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Aliases for PHRF1 Gene

Aliases for PHRF1 Gene

  • PHD And Ring Finger Domains 1 2 3
  • Protein Phosphatase 1, Regulatory Subunit 125 3
  • CTD Binding SR Like Protein RA9 2
  • CTD-Binding SR-Like Protein RA9 3
  • Regulatory Subunit 125 2
  • Protein Phosphatase 1 2
  • PPP1R125 3
  • KIAA1542 4
  • RNF221 3

External Ids for PHRF1 Gene

Previous HGNC Symbols for PHRF1 Gene

  • RNF221

Previous GeneCards Identifiers for PHRF1 Gene

  • GC11P000567
  • GC11P000371
  • GC11P000577

Summaries for PHRF1 Gene

GeneCards Summary for PHRF1 Gene

PHRF1 (PHD And Ring Finger Domains 1) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and RNA polymerase binding. An important paralog of this gene is SCAF11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHRF1 Gene

Genomics for PHRF1 Gene

Regulatory Elements for PHRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHRF1 Gene

576,220 bp from pter
612,222 bp from pter
36,003 bases
Plus strand

Genomic View for PHRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHRF1 Gene

Proteins for PHRF1 Gene

  • Protein details for PHRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PHD and RING finger domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6H8W1
    • B7ZM64
    • B9EGP0
    • C9JS82
    • Q6PJP2
    • Q8IVY2
    • Q8N2Y7
    • Q9BSM2

    Protein attributes for PHRF1 Gene

    1649 amino acids
    Molecular mass:
    178666 Da
    Quaternary structure:
    • Interacts with POLR2A (via the C-terminal domain).
    • Sequence=BAA96066.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHRF1 Gene


neXtProt entry for PHRF1 Gene

Proteomics data for PHRF1 Gene at MOPED

Post-translational modifications for PHRF1 Gene

  • Ubiquitination at Lys 1579
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHRF1 Gene

Domains & Families for PHRF1 Gene

Protein Domains for PHRF1 Gene

Suggested Antigen Peptide Sequences for PHRF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PHD-type zinc finger.
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PHRF1: view

Function for PHRF1 Gene

Gene Ontology (GO) - Molecular Function for PHRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0070063 RNA polymerase binding ISS --
genes like me logo Genes that share ontologies with PHRF1: view

Phenotypes for PHRF1 Gene

GenomeRNAi human phenotypes for PHRF1:
genes like me logo Genes that share phenotypes with PHRF1: view

Animal Model Products

miRNA for PHRF1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PHRF1 Gene

Localization for PHRF1 Gene

Subcellular locations from

Jensen Localization Image for PHRF1 Gene COMPARTMENTS Subcellular localization image for PHRF1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PHRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PHRF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHRF1 Gene

Pathways & Interactions for PHRF1 Gene

SuperPathways for PHRF1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PHRF1 Gene

Gene Ontology (GO) - Biological Process for PHRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with PHRF1: view

No data available for Pathways by source and SIGNOR curated interactions for PHRF1 Gene

Drugs & Compounds for PHRF1 Gene

No Compound Related Data Available

Transcripts for PHRF1 Gene

Unigene Clusters for PHRF1 Gene

PHD and ring finger domains 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHRF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: -
SP5: -

Relevant External Links for PHRF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHRF1 Gene

mRNA expression in normal human tissues for PHRF1 Gene

Protein differential expression in normal tissues from HIPED for PHRF1 Gene

This gene is overexpressed in Breast (15.8), Cervix (10.6), Bone (8.0), and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHRF1 Gene

SOURCE GeneReport for Unigene cluster for PHRF1 Gene Hs.325838

genes like me logo Genes that share expression patterns with PHRF1: view

Protein tissue co-expression partners for PHRF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHRF1 Gene

