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Aliases for PI15 Gene

Aliases for PI15 Gene

  • Peptidase Inhibitor 15 2 3
  • Cysteine-Rich Secretory Protein 8 3 4
  • 25 KDa Trypsin Inhibitor 3 4
  • Protease Inhibitor 15 2 3
  • SugarCrisp 3 4
  • CRISP-8 3 4
  • CRISP8 3 4
  • P25TI 3 4
  • PI-15 3 4
  • P24TI 3

External Ids for PI15 Gene

Previous GeneCards Identifiers for PI15 Gene

  • GC08P075724
  • GC08P075460
  • GC08P075786
  • GC08P075773
  • GC08P075899
  • GC08P071227

Summaries for PI15 Gene

Entrez Gene Summary for PI15 Gene

  • This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for PI15 Gene

PI15 (Peptidase Inhibitor 15) is a Protein Coding gene. Diseases associated with PI15 include glioblastoma and neuroblastoma. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is CLEC18B.

UniProtKB/Swiss-Prot for PI15 Gene

  • Serine protease inhibitor which displays weak inhibitory activity against trypsin.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PI15 Gene

Genomics for PI15 Gene

Genomic Location for PI15 Gene

Start:
74,824,537 bp from pter
End:
74,855,029 bp from pter
Size:
30,493 bases
Orientation:
Plus strand

Genomic View for PI15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PI15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PI15 Gene

Proteins for PI15 Gene

  • Protein details for PI15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43692-PI15_HUMAN
    Recommended name:
    Peptidase inhibitor 15
    Protein Accession:
    O43692
    Secondary Accessions:
    • Q68CY1

    Protein attributes for PI15 Gene

    Size:
    258 amino acids
    Molecular mass:
    29065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PI15 Gene

Proteomics data for PI15 Gene at MOPED

Post-translational modifications for PI15 Gene

Other Protein References for PI15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PI15 Gene

Domains for PI15 Gene

Protein Domains for PI15 Gene

Suggested Antigen Peptide Sequences for PI15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43692

UniProtKB/Swiss-Prot:

PI15_HUMAN :
  • O43692
Domain:
  • Contains 1 SCP domain.
Family:
  • Belongs to the CRISP family.
genes like me logo Genes that share domains with PI15: view

No data available for Gene Families for PI15 Gene

Function for PI15 Gene

Molecular function for PI15 Gene

UniProtKB/Swiss-Prot Function: Serine protease inhibitor which displays weak inhibitory activity against trypsin.

Gene Ontology (GO) - Molecular Function for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PI15: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PI15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PI15 Gene

Localization for PI15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PI15 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PI15 Gene COMPARTMENTS Subcellular localization image for PI15 gene
Compartment Confidence
extracellular 5
cytosol 1

Gene Ontology (GO) - Cellular Components for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PI15: view

Pathways for PI15 Gene

SuperPathways for PI15 Gene

No Data Available

Interacting Proteins for PI15 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000260113%0d%0a9606.ENSP00000280527%0d%0a
Selected Interacting proteins: ENSP00000260113 for PI15 Gene via STRING

Symbol External ID(s) Details
CRIM1

Gene Ontology (GO) - Biological Process for PI15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with PI15: view

No data available for Pathways by source for PI15 Gene

Transcripts for PI15 Gene

Unigene Clusters for PI15 Gene

Peptidase inhibitor 15:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PI15

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PI15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PI15 Gene

No ASD Table

Relevant External Links for PI15 Gene

GeneLoc Exon Structure for
PI15
ECgene alternative splicing isoforms for
PI15

Expression for PI15 Gene

mRNA expression in normal human tissues for PI15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PI15 Gene

This gene is overexpressed in Fallopian Tube (7.9), Breast - Mammary Tissue (5.9), and Prostate (5.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PI15 Gene

SOURCE GeneReport for Unigene cluster for PI15 Gene Hs.98558

mRNA Expression by UniProt/SwissProt for PI15 Gene

O43692-PI15_HUMAN
Tissue specificity: Weakly expressed. Expressed at low level in prostate, mammary gland, salivary gland and thyroid gland.
genes like me logo Genes that share expressions with PI15: view

In Situ Assay Products

Orthologs for PI15 Gene

This gene was present in the common ancestor of animals.

