Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PI16 Gene

protein-coding   GIFtS: 52
GCID: GC06P037312

Peptidase Inhibitor 16

(Previous name: protease inhibitor 16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Peptidase Inhibitor 161 2     Beta-Binding Protein1
Protease Inhibitor 161 2     microseminoprotein1
Cysteine-Rich Secretory Protein 92 3     MSMBBP2
CRISP92 3     Microseminoprotein, Beta-Binding Protein2
PSPBP2 3     CRISP-93
PSP94-Binding Protein2 3     PI-163

External Ids:    HGNC: 212451   Entrez Gene: 2214762   Ensembl: ENSG000001645307   UniProtKB: Q6UXB83   

Export aliases for PI16 gene to outside databases

Previous GC identifers: GC06P036923 GC06P036971 GC06P036972 GC06P037030 GC06P036922 GC06P036647 GC06P036555 GC06P037027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PI16 Gene:
PI16 (peptidase inhibitor 16) is a protein-coding gene. Diseases associated with PI16 include prostate adenocarcinoma, and prostatitis. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8
Function: Putative serine protease inhibitor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PI16 gene promoter:
         AML1a   Egr-1   Pax-2   Pax-2a   MIF-1   YY1   Egr-2   Pax-3   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPI16 promoter sequence
   Search Chromatin IP Primers for PI16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PI16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.31

PI16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PI16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037312:  view genomic region     (about GC identifiers)

Start:
36,916,039 bp from pter      End:
36,932,613 bp from pter
Size:
16,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8 (See protein sequence)
Recommended Name: Peptidase inhibitor 16 precursor  
Size: 463 amino acids; 49471 Da
Subunit: Interacts with PSP94/MSMB
Miscellaneous: May serve as a marker following prostatectomy for prostate cancer
Sequence caution: Sequence=AAH22399.2; Type=Frameshift; Positions=400;
Secondary accessions: Q6ZVG9 Q8IYL8 Q8NBK0 Q8TCB8
Alternative splicing: 2 isoforms:  Q6UXB8-1   Q6UXB8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PI16: NX_Q6UXB8

Explore proteomics data for PI16 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Asn114, Ser330, Ser336, Asn403, Asn409
  • Modification sites at PhosphoSitePlus

  • See PI16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186088.1  NP_699201.2  

    ENSEMBL proteins: 
     ENSP00000362778  

    PI16 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PI16
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PI16
    GenScript Custom Purified and Recombinant Proteins Services for PI16
    Novus Biologicals PI16 Protein
    Novus Biologicals PI16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PI16
    Cloud-Clone Corp. Proteins for PI16

    PI16 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for PI16 (Peptidase Inhibitor 16/PI16)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PI16
    Novus Biologicals PI16 Antibodies
    Abcam antibodies for PI16
    Cloud-Clone Corp. Antibodies for PI16
    ThermoFisher Antibodies for PI16
    LSBio Antibodies in human, mouse, rat for PI16

    PI16 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PI16
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PI16
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PI16
    Cloud-Clone Corp. CLIAs for PI16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS

    Graphical View of Domain Structure for InterPro Entry Q6UXB8

    ProtoNet protein and cluster: Q6UXB8

    1 Blocks protein domain: IPB001283 Allergen V5/Tpx-1 related

    UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain


    PI16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI16_HUMAN, Q6UXB8
    Function: Putative serine protease inhibitor (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030414peptidase inhibitor activity IEA--
         
    PI16 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pi16):
     hematopoietic system  immune system  skeleton 

    PI16 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PI16
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PI16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PI16
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PI16

    miRNA
    Products:
        
    miRTarBase miRNAs that target PI16:
    hsa-mir-1 (MIRT023574)

    Block miRNA regulation of human, mouse, rat PI16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PI16 (see all 9):
    hsa-miR-4283 hsa-miR-676 hsa-miR-205 hsa-miR-185* hsa-miR-3151 hsa-miR-2355-3p hsa-miR-324-3p hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidPI16 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PI16
    Predesigned siRNA for gene silencing in human, mouse, rat PI16

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PI16

    Clone
    Products:
         
    OriGene clones in human, mouse for PI16 (see all 8)
    OriGene ORF clones in mouse, rat for PI16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PI16 (NM_153370)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PI16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PI16

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PI16
    Browse ESI BIO Cell Lines and PureStem Progenitors for PI16 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI16


