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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PHRF1 Gene

protein-coding GIFtS: 48
GCID: GC11P000567

PHD and ring finger domains 1

(Previous symbol: RNF221)

Explore 5 diseases affiliated with
PHRF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PHD And Ring Finger Domains 1¹ ²
KIAA1542¹ ³ ⁵
RNF221¹ ²
CTD Binding SR Like Protein RA9²
CTD-Binding SR-Like Protein RA9²
PHD And RING Finger Domain-Containing Protein 1²

External Ids:	HGNC: 24351¹	Entrez Gene: 57661²	Ensembl: ENSG00000070047⁷	OMIM: 611780⁵	UniProtKB: Q9P1Y6³

Export aliases for PHRF1 gene to outside databases

Previous GC identifer: GC11P000371

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PHRF1 gene promoter:
ER-alpha E2F-4 E2F-3a E2F-5 E2F-2 Arnt E2F E2F-1 HSF2 HOXA5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PHRF1 promoter sequence

Search SABiosciences Chromatin IP Primers for PHRF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHRF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

PHRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHRF1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P000567: view genomic region (about GC identifiers)

Start:	576,483 bp from pter	End:	612,222 bp from pter
Size:	35,740 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHRF1_HUMAN, Q9P1Y6 (See protein sequence)

Recommended Name: PHD and RING finger domain-containing protein 1

Size: 1649 amino acids; 178666 Da

Subunit: Interacts with POLR2A (via the C-terminal domain) (By similarity)

Sequence caution: Sequence=BAA96066.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A6H8W1 B7ZM64 B9EGP0 C9JS82 Q6PJP2 Q8IVY2 Q8N2Y7 Q9BSM2

Alternative splicing: 3 isoforms: Q9P1Y6-1 Q9P1Y6-2 Q9P1Y6-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHRF1: NX_Q9P1Y6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P1Y6

PHRF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065952.2

ENSEMBL proteins:

ENSP00000435360 ENSP00000264555 ENSP00000388589 ENSP00000410626 ENSP00000431870

Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for PHRF1
	Novus Biologicals PHRF1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PHRF1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--

PHRF1 for ontologies About GeneDecksing

PHRF1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals PHRF1 Antibodies
	Search for Antibodies for PHRF1 at Abcam
	Uscn Antibodies for PHRF1
	Search ThermoFisher Antibodies for PHRF1

Assay Products for PHRF1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PHRF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PHRF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PHRF1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001841 Znf_RING

IPR001965 Znf_PHD

IPR013083 Znf_RING/FYVE/PHD

IPR017907 Znf_RING_CS

IPR011011 Znf_FYVE_PHD

Graphical View of Domain Structure for InterPro Entry Q9P1Y6

ProtoNet protein and cluster: Q9P1Y6

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: PHRF1_HUMAN, Q9P1Y6

Similarity: Contains 1 PHD-type zinc finger

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone: PHRF1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHRF1
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PHRF1 (see all 13):
		hsa-miR-576-5p hsa-miR-3688-3p hsa-miR-374b hsa-miR-4263 hsa-miR-374a hsa-miR-764 hsa-miR-3914 hsa-miR-3161

		SwitchGear 3'UTR luciferase reporter plasmid: PHRF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHRF1 (see all 7) OriGene shRNA RFP: PHRF1 OriGene siRNA: PHRF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHRF1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for PHRF1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHRF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHRF1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PHRF1 (NM_020901)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHRF1
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PHRF1
		Search LifeMap BioReagents cell lines for PHRF1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHRF1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0019904	protein domain specific binding	IEA	--
GO:0070063	RNA polymerase binding	ISS	--

PHRF1 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PHRF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for PHRF1 (ENSP00000410626⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
JMJD6	ENSP00000394085⁴	STRING: ENSP00000394085
PPP1CA	ENSP00000326031⁴	STRING: ENSP00000326031
SIRT7	ENSP00000329466⁴	STRING: ENSP00000329466
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
AGPAT2	ENSP00000360761⁴	STRING: ENSP00000360761

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	IEA	--
GO:0006397	mRNA processing	IEA	--

PHRF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PHRF1
Search CenterWatch for drugs/clinical trials and news about PHRF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PHRF1 gene:

