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Aliases for PIANP Gene

Aliases for PIANP Gene

  • PILR Alpha Associated Neural Protein 2 3 5
  • PILR-Associating Neural Protein 2 3 4
  • Paired Immunoglobin-Like Type 2 Receptor-Associating Neural Protein 3 4
  • C12orf53 3 4
  • PANP 3 4
  • Liver Endothelial Differentiation-Associated Protein-1 3
  • PILR Alpha-Associated Neural Protein 3
  • Chromosome 12 Open Reading Frame 53 2
  • Leda-1 3
  • LEDA1 3

External Ids for PIANP Gene

Previous HGNC Symbols for PIANP Gene

  • C12orf53

Previous GeneCards Identifiers for PIANP Gene

  • GC12M006803

Summaries for PIANP Gene

Entrez Gene Summary for PIANP Gene

  • This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011]

GeneCards Summary for PIANP Gene

PIANP (PILR Alpha Associated Neural Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PIANP Gene

  • Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIANP Gene

Genomics for PIANP Gene

Regulatory Elements for PIANP Gene

Enhancers for PIANP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F006777 1.4 Ensembl ENCODE 10.8 -78.4 -78425 3.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 CD4 GPR162 P3H3 ZNF384 ENSG00000219410 ING4 PIANP ACRBP LPAR5 ENSG00000255966
GH12F006643 1.4 Ensembl ENCODE 8.7 +56.5 56543 2.6 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PIANP ACRBP LPAR5
GH12F006213 1.9 FANTOM5 Ensembl ENCODE 5.8 +476.1 476050 23.4 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ENSG00000219410 CD9 ENSG00000247853 NCAPD2 SPSB2 GNB3 C1RL-AS1 ENSG00000256967 PLEKHG6 VWF
GH12F006783 0.9 Ensembl ENCODE 10.5 -85.0 -84958 4.4 HLF ZNF223 MAFG KAT2B ZNF121 ZFHX2 ZNF316 MAFF ZNF341 CUX1 CD4 GPR162 P3H3 ZNF384 ENSG00000219410 ING4 ACRBP PIANP LPAR5 ENSG00000255966
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIANP on UCSC Golden Path with GeneCards custom track

Promoters for PIANP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000172124 343 1001 KLF1 ZNF76 SIN3A KLF17 ZNF48 ZIC2 GLIS2 ZBTB48 POLR2A ZNF366

Genomic Location for PIANP Gene

6,690,934 bp from pter
6,700,843 bp from pter
9,910 bases
Minus strand

Genomic View for PIANP Gene

Genes around PIANP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIANP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIANP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIANP Gene

Proteins for PIANP Gene

  • Protein details for PIANP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PILR alpha-associated neural protein
    Protein Accession:
    Secondary Accessions:
    • A8K0T3
    • B3KPF7
    • B3KRI6
    • Q6UX35

    Protein attributes for PIANP Gene

    282 amino acids
    Molecular mass:
    30076 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PIANP Gene


neXtProt entry for PIANP Gene

Post-translational modifications for PIANP Gene

  • O-glycosylation at Thr-140 is essential for recognition by PILRA.
  • Glycosylation at Thr 140
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PIANP Gene

Domains & Families for PIANP Gene

Protein Domains for PIANP Gene


Suggested Antigen Peptide Sequences for PIANP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIANP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIANP Gene

Function for PIANP Gene

Molecular function for PIANP Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.

Phenotypes for PIANP Gene

genes like me logo Genes that share phenotypes with PIANP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIANP Gene

Localization for PIANP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIANP Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIANP gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PIANP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005912 adherens junction ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane ISS --
genes like me logo Genes that share ontologies with PIANP: view

Pathways & Interactions for PIANP Gene

SuperPathways for PIANP Gene

No Data Available

Interacting Proteins for PIANP Gene

Gene Ontology (GO) - Biological Process for PIANP Gene


No data available for Pathways by source and SIGNOR curated interactions for PIANP Gene

Transcripts for PIANP Gene

Unigene Clusters for PIANP Gene

PILR alpha associated neural protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIANP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for PIANP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIANP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIANP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIANP Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.5), Brain - Putamen (basal ganglia) (x4.8), Brain - Frontal Cortex (BA9) (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.2), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for PIANP Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIANP Gene

Protein tissue co-expression partners for PIANP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIANP Gene:


SOURCE GeneReport for Unigene cluster for PIANP Gene:


mRNA Expression by UniProt/SwissProt for PIANP Gene:

Tissue specificity: Mainly expressed in adult brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain.
genes like me logo Genes that share expression patterns with PIANP: view

Orthologs for PIANP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIANP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C12ORF53 35
  • 100 (a)
  • 99.52 (n)
(Bos Taurus)
Mammalia C5H12ORF53 35
  • 98 (a)
  • 91.3 (n)
(Canis familiaris)
Mammalia PIANP 35
  • 96 (a)
(Monodelphis domestica)
Mammalia PIANP 35
  • 91 (a)
(Rattus norvegicus)
Mammalia Pianp 34
  • 89.87 (n)
(Mus musculus)
Mammalia Pianp 34 16 35
  • 89.13 (n)
(Ornithorhynchus anatinus)
Mammalia PIANP 35
  • 80 (a)
(Gallus gallus)
Aves C1H12ORF53 34
  • 69.43 (n)
  • 63 (a)
(Anolis carolinensis)
Reptilia PIANP 35
  • 52 (a)
Species where no ortholog for PIANP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIANP Gene

Gene Tree for PIANP (if available)
Gene Tree for PIANP (if available)

Paralogs for PIANP Gene

No data available for Paralogs for PIANP Gene

Variants for PIANP Gene

Sequence variations from dbSNP and Humsavar for PIANP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10444482 -- 6,691,661(+) TCCAT(C/T)TTGAA utr-variant-3-prime
rs10849498 -- 6,695,736(+) GCCTC(A/G)CCCAG intron-variant
rs11064316 -- 6,691,835(+) GGTGA(C/T)GAGAC utr-variant-3-prime
rs11064317 -- 6,691,963(+) TCTCA(A/T)AGCCC utr-variant-3-prime
rs11064318 -- 6,692,828(+) CTTCC(C/T)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIANP Gene

Variant ID Type Subtype PubMed ID
esv2761725 CNV gain 21179565
esv3580394 CNV gain 25503493
nsv832322 CNV loss 17160897
nsv832323 CNV loss 17160897

Variation tolerance for PIANP Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIANP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIANP Gene

Disorders for PIANP Gene

Relevant External Links for PIANP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PIANP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIANP Gene

Publications for PIANP Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. PANP is a novel O-glycosylated PILRalpha ligand expressed in neural tissues. (PMID: 21241660) Kogure A. … Arase H. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization. (PMID: 23558288) Evdokimov K. … GAcraud C. (Biochem. Biophys. Res. Commun. 2013) 3 64
  5. Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. (PMID: 20578158) GAcraud C. … Goerdt S. (Hepatology 2010) 3 64

Products for PIANP Gene

Sources for PIANP Gene

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