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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIAS1 Gene

protein-coding   GIFtS: 64
GCID: GC15P068346

protein inhibitor of activated STAT, 1

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1 )
(Previous symbol: DDXBP1)
 Explore 15 diseases affiliated with
PIAS1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PIAS1    

Aliases
for PIAS1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Protein Inhibitor Of Activated STAT, 11 2     DEAD/H Box-Binding Protein 12 3
DDXBP11 2 3 5     RNA Helicase II-Binding Protein2 3
GBP1 2 3 5     AR Interacting Protein2
GU/RH-II1 2     E3 SUMO-Protein Ligase PIAS12
ZMIZ31 2     Protein Inhibitor Of Activated STAT-12
DEAD/H (Asp-Glu-Ala-Asp/His) Box Binding Protein 11 2     Zinc Finger, MIZ-Type Containing 32
Gu-Binding Protein2 3     EC 6.3.2.-3
Protein Inhibitor Of Activated STAT Protein 12 3     

External Ids:    HGNC: 27521   Entrez Gene: 85542   Ensembl: ENSG000000338007   OMIM: 6035665   UniProtKB: O759253   

Export aliases for PIAS1 gene to outside databases

Previous GC identifers: GC15P064182 GC15P061445 GC15P065925 GC15P066062 GC15P066133 GC15P045180


Summaries
for PIAS1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PIAS1:
This gene encodes a member of the mammalian PIAS (protein inhibitor of activated STAT-1 (signal transducer and
activator of transcription-1)) family. This member contains a putative zinc-binding motif and a highly acidic region.
It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box
polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor
transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PIAS1_HUMAN, O75925
Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between
UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in
various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In
vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary
depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late
phase of interferon gamma (IFN-gamma) signaling

Gene Wiki entry for PIAS1


Genomic Views
for PIAS1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIAS1 gene promoter:
         MEF-2A   AP-1   ATF-2   aMEF-2   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIAS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIAS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIAS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q

PIAS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIAS1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P068346:  view genomic region     (about GC identifiers)

Start:
 68,346,517 bp from pter      End:
 68,483,096 bp from pter
Size:
 136,580 bases      Orientation:
 plus strand

Proteins
for PIAS1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PIAS1_HUMAN, O75925 (See protein sequence)
Recommended Name: E3 SUMO-protein ligase PIAS1  
Size: 651 amino acids; 71836 Da
Subunit: Interacts with NCOA2 and AR. Interacts with NR2C1; the interaction promotes its sumoylation (By similarity).
Interacts with DDX21, CSRP2, AXIN1, JUN, UBE2I, SUMO1, SATB2, PLAG1, TP53 and STAT1 (dimer), following
IFNA1-stimulation. Interacts with SP3 (preferentially when SUMO-modified). Interacts with KLF8; the interaction
results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1)
phase. Interacts with STAT1. Interacts with CHUK/IKKA; this interaction induces PIAS1 phosphorylation. Interacts with
PTK2/FAK1; the interaction promotes its sumoylation. Interacts with DDX5
Subcellular location: Nucleus speckle. Note=Interaction with CSRP2 may induce a partial redistribution along the
cytoskeleton
1 PDB 3D structure from and Proteopedia for PIAS1:
1V66 (3D)    
Secondary accessions: B2RB67 Q147X4 Q99751 Q9UN02

Explore the universe of human proteins at neXtProt for PIAS1: NX_O75925

Post-translational modifications:

  • Sumoylated1
  • Dimethylated by PRMT1 at Arg-303 in the late phase of interferon gamma (IFN-gamma) signaling, leading to preferential
    • interaction with STAT1 and thus resulting in release of STAT1 from its target gene1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75925

    • PIAS1 Protein expression data from MOPED and PaxDb:    About this image 
    PIAS1 Protein Expression
    REFSEQ proteins: NP_057250.1  
    ENSEMBL proteins: 
     ENSP00000249636   ENSP00000456721   ENSP00000457698   ENSP00000438574   ENSP00000456558  
    Reactome Protein details: O75925
    Human Recombinant Protein Products for PIAS1: 
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    Enzo Life Sciences proteins for PIAS1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PIAS1
    OriGene Custom Protein Services for PIAS1 
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    Novus Biologicals PIAS1 Proteins
    Novus Biologicals PIAS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PIAS1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14752048
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck IEA--

    PIAS1 for ontologies           About GeneDecksing



    PIAS1 Antibody Products: 
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    ThermoFisher Antibody for PIAS1

    Assay Products for PIAS1: 
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    Uscn ELISAs and CLIAs for PIAS1

    Protein Domains /
    Families
    for PIAS1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIAS1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR004181 Znf_MIZ
     IPR003034 SAP_dom
     IPR023321 PINIT
     IPR027227 PIAS1

