Aliases for PI3 Gene
External Ids for PI3 Gene
Previous GeneCards Identifiers for PI3 Gene
This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
GeneCards Summary for PI3 Gene
PI3 (Peptidase Inhibitor 3) is a Protein Coding gene. Diseases associated with PI3 include Pustular Psoriasis and Impetigo Herpetiformis. Among its related pathways are Defensins and Innate Immune System. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and peptidase inhibitor activity.
UniProtKB/Swiss-Prot for PI3 Gene
Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.