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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PI16 Gene

protein-coding   GIFtS: 50
GCID: GC06P037027

Peptidase Inhibitor 16

(Previous name: protease inhibitor 16)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidase Inhibitor 161 2     Beta-Binding Protein1
Protease Inhibitor 161 2     microseminoprotein1
Cysteine-Rich Secretory Protein 92 3     MSMBBP2
CRISP92 3     Microseminoprotein, Beta-Binding Protein2
PSPBP2 3     CRISP-93
PSP94-Binding Protein2 3     PI-163

External Ids:    HGNC: 212451   Entrez Gene: 2214762   Ensembl: ENSG000001645307   UniProtKB: Q6UXB83   

Export aliases for PI16 gene to outside databases

Previous GC identifers: GC06P036923 GC06P036971 GC06P036972 GC06P037030 GC06P036922 GC06P036647 GC06P036555


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PI16 Gene: 
PI16 (peptidase inhibitor 16) is a protein-coding gene. Diseases associated with PI16 include prostate adenocarcinoma, and prostatitis. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8
Function: Putative serine protease inhibitor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PI16 gene promoter:
         AML1a   Egr-1   Pax-2   Pax-2a   MIF-1   YY1   Egr-2   Pax-3   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPI16 promoter sequence
   Search SABiosciences Chromatin IP Primers for PI16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PI16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.31

PI16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PI16 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037027:  view genomic region     (about GC identifiers)

Start:
36,916,039 bp from pter      End:
36,932,613 bp from pter
Size:
16,575 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8 (See protein sequence)
Recommended Name: Peptidase inhibitor 16 precursor  
Size: 463 amino acids; 49471 Da
Subunit: Interacts with PSP94/MSMB
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: May serve as a marker following prostatectomy for prostate cancer
Sequence caution: Sequence=AAH22399.2; Type=Frameshift; Positions=400;
Secondary accessions: Q6ZVG9 Q8IYL8 Q8NBK0 Q8TCB8
Alternative splicing: 2 isoforms:  Q6UXB8-1   Q6UXB8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PI16: NX_Q6UXB8

Explore proteomics data for PI16 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXB8

  • PI16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PI16 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186088.1  NP_699201.2  

    ENSEMBL proteins: 
     ENSP00000362778  

    Human Recombinant Protein Products for PI16: 
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    OriGene Protein Over-expression Lysate for PI16
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    Novus Biologicals PI16 Protein
    Novus Biologicals PI16 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PI16
    Cloud-Clone Corp. Proteins for PI16 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016021integral to membrane IEA--

    PI16 for ontologies           About GeneDecksing



    PI16 Antibody Products: 
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    Assay Products for PI16: 
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    Cloud-Clone Corp. ELISAs for PI16 
    Cloud-Clone Corp. CLIAs for PI16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS

    Graphical View of Domain Structure for InterPro Entry Q6UXB8

    ProtoNet protein and cluster: Q6UXB8

    1 Blocks protein domain: IPB001283 Allergen V5/Tpx-1 related

    UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain


    PI16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI16_HUMAN, Q6UXB8
    Function: Putative serine protease inhibitor (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030414peptidase inhibitor activity IEA--
         
    PI16 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pi16):
     hematopoietic system  immune system  skeleton 

    PI16 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PI16 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PI16

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PI16 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PI16
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PI16 (see all 9):
    hsa-miR-4283 hsa-miR-676 hsa-miR-205 hsa-miR-185* hsa-miR-3151 hsa-miR-2355-3p hsa-miR-324-3p hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidPI16 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): PI16 (NM_153370)
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                         Customized lentivirus expression plasmids for stable overexpression of PI16 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI16


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PI16

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PI16

    Search CenterWatch for drugs/clinical trials and news about PI16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PI16 gene (2 alternative transcripts): 
    NM_001199159.1  NM_153370.2  

    Unigene Cluster for PI16:

    Peptidase inhibitor 16
    Hs.25391  [show with all ESTs]
    Unigene Representative Sequence: AK124589
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373674(uc021yzd.1 uc003ona.3 uc011dts.1) ENST00000491324

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PI16
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate PI16 (see all 9):
    hsa-miR-4283 hsa-miR-676 hsa-miR-205 hsa-miR-185* hsa-miR-3151 hsa-miR-2355-3p hsa-miR-324-3p hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidPI16 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PI16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PI16
    Clone
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    OriGene clones in human, mouse for PI16 (see all 8)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PI16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PI16
    Sirion Biotech Customized lentivirus for stable overexpression of PI16 
                         Customized lentivirus expression plasmids for stable overexpression of PI16 
    Primer
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    OriGene qPCR primer pairs and template standards for PI16
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PI16
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PI16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PI16

    Additional mRNA sequence: 

    AK075470.1 AK124589.1 AK302193.1 AK303928.1 AK312785.1 AL050088.1 AY358422.1 BC022399.1 
    BC035634.1 

    6 DOTS entries:

    DT.112913  DT.100715669  DT.92418249  DT.121343213  DT.100701718  DT.121343215 

    24/119 AceView cDNA sequences (see all 119):