NM_020901.2

Unigene Cluster for PHRF1:

PHD and ring finger domains 1

Hs.325838 [show with all ESTs]

Unigene Representative Sequence: BC112931

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000534320 ENST00000264555(uc010qwc.2 uc010qwd.2 uc001lqe.3 uc010qwe.2 uc009yca.2)

ENST00000413872 ENST00000416188 ENST00000533464 ENST00000526724(uc009ybz.1)

ENST00000532550 ENST00000525848

miRNA Products:		OriGene 3'-UTR Clone: PHRF1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHRF1
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate PHRF1 (see all 13):
		hsa-miR-576-5p hsa-miR-3688-3p hsa-miR-374b hsa-miR-4263 hsa-miR-374a hsa-miR-764 hsa-miR-3914 hsa-miR-3161

		SwitchGear 3'UTR luciferase reporter plasmid: PHRF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHRF1 (see all 7) OriGene shRNA RFP: PHRF1 OriGene siRNA: PHRF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHRF1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHRF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHRF1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PHRF1 (NM_020901)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHRF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHRF1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHRF1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHRF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHRF1

Additional cDNA sequence:

AB040975.1 AK308541.1 BC004950.1 BC013381.2 BC029651.1 BC041631.1 BC112931.1 BC127876.1

BC136615.1 BC144293.1 BC144294.1 BC144295.1 BC146771.1

9 DOTS entries:

DT.444396 DT.100029364 DT.100029363 DT.108108 DT.95233840 DT.100785104 DT.120715005 DT.320147

DT.95361384

24/167 AceView cDNA sequences (see all 167):

AW450796 BU848992 BI115565 BQ691436 CD722462 BC004950 AI521741 BQ881774

BQ058681 BQ642174 AB040975 BU179446 BQ059713 BQ686458 AI623332 BQ888704

BQ877998 BX280648 AW294435 BQ061899 BU196370 BQ440287 BQ688529 BQ058874

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PHRF1 (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b
SP1:					-
SP2:					-
SP3:																																			-
SP4:
SP5:																									-

ECgene alternative splicing isoforms for PHRF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PHRF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGCCGTCG

About this image
See PHRF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PHRF1

SOURCE GeneReport for Unigene cluster: Hs.325838

SABiosciences Expression via Pathway-Focused PCR Array including PHRF1:

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHRF1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHRF1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHRF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PHRF1 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PHRF1¹	PHD and ring finger domains 1	68(n) 68.57(a)		426102 XM_423776.3 XP_423776.3
lizard (Anolis carolinensis)	Reptilia	PHRF1⁶	--	46(a)	1 ↔ 1	1(74445250-74474246)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.3343²	Transcribed sequence with weak similarity to protein refNP_004710.1 (H.sapiens) splicing factor, arginine/serine-rich 2, interacting protein; SC35-interacting protein 1 [Homo sapiens] less	82.93(n)		142003632
zebrafish (Danio rerio)	Actinopterygii	phrf1¹	PHD and ring finger domains 1	48.99(n) 46.22(a)		321905 XM_002666868.1 XP_002666914.1
fruit fly (Drosophila melanogaster)	Insecta	CG2926⁶	--	11(a)	1 → many	3R(1405023-1414097)

ENSEMBL Gene Tree for PHRF1 (if available)
TreeFam Gene Tree for PHRF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PHRF1 gene

