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Aliases for PI16 Gene

Aliases for PI16 Gene

  • Peptidase Inhibitor 16 2 3 5
  • Microseminoprotein, Beta-Binding Protein 2 3
  • Cysteine-Rich Secretory Protein 9 3 4
  • Protease Inhibitor 16 2 3
  • PSP94-Binding Protein 3 4
  • CRISP9 3 4
  • PSPBP 3 4
  • CRISP-9 4
  • MSMBBP 3
  • CD364 3
  • PI-16 4

External Ids for PI16 Gene

Previous GeneCards Identifiers for PI16 Gene

  • GC06P036923
  • GC06P036971
  • GC06P036972
  • GC06P037030
  • GC06P036922
  • GC06P036647
  • GC06P036555
  • GC06P037027
  • GC06P037312
  • GC06P037028
  • GC06P037198
  • GC06P037803
  • GC06P038425
  • GC06P039015
  • GC06P039603

Summaries for PI16 Gene

GeneCards Summary for PI16 Gene

PI16 (Peptidase Inhibitor 16) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CRISPLD2.

UniProtKB/Swiss-Prot for PI16 Gene

  • May inhibit cardiomyocyte growth.

Additional gene information for PI16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI16 Gene

Genomics for PI16 Gene

Regulatory Elements for PI16 Gene

Enhancers for PI16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H036422 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -524.7 -524734 2 MLX ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS DEK ETV7 KCTD20 LOC105375037 C6orf222 STK38 PI16 MAPK13 PXT1 SRSF3 CDKN1A
GH06H036439 1.8 FANTOM5 ENCODE dbSUPER 10.2 -505.4 -505416 6.9 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ETV7 KCTD20 SRSF3 TEAD3 PXT1 LOC105375037 RNF8 CDKN1A RPL10A PI16
GH06H036623 1.5 Ensembl ENCODE dbSUPER 10.3 -323.7 -323728 2.9 HDGF PKNOX1 ATF1 ARID4B ZNF2 SLC30A9 ZNF143 ZNF207 ATF7 RUNX3 ENSG00000251864 LAP3P2 CDKN1A CMTR1 RAB44 KCTD20 BRPF3 PI16 C6orf89 MIR3925
GH06H036616 1.4 Ensembl ENCODE dbSUPER 10.8 -330.9 -330940 1.5 TBP FOXA2 PKNOX1 NFIB RAD21 RFX5 YY1 ZNF121 HSF1 SCRT2 CMTR1 CDKN1A ENSG00000251864 LAP3P2 RNU1-88P RAB44 PI16 C6orf89 FGD2 MIR3925
GH06H036614 1.4 Ensembl ENCODE dbSUPER 10.8 -333.0 -332974 1 HDAC1 ARID4B RAD21 ZNF121 ZNF143 ATF7 RUNX3 MIXL1 ZNF654 ZNF362 ENSG00000251864 LAP3P2 CDKN1A RNU1-88P RAB44 KCTD20 PI16 C6orf89 FGD2 MIR3925
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PI16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PI16 Gene

Genomic Locations for PI16 Gene
16,575 bases
Plus strand

Genomic View for PI16 Gene

Genes around PI16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI16 Gene

Proteins for PI16 Gene

  • Protein details for PI16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidase inhibitor 16
    Protein Accession:
    Secondary Accessions:
    • Q6ZVG9
    • Q8IYL8
    • Q8NBK0
    • Q8TCB8

    Protein attributes for PI16 Gene

    463 amino acids
    Molecular mass:
    49471 Da
    Quaternary structure:
    • Interacts with PSP94/MSMB.
    • May serve as a marker following prostatectomy for prostate cancer.
    • Sequence=AAH22399.2; Type=Frameshift; Positions=400; Evidence={ECO:0000305};

    Alternative splice isoforms for PI16 Gene


neXtProt entry for PI16 Gene

Post-translational modifications for PI16 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn114, Ser330, posLast=403403, and Asn409
  • Modification sites at PhosphoSitePlus

Other Protein References for PI16 Gene

No data available for DME Specific Peptides for PI16 Gene

Domains & Families for PI16 Gene

Gene Families for PI16 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for PI16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CRISP family.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI16: view

Function for PI16 Gene

Molecular function for PI16 Gene

UniProtKB/Swiss-Prot Function:
May inhibit cardiomyocyte growth.

