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Aliases for PI16 Gene

Aliases for PI16 Gene

  • Peptidase Inhibitor 16 2 3 5
  • Microseminoprotein, Beta-Binding Protein 2 3
  • Cysteine-Rich Secretory Protein 9 3 4
  • Protease Inhibitor 16 2 3
  • PSP94-Binding Protein 3 4
  • CRISP9 3 4
  • PSPBP 3 4
  • CRISP-9 4
  • MSMBBP 3
  • CD364 3
  • PI-16 4

External Ids for PI16 Gene

Previous GeneCards Identifiers for PI16 Gene

  • GC06P036923
  • GC06P036971
  • GC06P036972
  • GC06P037030
  • GC06P036922
  • GC06P036647
  • GC06P036555
  • GC06P037027
  • GC06P037312
  • GC06P037028
  • GC06P037198
  • GC06P037803
  • GC06P038425

Summaries for PI16 Gene

GeneCards Summary for PI16 Gene

PI16 (Peptidase Inhibitor 16) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CRISPLD2.

UniProtKB/Swiss-Prot for PI16 Gene

  • May inhibit cardiomyocyte growth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI16 Gene

Genomics for PI16 Gene

Regulatory Elements for PI16 Gene

Enhancers for PI16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F036567 0.4 ENCODE 12.1 -380.5 -380475 0.4 ATF1 SAP130 CREB1 ZNF384 ZBTB33 DMAP1 KAT8 PI16 STK38 SRSF3 ETV7 RNU1-88P RAB44 KCTD20 PXT1 GC06P040045
GH06F036566 1.1 ENCODE 12.1 -381.4 -381421 1.3 ATF1 MLX ARID4B DMAP1 SLC30A9 SP5 MXD4 MIER2 KAT8 MIER3 PI16 SRSF3 RNU1-88P KCTD20 PXT1 RAB44 GC06P040045
GH06F036558 0.4 Ensembl 11.6 -389.1 -389063 0.8 PKNOX1 MTA2 BHLHE40 BMI1 TBX21 BCL11B ATF2 POLR2A SMARCA4 TARDBP PI16 GC06P040045 STK38
GH06F036557 0.9 Ensembl ENCODE 11.1 -390.8 -390763 1.0 SREBF1 KLF1 ZNF362 CTBP1 PRDM10 FOS ATF2 ETV7 PI16 KCTD20 GC06P040045 STK38
GH06F036554 0.6 ENCODE 11.1 -393.0 -393006 1.2 BCOR SMARCA5 ATF3 HNF4G NR2F2 YY1 PI16 ETV7 KCTD20 GC06P040045 STK38
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PI16 on UCSC Golden Path with GeneCards custom track

Genomic Location for PI16 Gene

36,948,263 bp from pter
36,964,837 bp from pter
16,575 bases
Plus strand

Genomic View for PI16 Gene

Genes around PI16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI16 Gene

Proteins for PI16 Gene

  • Protein details for PI16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidase inhibitor 16
    Protein Accession:
    Secondary Accessions:
    • Q6ZVG9
    • Q8IYL8
    • Q8NBK0
    • Q8TCB8

    Protein attributes for PI16 Gene

    463 amino acids
    Molecular mass:
    49471 Da
    Quaternary structure:
    • Interacts with PSP94/MSMB.
    • May serve as a marker following prostatectomy for prostate cancer.
    • Sequence=AAH22399.2; Type=Frameshift; Positions=400; Evidence={ECO:0000305};

    Alternative splice isoforms for PI16 Gene


neXtProt entry for PI16 Gene

Post-translational modifications for PI16 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn 114, Ser 330, Asn 403, and Asn 409
  • Modification sites at PhosphoSitePlus

Other Protein References for PI16 Gene

Antibody Products

  • R&D Systems Antibodies for PI16 (Peptidase Inhibitor 16/PI16)

No data available for DME Specific Peptides for PI16 Gene

Domains & Families for PI16 Gene

Gene Families for PI16 Gene

Protein Domains for PI16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI16: view

Function for PI16 Gene

Molecular function for PI16 Gene

UniProtKB/Swiss-Prot Function:
May inhibit cardiomyocyte growth.

