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Aliases for PIAS1 Gene

Aliases for PIAS1 Gene

  • Protein Inhibitor Of Activated STAT, 1 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Binding Protein 1 2 3
  • Protein Inhibitor Of Activated STAT Protein 1 3 4
  • RNA Helicase II-Binding Protein 3 4
  • DEAD/H Box-Binding Protein 1 3 4
  • Gu-Binding Protein 3 4
  • DDXBP1 3 4
  • GBP 3 4
  • Protein Inhibitor Of Activated STAT-1 3
  • Zinc Finger, MIZ-Type Containing 3 3
  • AR Interacting Protein 3
  • MIZ-Type Containing 3 2
  • Zinc Finger 2
  • EC 6.3.2.- 4
  • GU/RH-II 3
  • ZMIZ3 3

External Ids for PIAS1 Gene

Previous HGNC Symbols for PIAS1 Gene

  • DDXBP1

Previous GeneCards Identifiers for PIAS1 Gene

  • GC15P064182
  • GC15P061445
  • GC15P065925
  • GC15P066062
  • GC15P066133
  • GC15P068346
  • GC15P045180

Summaries for PIAS1 Gene

Entrez Gene Summary for PIAS1 Gene

  • This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIAS1 Gene

PIAS1 (Protein Inhibitor Of Activated STAT, 1) is a Protein Coding gene. Diseases associated with PIAS1 include germ cell cancer. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is ZMIZ1.

UniProtKB/Swiss-Prot for PIAS1 Gene

  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (atLys-65 and Lys-160) and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

Gene Wiki entry for PIAS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS1 Gene

Genomics for PIAS1 Gene

Regulatory Elements for PIAS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIAS1 Gene

Chromosome:
15
Start:
68,054,179 bp from pter
End:
68,198,603 bp from pter
Size:
144,425 bases
Orientation:
Plus strand

Genomic View for PIAS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for PIAS1 Gene

Proteins for PIAS1 Gene

  • Protein details for PIAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75925-PIAS1_HUMAN
    Recommended name:
    E3 SUMO-protein ligase PIAS1
    Protein Accession:
    O75925
    Secondary Accessions:
    • B2RB67
    • B3KSY9
    • C5J4B4
    • Q147X4
    • Q99751
    • Q9UN02

    Protein attributes for PIAS1 Gene

    Size:
    651 amino acids
    Molecular mass:
    71836 Da
    Quaternary structure:
    • Interacts with NCOA2 and AR. Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Interacts with DDX21, CSRP2, AXIN1, JUN, UBE2I, SUMO1, SATB2, PLAG1, TP53 and STAT1 (dimer), following IFNA1-stimulation. Interacts with SP3 (preferentially when SUMO-modified). Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Interacts with STAT1. Interacts with CHUK/IKKA; this interaction induces PIAS1 phosphorylation. Interacts with PTK2/FAK1; the interaction promotes its sumoylation. Interacts with DDX5. Interacts with PML (By similarity). Interacts with MTA1.

    Three dimensional structures from OCA and Proteopedia for PIAS1 Gene

    Alternative splice isoforms for PIAS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIAS1 Gene

Proteomics data for PIAS1 Gene at MOPED

Post-translational modifications for PIAS1 Gene

  • Dimethylated by PRMT1 at Arg-303 in the late phase of interferon gamma (IFN-gamma) signaling, leading to preferential interaction with STAT1 and thus resulting in release of STAT1 from its target gene
  • Sumoylated.
  • Ubiquitination at Lys 8, Lys 46, Lys 339, and Lys 493
  • Modification sites at PhosphoSitePlus

Other Protein References for PIAS1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIAS1 (PIAS1)
  • Cloud-Clone Corp. Antibodies for PIAS1

No data available for DME Specific Peptides for PIAS1 Gene

Domains & Families for PIAS1 Gene

Gene Families for PIAS1 Gene

Protein Domains for PIAS1 Gene

Graphical View of Domain Structure for InterPro Entry

O75925

UniProtKB/Swiss-Prot:

