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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PI15 Gene

protein-coding   GIFtS: 48
GCID: GC08P075773

Peptidase Inhibitor 15

(Previous name: protease inhibitor 15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Peptidase Inhibitor 151 2     P25TI2 3
Protease Inhibitor 151 2     PI-152 3
Cysteine-Rich Secretory Protein 82 3     P24TI2
25 KDa Trypsin Inhibitor2 3     sugarCrisp2
CRISP-82 3     SugarCrisp3
CRISP82 3     p25TI3

External Ids:    HGNC: 89461   Entrez Gene: 510502   Ensembl: ENSG000001375587   OMIM: 6070765   UniProtKB: O436923   

Export aliases for PI15 gene to outside databases

Previous GC identifers: GC08P074766 GC08P075724 GC08P075460 GC08P075786 GC08P075899 GC08P071227


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PI15 Gene:
This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian
testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human
neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PI15 Gene: 
PI15 (peptidase inhibitor 15) is a protein-coding gene. Diseases associated with PI15 include brain cancer, and glioblastoma. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692
Function: Serine protease inhibitor which displays weak inhibitory activity against trypsin




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PI15 gene promoter:
         SRF   SRF (504 AA)   FOXL1   c-Rel   PPAR-gamma1   FOXJ2 (long isoform)   HOXA5   PPAR-gamma2   FOXJ2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPI15 promoter sequence
   Search SABiosciences Chromatin IP Primers for PI15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PI15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q13.3

PI15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PI15 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P075773:  view genomic region     (about GC identifiers)

Start:
75,736,772 bp from pter      End:
75,767,264 bp from pter
Size:
30,493 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692 (See protein sequence)
Recommended Name: Peptidase inhibitor 15 precursor  
Size: 258 amino acids; 29065 Da
Subcellular location: Secreted
Secondary accessions: Q68CY1

Explore the universe of human proteins at neXtProt for PI15: NX_O43692

Explore proteomics data for PI15 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43692

  • PI15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PI15 Protein Expression
    REFSEQ proteins: NP_056970.1  
    ENSEMBL proteins: 
     ENSP00000260113   ENSP00000428567  

    Human Recombinant Protein Products for PI15: 
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    Cloud-Clone Corp. Proteins for PI15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005576extracellular region IEA--

    PI15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014044 CAP_domain
     IPR001283 Allrgn_V5/Tpx1
     IPR018244 Allrgn_V5/Tpx1_CS

    Graphical View of Domain Structure for InterPro Entry O43692

    ProtoNet protein and cluster: O43692

    1 Blocks protein domain: IPB001283 Allergen V5/Tpx-1 related

    UniProtKB/Swiss-Prot: PI15_HUMAN, O43692
    Similarity: Belongs to the CRISP family
    Similarity: Contains 1 SCP domain


    PI15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI15_HUMAN, O43692
    Function: Serine protease inhibitor which displays weak inhibitory activity against trypsin

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030414peptidase inhibitor activity IEA--
         
    PI15 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PI15

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    PI15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PI15

    Search CenterWatch for drugs/clinical trials and news about PI15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PI15 gene: 
    NM_015886.3  

    Unigene Cluster for PI15:

    Peptidase inhibitor 15
    Hs.98558  [show with all ESTs]
    Unigene Representative Sequence: CR749657
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260113(uc003yal.3 uc003yam.3) ENST00000523773
    miRNA
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    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate PI15 (see all 62):
    hsa-miR-4291 hsa-miR-3130-5p hsa-miR-579 hsa-miR-607 hsa-miR-4254 hsa-miR-376b hsa-miR-300 hsa-miR-29a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Additional mRNA sequence: 

    AK130318.1 AK130386.1 BC074931.2 BC074932.2 BC126290.1 BC126292.1 CR749657.1 D45027.1 

    3 DOTS entries:

    DT.40119398  DT.92071939  DT.75167727 

    24/43 AceView cDNA sequences (see all 43):

    AA442089 AL602500 AI568779 AI264197 AI803475 BC074932 AI088609 BF055516 
    BM555525 AK130318 BC074931 AI696838 AK130386 AI913435 AA428062 AI307145 
    NM_015886 AA429645 BM745220 D45027 BM729115 CR749657 BQ015744 AA442196 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PI15 expression in normal human tissues (normalized intensities)      PI15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAACTATT
    PI15 Expression
    About this image


