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SERPINB5 Gene

protein-coding GIFtS: 62

GC18P059297

serpin peptidase inhibitor, clade B (ovalbumin), member 5
(Previous names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PI5)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
Maspin ^³
PI5 ^², ³, ⁵
maspin ^¹, ²

Descriptions
Protease inhibitor 5 ^³
protease inhibitor 5 (maspin) ^²
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 ^¹, ²
serpin peptidase inhibitor, clade B (ovalbumin), member 5 ^²

External Ids
HGNC: 8949¹
Entrez Gene: 5268²
UniProtKB: P36952³
Ensembl: ENSG00000206075⁷

Search outside databases for aliases for SERPINB5 gene

Previous GC identifers: GC18P060982 GC18P061117 GC18P059293

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary

tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition

characteristic of active serpins, it exhibits no serine protease inhibitory activity

Gene Wiki entry for SERPINB5 (Maspin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SERPINB5 gene

Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.33 HGNC cytogenetic band: 18q21.3

SERPINB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P059297: (about GC identifiers)

Start:	59,295,199 bp from pter
End:	59,323,297 bp from pter
Size:	28,099 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_025028.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952 (See protein sequence)

Recommended Name: Serpin B5

Size: 375 amino acids; 42100 Da

Subcellular location: Secreted, extracellular space

PDB structures from and Proteopedia :

1WZ9 (3D)

1XQG (3D)

1XQJ (3D)

1XU8 (3D)

Secondary accessions: B2R6Y4 Q6N0B4 Q8WW89

Alternative splicing: 2 isoforms: P36952-1 P36952-2

REFSEQ proteins: NP_002630.2

ENSEMBL proteins:

ENSP00000372221

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MASPIN)
	Human Recombinant Proteins from Abnova (SERPINB5)

OriGene Purified Recombinant Human Protein: SERPINB5

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

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Antibodies for SERPINB5:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SERPINB5
	Sigma-Aldrich Antibodies for SERPINB5
	R&D Systems Antibodies for SERPINB5 (Serpin B5/Maspin)
	Antibodies from Abcam (MASPIN), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for SERPINB5

Assays for SERPINB5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P36952

ProtoNet protein and cluster: P36952

2 Blocks protein families:

IPB000215 Serpin

IPB000240 Maspin signature

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Similarity: Belongs to the serpin family. Ov-serpin subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SERPINB5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC020713

Applied Biosystems Silencer® siRNAs for SERPINB5

Sigma-Aldrich siRNA and siRNA Panels for SERPINB5

Sigma-Aldrich shRNA Panels and shRNA for SERPINB5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SERPINB5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002639
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002639
untagged cDNA clones in CMV expression vector (see all 2): BC020713

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002639

UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952

Function: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary

tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition

characteristic of active serpins, it exhibits no serine protease inhibitory activity

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Serpinb5):

cellular

embryogenesis

lethality-prenatal/perinatal

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for SERPINB5 (Your Favorite Gene powered by Ingenuity)

p53 Signaling

GeneDecks SERPINB5 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for SERPINB5

5/19 Interacting proteins for SERPINB5 (ENSP00000372221³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFSF11	ENSP00000239849³	STRING (score=.972)
TP53	ENSP00000269305³	STRING (score=.965)
PLAU	ENSP00000361848³	STRING (score=.957)
HDAC1	ENSP00000362649³	STRING (score=.913)
PLAT	ENSP00000220809³	STRING (score=.901)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cell motion	TAS	8290962

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SERPINB5
9 Novoseek chemical compound relationships for SERPINB5 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
scca1	68.75	4	14647462 (2), 9817977 (1)
matrigel	43.23	3	11601042 (1), 9433491 (1), 8814994 (1)
cytosine	21.05	10	10709100 (4), 16457875 (2), 14670180 (1), 12789271 (1)
p002	17.34	3	16918974 (1), 17174141 (1), 14647462 (1)
p005	5.18	1	14647462 (1)
lipid	1.78	2	12813462 (1), 12707024 (1)
nitric oxide	0.00	25	12707024 (5), 19147537 (5), 16546864 (3), 10936673 (1) (see all 5)
steroid	0.00	1	16625090 (1)
progesterone	0.00	2	16625090 (1), 16614520 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SERPINB5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC020713

Sigma-Aldrich siRNA and siRNA Panels for SERPINB5

Sigma-Aldrich shRNA Panels and shRNA for SERPINB5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002639

REFSEQ mRNAs for SERPINB5 gene:

NM_002639.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002639

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002639
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002639
                                 untagged cDNA clones in CMV expression vector (see all 2): BC020713

Additional cDNA sequence:

AF086216.1 AK301667.1 AK312765.1 BC020713.1 BX640597.1 U04313.1

8 DOTS entries:

DT.97838665 DT.212509 DT.100664178 DT.121103123 DT.95160144 DT.95262537 DT.91674020 DT.121103126

24/54 AceView cDNA sequences (see all 54 ):

