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Aliases for PHOSPHO1 Gene

Aliases for PHOSPHO1 Gene

  • Phosphatase, Orphan 1 2 3
  • EC 3.1.3.75 4

External Ids for PHOSPHO1 Gene

Previous GeneCards Identifiers for PHOSPHO1 Gene

  • GC00U991115
  • GC17M049780
  • GC17M047642
  • GC17M047775
  • GC17M044655
  • GC17M047300
  • GC17M042668

Summaries for PHOSPHO1 Gene

GeneCards Summary for PHOSPHO1 Gene

PHOSPHO1 (Phosphatase, Orphan 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include pyrophosphatase activity. An important paralog of this gene is PHOSPHO2.

UniProtKB/Swiss-Prot for PHOSPHO1 Gene

  • Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHOSPHO1 Gene

Genomics for PHOSPHO1 Gene

Regulatory Elements for PHOSPHO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHOSPHO1 Gene

Start:
49,223,362 bp from pter
End:
49,231,647 bp from pter
Size:
8,286 bases
Orientation:
Minus strand

Genomic View for PHOSPHO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHOSPHO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHOSPHO1 Gene

Proteins for PHOSPHO1 Gene

  • Protein details for PHOSPHO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCT1-PHOP1_HUMAN
    Recommended name:
    Phosphoethanolamine/phosphocholine phosphatase
    Protein Accession:
    Q8TCT1
    Secondary Accessions:
    • E9PAM0
    • Q17RU6

    Protein attributes for PHOSPHO1 Gene

    Size:
    267 amino acids
    Molecular mass:
    29713 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PHOSPHO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHOSPHO1 Gene

Proteomics data for PHOSPHO1 Gene at MOPED

Post-translational modifications for PHOSPHO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHOSPHO1 Gene

Antibody Products

No data available for DME Specific Peptides for PHOSPHO1 Gene

Domains for PHOSPHO1 Gene

Gene Families for PHOSPHO1 Gene

Protein Domains for PHOSPHO1 Gene

Suggested Antigen Peptide Sequences for PHOSPHO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCT1

UniProtKB/Swiss-Prot:

PHOP1_HUMAN :
  • Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
Family:
  • Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
genes like me logo Genes that share domains with PHOSPHO1: view

Function for PHOSPHO1 Gene

Molecular function for PHOSPHO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3 uM for PEA {ECO:0000269 PubMed:15175005}; KM=11.4 uM for PCho {ECO:0000269 PubMed:15175005}; pH dependence: Optimum pH is 6.7. {ECO:0000269 PubMed:15175005};
UniProtKB/Swiss-Prot CatalyticActivity:
O-phosphoethanolamine + H(2)O = ethanolamine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphocholine + H(2)O = choline + phosphate.
UniProtKB/Swiss-Prot Function:
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization

Enzyme Numbers (IUBMB) for PHOSPHO1 Gene

Gene Ontology (GO) - Molecular Function for PHOSPHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016462 pyrophosphatase activity IDA 19874193
GO:0016791 phosphatase activity IBA --
GO:0046872 metal ion binding IEA --
GO:0052731 phosphocholine phosphatase activity EXP --
GO:0052732 phosphoethanolamine phosphatase activity EXP --
genes like me logo Genes that share ontologies with PHOSPHO1: view
genes like me logo Genes that share phenotypes with PHOSPHO1: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PHOSPHO1 Gene

Localization for PHOSPHO1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHOSPHO1 Gene COMPARTMENTS Subcellular localization image for PHOSPHO1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PHOSPHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PHOSPHO1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHOSPHO1 Gene

Pathways for PHOSPHO1 Gene

genes like me logo Genes that share pathways with PHOSPHO1: view

Pathways by source for PHOSPHO1 Gene

Interacting Proteins for PHOSPHO1 Gene

Gene Ontology (GO) - Biological Process for PHOSPHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001958 endochondral ossification IEA --
GO:0006644 phospholipid metabolic process TAS --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with PHOSPHO1: view

Drugs for PHOSPHO1 Gene

(1) Drugbank Compounds for PHOSPHO1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Choline
  • Bilineurine
62-49-7 Target product of approved, nutraceutical

(8) HMDB Compounds for PHOSPHO1 Gene

Compound Synonyms Cas Number PubMed IDs
Choline
  • (2-Hydroxyethyl)trimethyl ammonium
62-49-7
Ethanolamine
  • 1-Amino-2-hydroxyethane
141-43-5
Magnesium
  • Magnesium
7439-95-4
O-Phosphoethanolamine
  • 2-Amino-Ethanol dihydrogen phosphate
1071-23-4
Phosphate
  • NFB Orthophosphate
14265-44-2
genes like me logo Genes that share compounds with PHOSPHO1: view

Transcripts for PHOSPHO1 Gene

Unigene Clusters for PHOSPHO1 Gene

Phosphatase, orphan 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHOSPHO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHOSPHO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: - - -
SP3: -

Relevant External Links for PHOSPHO1 Gene

GeneLoc Exon Structure for
PHOSPHO1
ECgene alternative splicing isoforms for
PHOSPHO1

Expression for PHOSPHO1 Gene

mRNA expression in normal human tissues for PHOSPHO1 Gene

mRNA differential expression in normal tissues according to GTEx for PHOSPHO1 Gene

This gene is overexpressed in Whole Blood (38.3) and Testis (8.9).

