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Aliases for PIANP Gene

Aliases for PIANP Gene

  • PILR Alpha Associated Neural Protein 2 3 5
  • PILR-Associating Neural Protein 2 3 4
  • Paired Immunoglobin-Like Type 2 Receptor-Associating Neural Protein 3 4
  • C12orf53 3 4
  • PANP 3 4
  • Liver Endothelial Differentiation-Associated Protein-1 3
  • Chromosome 12 Open Reading Frame 53 2
  • Leda-1 3
  • LEDA1 3

External Ids for PIANP Gene

Previous HGNC Symbols for PIANP Gene

  • C12orf53

Previous GeneCards Identifiers for PIANP Gene

  • GC12M006803

Summaries for PIANP Gene

Entrez Gene Summary for PIANP Gene

  • This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for PIANP Gene

PIANP (PILR Alpha Associated Neural Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PIANP Gene

  • Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIANP Gene

Genomics for PIANP Gene

Regulatory Elements for PIANP Gene

Enhancers for PIANP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIANP on UCSC Golden Path with GeneCards custom track

Promoters for PIANP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIANP on UCSC Golden Path with GeneCards custom track

Genomic Location for PIANP Gene

Chromosome:
12
Start:
6,690,934 bp from pter
End:
6,700,843 bp from pter
Size:
9,910 bases
Orientation:
Minus strand

Genomic View for PIANP Gene

Genes around PIANP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIANP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIANP Gene

Proteins for PIANP Gene

  • Protein details for PIANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYJ0-PIANP_HUMAN
    Recommended name:
    PILR alpha-associated neural protein
    Protein Accession:
    Q8IYJ0
    Secondary Accessions:
    • A8K0T3
    • B3KPF7
    • B3KRI6
    • Q6UX35

    Protein attributes for PIANP Gene

    Size:
    282 amino acids
    Molecular mass:
    30076 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PIANP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIANP Gene

Proteomics data for PIANP Gene at MOPED

Post-translational modifications for PIANP Gene

  • O-glycosylation at Thr-140 is essential for recognition by PILRA.
  • Glycosylation at Thr 140
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PIANP Gene

Domains & Families for PIANP Gene

Protein Domains for PIANP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIANP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIANP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIANP Gene

Function for PIANP Gene

Molecular function for PIANP Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.

Phenotypes for PIANP Gene

genes like me logo Genes that share phenotypes with PIANP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIANP Gene

Localization for PIANP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIANP Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIANP Gene COMPARTMENTS Subcellular localization image for PIANP gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PIANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane ISS --
genes like me logo Genes that share ontologies with PIANP: view

Pathways & Interactions for PIANP Gene

SuperPathways for PIANP Gene

No Data Available

Interacting Proteins for PIANP Gene

Gene Ontology (GO) - Biological Process for PIANP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PIANP Gene

Drugs & Compounds for PIANP Gene

No Compound Related Data Available

Transcripts for PIANP Gene

Unigene Clusters for PIANP Gene

PILR alpha associated neural protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIANP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for PIANP Gene

GeneLoc Exon Structure for
PIANP
ECgene alternative splicing isoforms for
PIANP

Expression for PIANP Gene

mRNA expression in normal human tissues for PIANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIANP Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.5), Brain - Putamen (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for PIANP Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIANP Gene



SOURCE GeneReport for Unigene cluster for PIANP Gene Hs.44067

mRNA Expression by UniProt/SwissProt for PIANP Gene

Q8IYJ0-PIANP_HUMAN
Tissue specificity: Mainly expressed in adult brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain.
genes like me logo Genes that share expression patterns with PIANP: view

Protein tissue co-expression partners for PIANP Gene

- Elite partner

Primer Products

Orthologs for PIANP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIANP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIANP 35
  • 91.3 (n)
  • 98.81 (a)
C5H12ORF53 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pianp 35
  • 89.13 (n)
  • 97.85 (a)
Pianp 16
Pianp 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIANP 35
  • 99.52 (n)
  • 100 (a)
C12ORF53 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pianp 35
  • 89.87 (n)
  • 98.24 (a)
dog
(Canis familiaris)
Mammalia PIANP 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIANP 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIANP 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF53 35
  • 69.43 (n)
  • 68.12 (a)
PIANP 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIANP 36
  • 52 (a)
OneToOne
Species with no ortholog for PIANP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIANP Gene

ENSEMBL:
Gene Tree for PIANP (if available)
TreeFam:
Gene Tree for PIANP (if available)

Paralogs for PIANP Gene

No data available for Paralogs for PIANP Gene

Variants for PIANP Gene

Sequence variations from dbSNP and Humsavar for PIANP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7134762 -- 6,700,574(+) GCCGG(C/G)CTCCC intron-variant, upstream-variant-2KB
rs7136090 -- 6,692,165(+) TTAGG(A/G)AGAGG utr-variant-3-prime
rs10849498 -- 6,695,736(+) GCCTC(A/G)CCCAG intron-variant
rs12819769 -- 6,692,776(+) ACACT(G/T)CCTCT intron-variant
rs7304875 -- 6,692,085(+) GTACA(A/G)TTCAG utr-variant-3-prime

Variation tolerance for PIANP Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for PIANP Gene

Disorders for PIANP Gene

Relevant External Links for PIANP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIANP

No disorders were found for PIANP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIANP Gene

Publications for PIANP Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization. (PMID: 23558288) Evdokimov K. … GAcraud C. (Biochem. Biophys. Res. Commun. 2013) 3
  3. PANP is a novel O-glycosylated PILRalpha ligand expressed in neural tissues. (PMID: 21241660) Kogure A. … Arase H. (Biochem. Biophys. Res. Commun. 2011) 3
  4. Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. (PMID: 20578158) GAcraud C. … Goerdt S. (Hepatology 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for PIANP Gene

Sources for PIANP Gene

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