Orthologs for PHRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHRF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PHRF1 35
  • 75.53 (n)
  • 71.16 (a)
PHRF1 36
  • 66 (a)
(Mus musculus)
Mammalia Phrf1 35
  • 72.89 (n)
  • 69.61 (a)
Phrf1 16
Phrf1 36
  • 62 (a)
(Pan troglodytes)
Mammalia PHRF1 35
  • 97.81 (n)
  • 97.26 (a)
PHRF1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Phrf1 35
  • 72.73 (n)
  • 68.35 (a)
(Bos Taurus)
Mammalia PHRF1 36
  • 60 (a)
(Monodelphis domestica)
Mammalia PHRF1 36
  • 49 (a)
(Gallus gallus)
Aves PHRF1 35
  • 61.36 (n)
  • 58.24 (a)
PHRF1 36
  • 47 (a)
(Anolis carolinensis)
Reptilia PHRF1 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3343 35
(Danio rerio)
Actinopterygii phrf1 36
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2926 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for PHRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHRF1 Gene

Gene Tree for PHRF1 (if available)
Gene Tree for PHRF1 (if available)

Paralogs for PHRF1 Gene

Paralogs for PHRF1 Gene

(3) SIMAP similar genes for PHRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHRF1: view

Variants for PHRF1 Gene

Sequence variations from dbSNP and Humsavar for PHRF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs58860894 -- 579,270(+) CTGCT(-/TTTCCCCCCAGCCCTGCT)CTGTT intron-variant
rs58875072 -- 580,290(+) TGAGG(A/C)CCTGG intron-variant
rs59144823 -- 590,072(+) GGGCA(C/T)GGAGC intron-variant
rs59180492 -- 592,666(+) GGCTG(C/T)GATGC reference, synonymous-codon
rs59284754 -- 596,480(+) CTCAG(C/T)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHRF1 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv931n71 CNV Loss 21882294
nsv896532 CNV Gain 21882294
essv23843 CNV CNV 17122850
dgv933n71 CNV Loss 21882294
nsv467634 CNV Loss 19166990
nsv896544 CNV Loss 21882294
nsv896545 CNV Loss 21882294
dgv934n71 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
nsv469924 CNV Gain 18288195
dgv936n71 CNV Loss 21882294
dgv939n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
nsv528415 CNV Loss 19592680
nsv518824 CNV Loss 19592680
nsv896560 CNV Loss 21882294
esv2743845 CNV Deletion 23290073
nsv7633 CNV Insertion 18451855
esv2743846 CNV Deletion 23290073
esv24854 CNV Loss 19812545
dgv141e201 CNV Deletion 23290073
dgv142e201 CNV Deletion 23290073
esv1008801 CNV Insertion 20482838
esv1760409 CNV Insertion 17803354
nsv825679 CNV Loss 20364138
dgv940n71 CNV Loss 21882294
esv1387942 CNV Insertion 17803354
nsv825680 CNV Gain 20364138
esv2663829 CNV Deletion 23128226
nsv825681 CNV Gain 20364138
dgv941n71 CNV Loss 21882294
nsv896569 CNV Loss 21882294

Variation tolerance for PHRF1 Gene

Residual Variation Intolerance Score: 7.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.86; 79.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHRF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHRF1 Gene

Disorders for PHRF1 Gene

Relevant External Links for PHRF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PHRF1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHRF1 Gene

Publications for PHRF1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. PHRF1 promotes genome integrity by modulating non-homologous end-joining. (PMID: 25855964) Chang C.F. … Chang M.S. (Cell Death Dis 2015) 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. (PMID: 23740937) Martin J.E. … Martin J. (Hum. Mol. Genet. 2013) 67
  5. Identification of PHRF1 as a tumor suppressor that promotes the TGF-I^ cytostatic program through selective release of TGIF-driven PML inactivation. (PMID: 23911286) Ettahar A. … Atfi A. (Cell Rep 2013) 67

Products for PHRF1 Gene

Sources for PHRF1 Gene

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