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Aliases for PI16 Gene

Aliases for PI16 Gene

  • Peptidase Inhibitor 16 2 3 5
  • Cysteine-Rich Secretory Protein 9 3 4
  • Protease Inhibitor 16 2 3
  • PSP94-Binding Protein 3 4
  • CRISP9 3 4
  • PSPBP 3 4
  • Microseminoprotein, Beta-Binding Protein 3
  • Beta-Binding Protein 2
  • Microseminoprotein 2
  • CRISP-9 4
  • MSMBBP 3
  • CD364 3
  • PI-16 4

External Ids for PI16 Gene

Previous GeneCards Identifiers for PI16 Gene

  • GC06P036923
  • GC06P036971
  • GC06P036972
  • GC06P037030
  • GC06P036922
  • GC06P036647
  • GC06P036555
  • GC06P037027
  • GC06P037312
  • GC06P037028
  • GC06P037198

Summaries for PI16 Gene

GeneCards Summary for PI16 Gene

PI16 (Peptidase Inhibitor 16) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for PI16 Gene

  • Putative serine protease inhibitor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI16 Gene

Genomics for PI16 Gene

Regulatory Elements for PI16 Gene

Enhancers for PI16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PI16 on UCSC Golden Path with GeneCards custom track

Genomic Location for PI16 Gene

36,948,263 bp from pter
36,964,837 bp from pter
16,575 bases
Plus strand

Genomic View for PI16 Gene

Genes around PI16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI16 Gene

Proteins for PI16 Gene

  • Protein details for PI16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidase inhibitor 16
    Protein Accession:
    Secondary Accessions:
    • Q6ZVG9
    • Q8IYL8
    • Q8NBK0
    • Q8TCB8

    Protein attributes for PI16 Gene

    463 amino acids
    Molecular mass:
    49471 Da
    Quaternary structure:
    • Interacts with PSP94/MSMB.
    • May serve as a marker following prostatectomy for prostate cancer.
    • Sequence=AAH22399.2; Type=Frameshift; Positions=400; Evidence={ECO:0000305};

    Alternative splice isoforms for PI16 Gene


neXtProt entry for PI16 Gene

Proteomics data for PI16 Gene at MOPED

Post-translational modifications for PI16 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Asn 114, Ser 330, Asn 403, and Asn 409
  • Modification sites at PhosphoSitePlus

Other Protein References for PI16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for PI16 (Peptidase Inhibitor 16/PI16)

No data available for DME Specific Peptides for PI16 Gene

Domains & Families for PI16 Gene

Gene Families for PI16 Gene

Protein Domains for PI16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI16: view

Function for PI16 Gene

Molecular function for PI16 Gene

UniProtKB/Swiss-Prot Function:
Putative serine protease inhibitor.
genes like me logo Genes that share phenotypes with PI16: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PI16

miRNA for PI16 Gene

miRTarBase miRNAs that target PI16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI16 Gene

Localization for PI16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI16 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PI16 Gene COMPARTMENTS Subcellular localization image for PI16 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PI16 Gene

Pathways & Interactions for PI16 Gene

SuperPathways for PI16 Gene

No Data Available

Interacting Proteins for PI16 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000362778 for PI16 Gene via STRING

Gene Ontology (GO) - Biological Process for PI16 Gene


No data available for Pathways by source and SIGNOR curated interactions for PI16 Gene

Drugs & Compounds for PI16 Gene

No Compound Related Data Available

Transcripts for PI16 Gene

Unigene Clusters for PI16 Gene

Peptidase inhibitor 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PI16 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8
SP1: - - -
SP2: - -
SP3: - -
SP5: -

Relevant External Links for PI16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PI16 Gene

mRNA expression in normal human tissues for PI16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI16 Gene

This gene is overexpressed in Heart - Atrial Appendage (x5.1) and Vagina (x4.9).

Protein differential expression in normal tissues from HIPED for PI16 Gene

This gene is overexpressed in Serum (34.9), Cerebrospinal fluid (14.5), and Plasma (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PI16 Gene

SOURCE GeneReport for Unigene cluster for PI16 Gene Hs.25391

mRNA Expression by UniProt/SwissProt for PI16 Gene

Tissue specificity: Expressed in prostate, testis, ovary and intestine. Concentrates in prostate cancer patients sera.
genes like me logo Genes that share expression patterns with PI16: view

Primer Products

No data available for Protein tissue co-expression partners for PI16 Gene

Orthologs for PI16 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PI16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PI16 35
  • 84.75 (n)
  • 76.4 (a)
PI16 36
  • 76 (a)
(Canis familiaris)
Mammalia PI16 35
  • 84.13 (n)
  • 76.64 (a)
PI16 36
  • 77 (a)
(Mus musculus)
Mammalia Pi16 35
  • 76.13 (n)
  • 67.84 (a)
Pi16 16
Pi16 36
  • 62 (a)
(Pan troglodytes)
Mammalia PI16 35
  • 99.4 (n)
  • 99.1 (a)
PI16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pi16 35
  • 76.4 (n)
  • 69.1 (a)
(Monodelphis domestica)
Mammalia PI16 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia PI16 36
  • 64 (a)
(Gallus gallus)
Aves PI16 36
  • 52 (a)
(Anolis carolinensis)
Reptilia PI16 36
  • 48 (a)
(Danio rerio)
Actinopterygii PI16 36
  • 37 (a)
(Hordeum vulgare)
Liliopsida Hv.9067 35
(Oryza sativa)
Liliopsida Os.9421 35
(Zea mays)
Liliopsida Zm.2437 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for PI16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PI16 Gene

Gene Tree for PI16 (if available)
Gene Tree for PI16 (if available)

Paralogs for PI16 Gene

(5) SIMAP similar genes for PI16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PI16: view

Variants for PI16 Gene

Sequence variations from dbSNP and Humsavar for PI16 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1405069 - 36,954,908(-) GGCCG(G/T)CGGGG reference, missense
rs16889318 - 36,963,588(+) GTGCC(C/G)TGGCT intron-variant, reference, missense
rs1023036 -- 36,946,397(+) CTCCA(C/T)GTGCT upstream-variant-2KB
rs1023037 -- 36,948,178(+) tcagc(A/G)cctgg upstream-variant-2KB
rs1046279 -- 36,964,795(+) GAAAG(C/T)AACTC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PI16 Gene

Variant ID Type Subtype PubMed ID
dgv380n21 CNV Gain 19592680
nsv885815 CNV Loss 21882294

Variation tolerance for PI16 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 76.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PI16 Gene

Disorders for PI16 Gene

Relevant External Links for PI16

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PI16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI16 Gene

Publications for PI16 Gene

  1. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. (PMID: 17062675) Reeves J.R. … Ramnani D.M. (Clin. Cancer Res. 2006) 3 4 23 67
  2. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. (PMID: 15344909) Reeves J.R. … Tanner J.E. (Biochem. J. 2005) 3 23
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. (PMID: 22533972) Nicholson I.C. … Krumbiegel D. (Cell. Immunol. 2012) 3

Products for PI16 Gene

Sources for PI16 Gene