Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PI4K2B Gene

Aliases for PI4K2B Gene

  • Phosphatidylinositol 4-Kinase Type 2 Beta 2 3 5
  • Phosphatidylinositol 4-Kinase Type II-Beta 3 4
  • PI4KII-BETA 3 4
  • EC 2.7.1.67 4 63
  • Phosphatidylinositol 4-Kinase Type-II Beta 3
  • PI4KIIB 3
  • PIK42B 3

External Ids for PI4K2B Gene

Previous GeneCards Identifiers for PI4K2B Gene

  • GC04U990105
  • GC04P025319
  • GC04P024924
  • GC04P024986
  • GC04P024911
  • GC04P024844
  • GC04P025236
  • GC04P024575
  • GC04P025163

Summaries for PI4K2B Gene

Entrez Gene Summary for PI4K2B Gene

  • Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]

GeneCards Summary for PI4K2B Gene

PI4K2B (Phosphatidylinositol 4-Kinase Type 2 Beta) is a Protein Coding gene. Among its related pathways are Metabolism and PI Metabolism. GO annotations related to this gene include kinase activity and 1-phosphatidylinositol 4-kinase activity. An important paralog of this gene is PI4K2A.

UniProtKB/Swiss-Prot for PI4K2B Gene

  • Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

Gene Wiki entry for PI4K2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI4K2B Gene

Genomics for PI4K2B Gene

Regulatory Elements for PI4K2B Gene

Enhancers for PI4K2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PI4K2B on UCSC Golden Path with GeneCards custom track

Promoters for PI4K2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PI4K2B on UCSC Golden Path with GeneCards custom track

Genomic Location for PI4K2B Gene

Chromosome:
4
Start:
25,233,975 bp from pter
End:
25,279,209 bp from pter
Size:
45,235 bases
Orientation:
Plus strand

Genomic View for PI4K2B Gene

Genes around PI4K2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI4K2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI4K2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI4K2B Gene

Proteins for PI4K2B Gene

  • Protein details for PI4K2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCG2-P4K2B_HUMAN
    Recommended name:
    Phosphatidylinositol 4-kinase type 2-beta
    Protein Accession:
    Q8TCG2
    Secondary Accessions:
    • Q9NUW2

    Protein attributes for PI4K2B Gene

    Size:
    481 amino acids
    Molecular mass:
    54744 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PI4K2B Gene

neXtProt entry for PI4K2B Gene

Proteomics data for PI4K2B Gene at MOPED

Post-translational modifications for PI4K2B Gene

  • Ubiquitination at Lys 137, Lys 161, Lys 272, Lys 352, and Lys 411
  • Modification sites at PhosphoSitePlus

Other Protein References for PI4K2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PI4K2B Gene

Gene Families for PI4K2B Gene

Protein Domains for PI4K2B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TCG2

UniProtKB/Swiss-Prot:

P4K2B_HUMAN :
  • Contains 1 PI3K/PI4K domain.
  • Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
Domain:
  • Contains 1 PI3K/PI4K domain.
Family:
  • Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
genes like me logo Genes that share domains with PI4K2B: view

Function for PI4K2B Gene

Molecular function for PI4K2B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Recruited and activated by membrane association. Binding to the microsomal membrane has been shown to enhance its activity.
UniProtKB/Swiss-Prot Function:
Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

Enzyme Numbers (IUBMB) for PI4K2B Gene

genes like me logo Genes that share phenotypes with PI4K2B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PI4K2B

miRNA for PI4K2B Gene

miRTarBase miRNAs that target PI4K2B

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI4K2B Gene

Localization for PI4K2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI4K2B Gene

Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PI4K2B Gene COMPARTMENTS Subcellular localization image for PI4K2B gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PI4K2B Gene

Pathways & Interactions for PI4K2B Gene

genes like me logo Genes that share pathways with PI4K2B: view

Gene Ontology (GO) - Biological Process for PI4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PI4K2B: view

No data available for SIGNOR curated interactions for PI4K2B Gene

Drugs & Compounds for PI4K2B Gene

(2) Drugs for PI4K2B Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist, agonist 384
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with PI4K2B: view

Transcripts for PI4K2B Gene

mRNA/cDNA for PI4K2B Gene

Unigene Clusters for PI4K2B Gene

Phosphatidylinositol 4-kinase type 2 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PI4K2B Gene

