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Aliases for PHPT1 Gene

Aliases for PHPT1 Gene

  • Phosphohistidine Phosphatase 1 2 3 4 5
  • Sex-Regulated Protein Janus-A 2 3
  • Protein Janus-A Homolog 3 4
  • PHP14 3 4
  • Epididymis Secretory Sperm Binding Protein Li 132P 3
  • Phosphohistidine Phosphatase 14kDa 2
  • HEL-S-132P 3
  • EC 3.1.3.- 4
  • EC 3.1.3 63
  • CGI-202 3
  • HSPC141 3

External Ids for PHPT1 Gene

Previous GeneCards Identifiers for PHPT1 Gene

  • GC09P135101
  • GC09P137019
  • GC09P138862
  • GC09P139743
  • GC09P109202

Summaries for PHPT1 Gene

Entrez Gene Summary for PHPT1 Gene

  • This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for PHPT1 Gene

PHPT1 (Phosphohistidine Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include ion channel binding and calcium channel inhibitor activity.

UniProtKB/Swiss-Prot for PHPT1 Gene

  • Exhibits phosphohistidine phosphatase activity.

Gene Wiki entry for PHPT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHPT1 Gene

Genomics for PHPT1 Gene

Regulatory Elements for PHPT1 Gene

Enhancers for PHPT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PHPT1 on UCSC Golden Path with GeneCards custom track

Promoters for PHPT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHPT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHPT1 Gene

136,848,724 bp from pter
136,851,043 bp from pter
2,320 bases
Plus strand

Genomic View for PHPT1 Gene

Genes around PHPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHPT1 Gene

Proteins for PHPT1 Gene

  • Protein details for PHPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    14 kDa phosphohistidine phosphatase
    Protein Accession:
    Secondary Accessions:
    • B1AMX0
    • B1AMX1
    • Q9H0Y3

    Protein attributes for PHPT1 Gene

    125 amino acids
    Molecular mass:
    13833 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for PHPT1 Gene

    Alternative splice isoforms for PHPT1 Gene


neXtProt entry for PHPT1 Gene

Proteomics data for PHPT1 Gene at MOPED

Selected DME Specific Peptides for PHPT1 Gene

Post-translational modifications for PHPT1 Gene

  • Ubiquitination at Lys 59
  • Modification sites at PhosphoSitePlus

Other Protein References for PHPT1 Gene

Antibody Products

  • Abcam antibodies for PHPT1

Domains & Families for PHPT1 Gene

Gene Families for PHPT1 Gene

Protein Domains for PHPT1 Gene


Suggested Antigen Peptide Sequences for PHPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the janus family.
  • Belongs to the janus family.
genes like me logo Genes that share domains with PHPT1: view

Function for PHPT1 Gene

Molecular function for PHPT1 Gene

UniProtKB/Swiss-Prot Function:
Exhibits phosphohistidine phosphatase activity.

Enzyme Numbers (IUBMB) for PHPT1 Gene

genes like me logo Genes that share phenotypes with PHPT1: view

Animal Models for PHPT1 Gene

MGI Knock Outs for PHPT1:

Animal Model Products

miRNA for PHPT1 Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHPT1 Gene

Localization for PHPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHPT1 Gene


Subcellular locations from

Jensen Localization Image for PHPT1 Gene COMPARTMENTS Subcellular localization image for PHPT1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PHPT1 Gene

Pathways & Interactions for PHPT1 Gene

SuperPathways for PHPT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0035971 peptidyl-histidine dephosphorylation IDA 16219293
GO:0050860 negative regulation of T cell receptor signaling pathway IMP 18796614
GO:2000147 positive regulation of cell motility IEA,IMP 19344975
GO:2000249 regulation of actin cytoskeleton reorganization IMP 19344975
genes like me logo Genes that share ontologies with PHPT1: view

No data available for Pathways by source and SIGNOR curated interactions for PHPT1 Gene

Drugs & Compounds for PHPT1 Gene

(3) Drugs for PHPT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiamine Approved Nutra 94,94
Thiamin Phosphate Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0

(11) Additional Compounds for PHPT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5-Amino-2,6-dioxy-4-(5'-phosphoribitylamino)pyrimidine
  • 5-Amino-6-(5-phosphoribitylamino)uracil
5-Amino-6-ribitylamino uracil
  • 1-[(5-Amino-2,6-dihydroxypyrimidin-4-yl)amino]-1-deoxy-D-ribitol
  • 1-[(5-Amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino]-1-deoxy-D-ribitol
  • 4-(1-D-Ribitylamino)-5-amino-2,6 dihydroxypyrimidine
  • 4-(1-D-Ribitylamino)-5-amino-2,6-dihydroxypyrimidine
  • 4-(1-D-Ribitylamino)-5-aminouracil
Beta-D-Fructose 2-phosphate
  • beta-D-Fructofuranose 2-phosphate
  • beta-D-Fructose 2-phosphate
  • beta-D-Arabino-hexulose
  • beta-D-Fructofuranose
  • beta-D-Fructose
  • beta-delta-Arabino-hexulose
  • beta-delta-Fructofuranose
  • alpha-Ribazole 5'-phosphate
  • alpha-Ribazole-5'-P
  • alpha-Ribazole-5'-PO4
  • N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
  • N1-(5-Phospho-alpha-delta-ribosyl)-5,6-dimethylbenzimidazole
genes like me logo Genes that share compounds with PHPT1: view

