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Aliases for PIAS1 Gene

Aliases for PIAS1 Gene

  • Protein Inhibitor Of Activated STAT 1 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Binding Protein 1 2 3
  • Protein Inhibitor Of Activated STAT Protein 1 3 4
  • Zinc Finger, MIZ-Type Containing 3 2 3
  • RNA Helicase II-Binding Protein 3 4
  • DEAD/H Box-Binding Protein 1 3 4
  • Gu-Binding Protein 3 4
  • DDXBP1 3 4
  • GBP 3 4
  • E3 SUMO-Protein Ligase PIAS1 3
  • AR Interacting Protein 3
  • EC 6.3.2.- 4
  • GU/RH-II 3
  • ZMIZ3 3

External Ids for PIAS1 Gene

Previous HGNC Symbols for PIAS1 Gene

  • DDXBP1

Previous GeneCards Identifiers for PIAS1 Gene

  • GC15P064182
  • GC15P061445
  • GC15P065925
  • GC15P066062
  • GC15P066133
  • GC15P068346
  • GC15P045180

Summaries for PIAS1 Gene

Entrez Gene Summary for PIAS1 Gene

  • This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for PIAS1 Gene

PIAS1 (Protein Inhibitor Of Activated STAT 1) is a Protein Coding gene. Diseases associated with PIAS1 include Testicular Germ Cell Cancer. Among its related pathways are Bacterial infections in CF airways and Interferon gamma signaling. GO annotations related to this gene include nucleic acid binding and ligase activity. An important paralog of this gene is PIAS3.

UniProtKB/Swiss-Prot for PIAS1 Gene

  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (atLys-65 and Lys-160) and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

Gene Wiki entry for PIAS1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIAS1 Gene

Genomics for PIAS1 Gene

Regulatory Elements for PIAS1 Gene

Enhancers for PIAS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G068275 1.7 Ensembl ENCODE dbSUPER 17.7 +225.2 225232 8.8 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 ENSG00000260657 SKOR1 PIAS1 CORO2B IQCH-AS1 NOX5 GC15M068298
GH15G068780 1.5 Ensembl ENCODE dbSUPER 17.2 +728.2 728208 3.2 SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF207 ZNF416 ZNF548 ZNF263 SP3 PIAS1 ANP32A MIR4312 CARSP1
GH15G067967 1.4 FANTOM5 Ensembl ENCODE 13 -85.7 -85737 1.5 PKNOX1 KLF1 BMI1 RAD21 ZFHX2 EGR1 POLR2A PATZ1 ZNF600 EGR2 PIAS1 LOC101929076 RNU6-1 SKOR1 ENSG00000260657 C15orf61 GC15M067974 GC15M067840
GH15G067060 1.7 Ensembl ENCODE dbSUPER 10.5 -988.0 -988026 11.0 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF263 SP3 TBX21 MEF2D ZNF610 ENSG00000260773 SKOR1 SMAD3 PIAS1 AAGAB IQCH LOC102723493 PIR44207
GH15G068524 1.7 FANTOM5 ENCODE dbSUPER 10 +471.2 471213 1.9 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KLF13 ZNF263 ITGA11 PIAS1 CORO2B GC15M068493
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIAS1 on UCSC Golden Path with GeneCards custom track

Promoters for PIAS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078431 921 2601 HDGF PKNOX1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for PIAS1 Gene

Chromosome:
15
Start:
68,054,179 bp from pter
End:
68,198,603 bp from pter
Size:
144,425 bases
Orientation:
Plus strand

Genomic View for PIAS1 Gene

Genes around PIAS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIAS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIAS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIAS1 Gene

Proteins for PIAS1 Gene

  • Protein details for PIAS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75925-PIAS1_HUMAN
    Recommended name:
    E3 SUMO-protein ligase PIAS1
    Protein Accession:
    O75925
    Secondary Accessions:
    • B2RB67
    • B3KSY9
    • C5J4B4
    • Q147X4
    • Q99751
    • Q9UN02

    Protein attributes for PIAS1 Gene

    Size:
    651 amino acids
    Molecular mass:
    71836 Da
    Quaternary structure:
    • Interacts with NCOA2 and AR. Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Interacts with DDX21, CSRP2, AXIN1, JUN, UBE2I, SUMO1, SATB2, PLAG1, TP53 and STAT1 (dimer), following IFNA1-stimulation. Interacts with SP3 (preferentially when SUMO-modified). Interacts with KLF8; the interaction results in SUMO ligation and repression of KLF8 transcriptional activity and of its cell cycle progression into G(1) phase. Interacts with STAT1. Interacts with CHUK/IKKA; this interaction induces PIAS1 phosphorylation. Interacts with PTK2/FAK1; the interaction promotes its sumoylation. Interacts with DDX5. Interacts with PML (By similarity). Interacts with MTA1.

