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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PI3 Gene

protein-coding   GIFtS: 57
GCID: GC20P043803

Peptidase Inhibitor 3, Skin-Derived

(Previous names: protease inhibitor 3, skin-derived (SKALP))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidase Inhibitor 3, Skin-Derived1 2     WAP32 3
Skin-Derived Antileukoproteinase1 2 3     WFDC142 3
Protease Inhibitor 3, Skin-Derived (SKALP)1 2     WAP Four-Disulfide Core Domain Protein 142 3
trappin-21 2     cementoin2
Elastase-Specific Inhibitor2 3     elafin2
Protease Inhibitor WAP32 3     pre-elafin2
ESI2 3     WAP Four-Disulfide Core Domain 142
PI-32 3     Peptidase Inhibitor 33
SKALP2 3     

External Ids:    HGNC: 89471   Entrez Gene: 52662   Ensembl: ENSG000001241027   OMIM: 1822575   UniProtKB: P199573   

Export aliases for PI3 gene to outside databases

Previous GC identifers: GC20P043531 GC20P044441 GC20P044489 GC20P044490 GC20P043236 GC20P040545


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PI3 Gene:
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive
and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a
member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters:
centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by
bacterial lipopolysaccharides and cytokines. (provided by RefSeq, Oct 2008)

GeneCards Summary for PI3 Gene: 
PI3 (peptidase inhibitor 3, skin-derived) is a protein-coding gene. Diseases associated with PI3 include impetigo herpetiformis, and impetigo. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: ELAF_HUMAN, P19957
Function: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue
proteolysis

Gene Wiki entry for PI3 (Elafin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PI3 gene promoter:
         GR   C/EBPbeta   p53   GR-beta   GR-alpha   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPI3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PI3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

PI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PI3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043803:  view genomic region     (about GC identifiers)

Start:
43,803,517 bp from pter      End:
43,805,185 bp from pter
Size:
1,669 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ELAF_HUMAN, P19957 (See protein sequence)
Recommended Name: Elafin precursor  
Size: 117 amino acids; 12270 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for PI3:
1FLE (3D)        2REL (3D)    
Secondary accessions: E1P618 Q6FG74

Explore the universe of human proteins at neXtProt for PI3: NX_P19957

Explore proteomics data for PI3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P19957

  • PI3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PI3 Protein Expression
    REFSEQ proteins: NP_002629.1  
    ENSEMBL proteins: 
     ENSP00000243924  

    Human Recombinant Protein Products for PI3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for PI3 (Trappin-2/Elafin)
    Enzo Life Sciences proteins for PI3
    OriGene Purified Protein for PI3
    OriGene Protein Over-expression Lysate for PI3
    OriGene MassSpec for PI3 
    OriGene Custom Protein Services for PI3
    GenScript Custom Purified and Recombinant Proteins Services for PI3
    Novus Biologicals PI3 Proteins
    Novus Biologicals PI3 Lysates
    Sino Biological Recombinant Protein for PI3
    Sino Biological Cell Lysate for PI3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PI3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005578proteinaceous extracellular matrix TAS8476637

    PI3 for ontologies           About GeneDecksing



    PI3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PI3 (Trappin-2/Elafin)
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    GenScript Superior Antibodies for PI3
    Novus Biologicals PI3 Antibodies
    Abcam antibodies for PI3
    Cloud-Clone Corp. Antibodies for PI3 
    Search ThermoFisher Antibodies for PI3
    LSBio Antibodies in human, mouse, rat for PI3 

    Assay Products for PI3: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for PI3 (Trappin-2/Elafin)
    GenScript Custom Assay Services for PI3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PI3 
    Cloud-Clone Corp. CLIAs for PI3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WFDC: WAP four-disulfide core domain containing

    3 InterPro protein domains:
     IPR002098 SVP_I
     IPR008197 WAP-type_4-diS_core
     IPR019541 Trappin_transglut-bd_rpt

    Graphical View of Domain Structure for InterPro Entry P19957

    ProtoNet protein and cluster: P19957

    1 Blocks protein domain: IPB008197 4-disulphide core signature

    UniProtKB/Swiss-Prot: ELAF_HUMAN, P19957
    Domain: Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase
    inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to
    specific sites on extracellular matrix proteins
    Similarity: Contains 1 WAP domain


    PI3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ELAF_HUMAN, P19957
    Function: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue
    proteolysis

         Genatlas biochemistry entry for PI3:
    elafin,serine proteinase inhibitor,epidermal,member of the troppin family,induced in epidermis by cellular
    stress,involved in the regulation of inflammation and in protection against tissue damage,regulated by neutrophil
    elastase in type II alveolar epithelial cells