SCAF1² SCAF11²

3 SIMAP similar genes for PHRF1 using alignment to 5 protein entries: PHRF1_HUMAN (see all proteins):

PHF21A SCAF11 AIRE

PHRF1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117214614^1,2	C,F,	--	369246(+)	`NNNNGG/ATGGTC`	1	--	us2k¹		1		NA	120
rs112815689^1,2		--	369301(+)	`TGGCCG/AAGGGG`	1	--	us2k¹		2		CSA WA	120
rs59604070^1,2	F,	--	372260(+)	`AGTGAT/GGGCTG`	2	--	int¹ nc-transcript-variant		1		WA	118
rs61877803^1,2	C,F,	--	372278(+)	`CCCAAC/TGCATT`	2	--	nc-transcript-variantint¹		4		NA	126
rs11246186^1,2		--	372804(+)	`GAGCAA/GGGCAG`	2	--	nc-transcript-variantint¹		0	--	--	--	--
rs12420704^1,2	C,H	--	373242(+)	`CCTGGT/GTCTGC`	2	--	nc-transcript-variantint¹		2		NA	4
rs11246188^1,2		--	373395(+)	`GCACAA/CAGTAC`	2	--	int¹ nc-transcript-variant		0	--	--	--	--
rs78104313^1,2	C,F,	--	373453(+)	`AGCACC/TCATCC`	2	--	int¹ nc-transcript-variant		1		WA	118
rs112786844^1,2	C,	--	380327(+)	`ATACAG/CTAATG`	1	--	int¹		5		CSA WA NA	242
rs116255671^1,2	C,F,	--	380342(+)	`CTGATA/GAGCTT`	1	--	int¹		2		WA NA	238

HapMap Linkage Disequilibrium report for PHRF1 (576483 - 612222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for PHRF1
4 CNVs: 3831 29884 29882 29883
1 Indel: 71218

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHRF1

DNA2.0 Custom Variant and Variant Library Synthesis for PHRF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PHRF1 for disorders           About GeneDecksing

OMIM gene information: 611780    OMIM disorders: --

5 diseases for PHRF1:    About MalaCards

systemic lupus erythematosus lupus erythematosus rheumatoid arthritis arthritis

malaria

1 disease from the University of Copenhagen DISEASES database for PHRF1:

Systemic lupus erythematosus

Human Genome Epidemiology (HuGE) Navigator: PHRF1 (0 documents)

Export disorders for PHRF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PHRF1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with PHRF1)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{1, 2} Nagase T.... Ohara O. (2000)
Association of PHRF1-IRF7 region polymorphism with cli nical manifestations of systemic lupus erythematosus in a Japanese population. (PubMed id 22433914)¹ Kawasaki A....Tsuchiya N. (2012)
Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)¹ Tsai Y.C....Cristea I.M. (2012)
Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients . (PubMed id 20881011)¹ Webb R....Sawalha A.H. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)¹ Rahman S....Howley P.M. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)¹ Chung S.A....Criswell L.A. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57661	HGNC: 24351	AceView: KIAA1542	Ensembl:ENSG00000070047	euGenes: HUgn57661
ECgene: PHRF1	H-InvDB: PHRF1

(According to HUGE)
About This Section

HUGE: KIAA1542

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PHRF1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PHRF1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PHRF1 gene:
Search GeneIP for patents involving PHRF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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	Browse OriGene Antibodies		OriGene shRNA RFP for PHRF1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PHRF1
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	GenScript Custom Purified and Recombinant Proteins Services for PHRF1		GenScript cDNA clones with any tag delivered in your preferred vector for PHRF1
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHRF1

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHRF1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PHRF1 gene at Home site.

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PHRF1 Gene

PHD and ring finger domains 1

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PHRF1 Gene

PHD and ring finger domains 1

Aliasesfor PHRF1 gene

Summariesfor PHRF1 gene

Genomic Viewsfor PHRF1 gene

Proteinsfor PHRF1 gene

Protein Domains /Familiesfor PHRF1 gene

Functionfor PHRF1 gene

Pathways & Interactionsfor PHRF1 gene

Drugs & Compoundsfor PHRF1 gene

Transcriptsfor PHRF1 gene

Expression for PHRF1 gene

Orthologsfor PHRF1 gene

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Publicationsfor PHRF1 gene

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Genome Databases showing PHRF1 gene

Other Databases showing PHRF1 gene

Specialized Databases showing PHRF1 gene

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Aliases
for PHRF1 gene

Summaries
for PHRF1 gene

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for PHRF1 gene

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for PHRF1 gene

Protein Domains /
Families
for PHRF1 gene

Function
for PHRF1 gene

Pathways & Interactions
for PHRF1 gene

Drugs & Compounds
for PHRF1 gene

Transcripts
for PHRF1 gene

Expression
for PHRF1 gene

Orthologs
for PHRF1 gene

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for PHRF1 gene

Genomic Variants
for PHRF1 gene

Disorders / Diseases
for PHRF1 gene

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for PHRF1 gene

Intellectual Property
for PHRF1 gene

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for PHRF1 gene