    Three dimensional structures from OCA and Proteopedia for PIAS1 Gene

    Alternative splice isoforms for PIAS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIAS1 Gene

Post-translational modifications for PIAS1 Gene

  • Dimethylated by PRMT1 at Arg-303 in the late phase of interferon gamma (IFN-gamma) signaling, leading to preferential interaction with STAT1 and thus resulting in release of STAT1 from its target gene.
  • Sumoylated.
  • Ubiquitination at Lys8, Lys46, Lys339, and posLast=493493
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIAS1 (PIAS1)
  • Cloud-Clone Corp. Antibodies for PIAS1

No data available for DME Specific Peptides for PIAS1 Gene

Domains & Families for PIAS1 Gene

Gene Families for PIAS1 Gene

Protein Domains for PIAS1 Gene

Graphical View of Domain Structure for InterPro Entry

O75925

UniProtKB/Swiss-Prot:

PIAS1_HUMAN :
  • The LXXLL motif is a transcriptional coregulator signature.
  • Belongs to the PIAS family.
Domain:
  • The LXXLL motif is a transcriptional coregulator signature.
  • The SP-RING-type domain is required for promoting EKLF sumoylation.
Family:
  • Belongs to the PIAS family.
genes like me logo Genes that share domains with PIAS1: view

Function for PIAS1 Gene

Molecular function for PIAS1 Gene

UniProtKB/Swiss-Prot Function:
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (atLys-65 and Lys-160) and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (By similarity).

Enzyme Numbers (IUBMB) for PIAS1 Gene

Gene Ontology (GO) - Molecular Function for PIAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity NAS 15572661
GO:0003714 transcription corepressor activity TAS 10805787
GO:0005515 protein binding IPI 14752048
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with PIAS1: view
genes like me logo Genes that share phenotypes with PIAS1: view

Animal Models for PIAS1 Gene

MGI Knock Outs for PIAS1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIAS1 Gene

Localization for PIAS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIAS1 Gene

Nucleus speckle. Nucleus, PML body. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIAS1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PIAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 14752048
GO:0005654 nucleoplasm TAS --
GO:0016605 colocalizes_with PML body ISS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with PIAS1: view

Pathways & Interactions for PIAS1 Gene

genes like me logo Genes that share pathways with PIAS1: view

UniProtKB/Swiss-Prot O75925-PIAS1_HUMAN

  • Pathway: Protein modification; protein sumoylation.

SIGNOR curated interactions for PIAS1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PIAS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007259 JAK-STAT cascade TAS 10805787
genes like me logo Genes that share ontologies with PIAS1: view

Drugs & Compounds for PIAS1 Gene

(8) Drugs for PIAS1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PIAS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIAS1: view

Transcripts for PIAS1 Gene

Unigene Clusters for PIAS1 Gene

Protein inhibitor of activated STAT, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIAS1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5: - - - -
SP6: - - - - -
SP7: - - -
SP8:

ExUns: 19 ^ 20
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for PIAS1 Gene

GeneLoc Exon Structure for
PIAS1
ECgene alternative splicing isoforms for
PIAS1

Expression for PIAS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIAS1 Gene

mRNA differential expression in normal tissues according to GTEx for PIAS1 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for PIAS1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.2), Heart (15.6), Placenta (13.1), and Testis (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIAS1 Gene



Protein tissue co-expression partners for PIAS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIAS1 Gene:

PIAS1

SOURCE GeneReport for Unigene cluster for PIAS1 Gene:

Hs.162458

mRNA Expression by UniProt/SwissProt for PIAS1 Gene:

O75925-PIAS1_HUMAN
Tissue specificity: Expressed in numerous tissues with highest level in testis.

Evidence on tissue expression from TISSUES for PIAS1 Gene

  • Nervous system(4.8)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with PIAS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIAS1 Gene