CB140067 BX282484 BG677096 BG741238 CB144455 AL602554 CB122363 BQ228585

CB119707 CA429745 AA294992 BU685516 BQ217236 CB122679 BC020713 AL703138

BF056445 BM955647 AW951580 AL701226 BM821493 CB122437 U04313 AL602439

highest scoring ESTs for SERPINB5:

U04313 AI633911 AI656426 AI656538 BE122695 BF056445 BF737955 BG285760 BG677096 BG682023

Unigene Cluster for SERPINB5:

Serpin peptidase inhibitor, clade B (ovalbumin), member 5

Hs.55279 [show with all ESTs]

Unigene Representative Sequence: BX640597

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000382771

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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SERPINB5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SERPINB5

¹ / ² / ³

7 probe-sets matching SERPINB5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
863_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.18	U04313	1.00	0.90	0.95	1
862_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.87	U04313	1.00	0.90	0.95	1
204855_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002639	0.60	1.00	0.82	1
234675_x_at²	U133-B	17	0.55	0.14	--	--	--	--	--	--	--
1555551_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204855_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
234675_x_at²	U133Plus2	17	0.55	0.14	--	--	--	--	--	--	--

GeneDecks SERPINB5 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CATTGTAAAT

SOURCE GeneReport for Unigene cluster: Hs.55279
Expression variation in blood from EXPOLDB for SERPINB5
UniProtKB/Swiss-Prot: SPB5_HUMAN, P36952
Tissue specificity: Normal mammary epithelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SERPINB5 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SERPINB5¹	--	serpin peptidase inhibitor, clade B (ovalbumin), member more	90.2(n) 92.51(a)	476177 XM_533382.2 XP_533382.2
chimpanzee (Pan troglodytes)	SERPINB5¹	--	serpin peptidase inhibitor, clade B (ovalbumin), member more	99.47(n) 99.2(a)	468566 XM_523955.2 XP_523955.2
cow (Bos taurus)	SERPINB5¹	--	serpin peptidase inhibitor, clade B (ovalbumin), member more	89.13(n) 88.77(a)	534323 XM_614054.3 XP_614054.3
rat (Rattus norvegicus)	Serpinb5¹	--	serine (or cysteine) peptidase inhibitor, clade B, more	85.96(n) 88(a)	116589 NM_057108.1 NP_476449.1
mouse (Mus musculus)	Serpinb5^{1, 5}	1⁵	serine (or cysteine) peptidase inhibitor, clade B, more^{1, 5}	86.58(n)¹ 89.07(a)¹	20724¹ NM_009257.3¹ NP_033283.1¹ AI462524⁵ AI646751⁵ (see all 10)

About this table Species with no ortholog for SERPINB5

ENSEMBL Gene Tree for SERPINB5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SERPINB5 gene

SERPINC1² SERPINH1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/277 NCBI SNPs in SERPINB5 are shown (see all 277 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 150)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11152386^1,2	A,C,F,H	59323213(-)	`ATGCAT/GGTCAA`	1	--	ut3¹ ese³		5	EU EA WA MN	592
	rs11659680^1,2	A,C,F,H	59294149(+)	`AGCTCC/TGTTTC`	1	--	ng5¹		16	EU EA WA NA	1456
	rs3744941^1,2	A,C,F,H	59295033(+)	`ATCATC/TTCTTT`	1	--	ng5¹		15	NA EU EA WA	1400
	rs7244369^1,2	A,C,F,H	59293627(+)	`tgaagC/Ataaag`	1	--	ng5¹		4	EU EA WA	392
	rs1455555^1,2	C,F,H,O	59321762(-)	`GTGGAT/CAACAT`	1	V/I	mis¹		15	MN EU EA WA NA	2936
	rs2289520^1,2	C,F,H	59311300(+)	`TCAGAG/CTCAAC`	1	L/V	mis¹		13	EA NA EU WA	2550
	rs2289519^1,2	C,F,H	59311267(+)	`AATTTC/TCTGAA`	1	S/P	mis¹ ese³		9	EU EA WA NA	910
	rs17071220^1,2	C,F,H	59322883(+)	`TGACTC/TGCACA`	1	--	ut3¹ ese³		16	NA EA EU WA	1456
	rs3744940^1,2	C,F,H	59295014(+)	`AACAGC/TAACTT`	1	--	ng5¹		3	EA WA	298
	rs17071138^1,2	C,F,H	59294888(+)	`GAATAT/CTTCAC`	1	--	ng5¹		11	NA EU EA WA	976

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HapMap Linkage Disequilibrium images for SERPINB5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 154790

