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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PI15 Gene

protein-coding GIFtS: 48
GCID: GC08P075773

peptidase inhibitor 15

(Previous name: protease inhibitor 15 )

Explore 6 diseases affiliated with
PI15 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Peptidase Inhibitor 15¹ ²		CRISP8² ³
P25TI¹ ² ³		PI-15² ³
Protease Inhibitor 15¹ ²		P24TI²
Cysteine-Rich Secretory Protein 8² ³		SugarCrisp³
25 KDa Trypsin Inhibitor² ³		SugarCrisp³
CRISP-8² ³		P25TI¹ ² ³

External Ids:	HGNC: 8946¹	Entrez Gene: 51050²	Ensembl: ENSG00000137558⁷	OMIM: 607076⁵	UniProtKB: O43692³

Export aliases for PI15 gene to outside databases

Previous GC identifers: GC08P074766 GC08P075724 GC08P075460 GC08P075786 GC08P075899 GC08P071227

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PI15:

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian

testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma

and glioblastoma cell lines, and thus may play a role in the central nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692

Function: Serine protease inhibitor which displays weak inhibitory activity against trypsin

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PI15 gene promoter:
SRF SRF (504 AA) FOXL1 c-Rel PPAR-gamma1 FOXJ2 (long isoform) HOXA5 PPAR-gamma2 FOXJ2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PI15 promoter sequence

Search SABiosciences Chromatin IP Primers for PI15

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PI15

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q13.3

PI15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PI15 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P075773: view genomic region (about GC identifiers)

Start:	75,736,772 bp from pter	End:	75,767,264 bp from pter
Size:	30,493 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692 (See protein sequence)

Recommended Name: Peptidase inhibitor 15 precursor

Size: 258 amino acids; 29065 Da

Subcellular location: Secreted

Secondary accessions: Q68CY1

Explore the universe of human proteins at neXtProt for PI15: NX_O43692

Post-translational modifications:

N-glycosylated (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43692

PI15 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056970.1

ENSEMBL proteins:

ENSP00000260113 ENSP00000428567

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005576	extracellular region	IEA	--

PI15 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PI15 for domains About GeneDecksing

3 InterPro domains/families:

IPR014044 CAP_domain

IPR001283 Allrgn_V5/Tpx1

IPR018244 Allrgn_V5/Tpx1_CS

Graphical View of Domain Structure for InterPro Entry O43692

ProtoNet protein and cluster: O43692

1 Blocks protein family: IPB001283 Allergen V5/Tpx-1 related

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692

Similarity: Belongs to the CRISP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692

Function: Serine protease inhibitor which displays weak inhibitory activity against trypsin

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030414	peptidase inhibitor activity	IEA	--

PI15 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PI15

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

PI15 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
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About This Section

REFSEQ mRNAs for PI15 gene:

NM_015886.3

Unigene Cluster for PI15:

Peptidase inhibitor 15

Hs.98558 [show with all ESTs]

Unigene Representative Sequence: CR749657

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000260113(uc003yal.3 uc003yam.3) ENST00000523773

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Additional cDNA sequence:

AK130318.1 AK130386.1 BC074931.2 BC074932.2 BC126290.1 BC126292.1 CR749657.1 D45027.1

3 DOTS entries:

DT.40119398 DT.92071939 DT.75167727

24/43 AceView cDNA sequences (see all 43):

AK130386 BM555525 AA428062 AI307145 AI913435 AI696838 AL602500 BC074931

AA442089 AI803475 BC074932 AI568779 AI264197 AK130318 AI088609 BF055516

NM_015886 D45027 AW058403 AA448738 AI760116 BI495101 CR749657 AI249368

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PI15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAACTATT

About this image

PI15 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Mature Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See PI15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PI15

SOURCE GeneReport for Unigene cluster: Hs.98558

UniProtKB/Swiss-Prot: PI15_HUMAN, O43692

Tissue specificity: Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid

gland

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PI15 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PI15¹	peptidase inhibitor 15	84.63(n) 90.31(a)		374241 NM_204334.1 NP_989665.1
lizard (Anolis carolinensis)	Reptilia	PI15⁶	--	86(a)	1 ↔ 1	4(34095828-34115619)
zebrafish (Danio rerio)	Actinopterygii	pi15a¹	peptidase inhibitor 15a	73.12(n) 76.61(a)		561978 NM_001159977.1 NP_001153449.1