PIAS1_HUMAN :
  • The LXXLL motif is a transcriptional coregulator signature
  • Belongs to the PIAS family.
  • Contains 1 SP-RING-type zinc finger.
Domain:
  • The LXXLL motif is a transcriptional coregulator signature
  • The SP-RING-type domain is required for promoting EKLF sumoylation.
  • Contains 1 PINIT domain.
  • Contains 1 SAP domain.
Family:
  • Belongs to the PIAS family.
Similarity:
  • Contains 1 SP-RING-type zinc finger.
genes like me logo Genes that share domains with PIAS1: view

Function for PIAS1 Gene

Molecular function for PIAS1 Gene

UniProtKB/Swiss-Prot Function:
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (atLys-65 and Lys-160) and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

Enzyme Numbers (IUBMB) for PIAS1 Gene

Gene Ontology (GO) - Molecular Function for PIAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0003714 transcription corepressor activity TAS 10805787
GO:0005515 protein binding IPI 14752048
GO:0008134 transcription factor binding IEA --
genes like me logo Genes that share ontologies with PIAS1: view
genes like me logo Genes that share phenotypes with PIAS1: view

Animal Models for PIAS1 Gene

MGI Knock Outs for PIAS1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIAS1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PIAS1 Gene

Localization for PIAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIAS1 Gene

Nucleus speckle. Nucleus, PML body. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIAS1 Gene COMPARTMENTS Subcellular localization image for PIAS1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for PIAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14752048
GO:0005654 nucleoplasm TAS --
GO:0016605 colocalizes_with PML body ISS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PIAS1: view

Pathways & Interactions for PIAS1 Gene

genes like me logo Genes that share pathways with PIAS1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O75925-PIAS1_HUMAN

  • Pathway: Protein modification; protein sumoylation

SIGNOR curated interactions for PIAS1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PIAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007259 JAK-STAT cascade TAS 10805787
GO:0008152 metabolic process --
GO:0016925 protein sumoylation TAS --
genes like me logo Genes that share ontologies with PIAS1: view

Drugs & Compounds for PIAS1 Gene

(8) Drugs for PIAS1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Zinc Approved Pharma 1404
estrogen Pharma 0
arginine Nutra 346

(1) Additional Compounds for PIAS1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Steroid
genes like me logo Genes that share compounds with PIAS1: view

Transcripts for PIAS1 Gene

Unigene Clusters for PIAS1 Gene

Protein inhibitor of activated STAT, 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIAS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIAS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8:

ExUns: 19 ^ 20
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PIAS1 Gene

GeneLoc Exon Structure for
PIAS1
ECgene alternative splicing isoforms for
PIAS1

Expression for PIAS1 Gene

mRNA expression in normal human tissues for PIAS1 Gene

mRNA differential expression in normal tissues according to GTEx for PIAS1 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for PIAS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Heart (15.6), Placenta (13.1), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIAS1 Gene



SOURCE GeneReport for Unigene cluster for PIAS1 Gene Hs.162458

mRNA Expression by UniProt/SwissProt for PIAS1 Gene

O75925-PIAS1_HUMAN
Tissue specificity: Expressed in numerous tissues with highest level in testis.
genes like me logo Genes that share expression patterns with PIAS1: view

Protein tissue co-expression partners for PIAS1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PIAS1 Gene

