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PHRF1 Gene

protein-coding   GIFtS: 50
GCID: GC11P000577

PHD And Ring Finger Domains 1


(Previous symbol: RNF221)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PHD And Ring Finger Domains 11 2
RNF2211 2
KIAA15423 5
CTD Binding SR Like Protein RA91
CTD-Binding SR-Like Protein RA92
PHD And RING Finger Domain-Containing Protein 12

External Ids:    HGNC: 243511   Entrez Gene: 576612   Ensembl: ENSG000000700477   OMIM: 6117805   UniProtKB: Q9P1Y63   

Export aliases for PHRF1 gene to outside databases

Previous GC identifers: GC11P000567 GC11P000371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PHRF1 Gene:
PHRF1 (PHD and ring finger domains 1) is a protein-coding gene. GO annotations related to this gene include RNA polymerase binding and protein domain specific binding. An important paralog of this gene is SCAF1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NT_187586.1  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHRF1 gene promoter:
         ER-alpha   E2F-4   E2F-3a   E2F-5   E2F-2   Arnt   E2F   E2F-1   HSF2   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHRF1 promoter sequence
   Search Chromatin IP Primers for PHRF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHRF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

PHRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHRF1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000577:  view genomic region     (about GC identifiers)

Start:
576,483 bp from pter      End:
612,222 bp from pter
Size:
35,740 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PHRF1_HUMAN, Q9P1Y6 (See protein sequence)
Recommended Name: PHD and RING finger domain-containing protein 1  
Size: 1649 amino acids; 178666 Da
Subunit: Interacts with POLR2A (via the C-terminal domain) (By similarity)
Sequence caution: Sequence=BAA96066.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6H8W1 B7ZM64 B9EGP0 C9JS82 Q6PJP2 Q8IVY2 Q8N2Y7 Q9BSM2
Alternative splicing: 3 isoforms:  Q9P1Y6-1   Q9P1Y6-2   Q9P1Y6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHRF1: NX_Q9P1Y6

Explore proteomics data for PHRF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1579
  • Modification sites at PhosphoSitePlus

  • See PHRF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273510.1  NP_001273511.1  NP_001273512.1  NP_065952.2  

    ENSEMBL proteins: 
     ENSP00000435360   ENSP00000264555   ENSP00000431870   ENSP00000388589   ENSP00000410626  

    PHRF1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHRF1
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    Novus Biologicals PHRF1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHRF1

     
    Search eBioscience for Proteins for PHRF1 

    PHRF1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for PHRF1
    Cloud-Clone Corp. Antibodies for PHRF1
    Search ThermoFisher Antibodies for PHRF1
    Search LSBio for Antibodies for PHRF1

    PHRF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PHRF1
    Cloud-Clone Corp. CLIAs for PHRF1
    Search eBioscience for ELISAs for PHRF1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 6):
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9P1Y6

    ProtoNet protein and cluster: Q9P1Y6

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: PHRF1_HUMAN, Q9P1Y6
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with PHRF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0019904protein domain specific binding IEA--
    GO:0046872metal ion binding ----
    GO:0070063RNA polymerase binding ISS--
         
    Find genes that share ontologies with PHRF1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHRF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHRF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHRF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHRF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHRF1:
    hsa-mir-222-3p (MIRT046812), hsa-mir-1229-3p (MIRT036274), hsa-mir-193b-3p (MIRT041602), hsa-mir-92b-3p (MIRT040686)

    Block miRNA regulation of human, mouse, rat PHRF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHRF1 (see all 13):
    hsa-miR-576-5p hsa-miR-3688-3p hsa-miR-374b hsa-miR-4263 hsa-miR-374a hsa-miR-764 hsa-miR-3914 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidPHRF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHRF1
    Predesigned siRNA for gene silencing in human, mouse, rat PHRF1

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for PHRF1 (see all 6)
    OriGene ORF clones in mouse, rat for PHRF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHRF1 (NM_020901)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHRF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHRF1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PHRF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHRF1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHRF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PHRF1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PHRF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for PHRF1 (ENSP000004106264) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JMJD6ENSP000003940854STRING: ENSP00000394085
    PPP1CAENSP000003260314STRING: ENSP00000326031
    SIRT7ENSP000003294664STRING: ENSP00000329466
    UBCENSP000003448184STRING: ENSP00000344818
    AGPAT2ENSP000003607614STRING: ENSP00000360761
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0006397mRNA processing IEA--

    Find genes that share ontologies with PHRF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHRF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PHRF1 gene (4 alternative transcripts): 
    NM_001286581.1  NM_001286582.1  NM_001286583.1  NM_020901.3  

    Unigene Cluster for PHRF1:

    PHD and ring finger domains 1
    Hs.325838  [show with all ESTs]
    Unigene Representative Sequence: BC112931
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534320 ENST00000264555(uc010qwc.2 uc010qwd.2 uc001lqe.3 uc010qwe.2 uc009yca.2)
    ENST00000533464 ENST00000413872 ENST00000416188 ENST00000532550
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHRF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHRF1 (see all 13):
    hsa-miR-576-5p hsa-miR-3688-3p hsa-miR-374b hsa-miR-4263 hsa-miR-374a hsa-miR-764 hsa-miR-3914 hsa-miR-3161
    SwitchGear 3'UTR luciferase reporter plasmidPHRF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHRF1
    Predesigned siRNA for gene silencing in human, mouse, rat PHRF1
    Clone
    Products:
         
    OriGene clones in human, mouse for PHRF1 (see all 6)
    OriGene ORF clones in mouse, rat for PHRF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHRF1 (NM_020901)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHRF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHRF1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHRF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHRF1
      QuantiTect SYBR Green Assays in human, mouse, rat PHRF1
      QuantiFast Probe-based Assays in human, mouse, rat PHRF1