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PI16_HUMAN, Q6UXB8: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytosol1
    endoplasmic reticulum1
    lysosome1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral component of membrane IEA--

    PI16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PI16
    Interactions:

        GeneGlobe Interaction Network for PI16

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PI16 (ENSP000003627784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPERENSP000002971614STRING: ENSP00000297161
    CRIM1ENSP000002805274STRING: ENSP00000280527
    KRTAP9-1ENSP000003814884STRING: ENSP00000381488
    --ENSP000003966644STRING: ENSP00000396664
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PI16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PI16 gene (2 alternative transcripts): 
    NM_001199159.1  NM_153370.2  

    Unigene Cluster for PI16:

    Peptidase inhibitor 16
    Hs.25391  [show with all ESTs]
    Unigene Representative Sequence: AK124589
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373674(uc021yzd.1 uc003ona.3 uc011dts.1) ENST00000491324

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PI16 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PI16 (see all 9):
    hsa-miR-4283 hsa-miR-676 hsa-miR-205 hsa-miR-185* hsa-miR-3151 hsa-miR-2355-3p hsa-miR-324-3p hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidPI16 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PI16
    Predesigned siRNA for gene silencing in human, mouse, rat PI16
    Clone
    Products:
         
    OriGene clones in human, mouse for PI16 (see all 8)
    OriGene ORF clones in mouse, rat for PI16
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PI16 (NM_153370)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PI16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PI16
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PI16
    OriGene qSTAR qPCR primer pairs in human, mouse for PI16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PI16
      QuantiTect SYBR Green Assays in human, mouse, rat PI16
      QuantiFast Probe-based Assays in human, mouse, rat PI16

    Additional mRNA sequence: 

    AK075470.1 AK124589.1 AK302193.1 AK303928.1 AK312785.1 AL050088.1 AY358422.1 BC022399.1 
    BC035634.1 

    6 DOTS entries:

    DT.112913  DT.100715669  DT.92418249  DT.121343213  DT.100701718  DT.121343215 

    Selected AceView cDNA sequences (see all 119):

    BP342209 AL050088 BM663032 AA035063 BF221986 BM662458 BU151097 CR626203 
    AL603065 BM708009 BQ030218 BC022399 BM718403 BX114783 BE675348 AK075470 
    BP373009 BP374798 CA390206 BP342360 BG059778 AA355188 BP340696 BI822132 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PI16 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
    SP1:                                      -                                               -     -         
    SP2:                                      -                             -                                 
    SP3:                          -           -                                                               
    SP4:                                                                                                      
    SP5:                                                                                            -         


    ECgene alternative splicing isoforms for PI16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PI16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGCTCTCC
    PI16 Expression
    About this image


    PI16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Blood (Hematopoietic System)
             T Helper Cells Peripheral Blood
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Heart (Cardiovascular System)
     
     Umbilical Cord (Extraembryonic Tissues)
    PI16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PI16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25391

    UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8
    Tissue specificity: Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patient's
    sera

        Custom PCR Arrays for PI16
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PI16
    OriGene qSTAR qPCR primer pairs in human, mouse for PI16
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PI16
    QuantiTect SYBR Green Assays in human, mouse, rat PI16
    QuantiFast Probe-based Assays in human, mouse, rat PI16
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PI16 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pi161 , 5 peptidase inhibitor 161, 5 76.13(n)1
    67.84(a)1
      17 (15.22 cM)5
    741161  NM_023734.31  NP_076223.31 
     293188775 
    chicken
    (Gallus gallus)
    Aves PI166
    peptidase inhibitor 16
    52(a)
    1 ↔ 1
    26(1580563-1587475)
    lizard
    (Anolis carolinensis)
    Reptilia PI166
    peptidase inhibitor 16
    48(a)
    1 ↔ 1
    4(123659023-123664510)
    zebrafish
    (Danio rerio)
    Actinopterygii PI166
    peptidase inhibitor 16
    37(a)
    1 ↔ 1
    23(41945385-41963203) ENSDARG00000046021
    rice
    (Oryza sativa)
    Liliopsida Os.94212 Oryza sativa (japonica cultivar-group) putative type-1 more 75.09(n)    NM_195297.1 


    ENSEMBL Gene Tree for PI16 (if available)
    TreeFam Gene Tree for PI16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PI16 gene
    CLEC18B2  CRISPLD22  CLEC18C2  GLIPR12  CRISP22  PI152  CRISP12  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    5 SIMAP similar genes for PI16 using alignment to 1 protein entry:     PI16_HUMAN:
    GLIPR1    R3HDML    CRISP2    CRISP3    PI15