Transcripts for PHPT1 Gene

Unigene Clusters for PHPT1 Gene

Phosphohistidine phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHPT1 Gene

No ASD Table

Relevant External Links for PHPT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHPT1 Gene

mRNA expression in normal human tissues for PHPT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHPT1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHPT1 Gene

SOURCE GeneReport for Unigene cluster for PHPT1 Gene Hs.409834

mRNA Expression by UniProt/SwissProt for PHPT1 Gene

Tissue specificity: Expressed abundantly in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with PHPT1: view

Protein tissue co-expression partners for PHPT1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for PHPT1 Gene

Orthologs for PHPT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHPT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PHPT1 35
  • 85.07 (n)
  • 84.8 (a)
PHPT1 36
  • 85 (a)
(Canis familiaris)
Mammalia PHPT1 35
  • 82.13 (n)
  • 86.4 (a)
PHPT1 36
  • 83 (a)
(Mus musculus)
Mammalia Phpt1 35
  • 83.61 (n)
  • 84.43 (a)
Phpt1 16
Phpt1 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Phpt1 35
  • 82.51 (n)
  • 84.43 (a)
(Monodelphis domestica)
Mammalia PHPT1 36
  • 78 (a)
(Pan troglodytes)
Mammalia PHPT1 36
  • 100 (a)
(Gallus gallus)
Aves PHPT1 35
  • 71.31 (n)
  • 63.11 (a)
PHPT1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia PHPT1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia phpt1 35
  • 69.7 (n)
  • 69.42 (a)
Str.20291 35
(Danio rerio)
Actinopterygii phpt1 35
  • 63.33 (n)
  • 66.67 (a)
wufb50e08 35
phpt1 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002078 35
  • 57.99 (n)
  • 47.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta janA 35
  • 52.1 (n)
  • 40.34 (a)
janA 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea phip-1 35
  • 52.05 (n)
  • 46.49 (a)
phip-1 36
  • 46 (a)
Species with no ortholog for PHPT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHPT1 Gene

Gene Tree for PHPT1 (if available)
Gene Tree for PHPT1 (if available)

Paralogs for PHPT1 Gene

(1) SIMAP similar genes for PHPT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PHPT1: view

No data available for Paralogs for PHPT1 Gene

Variants for PHPT1 Gene

Sequence variations from dbSNP and Humsavar for PHPT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs872463 -- 136,850,355(+) CCCAG(A/G)CATGG intron-variant, nc-transcript-variant
rs112973876 -- 136,848,362(+) ACACC(C/T)GCTCT upstream-variant-2KB
rs113703062 -- 136,849,156(+) CGGAC(C/T)CCGCT nc-transcript-variant, utr-variant-5-prime
rs114342653 -- 136,848,810(+) GCTGC(C/T)GTTGC upstream-variant-2KB
rs117386271 -- 136,848,232(+) CCAAG(A/G)GACGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PHPT1 Gene

Variant ID Type Subtype PubMed ID
dgv2426e1 CNV Complex 17122850
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
dgv2427e1 CNV Complex 17122850
esv2422220 CNV Deletion 17116639
dgv8408n71 CNV Loss 21882294
dgv8412n71 CNV Loss 21882294
dgv8414n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv818738 CNV Gain 17921354
dgv8417n71 CNV Loss 21882294
dgv8418n71 CNV Loss 21882294
dgv8419n71 CNV Loss 21882294
esv29973 CNV Loss 17803354
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8420n71 CNV Loss 21882294
nsv894483 CNV Loss 21882294
nsv894488 CNV Loss 21882294
nsv894489 CNV Loss 21882294
dgv8421n71 CNV Loss 21882294
nsv894491 CNV Loss 21882294
nsv8582 CNV Gain 18304495

Variation tolerance for PHPT1 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PHPT1 Gene

Disorders for PHPT1 Gene

Relevant External Links for PHPT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PHPT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHPT1 Gene

Publications for PHPT1 Gene

  1. Solution structure and catalytic mechanism of human protein histidine phosphatase 1. (PMID: 18991813) Gong W. … Xia B. (Biochem. J. 2009) 3 4 67
  2. 14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion. (PMID: 19344975) Xu A. … He D. (Lung Cancer 2010) 3 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  5. Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine. (PMID: 25574816) Ek P. … Zetterqvist A.9. (Ups. J. Med. Sci. 2015) 3

Products for PHPT1 Gene

Sources for PHPT1 Gene