Orthologs for PI15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PI15 35
  • 99.61 (n)
  • 100 (a)
PI15 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PI15 35
  • 93.67 (n)
  • 97.67 (a)
PI15 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PI15 35
  • 95.09 (n)
  • 98.06 (a)
PI15 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pi15 35
  • 87.6 (n)
  • 93.41 (a)
Pi15 16
Pi15 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PI15 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PI15 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pi15 35
  • 87.34 (n)
  • 91.47 (a)
chicken
(Gallus gallus)
Aves PI15 35
  • 84.63 (n)
  • 90.31 (a)
PI15 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PI15 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pi15 35
  • 75.06 (n)
  • 81.01 (a)
zebrafish
(Danio rerio)
Actinopterygii pi15a 35
  • 73.12 (n)
  • 76.61 (a)
pi15a 36
  • 73 (a)
OneToMany
pi15b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8483 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scl-22 36
  • 12 (a)
ManyToMany
scl-23 36
  • 17 (a)
ManyToMany
vap-1 36
  • 11 (a)
ManyToMany
Species with no ortholog for PI15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PI15 Gene

ENSEMBL:
Gene Tree for PI15 (if available)
TreeFam:
Gene Tree for PI15 (if available)

Paralogs for PI15 Gene

Selected SIMAP similar genes for PI15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PI15: view

Variants for PI15 Gene

Sequence variations from dbSNP and Humsavar for PI15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10701 -- 74,854,917(-) ACACT(C/G)ACAAT utr-variant-3-prime
rs1347238 -- 74,853,534(-) TGATA(C/T)TTGAC utr-variant-3-prime
rs1347239 -- 74,853,345(-) GAATC(A/G)AATGG utr-variant-3-prime
rs1368632 -- 74,831,861(+) TAGTA(C/G)ACTCG intron-variant
rs1368633 -- 74,832,222(+) CCTCC(A/G)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PI15 Gene

Variant ID Type Subtype PubMed ID
esv28358 CNV Gain+Loss 19812545
nsv891018 CNV Loss 21882294
nsv891019 CNV Loss 21882294
nsv524736 CNV Loss 19592680
nsv519265 CNV Loss 19592680

Relevant External Links for PI15 Gene

HapMap Linkage Disequilibrium report
PI15
Human Gene Mutation Database (HGMD)
PI15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PI15 Gene

Disorders for PI15 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PI15 Gene including...

Search for PI15 Gene in MalaCards »

Relevant External Links for PI15

Genetic Association Database (GAD)
PI15
genes like me logo Genes that share disorders with PI15: view

No data available for UniProtKB/Swiss-Prot for PI15 Gene

Publications for PI15 Gene

  1. Purification and identification of a novel and four known serine proteinase inhibitors secreted by human glioblastoma cells. (PMID: 8882727) Koshikawa N. … Miyazaki K. (J. Biochem. 1996) 2 3 4
  2. cDNA cloning of a novel trypsin inhibitor with similarity to pathogenesis-related proteins, and its frequent expression in human brain cancer cells. (PMID: 9473672) Yamakawa T. … Miyazaki K. (Biochim. Biophys. Acta 1998) 2 3 4
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 48
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Cloning and expression of a novel cysteine-rich secreted protein family member expressed in thyroid and pancreatic mesoderm within the chicken embryo. (PMID: 11287197) Smith D.M. … Tabin C.J. (Mech. Dev. 2001) 4

Products for PI15 Gene

  • Addgene plasmids for PI15

Sources for PI15 Gene

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