ENSEMBL Gene Tree for PI15 (if available)
TreeFam Gene Tree for PI15 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PI15 gene

CLEC18B² CRISPLD2² CLEC18C² PI16² GLIPR1² CRISP2² CRISP1² CRISPLD1²

CRISP3² GLIPR1L1² CLEC18A² GLIPR1L2² R3HDML²

6 SIMAP similar genes for PI15 using alignment to 1 protein entry: PI15_HUMAN:

CRISPLD2 R3HDML CRISPLD1 GLIPR1 PI16 GLIPR1L1

PI15 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150515454^1,2		--	75734792(+)	`ACAAAC/GGGTGT`	1	--	us2k¹		0	--	--	--	--
rs79634690^1,2		--	75734853(+)	`TCACCC/TTGGAG`	1	--	us2k¹		0	--	--	--	--
rs36086322^1,2	C,F,	--	75735030(+)	`TCTAAC/TCTCTG`	1	--	us2k¹		6		NA WA EA	364
rs183299229^1,2		--	75735085(+)	`AAGGTA/GCCATG`	1	--	us2k¹		0	--	--	--	--
rs185910112^1,2		--	75735138(+)	`TTGTTA/CAGATC`	1	--	us2k¹		0	--	--	--	--
rs139597806^1,2		--	75735178(+)	`TCTAGC/TTGCTC`	1	--	us2k¹		0	--	--	--	--
rs114928972^1,2	F,	--	75735193(+)	`GTTTCA/TTAATA`	1	--	us2k¹		1		WA	118
rs189893662^1,2		--	75735305(+)	`AAATGA/TTTTCA`	1	--	us2k¹		0	--	--	--	--
rs183160566^1,2		--	75735477(+)	`AGAACA/GTGAAT`	1	--	us2k¹		0	--	--	--	--
rs113447553^1,2		--	75735538(+)	`TTTGAC/TCACAC`	1	--	us2k¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for PI15 (75736772 - 75767264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PI15
2 CNVs: 52622 70392

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PI15 for disorders           About GeneDecksing

OMIM gene information: 607076    OMIM disorders: --

6 diseases for PI15:    About MalaCards

glioblastoma neuroblastoma brain cancer thyroiditis

pancreatitis prostatitis

Export disorders for PI15 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PI15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PI15)

Utopia: connect your pdf to the dynamic
world of online information

cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. (PubMed id 9473672)^{1, 2, 3} Yamakawa T.... Miyazaki K. (1998)
Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. (PubMed id 8882727)^{1, 2, 3} Koshikawa N.... Miyazaki K. (1996)
A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)¹ Melzer D....Ferrucci L. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo. (PubMed id 11287197)² Smith D.M....Tabin C.J. (2001)
A novel developmentally regulated gene in lung mesenchyme: homology to a tumor-derived trypsin inhibitor. (PubMed id 10362728)¹ Kaplan F....Sweezey N.B. (1999)
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense. (PubMed id 18824526)⁹ Gibbs G.M....O'Bryan M.K. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51050	HGNC: 8946	AceView: PI15	Ensembl:ENSG00000137558	euGenes: HUgn51050
ECgene: PI15	H-InvDB: PI15

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PI15	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PI15 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PI15 gene:
Search GeneIP for patents involving PI15

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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	OriGene Custom Antibody Services for PI15		OriGene Custom Protein Services for PI15
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PI15
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PI15
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	GenScript Custom Purified and Recombinant Proteins Services for PI15		GenScript cDNA clones with any tag delivered in your preferred vector for PI15
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	GenScript Custom overexpressing Cell Line Services for PI15		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ThermoFisher Antibody for PI15

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PI15

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PI15 gene at Home site.

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PI15 Gene

peptidase inhibitor 15

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PI15 Gene

peptidase inhibitor 15

Aliasesfor PI15 gene

Summariesfor PI15 gene

Genomic Viewsfor PI15 gene

Proteinsfor PI15 gene

Protein Domains /Familiesfor PI15 gene

Functionfor PI15 gene

Pathways & Interactionsfor PI15 gene

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Genome Databases showing PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

Expression
for PI15 gene

Orthologs
for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene

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for PI15 gene