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PHYH Gene

protein-coding GIFtS: 63

GC10M013359

phytanoyl-CoA 2-hydroxylase
(Previous names: phytanoyl-CoA hydroxylase (Refsum disease), phytanoyl-CoA hydroxylase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EC 1.14.11.18 ^³
LN1 ^²
LNAP1 ^²
PAHX ^¹, ², ³, ⁵
PHYH1 ^¹, ²
PhyH ^³
RD ^¹, ²

Descriptions
Phytanic acid oxidase ^², ³
Phytanoyl-CoA alpha-hydroxylase ^², ³
phytanoil-CoA alpha hydroxylase ^²
phytanoyl-CoA 2 oxoglutarate dioxygenase ^²
phytanoyl-CoA 2-hydroxylase ^²
phytanoyl-CoA dioxygenase, peroxisomal ^²
phytanoyl-CoA hydroxylase ^¹
phytanoyl-CoA hydroxylase (Refsum disease) ^¹, ²

External Ids
HGNC: 8940¹
Entrez Gene: 5264²
UniProtKB: O14832³
Ensembl: ENSG00000107537⁷

Search outside databases for aliases for PHYH gene

Previous GC identifers: GC10M013302 GC10M013470 GC10M013323

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for PHYH:

This gene is a member of the PhyH family and encodes a peroxisomal protein that is involved in the

alpha-oxidation of 3-methyl branched fatty acids. Specifically, this protein converts

phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Mutations in this gene have been associated with Refsum

disease (RD) and deficient protein activity has been associated with Zellweger syndrome and

rhizomelic chondrodysplasia punctata. Alternate transcriptional splice variants, encoding

different isoforms, have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832

Function: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PHYH gene

Entrez Gene cytogenetic band: 10p13 Ensembl cytogenetic band: 10p13 HGNC cytogenetic band: 10p13

PHYH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M013359: (about GC identifiers)

Start:	13,359,802 bp from pter
End:	13,384,418 bp from pter
Size:	24,617 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_077569.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832 (See protein sequence)

Recommended Name: Phytanoyl-CoA dioxygenase, peroxisomal precursor

Size: 338 amino acids; 38538 Da

Cofactor: Iron

Cofactor: Ascorbate

Subunit: Interacts specifically with the immunophilin FKBP52 and PHYHIP

Subcellular location: Peroxisome

PDB structures from and Proteopedia :

2A1X (3D)

Secondary accessions: B1ALH5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001032626.1 NP_006205.1

ENSEMBL proteins:

ENSP00000380121 ENSP00000367928 ENSP00000263038 ENSP00000380126

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PHYH)
	Human Recombinant Proteins from Abnova (PHYH)

OriGene Purified Recombinant Human Protein: PHYH

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005777	peroxisome	TAS	8954107

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Antibodies for PHYH:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PHYH
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PHYH), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PHYH)
	Novus Biologicals Antibodies for PHYH

Assays for PHYH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O14832

ProtoNet protein and cluster: O14832

1 Blocks protein family: IPB008775 Phytanoyl-CoA dioxygenase

UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832

Similarity: Belongs to the PhyH family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PHYH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PHYH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006214

Applied Biosystems Silencer® siRNAs for PHYH

Sigma-Aldrich siRNA and siRNA Panels for PHYH

Sigma-Aldrich shRNA for PHYH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PHYH
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001037537
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001037537
untagged cDNA clones in CMV expression vector (see all 2): NM_001037537

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006214

UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832

Function: Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA

Catalytic activity: Phytanoyl-CoA + 2-oxoglutarate + O(2) = 2-hydroxyphytanoyl-CoA + succinate +

CO(2)

Enzyme Number (IUBMB): EC 1.14.11.18

Genatlas biochemistry entry for PHYH:

phytanoyl-CoA hydroxylase,41.2kDa,FKBP-associated protein,containing a cleavable peroxisomal

targetting signal type 2 (PTS2)

8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Phyh):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	immune system
liver/biliary system	nervous system	reproductive system