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS2394696
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
    GO:0030414peptidase inhibitor activity ----
         
    PI3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PI3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PI3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PI3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PI3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PI3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PI3
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    SwitchGear 3'UTR luciferase reporter plasmidPI3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PI3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PI3 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: PI3 (NM_002638)
    Sino Biological Human cDNA Clone for PI3
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                         Customized lentivirus expression plasmids for stable overexpression of PI3 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PI3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for PI3 (P199572, 3 ENSP000002439244) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LORP234903, ENSP000003577314I2D: score=1 STRING: ENSP00000357731
    CELA1Q9UNI13, ENSP000002936364I2D: score=2 STRING: ENSP00000293636
    CSTAP010403, ENSP000002644744I2D: score=1 STRING: ENSP00000264474
    EVPLQ928173, ENSP000003016074I2D: score=2 STRING: ENSP00000301607
    KRT1P042643, ENSP000002522444I2D: score=1 STRING: ENSP00000252244
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007620copulation IEA--
    GO:0010951negative regulation of endopeptidase activity TAS2394696

    PI3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PI3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PI3 (ELAF)

    10/26 Novoseek inferred chemical compound relationships for PI3 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hbd2 76.3 3 17664005 (1), 17362705 (1), 18981165 (1)
    serine 61.3 40 17964057 (3), 15899702 (2), 16300411 (2), 19241385 (2) (see all 27)
    whey 59 8 9252357 (1), 17044815 (1), 17964057 (1), 17664005 (1) (see all 7)
    ly294002 52.9 6 15090468 (1), 18701693 (1), 15607817 (1), 15194442 (1) (see all 5)
    dithranol 51.3 2 12542536 (1), 12218287 (1)
    sodium dodecylsulfate 24.6 6 9534887 (3), 9540975 (2), 8011497 (1)
    wortmannin 23.7 1 15602573 (1)
    phosphatidylinositol 23.3 2 15090468 (1), 1708917 (1)
    retinoic acid 20.8 3 18588690 (1), 10222145 (1), 12218287 (1)
    ctab 12.6 2 9540975 (1), 7582300 (1)

    Search CenterWatch for drugs/clinical trials and news about PI3 / ELAF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PI3 gene: 
    NM_002638.3  

    Unigene Cluster for PI3:

    Peptidase inhibitor 3, skin-derived
    Hs.112341  [show with all ESTs]
    Unigene Representative Sequence: CF596521
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000243924(uc002xng.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PI3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PI3
    SwitchGear 3'UTR luciferase reporter plasmidPI3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PI3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PI3
    Clone
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    OriGene clones in human, mouse for PI3 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PI3 (NM_002638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PI3
    Sirion Biotech Customized lentivirus for stable overexpression of PI3 
                         Customized lentivirus expression plasmids for stable overexpression of PI3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PI3
    OriGene qSTAR qPCR primer pairs in human, mouse for PI3
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PI3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PI3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PI3

    Additional mRNA sequence: 

    BC010952.1 CR542234.1 Z18538.1 

    2 DOTS entries:

    DT.213338  DT.92444421 

    24/132 AceView cDNA sequences (see all 132):

    AI393896 AI582329 AA586974 AA586978 BF838555 AI285400 AA586943 Z18538 
    AA583997 AW137392 AI392753 CR542234 AA584342 NM_002638 AA586983 BF824935 
    AW845103 BX283256 T28445 AW845125 AW844969 BG490472 AW844984 AA583773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PI3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAATCCCC
    PI3 Expression
    About this image


    See PI3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PI3

    SOURCE GeneReport for Unigene cluster: Hs.112341
        SABiosciences Custom PCR Arrays for PI3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PI3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for PI3 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia PI31 peptidase inhibitor 3, skin-derived 76.95(n)
    71.96(a)
      477241  XM_534433.3  XP_534433.1 


    ENSEMBL Gene Tree for PI3 (if available)
    TreeFam Gene Tree for PI3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 SNPs in PI3 are shown (see all 131)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs60736681,2
    H--43801612(+) aatgtA/Gtattg 1 -- us2k14Minor allele frequency- G:0.00NS EA 416
    rs576099721,2
    C,F--43801628(+) AGAATG/AAATAT 1 -- us2k12Minor allele frequency- A:0.06WA 120
    rs1414311531,2
    C--43801655(+) TTTCA-/ATATA 
            