    Graphical View of Domain Structure for InterPro Entry O75925

    ProtoNet protein and cluster: O75925

    2 Blocks protein families:
    IPB003034 DNA-binding SAP
    IPB004181 Zn-finger


    UniProtKB/Swiss-Prot: PIAS1_HUMAN, O75925
    Domain: The LXXLL motif is a transcriptional coregulator signature
    Domain: The SP-RING-type domain is required for promoting EKLF sumoylation (By similarity)
    Similarity: Belongs to the PIAS family
    Similarity: Contains 1 PINIT domain
    Similarity: Contains 1 SAP domain
    Similarity: Contains 1 SP-RING-type zinc finger


    Function
    for PIAS1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIAS1_HUMAN, O75925
    Function: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between
    UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in
    various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In
    vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary
    depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late
    phase of interferon gamma (IFN-gamma) signaling

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity NAS15572661
    GO:0003714transcription corepressor activity TAS10805787
    GO:0005515protein binding IPI18579533
         
    PIAS1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIAS1:
     Increased circadian rhythm amp  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pias1):
     growth/size  immune system  mortality/aging 

    PIAS1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Pias1tm1Kes for PIAS1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PIAS1 

    miRNA
    Products:            		miRTarBase miRNAs that target PIAS1:
    hsa-mir-424 (MIRT003227)

    OriGene 3'-UTR Clone: PIAS1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIAS1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PIAS1 (see all 21):
    hsa-miR-548j hsa-miR-300 hsa-miR-548i hsa-miR-548a-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-375 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: PIAS1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIAS1 (see all 7)
    OriGene shRNA RFP: PIAS1
    OriGene siRNA: PIAS1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIAS1
    Sirion Biotech Custom design and validation of potent shRNA sequences against PIAS1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PIAS1
    Sirion Biotech Customized adenovirus for overexpression of PIAS1 
    Sirion Biotech Customized adenovirus for potent knockdown of PIAS1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIAS1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIAS1
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIAS1


    Pathways & Interactions
    for PIAS1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development Thrombopoetin signaling via JAK-STAT pathway
    		Development_Thrombopoetin signaling via JAK-STAT pathway1.00
    		Jak/Stat Pathway0.29
    		Development Thrombopoetin signaling via JAK-STAT pathway1.00
    2Transcription_P53 signaling pathway
    		Transcription_P53 signaling pathway1.00
    		Transcription P53 signaling pathway0.98
    3Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		Bacterial infections in CF airways0.78
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Proteolysis Putative SUMO-1 pathway
    		Proteolysis Putative SUMO-1 pathway1.00
    		Proteolysis_Putative SUMO-1 pathway0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for PIAS1
        Proteolysis Putative SUMO-1 pathway
    DNA damage Role of SUMO in p53 regulation
    Transcription P53 signaling pathway
    Development Thrombopoetin signaling via JAK-STAT pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIAS1
        p53 Signaling
    JAK-STAT Pathway
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for PIAS1
        Jak/Stat Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for PIAS1 (see all 6)
        Immune response Bacterial infections in normal airways
    Proteolysis Putative SUMO-1 pathway
    Transcription P53 signaling pathway
    DNA damage Role of SUMO in p53 regulation
    Bacterial infections in CF airways

    5/12 BioSystems Pathways for PIAS1 (see all 12) 
        Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Interleukin-11 Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Androgen receptor signaling pathway

    5        Reactome Pathways for PIAS1
        Interferon gamma signaling
    Regulation of IFNG signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System


    5         Kegg Pathways  (Kegg details for PIAS1):
        Ubiquitin mediated proteolysis
    Jak-STAT signaling pathway
    Hepatitis C
    Pathways in cancer
    Small cell lung cancer

    UniProtKB/Swiss-Prot: PIAS1_HUMAN, O75925
    Pathway: Protein modification; protein sumoylation


    PIAS1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIAS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/197 Interacting proteins for PIAS1 (O759251, 2, 3 ENSP000002496364) via UniProtKB, MINT, STRING, and/or I2D (see all 197)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 3, ENSP000002693054EBI-629434,EBI-366083 I2D: score=6 STRING: ENSP00000269305
    UBE2IP632792, 3, ENSP000003248974MINT-7230924 I2D: score=6 STRING: ENSP00000324897
    SUMO1P631652, 3, ENSP000003760764MINT-7230924 I2D: score=4 STRING: ENSP00000376076
    SMAD7O151052, 3, ENSP000002621584MINT-61806 I2D: score=3 STRING: ENSP00000262158
    PRPF40AO754002, 3MINT-61844 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007259JAK-STAT cascade TAS10805787
    GO:0007283spermatogenesis IEA--
    GO:0016925protein sumoylation IEA--