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0009055	electron carrier activity	TAS	8954107
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0031418	L-ascorbic acid binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832

Pathway: Lipid metabolism; fatty acid metabolism

Gene Network Central^TM Interacting Genes and Proteins Network for PHYH

5/24 Interacting proteins for PHYH (ENSP00000367928³ O14832^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COPS3	Q9UNS2¹	EBI-721853, EBI-350590
WDR8	Q9P2S5¹	EBI-721853, EBI-1054904
MAGEA11	P43364²	MINT-66763
TOM1L1	O75674²	MINT-63080
PHYHIP	ENSP00000320017³	STRING (score=.991)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	8954107
GO:0007399	nervous system development	TAS	9326940
GO:0007601	visual perception	IEA	--
GO:0007605	sensory perception of sound	IEA	--
GO:0050896	response to stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PHYH
6 Novoseek chemical compound relationships for PHYH gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-hydroxyphytanoyl-coa	96.98	5	10588950 (1), 8954107 (1), 11341778 (1), 11948235 (1)
phytanic acid	96.76	22	10866807 (5), 10588950 (2), 8954107 (2), 18612766 (2) (see all 12)
fatty acid	34.37	2	17956237 (1)
histidine	11.89	1	16186124 (1)
iron	2.22	4	9326939 (1), 15930519 (1), 16186124 (1)
lipid	0.00	1	15452860 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PHYH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PHYH)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006214

Sigma-Aldrich siRNA and siRNA Panels for PHYH

Sigma-Aldrich shRNA for PHYH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001037537 NM_006214

REFSEQ mRNAs for PHYH gene (2 alternative transcripts):

NM_001037537.1 NM_006214.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001037537 NM_006214

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001037537
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001037537
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001037537

Additional cDNA sequence:

AF023462.1 AF112977.1 BC021011.1 BC029512.1 CR542055.1 CR591194.1 CR597553.1 CR600223.1

CR610525.1 CR623416.1 CR623967.1

12 DOTS entries:

DT.216103 DT.75120414 DT.100796169 DT.100796173 DT.92432991 DT.95107144 DT.100796168 DT.100796171

DT.121216358 DT.86848595 DT.92432993 DT.95268160

24/201 AceView cDNA sequences (see all 201 ):

CR597553 T32499 Z43616 CK822288 CR591194 BC021011 CR610525 CR623416

BM985421 CR600223 BM701313 BU730211 CR623967 N72414 AV653048 CB164091

T81584 AA553549 AW614260 H80645 BI765740 AW515470 AI800402 CB148518

highest scoring ESTs for PHYH:

AF023462 AA337631 AF112977 AL515362 BC021011 BC029512 BE876320 BF185692 BF876138 BF876150

Unigene Cluster for PHYH:

Phytanoyl-CoA 2-hydroxylase

Hs.498732 [show with all ESTs]

Unigene Representative Sequence: CR623416

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for PHYH

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10
SP1:			-						-
SP2:									-
SP3:					-				-
SP4:			-

About this scheme

ECgene alternative splicing isoforms for PHYH

4 Ensembl transcripts including schematic representations:

ENST00000396913 ENST00000378659 ENST00000263038 ENST00000396920

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PHYH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PHYH

¹ / ² / ³

3 probe-sets matching PHYH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32724_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF023462	1.00	1.00	1.00	1
203335_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006214	0.60	1.00	0.82	1
203335_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PHYH for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGTCCAAAT

SOURCE GeneReport for Unigene cluster: Hs.498732
Expression variation in blood from EXPOLDB for PHYH
UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832
Tissue specificity: Expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung
and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PHYH gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PHYH¹	--	phytanoyl-CoA 2-hydroxylase	79.98(n) 77.22(a)	478000 XM_535184.2 XP_535184.2
chimpanzee (Pan troglodytes)	PHYH¹	--	phytanoyl-CoA 2-hydroxylase	99.11(n) 98.82(a)	450310 XM_507662.2 XP_507662.2
cow (Bos taurus)	PHYH¹	--	phytanoyl-CoA 2-hydroxylase	83.48(n) 82.63(a)	281400 NM_174142.1 NP_776567.1
rat (Rattus norvegicus)	Phyh¹	--	phytanoyl-CoA 2-hydroxylase	79.49(n) 78.11(a)	114209 NM_053674.1 NP_446126.1
mouse (Mus musculus)	Phyh^{1, 5}	2⁵	phytanoyl-CoA hydroxylase^{1, 5}	79.59(n)¹ 78.11(a)¹	16922¹ NM_010726.1¹ NP_034856.1¹ AF023463⁵ AI256161⁵ (see all 18)