    TAGAA
    1 -- us2k10--------
    rs607176101,2
    C--43801657(+) TCATATAATA/
            
    GAATA
    1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs130448261,2
    C,F,H--43801865(+) caaggG/Actaat 1 -- us2k132Minor allele frequency- A:0.11NS EA NA WA CSA 3031
    rs60320381,2
    H--43801886(+) tcttaG/Agaagc 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs60320391,2
    C,H--43802012(+) ATATAG/AGTATT 1 -- us2k16Minor allele frequency- A:0.00NS EA NA 378
    rs561919521,2
    C,F--43802487(+) GTCTCA/GGTGTA 1 -- us2k19Minor allele frequency- G:0.10NA WA CSA 252
    rs557674221,2
    C,F--43802497(+) ATTAGA/GGTCGT 1 -- us2k19Minor allele frequency- G:0.10NA WA CSA 252
    rs759192901,2
    C,F--43802501(+) GAGTCG/ATTTTT 1 -- us2k11Minor allele frequency- A:0.23WA 118

    HapMap Linkage Disequilibrium report for PI3 (43803517 - 43805185 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PI3: --

    Human Gene Mutation Database (HGMD): PI3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PI3
    DNA2.0 Custom Variant and Variant Library Synthesis for PI3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182257    OMIM disorders: --

    20/37 diseases for PI3 (see all 37):    About MalaCards
    impetigo herpetiformis    impetigo    erysipelas    rhinotracheitis
    pasteurellosis    generalized pustular psoriasis    trichuriasis    farmer's lung
    ascariasis    allergic contact dermatitis    hepatopulmonary syndrome    ethmoid sinusitis
    contact dermatitis    netherton syndrome    leptospirosis    vaginitis
    psoriasis    sinusitis    ulcerative colitis    skin disease

    2 diseases from the University of Copenhagen DISEASES database for PI3:
    Rhinotracheitis     Cancer

    PI3 for disorders           About GeneDecksing

    10/30 Novoseek inferred disease relationships for PI3 gene (see all 30)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uterine infection 72.4 1 12970320 (1)
    psoriasis 67 29 8931865 (4), 7829874 (3), 9727750 (3), 9510372 (1) (see all 16)
    pustular psoriasis 62.6 14 8931865 (4), 9727750 (3), 7604637 (2), 10877128 (1)
    parainfluenza 57.7 9 7474124 (2), 1280227 (1), 8985396 (1), 15710345 (1) (see all 8)
    skin diseases 51 5 11069448 (2), 7829874 (1), 8844125 (1), 7983189 (1)
    keratocysts 47.1 3 8860145 (1), 8018055 (1), 8809307 (1)
    erysipelas 47.1 1 7829874 (1)
    inflammation 43.3 17 7829874 (1), 8931871 (1), 9988537 (1), 8427705 (1) (see all 15)
    acute respiratory distress 35.7 5 19251943 (2), 19197381 (1), 10414400 (1)
    lung diseases 31.7 7 11868825 (2), 17964057 (1), 11667971 (1), 16719916 (1) (see all 6)

    Genetic Association Database (GAD): PI3
    Human Genome Epidemiology (HuGE) Navigator: PI3 (7 documents)

    Export disorders for PI3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PI3 gene, integrated from 9 sources (see all 241):
    (articles sorted by number of sources associating them with PI3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic Polymorphisms of Peptidase Inhibitor 3 (Elafin) are Associated with ARDS. (PubMed id 19251943)1, 4, 9 Tejera P....Christiani D.C. (2009)
    2. SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. (PubMed id 7685029)1, 2, 9 Molhuizen H.O.F.... Schalkwijk J. (1993)
    3. SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. (PubMed id 9727750)1, 4, 9 Kuijpers A.L....Schalkwijk J. (1998)
    4. Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. (PubMed id 8476637)1, 2, 9 Sallenave J.-M. and Silva A. (1993)
    5. Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13. (PubMed id 8287685)1, 3, 9 Molhuizen H.O....Schalkwijk J. (1994)
    6. Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity. (PubMed id 1536690)1, 2, 9 Sallenave J.-M.... Ryle A.P. (1992)
    7. Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties. (PubMed id 2001428)1, 2, 9 Schalkwijk J.... de Jongh G.J. (1991)
    8. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein. (PubMed id 12206714)1, 3 Clauss A.... Lundwall A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5266 HGNC: 8947 AceView: PI3 Ensembl:ENSG00000124102 euGenes: HUgn5266
    ECgene: PI3 H-InvDB: PI3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for PI3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PI3 gene:
    Search GeneIP for patents involving PI3

    GeneCards and IP:
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