    PIAS1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIAS1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIAS1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIAS1
    9 Novoseek chemical compound relationships for PIAS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 54.3 1 17066076 (1)
    testosterone 33.5 7 11877418 (2), 14644130 (1), 18656483 (1), 12177000 (1)
    arginine 23 6 19136629 (3), 12171910 (2)
    zinc 21 8 17934332 (4)
    steroid 15.7 1 14644130 (1)
    progesterone 14.6 1 11117529 (1)
    serine 11 1 11773441 (1)
    estrogen 7.87 3 11117529 (1), 14644130 (1), 15666801 (1)
    tyrosine 0 1 12171910 (1)

    Search CenterWatch for drugs/clinical trials and news about PIAS1 

    Transcripts
    for PIAS1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIAS1 gene: 
    NM_016166.1  

    Unigene Cluster for PIAS1:

    Protein inhibitor of activated STAT, 1
    Hs.162458  [show with all ESTs]
    Unigene Representative Sequence: AK128379
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249636(uc010ujx.2 uc002aqz.3) ENST00000564915 ENST00000562190
    ENST00000545237 ENST00000564009 ENST00000567417 ENST00000563996

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PIAS1 (see all 21):
    hsa-miR-548j hsa-miR-300 hsa-miR-548i hsa-miR-548a-3p hsa-miR-548a-5p hsa-miR-548d-5p hsa-miR-375 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: PIAS1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIAS1 (see all 7)
    OriGene shRNA RFP: PIAS1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against PIAS1 
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIAS1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIAS1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIAS1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIAS1

    Additional cDNA sequence: 

    AF077951.1 AF167160.1 AK094641.1 AK128379.1 AK314515.1 AY826819.1 BC053685.1 BC104646.1 
    BC118587.1 BC121797.1 EF487997.1 EF487998.1 FJ997900.1 U78524.1 

    15 DOTS entries:

    DT.117380  DT.100777930  DT.95148132  DT.97782925  DT.97843831  DT.100026938  DT.121060474  DT.100019100 
    DT.100026939  DT.100777931  DT.91642277  DT.91754892  DT.91754893  DT.95143477  DT.436306 

    24/352 AceView cDNA sequences (see all 352):

    BX098741 BP351615 CB139868 AI151229 T50552 BQ720672 AA463666 AU121697 
    AW305107 AI679413 BE886798 T16734 BU158952 BM505486 AU119223 N24089 
    BM552077 AA411233 AA504633 AA608955 CD678463 AI040228 BM677276 BM984623 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PIAS1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                      -     -     -                       -                                                                                 
    SP2:                          -     -     -     -     -                       -                                                                                 
    SP3:                          -     -                 -                       -                                                                                 
    SP4:                                                                                                                                                            
    SP5:                          -     -     -     -                                                                                                               

    ExUns: 19 ^ 20
    SP1:  -         
    SP2:  -         
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for PIAS1

    Expression
    for PIAS1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIAS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    PIAS1 Expression
    About this image
    See PIAS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIAS1

    SOURCE GeneReport for Unigene cluster: Hs.162458

    UniProtKB/Swiss-Prot: PIAS1_HUMAN, O75925
    Tissue specificity: Expressed in numerous tissues with highest level in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including PIAS1: 
              JAK / STAT Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PIAS1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIAS1 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PIAS11 protein inhibitor of activated STAT, 1 85.9(n)
    96.38(a)    		   427514  NM_001031456.1  NP_001026627.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PIAS16
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343467.1(708014-727932)
    African clawed frog
    (Xenopus laevis)    		 Amphibia pias1-A2 protein inhibitor of activated STAT, 1 80.05(n)    AY100476.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-9i9.16
    BX511006.16
    		 --
    		 75(a)
    74(a)
    		 1 ↔ many
    1 ↔ many
    		 18(19771126-19806075)
    7(35221111-35256121)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Su(var)2-101 , 3 chromosome condensation DNA binding3
    Suppressor of variegation 2-101    		 42(a)3
    47.64(n)1
    41.65(a)1    		   2 45A83
    359271  NM_165645.11  NP_724749.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea W10D5.3d3   -- 37(a)
    (best of 3)    		   I(9109234-9115598)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G415806
    SIZ16
    (see all 3)    		 E3 SUMO-protein ligase SIZ1
    (see all 3)    		 13(a)
    11(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 5(16626337-16630783)
    5(24294890-24301147)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 ATSIZ1/SIZ1, putative, expressed
    (see all 4)    		 20(a)
    12(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 7(14865142-14866597)
    3(29119839-29128018)