Phenotypes From GWAS Catalog for PI16 Gene

Gene Ontology (GO) - Molecular Function for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PI16: view
genes like me logo Genes that share phenotypes with PI16: view

miRNA for PI16 Gene

miRTarBase miRNAs that target PI16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI16 Gene

Localization for PI16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI16 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PI16 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PI16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PI16 Gene

Pathways & Interactions for PI16 Gene

No Data Available

Interacting Proteins for PI16 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: Q6UXB8-PI16_HUMAN ENSP00000362778 for PI16 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with PI16: view

No data available for Pathways by source and SIGNOR curated interactions for PI16 Gene

Drugs & Compounds for PI16 Gene

No Compound Related Data Available

Transcripts for PI16 Gene

Unigene Clusters for PI16 Gene

Peptidase inhibitor 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PI16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP5: -

Relevant External Links for PI16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PI16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PI16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI16 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.1) and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for PI16 Gene

This gene is overexpressed in Serum (34.9), Cerebrospinal fluid (14.5), and Plasma (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PI16 Gene

NURSA nuclear receptor signaling pathways regulating expression of PI16 Gene:


SOURCE GeneReport for Unigene cluster for PI16 Gene:


mRNA Expression by UniProt/SwissProt for PI16 Gene:

Tissue specificity: Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patients sera.

Evidence on tissue expression from TISSUES for PI16 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Blood(4.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with PI16: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PI16 Gene

Orthologs for PI16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PI16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PI16 33 34
  • 99.4 (n)
(Bos Taurus)
Mammalia PI16 33 34
  • 84.75 (n)
(Canis familiaris)
Mammalia PI16 33 34
  • 84.13 (n)
(Rattus norvegicus)
Mammalia Pi16 33
  • 76.4 (n)
(Mus musculus)
Mammalia Pi16 33 16 34
  • 76.13 (n)
(Ornithorhynchus anatinus)
Mammalia PI16 34
  • 64 (a)
(Monodelphis domestica)
Mammalia PI16 34
  • 54 (a)
(Gallus gallus)
Aves PI16 34
  • 52 (a)
(Anolis carolinensis)
Reptilia PI16 34
  • 48 (a)
(Danio rerio)
Actinopterygii PI16 34
  • 37 (a)
(Hordeum vulgare)
Liliopsida Hv.9067 33
(Oryza sativa)
Liliopsida Os.9421 33
(Zea mays)
Liliopsida Zm.2437 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for PI16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PI16 Gene

Gene Tree for PI16 (if available)
Gene Tree for PI16 (if available)

Paralogs for PI16 Gene

(5) SIMAP similar genes for PI16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PI16: view

Variants for PI16 Gene

Sequence variations from dbSNP and Humsavar for PI16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000123836 -- 36,947,767(+) CACAG(C/G)TTTGG upstream-variant-2KB
rs1000185126 -- 36,959,684(+) CCTGG(A/G)CAACA intron-variant
rs1000254375 -- 36,953,490(+) TCCTG(A/C)AACTT intron-variant, upstream-variant-2KB
rs1000523582 -- 36,958,561(+) GCCGT(C/T)GACAA intron-variant
rs1000627460 -- 36,964,061(+) GTGGC(C/T)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PI16 Gene

Variant ID Type Subtype PubMed ID
nsv1015689 CNV gain 25217958
esv3608715 CNV loss 21293372
esv3608714 CNV loss 21293372
dgv380n21 CNV gain 19592680

Variation tolerance for PI16 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 76.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PI16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI16 Gene

Disorders for PI16 Gene

Relevant External Links for PI16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PI16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI16 Gene

Publications for PI16 Gene

  1. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. (PMID: 17062675) Reeves JR … Ramnani DM (Clinical cancer research : an official journal of the American Association for Cancer Research 2006) 3 4 22 60
  2. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PMID: 15344909) Reeves JR … Tanner JE (The Biochemical journal 2005) 3 4 22 60
  3. Chemerin, a novel adipokine in the regulation of angiogenesis. (PMID: 20237162) Bozaoglu K … Jowett JB (The Journal of clinical endocrinology and metabolism 2010) 3 45 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for PI16 Gene

Sources for PI16 Gene

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