    PI16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PI16 (see all 466)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580880681,2
    C,F--36914095(+) ACACCG/ATCTAC 1 -- us2k14Minor allele frequency- A:0.19WA CSA NA 242
    rs1902361621,2
    --36914107(+) CTGATA/GCTGCC 1 -- us2k10--------
    rs10230361,2
    C,F,A,H--36914173(+) CTCCAC/TGTGCT 1 -- us2k113Minor allele frequency- T:0.41EA NS NA WA CSA 668
    rs1809375161,2
    --36914181(+) GCTTGC/TCTTAA 1 -- us2k10--------
    rs728468811,2
    C--36914206(+) TAGTGA/GCAGGT 1 -- us2k10--------
    rs795885451,2
    F--36914258(+) TCCCCG/AACCTA 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs605689511,2
    C,F--36914264(+) ACCTAT/CACTGG 1 -- us2k14Minor allele frequency- C:0.19WA CSA NA 242
    rs1161572731,2
    C,F--36914271(+) CTGGGG/AAAATC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs2009307271,2
    C--36914277(+) GAAAT-/ACTT  
            
    CTTAC
    1 -- us2k10--------
    rs606072081,2
    C,F--36914325(+) GAGACT/CCACCT 1 -- us2k15Minor allele frequency- C:0.19NA WA CSA 244

    HapMap Linkage Disequilibrium report for PI16 (36916039 - 36932613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PI16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885815CNV Loss21882294
    dgv380n21CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PI16
    DNA2.0 Custom Variant and Variant Library Synthesis for PI16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    4 diseases for PI16:    
    About MalaCards
    prostate adenocarcinoma    prostatitis    adenocarcinoma    prostate cancer


    PI16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PI16

    Export disorders for PI16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PI16 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with PI16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. (PubMed id 17062675)1, 2, 9 Reeves J.R.... Ramnani D.M. (Clin. Cancer Res. 2006)
    2. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PubMed id 15344909)1, 2, 9 Reeves J.R.... Tanner J.E. (Biochem. J. 2005)
    3. Chemerin, a novel adipokine in the regulation of angiogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (J. Clin. Endocrinol. Metab. 2010)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. (PubMed id 22533972)1 Nicholson I.C....Krumbiegel D. (Cell. Immunol. 2012)
    7. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (Mol. Cell. Proteomics 2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 221476 HGNC: 21245 AceView: PI16 Ensembl:ENSG00000164530 euGenes: HUgn221476
    ECgene: PI16 H-InvDB: PI16

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PI16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PI16 gene:
    Search GeneIP for patents involving PI16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for PI16 (Peptidase Inhibitor 16/PI16)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PI16  
     OriGene qPCR primer pairs and template standards for PI16   OriGene Protein Over-expression Lysate for PI16  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PI16  
     OriGene qSTAR qPCR primer pairs in human, mouse for PI16   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PI16   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PI16   OriGene Custom Protein Services for PI16  

     
     
     Block miRNA regulation of human, mouse, rat PI16 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PI16
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PI16 Predesigned siRNA for gene silencing in human, mouse, rat PI16
     QuantiFast Probe-based Assays in human, mouse, rat PI16 QuantiTect SYBR Green Assays in human, mouse, rat PI16
     Custom PCR Arrays for PI16 Search Chromatin IP Primers for PI16
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PI16  GeneGlobe Interaction Network for PI16
     Regulatory tfbs in PI16 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PI16 GenScript cDNA clones with any tag delivered in your preferred vector for PI16
     GenScript Custom Assay Services for PI16 GenScript Custom overexpressing Cell Line Services for PI16
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PI16
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PI16 antibodies
     PI16 proteins
     PI16 lysates
     Antibodies for PI16
     See all of Abcam's Antibodies, Kits and Proteins for PI16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PI16
     Proteins for PI16
     Antibodies for PI16
     ELISAs for PI16
     CLIAs for PI16



     Browse ESI BIO Cell Lines and PureStem Progenitors for PI16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI16
     SwitchGear 3'UTR luciferase reporter plasmids for PI16
     SwitchGear Promoter luciferase reporter plasmids for PI16
     ThermoFisher Antibodies for PI16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PI16
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PI16
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PI16
     LSBio Antibodies in human, mouse, rat for PI16
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PI16 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4