    ENSEMBL Gene Tree for PIAS1 (if available)
    TreeFam Gene Tree for PIAS1 (if available) 

    Paralogs
    for PIAS1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIAS1 gene
    PIAS32  ZMIZ22  PIAS22  ZMIZ12  PIAS42  
    5 SIMAP similar genes for PIAS1 using alignment to 9 protein entries:     PIAS1_HUMAN (see all proteins):
    DKFZp434O0617    PIAS2    PIAS3    PIAS4    DKFZp727A051

    PIAS1 for paralogs           About GeneDecksing



    Genomic Variants
    for PIAS1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2169 NCBI SNPs in PIAS1 are shown (see all 2169)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs801311341,2
    		C--68344847(+) TCTTGA/GCAATG 1 -- int12Minor allele frequency- G:0.09CSA WA 120
    rs1886546171,2
    		--68344848(+) CTTGAC/TAATGG 1 -- int10--------
    rs1916679631,2
    		--68344890(+) CATGAG/TCATAT 1 -- int10--------
    rs1837542391,2
    		--68345004(+) GAGGAA/GAAACC 1 -- int10--------
    rs1422012641,2
    		--68345116(+) ATTCGC/TGATTC 1 -- int10--------
    rs1881832821,2
    		--68345195(+) TCTTGA/GTAAGT 1 -- int10--------
    rs1806741661,2
    		--68345426(+) ATTCAA/GTTGAG 1 -- int10--------
    rs1179056731,2
    		F--68345525(+) AGGGAC/GTGGCC 1 -- int11Minor allele frequency- G:0.07EA 120
    rs1507279861,2
    		--68345558(+) ATTCAC/TAGCAA 1 -- int10--------
    rs1385954881,2
    		C--68345686(+) GGGTT-/GGGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PIAS1 (68346517 - 68483096 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for PIAS1
         7 CNVs: 5792 43913 23499 102124 39170 43517 61456
    Human Gene Mutation Database (HGMD): PIAS1

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    Disorders / Diseases
    for PIAS1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIAS1 for disorders           About GeneDecksing

    OMIM gene information: 603566    OMIM disorders: --

    15 diseases for PIAS1:    About MalaCards
    testicular germ cell cancer    hepatitis c    germ cell cancer    multiple sclerosis
    prostate cancer    colon carcinoma    colon cancer    gastric cancer
    hepatitis    lung cancer    prostatitis    cholesterol
    carcinoma    malaria    leukemia

    5 Novoseek disease relationships for PIAS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 23.1 2 14500761 (1)
    prostate cancer 22.1 2 14871982 (2)
    hepatitis c chronic 12.6 1 14699505 (1)
    tumors 7.15 7 14871982 (2), 15133049 (2), 15657437 (1), 18755518 (1)
    breast cancer 0 1 17717071 (1)

    Human Genome Epidemiology (HuGE) Navigator: PIAS1 (2 documents)

    Export disorders for PIAS1 gene to outside databases

    Publications
    for PIAS1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIAS1 gene, integrated from 9 sources (see all 162):
    (articles sorted by number of sources associating them with PIAS1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of Stat1-mediated gene activation by PIAS1. (PubMed id 9724754)1, 2, 3, 9 Liu B....Shuai K. (1998)
    2. Cloning and characterization of Gu/RH-II binding protein. (PubMed id 9177271)1, 2, 3 Valdez B.C....Busch H. (1997)
    3. Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. (PubMed id 17540171)1, 2, 9 Liu B....Shuai K. (2007)
    4. NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. (PubMed id 15133049)1, 2, 9 Okubo S.... Shindo H. (2004)
    5. Transcription factor Sp3 is silenced through SUMO modification by PIAS1. (PubMed id 12356736)1, 2, 9 Sapetschnig A.... Suske G. (2002)
    6. Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. (PubMed id 12393906)1, 2, 9 Miyauchi Y.... Yasuda H. (2002)
    7. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. (PubMed id 11867732)1, 2, 9 Schmidt D. and Mueller S. (2002)
    8. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PubMed id 12223491)1, 2, 9 Rui H.L....Lin S.C. (2002)
    9. Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. (PubMed id 10628744)1, 2, 9 Tan J.... French F.S. (2000)
    10. SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1. (PubMed id 17369852)1, 2 Jacobs A.M....Fuller-Pace F.V. (2007)

    External Searches for PIAS1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PIAS1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8554 HGNC: 2752 AceView: PIAS1 Ensembl:ENSG00000033800 euGenes: HUgn8554
    ECgene: PIAS1 Kegg: 8554 H-InvDB: PIAS1

    Other Databases showing PIAS1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PIAS1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIAS1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PIAS1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIAS1 gene:
    Search GeneIP for patents involving PIAS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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