    BM662458 BQ030218 AL603065 BU151097 AL050088 BC022399 CR626203 BM708009 
    BM718403 AA035063 BP342209 BM663032 BF221986 C04744 AA310225 BP342360 
    BM705204 AI090096 AI095899 BM808568 BP340696 BU731412 BP374774 AA355188 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PI16 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
    SP1:                                      -                                               -     -         
    SP2:                                      -                             -                                 
    SP3:                          -           -                                                               
    SP4:                                                                                                      
    SP5:                                                                                            -         


    ECgene alternative splicing isoforms for PI16

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PI16 expression in normal human tissues (normalized intensities)      PI16 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGCTCTCC
    PI16 Expression
    About this image


    PI16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Fibroblast
             BH2 Dermal Fibroblasts   
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             BH2 Dermal Fibroblasts   
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Heart (Cardiovascular System)

    See PI16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PI16

    SOURCE GeneReport for Unigene cluster: Hs.25391

    UniProtKB/Swiss-Prot: PI16_HUMAN, Q6UXB8
    Tissue specificity: Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patient's
    sera

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PI16 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pi161 , 5 peptidase inhibitor 161, 5 75.46(n)1
    67.47(a)1
      17 (15.22 cM)5
    741161  NM_023734.31  NP_076223.31 
     293188775 
    chicken
    (Gallus gallus)
    Aves PI161 peptidase inhibitor 16 53.57(n)
    49.81(a)
      419818  XM_417954.3  XP_417954.3 
    lizard
    (Anolis carolinensis)
    Reptilia PI166
    Uncharacterized protein
    46(a)
    1 ↔ 1
    4(123659023-123664510)
    zebrafish
    (Danio rerio)
    Actinopterygii PI166
    peptidase inhibitor 16
    33(a)
    1 ↔ 1
    23(41945385-41963203)
    worm
    (Caenorhabditis elegans)
    Secernentea scl-181 Protein SCL-18 46.67(n)
    50.77(a)
      188436  NM_069827.1  NP_502228.1 
    rice
    (Oryza sativa)
    Liliopsida Os.94212 Oryza sativa (japonica cultivar-group) putative type-1 more 75.09(n)    NM_195297.1 


    ENSEMBL Gene Tree for PI16 (if available)
    TreeFam Gene Tree for PI16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PI16 gene
    CLEC18B2  CRISPLD22  CLEC18C2  GLIPR12  CRISP22  PI152  CRISP12  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    5 SIMAP similar genes for PI16 using alignment to 1 protein entry:     PI16_HUMAN:
    GLIPR1    R3HDML    CRISP2    CRISP3    PI15

    PI16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in PI16 are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs580880681,2
    C,F--36914095(+) ACACCG/ATCTAC 1 -- us2k14Minor allele frequency- A:0.19WA CSA NA 242
    rs1902361621,2
    --36914107(+) CTGATA/GCTGCC 1 -- us2k10--------
    rs10230361,2
    C,F,A,H--36914173(+) CTCCAC/TGTGCT 1 -- us2k113Minor allele frequency- T:0.41EA NS NA WA CSA 668
    rs1809375161,2
    --36914181(+) GCTTGC/TCTTAA 1 -- us2k10--------
    rs728468811,2
    C--36914206(+) TAGTGA/GCAGGT 1 -- us2k10--------
    rs795885451,2
    F--36914258(+) TCCCCG/AACCTA 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs605689511,2
    C,F--36914264(+) ACCTAT/CACTGG 1 -- us2k14Minor allele frequency- C:0.19WA CSA NA 242
    rs1161572731,2
    C,F--36914271(+) CTGGGG/AAAATC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs2009307271,2
    C--36914277(+) GAAAT-/ACTT  
            
    CTTAC
    1 -- us2k10--------
    rs606072081,2
    C,F--36914325(+) GAGACT/CCACCT 1 -- us2k15Minor allele frequency- C:0.19NA WA CSA 244

    HapMap Linkage Disequilibrium report for PI16 (36916039 - 36932613 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PI16:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885815CNV Loss21882294
    dgv380n21CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PI16
    DNA2.0 Custom Variant and Variant Library Synthesis for PI16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for PI16:    About MalaCards
    prostate adenocarcinoma    prostatitis    adenocarcinoma    prostate cancer


    PI16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PI16

    Export disorders for PI16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PI16 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with PI16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. (PubMed id 17062675)1, 2, 9 Reeves J.R.... Ramnani D.M. (2006)
    2. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PubMed id 15344909)1, 2, 9 Reeves J.R.... Tanner J.E. (2005)
    3. Chemerin, a novel adipokine in the regulation of angi ogenesis. (PubMed id 20237162)1, 4 Bozaoglu K....Jowett J.B. (2010)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. PI16 is expressed by a subset of human memory Treg wit h enhanced migration to CCL17 and CCL20. (PubMed id 22533972)1 Nicholson I.C....Krumbiegel D. (2012)
    7. Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD. (PubMed id 22171320)2 Halim A.... Larson G. (2011)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221476 HGNC: 21245 AceView: PI16 Ensembl:ENSG00000164530 euGenes: HUgn221476
    ECgene: PI16 H-InvDB: PI16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PI16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PI16 gene:
    Search GeneIP for patents involving PI16

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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