10/62 Novoseek disease relationships for SERPINB5 gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	67.04	122	17352241 (6), 18367129 (5), 12507299 (4), 16540429 (4) (see all 79)
tumors	66.64	443	17396143 (8), 16799655 (7), 12011991 (7), 12425757 (6) (see all 99)
breast cancer	63.58	134	12493023 (8), 16491398 (7), 11440731 (7), 12220518 (6) (see all 57)
myoepithelioma	63.24	2	12610349 (1), 11795829 (1)
carcinoma	60.51	84	15009909 (5), 18236066 (5), 15608662 (4), 17936671 (4) (see all 38)
prostate cancer	59.48	73	12006534 (6), 18931702 (6), 19285254 (6), 17458898 (4) (see all 33)
adenoma follicular	54.86	4	12964023 (1), 15009909 (1), 16892558 (1), 14532972 (1)
breast carcinoma	53.80	10	9865722 (2), 12425757 (1), 12231537 (1), 11596016 (1) (see all 7)
cancer	53.58	93	9299418 (3), 14991928 (3), 11309327 (2), 15872371 (2) (see all 58)
carcinoma ductal	50.51	13	12786889 (6), 12425757 (1), 15256060 (1), 12493023 (1) (see all 5)

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Human Gene Mutation Database: SERPINB5

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/286 PubMed articles for SERPINB5 gene (see all 286 ):

Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. (PubMed id 8290962)^{1, 2, 3, 4} Zou Z.... Sager R. (1994)
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. (PubMed id 15760906)^{1, 3, 4} Law R.H.... Whisstock J.C. (2005)
The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin. (PubMed id 7797587)^{1, 3, 4} Pemberton P.A.... Barr P.J. (1995)
Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells. (PubMed id 16720730)^{1, 2, 3} Cella N....Zhang M. (2006)
A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PubMed id 7724531)^{1, 2, 3} Schneider S.S....Silverman G.A. (1995)
The paradoxical expression of maspin in ovarian carcinoma. (PubMed id 12231537)^{1, 3} Sood A.K....Hendrix M.J. (2002)
Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer. (PubMed id 14991928)^{1, 3} Wang M.C....Li Y. (2004)
Tamoxifen induces the expression of maspin through estrogen receptor-alpha. (PubMed id 15145521)^{1, 3} Liu Z....Zhang M. (2004)
Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. (PubMed id 11751384)^{1, 3} Biliran H. and Sheng S. (2001)
Maspin and p53 protein expression in gastric adenocarcinoma and its clinical applications. (PubMed id 18091326)^{1, 3} Lee D.Y....Lee S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5268	HGNC: 8949	AceView: SERPINB5	Ensembl:ENSG00000206075	euGenes: HUgn5268
ECgene: SERPINB5	H-InvDB: SERPINB5

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for SERPINB5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SERPINB5
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SERPINB5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SERPINB5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SERPINB5		Antibodies for SERPINB5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SERPINB5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SERPINB5)
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	Antibodies (MASPIN)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for SERPINB5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SERPINB5

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SERPINB5 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for SERPINB5

Summaries
for SERPINB5

Genomic Location
for SERPINB5

Proteins
for SERPINB5

Protein Domains/
Families
for SERPINB5

Gene Function
for SERPINB5

Pathways & Interactions
for SERPINB5

Drugs & Compounds
for SERPINB5

Transcripts
for SERPINB5

Expression
for SERPINB5

Orthologs
for SERPINB5

Paralogs
for SERPINB5

SNPs/Variants
for SERPINB5

Disorders & Mutations
for SERPINB5

Medical News
for SERPINB5

Publications
for SERPINB5

Search for SERPINB5

Genome Databases showing SERPINB5

Other Databases showing SERPINB5

Specialized Databases showing SERPINB5

Licensable Technologies
for SERPINB5

Services
for SERPINB5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SERPINB5 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor SERPINB5

Summariesfor SERPINB5

Genomic Locationfor SERPINB5

Proteinsfor SERPINB5

Protein Domains/Familiesfor SERPINB5

Gene Functionfor SERPINB5

Pathways & Interactionsfor SERPINB5

Drugs & Compoundsfor SERPINB5

Transcriptsfor SERPINB5

Expression for SERPINB5

Orthologsfor SERPINB5

Paralogsfor SERPINB5

SNPs/Variantsfor SERPINB5

Disorders & Mutationsfor SERPINB5

Medical Newsfor SERPINB5

Publicationsfor SERPINB5

Search for SERPINB5

Genome Databases showing SERPINB5

Other Databases showing SERPINB5

Specialized Databases showing SERPINB5

Licensable Technologiesfor SERPINB5

Servicesfor SERPINB5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SERPINB5

Summaries
for SERPINB5

Genomic Location
for SERPINB5

Proteins
for SERPINB5

Protein Domains/
Families
for SERPINB5

Gene Function
for SERPINB5

Pathways & Interactions
for SERPINB5

Drugs & Compounds
for SERPINB5

Transcripts
for SERPINB5

Expression
for SERPINB5

Orthologs
for SERPINB5

Paralogs
for SERPINB5

SNPs/Variants
for SERPINB5

Disorders & Mutations
for SERPINB5

Medical News
for SERPINB5

Publications
for SERPINB5

Licensable Technologies
for SERPINB5

Services
for SERPINB5