STAT X 3 4
  • Msx-Interacting Zinc Finger Protein 3 4
  • Zinc Finger, MIZ-Type Containing 4 2 3
  • DAB2-Interacting Protein 3 4
  • ARIP3 3 4
  • PIASX 3 4
  • MIZ1 3 4
  • DIP 3 4
  • Protein Inhibitor Of Activated STAT2 4
  • E3 SUMO-Protein Ligase PIAS2 3
  • PIAS-NY Protein 4
  • PIASX-ALPHA 3
  • PIASX-BETA 3
  • EC 6.3.2.- 4
  • ZMIZ4 3
  • SIZ2 3
  • MIZ 3

External Ids for PIAS2 Gene

Previous GeneCards Identifiers for PIAS2 Gene

  • GC18M042645
  • GC18M042646
  • GC18M044392
  • GC18M041249

Summaries for PIAS2 Gene

Entrez Gene Summary for PIAS2 Gene

  • This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]

GeneCards Summary for PIAS2 Gene

PIAS2 (Protein Inhibitor Of Activated STAT 2) is a Protein Coding gene. Among its related pathways are Jak/STAT Signaling Pathway Intracellular Regulation and Pathways in cancer. GO annotations related to this gene include nucleic acid binding and transcription factor binding. An important paralog of this gene is PIAS1.

UniProtKB/Swiss-Prot for PIAS2 Gene

  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML atLys-65 and Lys-160.

Gene Wiki entry for PIAS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS2 Gene

Genomics for PIAS2 Gene

Regulatory Elements for PIAS2 Gene

Enhancers for PIAS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G046710 1.1 ENCODE dbSUPER 10.1 +208.2 208199 2.7 HDAC1 PKNOX1 ATF1 TBL1XR1 TCF12 GATA2 ZNF366 CREM MEF2D NFIC ST8SIA5 PIAS2 RPS21P6 LOC105372096
GH18G046754 1 Ensembl ENCODE 10.4 +163.8 163805 3.9 CTCF KLF1 SUZ12 ZNF704 ZNF76 ZFHX2 POLR2A ZBTB48 PATZ1 EZH2 LOC105372097 PIAS2 HDHD2 IER3IP1 RPS21P6
GH18G047243 1.4 VISTA 6.9 -324.2 -324240 1.0 ZNF530 EP300 ENSG00000267724 HDHD2 PIAS2 GC18P047244 RNU6-1131P GC18M047235
GH18G046767 0.4 ENCODE 10.7 +152.1 152094 0.4 REST PIAS2 LOC105372097 ST8SIA5 ENSG00000274776
GH18G046790 0.3 FANTOM5 13.4 +129.7 129737 0.3 KATNAL2 PIAS2 RNF165 ENSG00000274776 GC18P046803
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIAS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIAS2 Gene

Chromosome:
18
Start:
46,803,224 bp from pter
End:
46,920,167 bp from pter
Size:
116,944 bases
Orientation:
Minus strand

Genomic View for PIAS2 Gene

Genes around PIAS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIAS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIAS2 Gene

Proteins for PIAS2 Gene

  • Protein details for PIAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75928-PIAS2_HUMAN
    Recommended name:
    E3 SUMO-protein ligase PIAS2
    Protein Accession:
    O75928
    Secondary Accessions:
    • O75927
    • Q96BT5
    • Q96KE3

    Protein attributes for PIAS2 Gene

    Size:
    621 amino acids
    Molecular mass:
    68240 Da
    Quaternary structure:
    • Binds SUMO1 and UBE2I. Interacts with AXIN1, JUN, MDM2, PARK7, TP53 and TP73 isoform alpha, but not TP73 isoform beta. Interacts with STAT4 following IL12 and IFN-alpha stimulation of T-cells. Interacts also with GTF2I, GTF2IRD1, IKFZ1, DAB2 and MSX2, as well as with several steroid receptors, including ESR1, ESR2, NR3C1, PGR, AR, and with NCOA2 (By similarity). Sumoylation of a target protein seems to enhance the interaction. Binds to sumoylated ELK1. Binds DNA, such as CDKN1A promoter, in a sequence-specific manner. Interacts with PLAG1. Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. PIAS2-beta interacts with IFIH1/MDA5. Isoform PIAS2-alpha interacts with PML (isoform PML-12).

