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Aliases for PI15 Gene

Aliases for PI15 Gene

  • Peptidase Inhibitor 15 2 3 5
  • Cysteine-Rich Secretory Protein 8 3 4
  • 25 KDa Trypsin Inhibitor 3 4
  • Protease Inhibitor 15 2 3
  • SugarCrisp 3 4
  • CRISP-8 3 4
  • CRISP8 3 4
  • P25TI 3 4
  • PI-15 3 4
  • P24TI 3

External Ids for PI15 Gene

Previous GeneCards Identifiers for PI15 Gene

  • GC08P075724
  • GC08P075460
  • GC08P075786
  • GC08P075773
  • GC08P075899
  • GC08P071227

Summaries for PI15 Gene

Entrez Gene Summary for PI15 Gene

  • This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for PI15 Gene

PI15 (Peptidase Inhibitor 15) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for PI15 Gene

  • Serine protease inhibitor which displays weak inhibitory activity against trypsin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI15 Gene

Genomics for PI15 Gene

Regulatory Elements for PI15 Gene

Enhancers for PI15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PI15 on UCSC Golden Path with GeneCards custom track

Genomic Location for PI15 Gene

Chromosome:
8
Start:
74,824,469 bp from pter
End:
74,855,044 bp from pter
Size:
30,576 bases
Orientation:
Plus strand

Genomic View for PI15 Gene

Genes around PI15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PI15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PI15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI15 Gene

Proteins for PI15 Gene

  • Protein details for PI15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43692-PI15_HUMAN
    Recommended name:
    Peptidase inhibitor 15
    Protein Accession:
    O43692
    Secondary Accessions:
    • Q68CY1

    Protein attributes for PI15 Gene

    Size:
    258 amino acids
    Molecular mass:
    29065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PI15 Gene

Proteomics data for PI15 Gene at MOPED

Post-translational modifications for PI15 Gene

Other Protein References for PI15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PI15 Gene

Domains & Families for PI15 Gene

Protein Domains for PI15 Gene

Suggested Antigen Peptide Sequences for PI15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43692

UniProtKB/Swiss-Prot:

PI15_HUMAN :
  • Contains 1 SCP domain.
  • Belongs to the CRISP family.
Domain:
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI15: view

No data available for Gene Families for PI15 Gene

Function for PI15 Gene

Molecular function for PI15 Gene

UniProtKB/Swiss-Prot Function:
Serine protease inhibitor which displays weak inhibitory activity against trypsin.
genes like me logo Genes that share phenotypes with PI15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PI15

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PI15 Gene

Localization for PI15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PI15 Gene COMPARTMENTS Subcellular localization image for PI15 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for PI15 Gene

Pathways & Interactions for PI15 Gene

SuperPathways for PI15 Gene

No Data Available

Interacting Proteins for PI15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000260113%0d%0a9606.ENSP00000280527%0d%0a
Selected Interacting proteins: ENSP00000260113 for PI15 Gene via STRING

Symbol External ID(s) Details
CRIM1

Gene Ontology (GO) - Biological Process for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with PI15: view

No data available for Pathways by source and SIGNOR curated interactions for PI15 Gene

Drugs & Compounds for PI15 Gene

No Compound Related Data Available

Transcripts for PI15 Gene

Unigene Clusters for PI15 Gene

Peptidase inhibitor 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PI15 Gene

No ASD Table

Relevant External Links for PI15 Gene

GeneLoc Exon Structure for
PI15
ECgene alternative splicing isoforms for
PI15

Expression for PI15 Gene

mRNA expression in normal human tissues for PI15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI15 Gene

This gene is overexpressed in Fallopian Tube (x7.9), Breast - Mammary Tissue (x5.9), and Prostate (x5.8).

Protein differential expression in normal tissues from HIPED for PI15 Gene

This gene is overexpressed in Prostate (43.5) and Fetal heart (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PI15 Gene



SOURCE GeneReport for Unigene cluster for PI15 Gene Hs.98558

mRNA Expression by UniProt/SwissProt for PI15 Gene

O43692-PI15_HUMAN
Tissue specificity: Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.
genes like me logo Genes that share expression patterns with PI15: view

Protein tissue co-expression partners for PI15 Gene

Primer Products

Orthologs for PI15 Gene

This gene was present in the common ancestor of animals.

Orthologs for PI15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PI15 35
  • 93.67 (n)
  • 97.67 (a)
PI15 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PI15 35
  • 95.09 (n)
  • 98.06 (a)
PI15 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pi15 35
  • 87.6 (n)
  • 93.41 (a)
Pi15 16
Pi15 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PI15 35
  • 99.61 (n)
  • 100 (a)
PI15 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pi15 35
  • 87.34 (n)
  • 91.47 (a)
oppossum
(Monodelphis domestica)
Mammalia PI15 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PI15 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PI15 35
  • 84.63 (n)
  • 90.31 (a)
PI15 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PI15 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pi15 35
  • 75.06 (n)
  • 81.01 (a)
zebrafish
(Danio rerio)
Actinopterygii pi15a 35
  • 73.12 (n)
  • 76.61 (a)
pi15a 36
  • 73 (a)
OneToMany
pi15b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 12 (a)
ManyToMany
scl-23 36
  • 17 (a)
ManyToMany
vap-1 36
  • 11 (a)
ManyToMany
Species with no ortholog for PI15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PI15 Gene

ENSEMBL:
Gene Tree for PI15 (if available)
TreeFam:
Gene Tree for PI15 (if available)

Paralogs for PI15 Gene

(5) SIMAP similar genes for PI15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PI15: view

Variants for PI15 Gene

Sequence variations from dbSNP and Humsavar for PI15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7835278 -- 74,853,712(+) TGACA(A/G)CACCT utr-variant-3-prime
rs7835875 -- 74,843,480(+) cccca(C/T)gcttt intron-variant
rs7836633 -- 74,843,828(+) ccatt(C/G)cactc intron-variant
rs2570177 -- 74,848,734(+) atata(G/T)aGAGA intron-variant
rs2570178 -- 74,854,093(+) ATTGA(A/C)CTAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PI15 Gene

Variant ID Type Subtype PubMed ID
esv28358 CNV Gain+Loss 19812545
nsv891018 CNV Loss 21882294
nsv891019 CNV Loss 21882294
nsv524736 CNV Loss 19592680
nsv519265 CNV Loss 19592680

Variation tolerance for PI15 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PI15 Gene

Human Gene Mutation Database (HGMD)
PI15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI15 Gene

Disorders for PI15 Gene

Relevant External Links for PI15

Genetic Association Database (GAD)
PI15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PI15

No disorders were found for PI15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PI15 Gene

Publications for PI15 Gene

  1. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. (PMID: 9473672) Yamakawa T. … Miyazaki K. (Biochim. Biophys. Acta 1998) 2 3 4 67
  2. Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. (PMID: 8882727) Koshikawa N. … Miyazaki K. (J. Biochem. 1996) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3

Products for PI15 Gene

Sources for PI15 Gene

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