About this table Species with no ortholog for PHYH

ENSEMBL Gene Tree for PHYH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/230 NCBI SNPs in PHYH are shown (see all 230 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 81)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7914269^1,2	A,C,F,H	13383494(+)	`aatttC/Attttt`	2	--	ng3¹ trp³		3	EA WA	298
	rs11133^1,2	C,F,H,O	13360242(-)	`AAAATG/ATTTTC`	2	--	ut3¹		7	MN EA EU WA	2292
	rs1747682^1,2	C,F,H,O	13377594(-)	`AATAAT/CGTTCT`	2	N/N	syn¹ ut5¹		7	EU EA WA NA	558
	rs4615920^1,2	A,C,F,H	13382660(+)	`CTTCCA/GCTGAC`	2	--	ng3¹		12	EU EA WA NA	1046
	rs6602647^1,2	A,C,F,H	13383527(+)	`gccgaA/Cgttcc`	2	--	ng3¹		3	EU EA	292
	rs732701^1,2	A,F,H	13381737(+)	`AGGGCA/GACGCG`	2	--	int¹ ut5¹		4	MN EA WA	458
	rs608353^1,2	C,F,H	13381815(+)	`GCTCCG/TGGAAG`	2	--	ng3¹ int¹		6	MN EU EA WA	2054
	rs1058596^1,2	A,C,F	13381585(-)	`GGAACG/CGGCCC`	2	--	ut5¹ int¹		2	EA MN	1678
	rs511959^1,2	C,F,H	13381842(+)	`GGGACC/GCGGCG`	2	--	ng3¹ int¹		5	MN EU EA WA	552
--	rs11598373^1,2	C,F,H	13383534(+)	`ttcccG/Agccta`	2	--	ng3¹		3	EU EA	286

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HapMap Linkage Disequilibrium images for PHYH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602026 disorders: 266500

UniProtKB/Swiss-Prot: PAHX_HUMAN, O14832

Defects in PHYH are a cause of Refsum disease (RD) [MIM:266500]. RD is an autosomal

recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentosa,

peripheral neuropathy, cerebellar ataxia, and elevated protein levels in the cerebrospinal fluid

(CSF). Patients exhibit accumulation of the branched-chain fatty acid, phytanic acid, in blood and

tissues. Less constant features are nerve deafness, anosmia, skeletal abnormalities, ichthyosis,

cataracts and cardiac impairment. Manifestations of the disease appear in the second or third

decade of life

7 Novoseek disease relationships for PHYH gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
refsum disease	97.18	33	9326939 (3), 17956235 (2), 10951529 (2), 14974078 (2) (see all 19)
peroxisomal disorders	83.30	1	8341225 (1)
chondrodysplasia punctata rhizomelic	83.25	1	9266377 (1)
retinitis pigmentosa	65.78	1	17905308 (1)
lymphoma follicular	46.95	2	2179300 (1), 1689087 (1)
lymphoma	4.77	1	2179300 (1)
alzheimers disease	3.08	2	2251906 (1), 1685745 (1)

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1 PharmGKB disease relationship for PHYH gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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GeneTests: PHYH

Refsum Disease

Human Gene Mutation Database: PHYH

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/68 PubMed articles for PHYH gene (see all 68 ):

