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Aliases for PHRF1 Gene

Aliases for PHRF1 Gene

  • PHD And Ring Finger Domains 1 2 3
  • KIAA1542 4 6
  • PHD And RING Finger Domain-Containing Protein 1 3
  • Protein Phosphatase 1, Regulatory Subunit 125 3
  • CTD Binding SR Like Protein RA9 2
  • CTD-Binding SR-Like Protein RA9 3
  • Regulatory Subunit 125 2
  • Protein Phosphatase 1 2
  • PPP1R125 3
  • RNF221 3

External Ids for PHRF1 Gene

Previous HGNC Symbols for PHRF1 Gene

  • RNF221

Previous GeneCards Identifiers for PHRF1 Gene

  • GC11P000567
  • GC11P000371

Summaries for PHRF1 Gene

GeneCards Summary for PHRF1 Gene

PHRF1 (PHD And Ring Finger Domains 1) is a Protein Coding gene. GO annotations related to this gene include protein domain specific binding and RNA polymerase binding. An important paralog of this gene is SCAF11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHRF1 Gene

Genomics for PHRF1 Gene

Regulatory Elements for PHRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHRF1 Gene

Start:
576,226 bp from pter
End:
612,222 bp from pter
Size:
35,997 bases
Orientation:
Plus strand

Genomic View for PHRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHRF1 Gene

Proteins for PHRF1 Gene

  • Protein details for PHRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P1Y6-PHRF1_HUMAN
    Recommended name:
    PHD and RING finger domain-containing protein 1
    Protein Accession:
    Q9P1Y6
    Secondary Accessions:
    • A6H8W1
    • B7ZM64
    • B9EGP0
    • C9JS82
    • Q6PJP2
    • Q8IVY2
    • Q8N2Y7
    • Q9BSM2

    Protein attributes for PHRF1 Gene

    Size:
    1649 amino acids
    Molecular mass:
    178666 Da
    Quaternary structure:
    • Interacts with POLR2A (via the C-terminal domain).
    SequenceCaution:
    • Sequence=BAA96066.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHRF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHRF1 Gene

Proteomics data for PHRF1 Gene at MOPED

Post-translational modifications for PHRF1 Gene

  • Ubiquitination at Lys1579
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHRF1 Gene

Domains for PHRF1 Gene

Gene Families for PHRF1 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for PHRF1 Gene

Suggested Antigen Peptide Sequences for PHRF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P1Y6

UniProtKB/Swiss-Prot:

PHRF1_HUMAN :
  • Q9P1Y6
Similarity:
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PHRF1: view

Function for PHRF1 Gene

Gene Ontology (GO) - Molecular Function for PHRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0046872 metal ion binding --
GO:0070063 RNA polymerase binding ISS --
genes like me logo Genes that share ontologies with PHRF1: view

Animal Model Products

CRISPR Products

miRNA for PHRF1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHRF1 Gene

Localization for PHRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHRF1 Gene COMPARTMENTS Subcellular localization image for PHRF1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PHRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PHRF1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHRF1 Gene

Pathways for PHRF1 Gene

SuperPathways for PHRF1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PHRF1 Gene

Gene Ontology (GO) - Biological Process for PHRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with PHRF1: view

No data available for Pathways by source for PHRF1 Gene

Transcripts for PHRF1 Gene

Unigene Clusters for PHRF1 Gene

PHD and ring finger domains 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHRF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PHRF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for PHRF1 Gene

GeneLoc Exon Structure for
PHRF1
ECgene alternative splicing isoforms for
PHRF1

Expression for PHRF1 Gene

mRNA expression in normal human tissues for PHRF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHRF1 Gene

SOURCE GeneReport for Unigene cluster for PHRF1 Gene Hs.325838

genes like me logo Genes that share expressions with PHRF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHRF1 Gene

Orthologs for PHRF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHRF1 35
  • 97.81 (n)
  • 97.26 (a)
PHRF1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHRF1 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHRF1 35
  • 75.53 (n)
  • 71.16 (a)
PHRF1 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phrf1 35
  • 72.89 (n)
  • 69.61 (a)
Phrf1 16
Phrf1 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHRF1 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phrf1 35
  • 72.73 (n)
  • 68.35 (a)
chicken
(Gallus gallus)
Aves PHRF1 35
  • 61.36 (n)
  • 58.24 (a)
PHRF1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHRF1 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3343 35
zebrafish
(Danio rerio)
Actinopterygii phrf1 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2926 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for PHRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHRF1 Gene

ENSEMBL:
Gene Tree for PHRF1 (if available)
TreeFam:
Gene Tree for PHRF1 (if available)

Paralogs for PHRF1 Gene

Paralogs for PHRF1 Gene

Selected SIMAP similar genes for PHRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHRF1: view

Variants for PHRF1 Gene

Sequence variations from dbSNP and Humsavar for PHRF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs702965 -- 611,868(-) GCCCC(A/G)ATTCC utr-variant-3-prime
rs702966 -- 611,919(-) GCATG(C/G)TGATG utr-variant-3-prime
rs936468 -- 607,175(-) CCTGA(C/T)GGGCC synonymous-codon, reference
rs936469 -- 606,749(-) CTGCT(C/T)AAGAA intron-variant
rs936470 -- 606,656(-) GCTTG(C/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHRF1 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv527327 CNV Loss 19592680
dgv182e199 CNV Deletion 23128226
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv931n71 CNV Loss 21882294
nsv896532 CNV Gain 21882294
essv23843 CNV CNV 17122850
dgv933n71 CNV Loss 21882294
nsv467634 CNV Loss 19166990
nsv896544 CNV Loss 21882294
nsv896545 CNV Loss 21882294
dgv934n71 CNV Loss 21882294
dgv935n71 CNV Loss 21882294
nsv469924 CNV Gain 18288195
dgv936n71 CNV Loss 21882294
dgv939n71 CNV Loss 21882294
nsv467635 CNV Loss 19166990
nsv528415 CNV Loss 19592680
nsv518824 CNV Loss 19592680
nsv896560 CNV Loss 21882294
esv2743845 CNV Deletion 23290073
nsv7633 CNV Insertion 18451855
esv2743846 CNV Deletion 23290073
esv24854 CNV Loss 19812545
dgv141e201 CNV Deletion 23290073
dgv142e201 CNV Deletion 23290073
esv1008801 CNV Insertion 20482838
esv1760409 CNV Insertion 17803354
nsv825679 CNV Loss 20364138
dgv940n71 CNV Loss 21882294
esv1387942 CNV Insertion 17803354
nsv825680 CNV Gain 20364138
esv2663829 CNV Deletion 23128226
nsv825681 CNV Gain 20364138
dgv941n71 CNV Loss 21882294
nsv896569 CNV Loss 21882294

Relevant External Links for PHRF1 Gene

HapMap Linkage Disequilibrium report
PHRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHRF1 Gene

Disorders for PHRF1 Gene

(1) University of Copenhagen DISEASES for PHRF1 Gene

Relevant External Links for PHRF1

Genetic Association Database (GAD)
PHRF1
Human Genome Epidemiology (HuGE) Navigator
PHRF1
genes like me logo Genes that share disorders with PHRF1: view

No data available for UniProtKB/Swiss-Prot for PHRF1 Gene

Publications for PHRF1 Gene

  1. Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. (PMID: 21408207) Chung S.A. … Criswell L.A. (PLoS Genet. 2011) 3 48
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. (PMID: 18204446) Harley J.B. … Kelly J.A. (Nat. Genet. 2008) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PHRF1 Gene

Sources for PHRF1 Gene

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