Orthologs for PIAS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIAS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIAS1 35
  • 95.55 (n)
  • 99.08 (a)
PIAS1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIAS1 35
  • 96.26 (n)
  • 99.69 (a)
PIAS1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pias1 35
  • 90.68 (n)
  • 98 (a)
Pias1 16
Pias1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIAS1 35
  • 99.8 (n)
  • 100 (a)
PIAS1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pias1 35
  • 91.81 (n)
  • 98 (a)
oppossum
(Monodelphis domestica)
Mammalia PIAS1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIAS1 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIAS1 35
  • 85.96 (n)
  • 96.38 (a)
PIAS1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIAS1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pias1 35
  • 77.43 (n)
  • 87.94 (a)
Str.2277 35
African clawed frog
(Xenopus laevis)
Amphibia pias1-A 35
zebrafish
(Danio rerio)
Actinopterygii PIAS1 (1 of 2) 36
  • 76 (a)
OneToMany
pias1b 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Su(var)2-10 37
  • 42 (a)
Su(var)2-10 35
  • 51.57 (n)
  • 49.16 (a)
Su(var)2-10 36
  • 36 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005031 35
  • 51.42 (n)
  • 50.75 (a)
worm
(Caenorhabditis elegans)
Secernentea gei-17 37
  • 37 (a)
W10D5.3a 37
  • 37 (a)
W10D5.3d 37
  • 37 (a)
gei-17 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 36
  • 13 (a)
ManyToMany
SIZ1 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for PIAS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIAS1 Gene

ENSEMBL:
Gene Tree for PIAS1 (if available)
TreeFam:
Gene Tree for PIAS1 (if available)

Paralogs for PIAS1 Gene

Paralogs for PIAS1 Gene

genes like me logo Genes that share paralogs with PIAS1: view

Variants for PIAS1 Gene

Sequence variations from dbSNP and Humsavar for PIAS1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1027154 -- 68,111,955(+) ctttt(C/G)tatct intron-variant
rs1049493 -- 68,188,549(-) CACAC(A/G)TGAGT downstream-variant-500B, utr-variant-3-prime
rs1052174 -- 68,189,586(+) GCCAC(C/T)AAATT utr-variant-3-prime
rs1114159 -- 68,163,043(-) tctgc(A/G)agtgt intron-variant
rs1133306 -- 68,161,698(+) tgcca(A/G)agcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIAS1 Gene

Variant ID Type Subtype PubMed ID
nsv517512 CNV Gain 19592680
nsv521762 CNV Gain 19592680
esv2665979 CNV Deletion 23128226
nsv1580 CNV Loss 18451855
esv2670973 CNV Deletion 23128226
esv2749813 CNV Deletion 23290073
esv1003872 CNV Deletion 20482838
esv2596512 CNV Deletion 19546169
esv2068352 CNV Deletion 18987734
esv2640694 CNV Loss 19546169
nsv512400 CNV Loss 21212237
esv2986 CNV Deletion 18987735
esv2749814 CNV Deletion 23290073
esv994874 CNV Deletion 20482838
nsv498848 CNV Loss 21111241
esv8835 CNV Loss 19470904
esv1172926 CNV Deletion 17803354
nsv94922 CNV Loss 16902084
nsv1581 CNV Insertion 18451855

Variation tolerance for PIAS1 Gene

Residual Variation Intolerance Score: 5.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIAS1 Gene

HapMap Linkage Disequilibrium report
PIAS1
Human Gene Mutation Database (HGMD)
PIAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS1 Gene

Disorders for PIAS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIAS1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
germ cell cancer
  • malignant tumor of the germ cell
- elite association
Search PIAS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIAS1

Genetic Association Database (GAD)
PIAS1
Human Genome Epidemiology (HuGE) Navigator
PIAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIAS1
genes like me logo Genes that share disorders with PIAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIAS1 Gene

Publications for PIAS1 Gene

  1. Inhibition of Stat1-mediated gene activation by PIAS1. (PMID: 9724754) Liu B. … Shuai K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 23 67
  2. The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. (PMID: 20209145) Marongiu M. … Crisponi L. (PLoS ONE 2010) 23 67
  3. Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1. (PMID: 20351170) Tan J.A. … Durrin L.K. (Mol. Cell. Biol. 2010) 23 67
  4. Gene expression profiles in radiation workers occupationally exposed to ionizing radiation. (PMID: 19218781) Fachin A.L. … Sakamoto-Hojo E.T. (J. Radiat. Res. 2009) 23 67
  5. SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. (PMID: 19620279) Diao Y. … Wu Z. (Mol. Cell. Biol. 2009) 23 67

Products for PIAS1 Gene

Sources for PIAS1 Gene

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