Identification of PAHX, a Refsum disease gene. (PubMed id 9326939)^{1, 2, 3, 4} Mihalik S.J....Gould S.J. (1997)
Molecular basis of Refsum disease: sequence variations in phytanoyl- CoA hydroxylase (PHYH) and the PTS2 receptor (PEX7). (PubMed id 14974078)^{1, 3, 4} Jansen G.A.... Wanders R.J.A. (2004)
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. (PubMed id 16186124)^{1, 3, 4} McDonough M.A....Schofield C.J. (2005)
Human phytanoyl-CoA hydroxylase: resolution of the gene structure and the molecular basis of Refsum's disease. (PubMed id 10767344)^{1, 3, 4} Jansen G.A.... Wanders R.J.A. (2000)
Refsum disease is caused by mutations in the phytanoyl-CoA hydroxylase gene. (PubMed id 9326940)^{1, 3, 4} Jansen G.A....Wanders R.J.A. (1997)
Phytanoyl-CoA hydroxylase deficiency. Enzymological and molecular basis of classical Refsum disease. (PubMed id 10709665)^{1, 3, 4} Jansen G.A.... Wanders R.J.A. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of a brain specific protein that associates with a refsum disease gene product, phytanoyl-CoA alpha-hydroxylase. (PubMed id 10686344)^{3, 4} Lee Z.H....Kim K.K. (2000)
Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-CoA alpha-hydroxylase is a new FKBP-associated protein. (PubMed id 10051602)^{3, 4} Chambraud B....Baulieu E.-E. (1999)
Phytanoyl-CoA hydroxylase from rat liver. Protein purification and cDNA cloning with implications for the subcellular localization of phytanic acid alpha-oxidation. (PubMed id 10588950)^{1, 3} Jansen G.A....Wanders R.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5264	HGNC: 8940	AceView: PHYH	Ensembl:ENSG00000107537	euGenes: HUgn5264
ECgene: PHYH	H-InvDB: PHYH

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=PHYH

Licensable Technologies for PHYH
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PHYH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PHYH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PHYH		Antibodies for PHYH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PHYH		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PHYH)
	Antibodies (PHYH)
	Chimera RNAi (PHYH)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (PHYH)
	Antibodies (PHYH)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for PHYH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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PHYH Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for PHYH

Summaries
for PHYH

Genomic Location
for PHYH

Proteins
for PHYH

Protein Domains/
Families
for PHYH

Gene Function
for PHYH

Pathways & Interactions
for PHYH

Drugs & Compounds
for PHYH

Transcripts
for PHYH

Expression
for PHYH

Orthologs
for PHYH

Paralogs
for PHYH

SNPs/Variants
for PHYH

Disorders & Mutations
for PHYH

Medical News
for PHYH

Publications
for PHYH

Search for PHYH

Genome Databases showing PHYH

Other Databases showing PHYH

Specialized Databases showing PHYH

Licensable Technologies
for PHYH

Services
for PHYH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PHYH Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor PHYH

Summariesfor PHYH

Genomic Locationfor PHYH

Proteinsfor PHYH

Protein Domains/Familiesfor PHYH

Gene Functionfor PHYH

Pathways & Interactionsfor PHYH

Drugs & Compoundsfor PHYH

Transcriptsfor PHYH

Expression for PHYH

Orthologsfor PHYH

Paralogsfor PHYH

SNPs/Variantsfor PHYH

Disorders & Mutationsfor PHYH

Medical Newsfor PHYH

Publicationsfor PHYH

Search for PHYH

Genome Databases showing PHYH

Other Databases showing PHYH

Specialized Databases showing PHYH

Licensable Technologiesfor PHYH

Servicesfor PHYH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PHYH

Summaries
for PHYH

Genomic Location
for PHYH

Proteins
for PHYH

Protein Domains/
Families
for PHYH

Gene Function
for PHYH

Pathways & Interactions
for PHYH

Drugs & Compounds
for PHYH

Transcripts
for PHYH

Expression
for PHYH

Orthologs
for PHYH

Paralogs
for PHYH

SNPs/Variants
for PHYH

Disorders & Mutations
for PHYH

Medical News
for PHYH

Publications
for PHYH

Licensable Technologies
for PHYH

Services
for PHYH