    Additional mRNA sequence: 

    AB040975.1 AK308541.1 BC004950.1 BC013381.2 BC029651.1 BC041631.1 BC112931.1 BC127876.1 
    BC136615.1 BC144293.1 BC144294.1 BC144295.1 BC146771.1 

    9 DOTS entries:

    DT.444396  DT.100029364  DT.100029363  DT.108108  DT.95233840  DT.100785104  DT.120715005  DT.320147 
    DT.95361384 

    Selected AceView cDNA sequences (see all 167):

    BQ688529 BQ688963 BU179446 BC029651 BQ691436 AA309560 BQ440287 BU196370 
    AW294435 BQ058874 BX280648 BQ888704 BQ061899 BQ059713 AB040975 BI115565 
    BU848992 BU501234 BU168453 AW450796 BU184770 BQ064785 BQ642174 BQ881774 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PHRF1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:              -                                                                                                                     
    SP2:              -                                                                                                                     
    SP3:                                                                                                        -                           
    SP4:                                                                                                                                    
    SP5:                                                                          -                                                         


    ECgene alternative splicing isoforms for PHRF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHRF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGCCGTCG
    PHRF1 Expression
    About this image

    PHRF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHRF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.325838
        Pathway & Disease-focused RT2 Profiler PCR Array including PHRF1: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHRF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHRF1
    QuantiTect SYBR Green Assays in human, mouse, rat PHRF1
    QuantiFast Probe-based Assays in human, mouse, rat PHRF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHRF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PHRF1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phrf11 , 5 PHD and ring finger domains 11, 5 72.89(n)1
    69.61(a)1
      7 (86.53 cM)5
    1014711  NM_001081118.11  NP_001074587.11 
     1412287845 
    chicken
    (Gallus gallus)
    Aves PHRF11 PHD and ring finger domains 1 61.36(n)
    58.24(a)
      426102  XM_004941463.1  XP_004941520.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHRF16
    PHD and ring finger domains 1
    45(a)
    1 ↔ 1
    1(74445250-74474246)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.33432 Transcribed sequence with weak similarity to protein more 82.93(n)    142003632 
    zebrafish
    (Danio rerio)
    Actinopterygii phrf16
    PHD and ring finger domains 1
    27(a)
    1 ↔ 1
    25(26373935-26411808) ENSDARG00000075252
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29266
    --
    16(a)
    1 → many
    3R(1405023-1414097)


    ENSEMBL Gene Tree for PHRF1 (if available)
    TreeFam Gene Tree for PHRF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHRF1 gene
    SCAF12  SCAF112  
    3 SIMAP similar genes for PHRF1 using alignment to 5 protein entries:     PHRF1_HUMAN (see all proteins):
    PHF21A    SCAF11    AIRE

    Find genes that share paralogs with PHRF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHRF1 (see all 1723)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172146141,2
    C,F--369246(+) GGGGGG/ATGGTC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1841569841,2
    --369286(+) TGCTAA/GAATTG 1 -- us2k10--------
    rs1128156891,2
    F--369301(+) TGGCCG/AAGGGG 1 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs1897036231,2
    --369321(+) GAGCTC/GCGAGT 1 -- us2k10--------
    rs112461841,2
    C,A,H--369343(+) TTGCCG/AGCCCC 1 -- us2k16Minor allele frequency- A:0.47NA WA EA 364
    rs1157545531,2
    F--369360(+) AGAGCC/TACCTC 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1483625961,2
    --369396(+) AGCTGC/TTCGCC 1 -- us2k10--------
    rs1415222081,2
    --369434(+) CTCCCA/GTCTCC 1 -- us2k10--------
    rs122776111,2
    C,F,A,H--369482(+) CCCGTC/TCCCTC 1 -- us2k117Minor allele frequency- T:0.44NS EA NA CSA WA 2112
    rs1930734501,2
    --369554(+) TGCGGG/TTTACT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHRF1 (576483 - 612222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PHRF1 (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2743846CNV Deletion23290073
    esv2743845CNV Deletion23290073
    esv2663829CNV Deletion23128226
    dgv142e201CNV Deletion23290073
    dgv141e201CNV Deletion23290073
    dgv182e199CNV Deletion23128226
    esv1387942CNV Insertion17803354
    esv1008801CNV Insertion20482838
    esv1760409CNV Insertion17803354
    nsv7633CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHRF1
    DNA2.0 Custom Variant and Variant Library Synthesis for PHRF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611780    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PHRF1:
    Systemic lupus erythematosus

    Find genes that share disorders with PHRF1           About GenesLikeMe

    Genetic Association Database (GAD): PHRF1
    Human Genome Epidemiology (HuGE) Navigator: PHRF1 (0 documents)

    Export disorders for PHRF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHRF1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PHRF1)
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    1. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PubMed id 21408207)1, 4 Chung S.A....Criswell L.A. (PLoS Genet. 2011)
    2. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PubMed id 18204446)1, 4 Harley J.B.... Kelly J.A. (Nat. Genet. 2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. (PubMed id 23740937)1 Martin J.E....Martin J. (Hum. Mol. Genet. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population. (PubMed id 22433914)1 Kawasaki A....Tsuchiya N. (Lupus 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57661 HGNC: 24351 AceView: KIAA1542 Ensembl:ENSG00000070047 euGenes: HUgn57661
    ECgene: PHRF1 H-InvDB: PHRF1

    (According to HUGE)
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    HUGE: KIAA1542

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PHRF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PHRF1 gene:
    Search GeneIP for patents involving PHRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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