Protein differential expression in normal tissues for PHOSPHO1 Gene

This gene is overexpressed in Liver, secretome (40.6) and Heart (27.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PHOSPHO1 Gene

SOURCE GeneReport for Unigene cluster for PHOSPHO1 Gene Hs.405607

mRNA Expression by UniProt/SwissProt for PHOSPHO1 Gene

Q8TCT1-PHOP1_HUMAN
Tissue specificity: Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.
genes like me logo Genes that share expressions with PHOSPHO1: view

Expression partners for PHOSPHO1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for PHOSPHO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHOSPHO1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PHOSPHO1 35
  • 91.21 (n)
  • 91.73 (a)
PHOSPHO1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHOSPHO1 35
  • 92.78 (n)
  • 94.16 (a)
PHOSPHO1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phospho1 35
  • 88.14 (n)
  • 92.89 (a)
Phospho1 16
Phospho1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PHOSPHO1 35
  • 99.54 (n)
  • 99.32 (a)
PHOSPHO1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phospho1 35
  • 87.77 (n)
  • 90.66 (a)
oppossum
(Monodelphis domestica)
Mammalia PHOSPHO1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHOSPHO1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHOSPHO1 35
  • 65.86 (n)
  • 61.69 (a)
PHOSPHO1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHOSPHO1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phospho1 35
  • 56.82 (n)
  • 56.12 (a)
zebrafish
(Danio rerio)
Actinopterygii phospho1 35
  • 60.03 (n)
  • 53.25 (a)
phospho1 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12237 36
  • 24 (a)
ManyToMany
CG14212 36
  • 27 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PS2 35
  • 41.22 (n)
  • 32.14 (a)
rice
(Oryza sativa)
Liliopsida Os01g0720400 35
  • 52.25 (n)
  • 36.94 (a)
Species with no ortholog for PHOSPHO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHOSPHO1 Gene

ENSEMBL:
Gene Tree for PHOSPHO1 (if available)
TreeFam:
Gene Tree for PHOSPHO1 (if available)

Paralogs for PHOSPHO1 Gene

Paralogs for PHOSPHO1 Gene

(1) SIMAP similar genes for PHOSPHO1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for PHOSPHO1 Gene

genes like me logo Genes that share paralogs with PHOSPHO1: view

Variants for PHOSPHO1 Gene

Sequence variations from dbSNP and Humsavar for PHOSPHO1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs850527 -- 49,228,768(-) ctgtc(A/G)cccag intron-variant
rs850529 -- 49,228,599(-) gttag(A/C)cagga intron-variant
rs9807042 -- 49,225,559(+) TGCTT(C/G)TAGCC intron-variant
rs34555265 -- 49,229,244(+) CCAAA(A/G)GGTCT intron-variant
rs34692121 -- 49,229,006(+) CATTT(C/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHOSPHO1 Gene

Variant ID Type Subtype PubMed ID
nsv2074 CNV Insertion 18451855

Relevant External Links for PHOSPHO1 Gene

HapMap Linkage Disequilibrium report
PHOSPHO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHOSPHO1 Gene

Disorders for PHOSPHO1 Gene

Relevant External Links for PHOSPHO1

Genetic Association Database (GAD)
PHOSPHO1
Human Genome Epidemiology (HuGE) Navigator
PHOSPHO1

No disorders were found for PHOSPHO1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PHOSPHO1 Gene

Publications for PHOSPHO1 Gene

  1. Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene. (PMID: 12464021) Houston B. … Farquharson C. (Anim. Genet. 2002) 2 3 4
  2. PHOSPHO1 -- a novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage. (PMID: 15050893) Houston B. … Farquharson C. (Bone 2004) 3 4 23
  3. Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1. (PMID: 18471996) Roberts S.J. … Farquharson C. (Biochem. Biophys. Res. Commun. 2008) 3 4
  4. Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. (PMID: 16054448) Roberts S.J. … Farquharson C. (Biochim. Biophys. Acta 2005) 3 4
  5. Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. (PMID: 15175005) Roberts S.J. … Farquharson C. (Biochem. J. 2004) 3 4

Products for PHOSPHO1 Gene

Sources for PHOSPHO1 Gene

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