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Aliases for PI16 Gene

Aliases for PI16 Gene

  • Peptidase Inhibitor 16 2 3
  • Cysteine-Rich Secretory Protein 9 3 4
  • Protease Inhibitor 16 2 3
  • PSP94-Binding Protein 3 4
  • CRISP9 3 4
  • PSPBP 3 4
  • Microseminoprotein, Beta-Binding Protein 3
  • Beta-Binding Protein 2
  • Microseminoprotein 2
  • CRISP-9 4
  • MSMBBP 3
  • PI-16 4

External Ids for PI16 Gene

Previous GeneCards Identifiers for PI16 Gene

  • GC06P036923
  • GC06P036971
  • GC06P036972
  • GC06P037030
  • GC06P036922
  • GC06P036647
  • GC06P036555
  • GC06P037027
  • GC06P037312

Summaries for PI16 Gene

GeneCards Summary for PI16 Gene

PI16 (Peptidase Inhibitor 16) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for PI16 Gene

  • Putative serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI16 Gene

Genomics for PI16 Gene

Regulatory Elements for PI16 Gene

Genomic Location for PI16 Gene

Start:
36,948,263 bp from pter
End:
36,964,837 bp from pter
Size:
16,575 bases
Orientation:
Plus strand

Genomic View for PI16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PI16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI16 Gene

Proteins for PI16 Gene

  • Protein details for PI16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB8-PI16_HUMAN
    Recommended name:
    Peptidase inhibitor 16
    Protein Accession:
    Q6UXB8
    Secondary Accessions:
    • Q6ZVG9
    • Q8IYL8
    • Q8NBK0
    • Q8TCB8

    Protein attributes for PI16 Gene

    Size:
    463 amino acids
    Molecular mass:
    49471 Da
    Quaternary structure:
    • Interacts with PSP94/MSMB.
    Miscellaneous:
    • May serve as a marker following prostatectomy for prostate cancer
    SequenceCaution:
    • Sequence=AAH22399.2; Type=Frameshift; Positions=400; Evidence={ECO:0000305};

    Alternative splice isoforms for PI16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PI16 Gene

Proteomics data for PI16 Gene at MOPED

Post-translational modifications for PI16 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn114, Ser330, Ser336, Asn403, and Asn409
  • Modification sites at PhosphoSitePlus

Other Protein References for PI16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PI16 Gene

Domains for PI16 Gene

Protein Domains for PI16 Gene

Graphical View of Domain Structure for InterPro Entry

Q6UXB8

UniProtKB/Swiss-Prot:

PI16_HUMAN :
  • Q6UXB8
Domain:
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI16: view

No data available for Gene Families for PI16 Gene

Function for PI16 Gene

Molecular function for PI16 Gene

UniProtKB/Swiss-Prot Function: Putative serine protease inhibitor.

Gene Ontology (GO) - Molecular Function for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PI16: view
genes like me logo Genes that share phenotypes with PI16: view

miRNA for PI16 Gene

miRTarBase miRNAs that target PI16

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PI16 Gene

Localization for PI16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI16 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PI16 Gene COMPARTMENTS Subcellular localization image for PI16 gene
Compartment Confidence
extracellular 3
cytosol 1
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PI16: view

Pathways for PI16 Gene

SuperPathways for PI16 Gene

No Data Available

Interacting Proteins for PI16 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362778%0d%0a9606.ENSP00000280527%0d%0a9606.ENSP00000421280%0d%0a9606.ENSP00000265944%0d%0a
Selected Interacting proteins: ENSP00000362778 for PI16 Gene via STRING

Gene Ontology (GO) - Biological Process for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development IEA --
genes like me logo Genes that share ontologies with PI16: view

No data available for Pathways by source for PI16 Gene

Transcripts for PI16 Gene

Unigene Clusters for PI16 Gene

Peptidase inhibitor 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PI16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for PI16 Gene

GeneLoc Exon Structure for
PI16
ECgene alternative splicing isoforms for
PI16

Expression for PI16 Gene

mRNA expression in normal human tissues for PI16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI16 Gene

This gene is overexpressed in Heart - Atrial Appendage (5.1) and Vagina (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PI16 Gene

SOURCE GeneReport for Unigene cluster for PI16 Gene Hs.25391

mRNA Expression by UniProt/SwissProt for PI16 Gene

Q6UXB8-PI16_HUMAN
Tissue specificity: Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patients sera.
genes like me logo Genes that share expressions with PI16: view

Orthologs for PI16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PI16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PI16 35
  • 99.4 (n)
  • 99.1 (a)
PI16 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PI16 35
  • 84.75 (n)
  • 76.4 (a)
PI16 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PI16 35
  • 84.13 (n)
  • 76.64 (a)
PI16 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pi16 35
  • 76.13 (n)
  • 67.84 (a)
Pi16 16
Pi16 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PI16 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PI16 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pi16 35
  • 76.4 (n)
  • 69.1 (a)
chicken
(Gallus gallus)
Aves PI16 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PI16 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PI16 36
  • 37 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.9067 35
corn
(Zea mays)
Liliopsida Zm.2437 35
rice
(Oryza sativa)
Liliopsida Os.9421 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for PI16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PI16 Gene

ENSEMBL:
Gene Tree for PI16 (if available)
TreeFam:
Gene Tree for PI16 (if available)

Paralogs for PI16 Gene

Selected SIMAP similar genes for PI16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PI16: view

Variants for PI16 Gene

Sequence variations from dbSNP and Humsavar for PI16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs697746 -- 36,958,636(-) TTGGG(A/T)CACCC intron-variant
rs697747 -- 36,957,144(-) ctgaa(A/G)cagta intron-variant
rs697748 -- 36,956,862(-) ATAAC(A/C)CCCAC intron-variant
rs707542 -- 36,956,326(-) TGAAG(C/T)CCAAC intron-variant
rs707543 -- 36,964,044(+) TGGGC(A/G)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PI16 Gene

Variant ID Type Subtype PubMed ID
dgv380n21 CNV Gain 19592680
nsv885815 CNV Loss 21882294

Relevant External Links for PI16 Gene

HapMap Linkage Disequilibrium report
PI16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI16 Gene

Disorders for PI16 Gene

Relevant External Links for PI16

Genetic Association Database (GAD)
PI16
genes like me logo Genes that share disorders with PI16: view

No data available for UniProtKB/Swiss-Prot for PI16 Gene

Publications for PI16 Gene

  1. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PMID: 15344909) Reeves J.R. … Tanner J.E. (Biochem. J. 2005) 3 4 23
  2. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. (PMID: 17062675) Reeves J.R. … Ramnani D.M. (Clin. Cancer Res. 2006) 3 4 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. Chemerin, a novel adipokine in the regulation of angiogenesis. (PMID: 20237162) Bozaoglu K. … Jowett J.B. (J. Clin. Endocrinol. Metab. 2010) 3 48

Products for PI16 Gene

Sources for PI16 Gene

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