Gene Ontology (GO) - Molecular Function for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PI16: view
genes like me logo Genes that share phenotypes with PI16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PI16

miRNA for PI16 Gene

miRTarBase miRNAs that target PI16

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI16 Gene

Localization for PI16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI16 Gene


Subcellular locations from

Jensen Localization Image for PI16 Gene COMPARTMENTS Subcellular localization image for PI16 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PI16: view

Pathways & Interactions for PI16 Gene

SuperPathways for PI16 Gene

No Data Available

Interacting Proteins for PI16 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q6UXB8-PI16_HUMAN ENSP00000362778 for PI16 Gene via IID STRING

Gene Ontology (GO) - Biological Process for PI16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with PI16: view

No data available for Pathways by source and SIGNOR curated interactions for PI16 Gene

Transcripts for PI16 Gene

Unigene Clusters for PI16 Gene

Peptidase inhibitor 16:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PI16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP5: -

Relevant External Links for PI16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PI16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PI16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI16 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.1) and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for PI16 Gene

This gene is overexpressed in Serum (34.9), Cerebrospinal fluid (14.5), and Plasma (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PI16 Gene

NURSA nuclear receptor signaling pathways regulating expression of PI16 Gene:


SOURCE GeneReport for Unigene cluster for PI16 Gene:


mRNA Expression by UniProt/SwissProt for PI16 Gene:

Tissue specificity: Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patients sera.
genes like me logo Genes that share expression patterns with PI16: view

Primer Products

No data available for Protein tissue co-expression partners for PI16 Gene

Orthologs for PI16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PI16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PI16 34 35
  • 99.4 (n)
(Bos Taurus)
Mammalia PI16 34 35
  • 84.75 (n)
(Canis familiaris)
Mammalia PI16 34 35
  • 84.13 (n)
(Rattus norvegicus)
Mammalia Pi16 34
  • 76.4 (n)
(Mus musculus)
Mammalia Pi16 34 16 35
  • 76.13 (n)
(Ornithorhynchus anatinus)
Mammalia PI16 35
  • 64 (a)
(Monodelphis domestica)
Mammalia PI16 35
  • 54 (a)
(Gallus gallus)
Aves PI16 35
  • 52 (a)
(Anolis carolinensis)
Reptilia PI16 35
  • 48 (a)
(Danio rerio)
Actinopterygii PI16 35
  • 37 (a)
(Hordeum vulgare)
Liliopsida Hv.9067 34
(Oryza sativa)
Liliopsida Os.9421 34
(Zea mays)
Liliopsida Zm.2437 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
Species where no ortholog for PI16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PI16 Gene

Gene Tree for PI16 (if available)
Gene Tree for PI16 (if available)

Paralogs for PI16 Gene

(5) SIMAP similar genes for PI16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PI16: view

Variants for PI16 Gene

Sequence variations from dbSNP and Humsavar for PI16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1023036 -- 36,946,397(+) CTCCA(C/T)GTGCT upstream-variant-2KB
rs1023037 -- 36,948,178(+) tcagc(A/G)cctgg upstream-variant-2KB
rs1046279 -- 36,964,795(+) GAAAG(C/T)AACTC utr-variant-3-prime
rs1063021 -- 36,964,551(+) TCAGG(A/G)GGCCG utr-variant-3-prime
rs10664545 -- 36,960,364(+) TGTGT(-/GT/GTGG/GTGTGG)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PI16 Gene

Variant ID Type Subtype PubMed ID
dgv380n21 CNV gain 19592680
esv3608714 CNV loss 21293372
esv3608715 CNV loss 21293372
nsv1015689 CNV gain 25217958

Variation tolerance for PI16 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 76.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PI16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI16 Gene

Disorders for PI16 Gene

Relevant External Links for PI16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PI16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI16 Gene

Publications for PI16 Gene

  1. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. (PMID: 17062675) Reeves J.R. … Ramnani D.M. (Clin. Cancer Res. 2006) 3 4 22 64
  2. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PMID: 15344909) Reeves J.R. … Tanner J.E. (Biochem. J. 2005) 3 4 22 64
  3. Chemerin, a novel adipokine in the regulation of angiogenesis. (PMID: 20237162) Bozaoglu K. … Jowett J.B. (J. Clin. Endocrinol. Metab. 2010) 3 46 64
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for PI16 Gene

  • Cloud-Clone Corp. Antibodies for PI16
  • Cloud-Clone Corp. Proteins for PI16
  • Cloud-Clone Corp Assay Kits for PI16

Sources for PI16 Gene

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