    PI15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Mature Cardiac Fibroblasts Myocardium
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Smooth Muscle (Muscoskeletal System)
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Breast (Uncategorized)
             breast ductal cells   
     
     Endothelium (Cardiovascular System)
             aorta   

    See PI15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PI15

    SOURCE GeneReport for Unigene cluster: Hs.98558

    UniProtKB/Swiss-Prot: PI15_HUMAN, O43692
    Tissue specificity: Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and
    thyroid gland

        SABiosciences Custom PCR Arrays for PI15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PI15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PI15 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pi151 , 5 peptidase inhibitor 151, 5 87.6(n)1
    93.41(a)1
      1 (5.32 cM)5
    942271  NM_053191.21  NP_444421.21 
     176019015 
    chicken
    (Gallus gallus)
    Aves PI151 peptidase inhibitor 15 84.63(n)
    90.31(a)
      374241  NM_204334.1  NP_989665.1 
    lizard
    (Anolis carolinensis)
    Reptilia PI156
    Uncharacterized protein
    86(a)
    1 ↔ 1
    4(34094538-34120224)
    zebrafish
    (Danio rerio)
    Actinopterygii pi15a1 peptidase inhibitor 15a 73.12(n)
    76.61(a)
      561978  NM_001159977.1  NP_001153449.1 


    ENSEMBL Gene Tree for PI15 (if available)
    TreeFam Gene Tree for PI15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PI15 gene
    CLEC18B2  CRISPLD22  CLEC18C2  PI162  GLIPR12  CRISP22  CRISP12  CRISPLD12  
    CRISP32  GLIPR1L12  CLEC18A2  GLIPR1L22  R3HDML2  
    5 SIMAP similar genes for PI15 using alignment to 1 protein entry:     PI15_HUMAN:
    CRISPLD2    R3HDML    CRISPLD1    GLIPR1    PI16

    PI15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/591 SNPs in PI15 are shown (see all 591)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505154541,2
    --75734792(+) ACAAAC/GGGTGT 1 -- us2k10--------
    rs796346901,2
    F--75734853(+) TCACCC/TTGGAG 1 -- us2k10--------
    rs360863221,2
    C,F--75735030(+) TCTAAC/TCTCTG 1 -- us2k16Minor allele frequency- T:0.09NA WA EA 364
    rs1832992291,2
    --75735085(+) AAGGTA/GCCATG 1 -- us2k10--------
    rs1859101121,2
    --75735138(+) TTGTTA/CAGATC 1 -- us2k10--------
    rs1395978061,2
    --75735178(+) TCTAGC/TTGCTC 1 -- us2k10--------
    rs1149289721,2
    F--75735193(+) GTTTCA/TTAATA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1898936621,2
    --75735305(+) AAATGA/TTTTCA 1 -- us2k10--------
    rs1831605661,2
    --75735477(+) AGAACA/GTGAAT 1 -- us2k10--------
    rs1134475531,2
    F--75735538(+) TTTGAC/TCACAC 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for PI15 (75736772 - 75767264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for PI15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv891018CNV Loss21882294
    nsv891019CNV Loss21882294
    nsv519265CNV Loss19592680
    nsv524736CNV Loss19592680
    esv28358CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607076    OMIM disorders: --

    6 diseases for PI15:    About MalaCards
    brain cancer    glioblastoma    neuroblastoma    thyroiditis
    pancreatitis    prostatitis


    PI15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PI15

    Export disorders for PI15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PI15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PI15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. (PubMed id 9473672)1, 2, 3 Yamakawa T.... Miyazaki K. (1998)
    2. Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. (PubMed id 8882727)1, 2, 3 Koshikawa N.... Miyazaki K. (1996)
    3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (2008)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo. (PubMed id 11287197)2 Smith D.M....Tabin C.J. (2001)
    9. A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor. (PubMed id 10362728)1 Kaplan F....Sweezey N.B. (1999)
    10. The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PubMed id 18824526)9 Gibbs G.M....O'Bryan M.K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51050 HGNC: 8946 AceView: PI15 Ensembl:ENSG00000137558 euGenes: HUgn51050
    ECgene: PI15 H-InvDB: PI15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PI15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PI15 gene:
    Search GeneIP for patents involving PI15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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