    Three dimensional structures from OCA and Proteopedia for PIAS2 Gene

    Alternative splice isoforms for PIAS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIAS2 Gene

Post-translational modifications for PIAS2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PIAS2

No data available for DME Specific Peptides for PIAS2 Gene

Domains & Families for PIAS2 Gene

Gene Families for PIAS2 Gene

Protein Domains for PIAS2 Gene

Graphical View of Domain Structure for InterPro Entry

O75928

UniProtKB/Swiss-Prot:

PIAS2_HUMAN :
  • The LXXLL motif is a transcriptional coregulator signature.
  • Belongs to the PIAS family.
Domain:
  • The LXXLL motif is a transcriptional coregulator signature.
Family:
  • Belongs to the PIAS family.
genes like me logo Genes that share domains with PIAS2: view

Function for PIAS2 Gene

Molecular function for PIAS2 Gene

UniProtKB/Swiss-Prot Function:
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML atLys-65 and Lys-160.
UniProtKB/Swiss-Prot Induction:
Up-regulated transiently during myeloid differentiation in various cells lines, such as HL-60, U-937, K-562, induced by either phorbol ester (TPA) or retinoic acid.

Enzyme Numbers (IUBMB) for PIAS2 Gene

Gene Ontology (GO) - Molecular Function for PIAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 11477070
GO:0008134 transcription factor binding IPI 20408817
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PIAS2: view
genes like me logo Genes that share phenotypes with PIAS2: view

Animal Models for PIAS2 Gene

MGI Knock Outs for PIAS2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PIAS2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIAS2 Gene

Localization for PIAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIAS2 Gene

Nucleus speckle. Nucleus, PML body. Nucleus. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). {ECO:0000250 UniProtKB:Q8C5D8, ECO:0000269 PubMed:22406621}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIAS2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PIAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11477070
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IEA --
GO:0016605 colocalizes_with PML body IDA,IEA 22406621
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PIAS2: view

Pathways & Interactions for PIAS2 Gene

genes like me logo Genes that share pathways with PIAS2: view

UniProtKB/Swiss-Prot O75928-PIAS2_HUMAN

  • Pathway: Protein modification; protein sumoylation.

Gene Ontology (GO) - Biological Process for PIAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0016925 protein sumoylation IEA --
GO:0030521 androgen receptor signaling pathway NAS 15572661
genes like me logo Genes that share ontologies with PIAS2: view

No data available for SIGNOR curated interactions for PIAS2 Gene

Drugs & Compounds for PIAS2 Gene

(3) Drugs for PIAS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PIAS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIAS2: view

Transcripts for PIAS2 Gene

Unigene Clusters for PIAS2 Gene

Protein inhibitor of activated STAT, 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PIAS2

Alternative Splicing Database (ASD) splice patterns (SP) for PIAS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: -
SP5:
SP6: -
SP7: - - -
SP8:
SP9: - - -
SP10: - - - -
SP11: - - -

ExUns: 18 ^ 19 ^ 20
SP1:
SP2: -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PIAS2 Gene

GeneLoc Exon Structure for
PIAS2
ECgene alternative splicing isoforms for
PIAS2

Expression for PIAS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIAS2 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for PIAS2 Gene

This gene is overexpressed in Bone marrow stromal cell (42.9) and Heart (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIAS2 Gene



Protein tissue co-expression partners for PIAS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIAS2 Gene:

PIAS2

SOURCE GeneReport for Unigene cluster for PIAS2 Gene:

Hs.657844

mRNA Expression by UniProt/SwissProt for PIAS2 Gene:

O75928-PIAS2_HUMAN
Tissue specificity: Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.