No ASD Table

Relevant External Links for PI4K2B Gene

GeneLoc Exon Structure for
PI4K2B
ECgene alternative splicing isoforms for
PI4K2B

Expression for PI4K2B Gene

mRNA expression in normal human tissues for PI4K2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PI4K2B Gene

This gene is overexpressed in Cervix (33.5) and Breast (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PI4K2B Gene



SOURCE GeneReport for Unigene cluster for PI4K2B Gene Hs.191701

mRNA Expression by UniProt/SwissProt for PI4K2B Gene

Q8TCG2-P4K2B_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with PI4K2B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PI4K2B Gene

Orthologs for PI4K2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PI4K2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PI4K2B 35
  • 88.09 (n)
  • 84.14 (a)
PI4K2B 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PI4K2B 35
  • 91.92 (n)
  • 90.72 (a)
PI4K2B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pi4k2b 35
  • 84.23 (n)
  • 82.14 (a)
Pi4k2b 16
Pi4k2b 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PI4K2B 35
  • 98.73 (n)
  • 98.09 (a)
PI4K2B 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pi4k2b 35
  • 83.3 (n)
  • 80.42 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PI4K2B 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves PI4K2B 35
  • 76.09 (n)
  • 77.6 (a)
PI4K2B 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PI4K2B 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pi4k2b 35
  • 72.78 (n)
  • 76.47 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11769 35
zebrafish
(Danio rerio)
Actinopterygii pi4k2b 35
  • 73.39 (n)
  • 79.59 (a)
pi4k2b 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pi4KIIalpha 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZC8.6 36
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR087W 35
  • 50.17 (n)
  • 45.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F14080g 35
  • 53.46 (n)
  • 48.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LSB6 35
  • 52.56 (n)
  • 44.87 (a)
LSB6 36
  • 25 (a)
OneToMany
LSB6 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4109 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04355 35
  • 51.08 (n)
  • 45.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes lsb6 35
  • 52.55 (n)
  • 42.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2475 36
  • 60 (a)
OneToMany
Species with no ortholog for PI4K2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PI4K2B Gene

ENSEMBL:
Gene Tree for PI4K2B (if available)
TreeFam:
Gene Tree for PI4K2B (if available)

Paralogs for PI4K2B Gene

Paralogs for PI4K2B Gene

(1) SIMAP similar genes for PI4K2B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for PI4K2B Gene

genes like me logo Genes that share paralogs with PI4K2B: view

Variants for PI4K2B Gene

Sequence variations from dbSNP and Humsavar for PI4K2B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_031974 -
rs13457 -- 25,278,815(-) TATGG(C/T)AATTC utr-variant-3-prime
rs182597 -- 25,246,945(+) gaact(C/T)gcgct intron-variant
rs220375 -- 25,257,157(+) GGCTC(A/G)GATAA intron-variant
rs515809 -- 25,265,334(+) TTATT(A/T)AATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PI4K2B Gene

Variant ID Type Subtype PubMed ID
esv2662257 CNV Deletion 23128226
esv2727308 CNV Deletion 23290073
nsv518834 CNV Loss 19592680
nsv524925 CNV Loss 19592680

Variation tolerance for PI4K2B Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PI4K2B Gene

Disorders for PI4K2B Gene

Relevant External Links for PI4K2B

Genetic Association Database (GAD)
PI4K2B
Human Genome Epidemiology (HuGE) Navigator
PI4K2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PI4K2B

No disorders were found for PI4K2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI4K2B Gene

Publications for PI4K2B Gene

  1. Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments. (PMID: 11923287) Balla A. … Balla T. (J. Biol. Chem. 2002) 2 3 4 67
  2. A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B. (PMID: 19539307) Houlihan L.M. … Evans K.L. (J Psychiatr Res 2009) 3 23
  3. Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity. (PMID: 18316730) Griffioen M. … Falkenburg J.H. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. The high-resolution crystal structure of phosphatidylinositol 4-kinase III^ and the crystal structure of phosphatidylinositol 4-kinase III+ containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design. (PMID: 26143926) Klima M. … Boura E. (Acta Crystallogr. D Biol. Crystallogr. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PI4K2B Gene

Sources for PI4K2B Gene

Content