Orthologs for PIAS1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIAS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIAS1 34 35
  • 99.8 (n)
dog
(Canis familiaris)
Mammalia PIAS1 34 35
  • 96.26 (n)
cow
(Bos Taurus)
Mammalia PIAS1 34 35
  • 95.55 (n)
oppossum
(Monodelphis domestica)
Mammalia PIAS1 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIAS1 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pias1 34
  • 91.81 (n)
mouse
(Mus musculus)
Mammalia Pias1 16 35 34
  • 90.68 (n)
chicken
(Gallus gallus)
Aves PIAS1 34 35
  • 85.96 (n)
lizard
(Anolis carolinensis)
Reptilia PIAS1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pias1 34
  • 77.43 (n)
Str.2277 34
African clawed frog
(Xenopus laevis)
Amphibia pias1-A 34
zebrafish
(Danio rerio)
Actinopterygii pias1b 35
  • 77 (a)
OneToMany
PIAS1 (1 of 2) 35
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Su(var)2-10 35 34 36
  • 51.57 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005031 34
  • 51.42 (n)
worm
(Caenorhabditis elegans)
Secernentea W10D5.3a 36
  • 37 (a)
W10D5.3d 36
  • 37 (a)
gei-17 35 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NFI1 35
  • 13 (a)
ManyToMany
SIZ1 35
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for PIAS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIAS1 Gene

ENSEMBL:
Gene Tree for PIAS1 (if available)
TreeFam:
Gene Tree for PIAS1 (if available)

Paralogs for PIAS1 Gene

Paralogs for PIAS1 Gene

genes like me logo Genes that share paralogs with PIAS1: view

Variants for PIAS1 Gene

Sequence variations from dbSNP and Humsavar for PIAS1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000041049 -- 68,058,185(+) GATGT(A/C)GCCTT intron-variant
rs1000047197 -- 68,128,880(+) TAAAT(C/G)TTAGA intron-variant
rs1000049113 -- 68,169,265(+) TTGCT(A/T)TTTGG intron-variant
rs1000061510 -- 68,153,132(+) TTGTC(A/G)TTTAA intron-variant
rs1000068296 -- 68,180,524(+) AATTC(-/TTGTT)TTATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIAS1 Gene

Variant ID Type Subtype PubMed ID
dgv1231n106 CNV deletion 24896259
dgv2615n100 CNV loss 25217958
dgv63n73 CNV deletion 24416366
esv1003872 CNV deletion 20482838
esv1172926 CNV deletion 17803354
esv2068352 CNV deletion 18987734
esv2596512 CNV deletion 19546169
esv2640694 CNV loss 19546169
esv2665979 CNV deletion 23128226
esv2670973 CNV deletion 23128226
esv2749813 CNV deletion 23290073
esv2749814 CNV deletion 23290073
esv2986 CNV loss 18987735
esv3224901 CNV deletion 24192839
esv3552606 CNV deletion 23714750
esv3636800 CNV loss 21293372
esv3636801 CNV loss 21293372
esv8835 CNV loss 19470904
esv994874 CNV deletion 20482838
nsv1037980 CNV loss 25217958
nsv1042724 CNV loss 25217958
nsv1069599 CNV deletion 25765185
nsv1120310 CNV tandem duplication 24896259
nsv1138383 CNV deletion 24896259
nsv1144739 CNV deletion 24896259
nsv1152960 CNV deletion 26484159
nsv1580 CNV deletion 18451855
nsv1581 CNV insertion 18451855
nsv498848 CNV loss 21111241
nsv512400 CNV loss 21212237
nsv517512 CNV gain 19592680
nsv521762 CNV gain 19592680
nsv569803 CNV gain 21841781
nsv569805 CNV loss 21841781
nsv94922 CNV deletion 16902084
nsv951980 CNV duplication 24416366
nsv951981 CNV duplication 24416366

Variation tolerance for PIAS1 Gene

Residual Variation Intolerance Score: 5.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIAS1 Gene

Human Gene Mutation Database (HGMD)
PIAS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIAS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIAS1 Gene

Disorders for PIAS1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIAS1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
testicular germ cell cancer
  • testicular germ cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search PIAS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIAS1

Genetic Association Database (GAD)
PIAS1
Human Genome Epidemiology (HuGE) Navigator
PIAS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIAS1
genes like me logo Genes that share disorders with PIAS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIAS1 Gene

Publications for PIAS1 Gene

  1. Inhibition of Stat1-mediated gene activation by PIAS1. (PMID: 9724754) Liu B. … Shuai K. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 22 64
  2. Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. (PMID: 17540171) Liu B. … Shuai K. (Cell 2007) 3 4 22 64
  3. NMR structure of the N-terminal domain of SUMO ligase PIAS1 and its interaction with tumor suppressor p53 and A/T-rich DNA oligomers. (PMID: 15133049) Okubo S. … Shindo H. (J. Biol. Chem. 2004) 3 4 22 64
  4. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. (PMID: 11867732) Schmidt D. … Mueller S. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 22 64
  5. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PMID: 12223491) Rui H.L. … Lin S.C. (J. Biol. Chem. 2002) 3 4 22 64

Products for PIAS1 Gene

Sources for PIAS1 Gene

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