Evidence on tissue expression from TISSUES for PIAS2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with PIAS2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PIAS2 Gene

Orthologs for PIAS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIAS2 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia PIAS2 34 35
  • 96.41 (n)
cow
(Bos Taurus)
Mammalia PIAS2 34 35
  • 94.79 (n)
mouse
(Mus musculus)
Mammalia Pias2 34 16 35
  • 93.61 (n)
rat
(Rattus norvegicus)
Mammalia Pias2 34
  • 92.55 (n)
oppossum
(Monodelphis domestica)
Mammalia PIAS2 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIAS2 35
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIAS2 34 35
  • 81.21 (n)
lizard
(Anolis carolinensis)
Reptilia PIAS2 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pias2 34
  • 72.13 (n)
zebrafish
(Danio rerio)
Actinopterygii pias2 34 35
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Su(var)2-10 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gei-17 35
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 35
  • 14 (a)
ManyToMany
SIZ1 35
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for PIAS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIAS2 Gene

ENSEMBL:
Gene Tree for PIAS2 (if available)
TreeFam:
Gene Tree for PIAS2 (if available)

Paralogs for PIAS2 Gene

Paralogs for PIAS2 Gene

(5) SIMAP similar genes for PIAS2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for PIAS2 Gene

genes like me logo Genes that share paralogs with PIAS2: view

Variants for PIAS2 Gene

Sequence variations from dbSNP and Humsavar for PIAS2 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000024963 -- 46,915,121(+) CCAGA(A/C)TCTAA intron-variant
rs1000056184 -- 46,867,943(+) TATAA(A/G)GAAGC intron-variant
rs1000086008 -- 46,823,980(+) GTGAT(A/G)CTATA intron-variant, utr-variant-3-prime
rs1000087896 -- 46,847,392(+) GATAA(A/T)CAACA intron-variant
rs1000150620 -- 46,833,949(+) TAAAG(-/TTCC)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIAS2 Gene

Variant ID Type Subtype PubMed ID
dgv614e214 CNV gain 21293372
esv2669583 CNV deletion 23128226
esv2717037 CNV deletion 23290073
esv2763189 CNV gain 21179565
esv3583037 CNV loss 25503493
esv3642444 CNV loss 21293372
esv3642445 CNV loss 21293372
esv999328 CNV deletion 20482838
nsv1059378 CNV gain 25217958
nsv428355 CNV gain 18775914
nsv477250 CNV novel sequence insertion 20440878
nsv522397 CNV loss 19592680
nsv576813 CNV loss 21841781
nsv833639 CNV loss 17160897
nsv9629 CNV gain+loss 18304495

Variation tolerance for PIAS2 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIAS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIAS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS2 Gene

Disorders for PIAS2 Gene

Relevant External Links for PIAS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIAS2

No disorders were found for PIAS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIAS2 Gene

Publications for PIAS2 Gene

  1. Small ubiquitin-like modifier (SUMO) recognition of a SUMO binding motif: a reversal of the bound orientation. (PMID: 16204249) Song J. … Chen Y. (J. Biol. Chem. 2005) 3 4 22 64
  2. Molecular cloning and characterization of a novel splicing variant of PIASx. (PMID: 15301740) Zheng Y. … Sha J.-H. (Acta Pharmacol. Sin. 2004) 3 4 22 64
  3. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. (PMID: 11867732) Schmidt D. … Mueller S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 22 64
  4. Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. (PMID: 12393906) Miyauchi Y. … Yasuda H. (J. Biol. Chem. 2002) 3 4 22 64
  5. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. (PMID: 11477070) Takahashi K. … Ariga H. (J. Biol. Chem. 2001) 3 4 22 64

Products for PIAS2 Gene

  • Addgene plasmids for PIAS2

Sources for PIAS2 Gene

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