Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PHOSPHO1 Gene

Aliases for PHOSPHO1 Gene

  • Phosphoethanolamine/Phosphocholine Phosphatase 2 3
  • Phosphatase, Orphan 1 2 5
  • EC 4

External Ids for PHOSPHO1 Gene

Previous GeneCards Identifiers for PHOSPHO1 Gene

  • GC00U991115
  • GC17M049780
  • GC17M047642
  • GC17M047775
  • GC17M044655
  • GC17M047300
  • GC17M042668

Summaries for PHOSPHO1 Gene

GeneCards Summary for PHOSPHO1 Gene

PHOSPHO1 (Phosphoethanolamine/Phosphocholine Phosphatase) is a Protein Coding gene. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. GO annotations related to this gene include phosphatase activity and phosphocholine phosphatase activity. An important paralog of this gene is PHOSPHO2.

UniProtKB/Swiss-Prot for PHOSPHO1 Gene

  • Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHOSPHO1 Gene

Genomics for PHOSPHO1 Gene

Regulatory Elements for PHOSPHO1 Gene

Enhancers for PHOSPHO1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PHOSPHO1 on UCSC Golden Path with GeneCards custom track

Promoters for PHOSPHO1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHOSPHO1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHOSPHO1 Gene

49,223,362 bp from pter
49,231,692 bp from pter
8,331 bases
Minus strand

Genomic View for PHOSPHO1 Gene

Genes around PHOSPHO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHOSPHO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHOSPHO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHOSPHO1 Gene

Proteins for PHOSPHO1 Gene

  • Protein details for PHOSPHO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphoethanolamine/phosphocholine phosphatase
    Protein Accession:
    Secondary Accessions:
    • E9PAM0
    • Q17RU6

    Protein attributes for PHOSPHO1 Gene

    267 amino acids
    Molecular mass:
    29713 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PHOSPHO1 Gene


neXtProt entry for PHOSPHO1 Gene

Proteomics data for PHOSPHO1 Gene at MOPED

Post-translational modifications for PHOSPHO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHOSPHO1 Gene

No data available for DME Specific Peptides for PHOSPHO1 Gene

Domains & Families for PHOSPHO1 Gene

Gene Families for PHOSPHO1 Gene

Protein Domains for PHOSPHO1 Gene

Suggested Antigen Peptide Sequences for PHOSPHO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
  • Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.
genes like me logo Genes that share domains with PHOSPHO1: view

Function for PHOSPHO1 Gene

Molecular function for PHOSPHO1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3 uM for PEA {ECO:0000269 PubMed:15175005}; KM=11.4 uM for PCho {ECO:0000269 PubMed:15175005}; pH dependence: Optimum pH is 6.7. {ECO:0000269 PubMed:15175005};
UniProtKB/Swiss-Prot CatalyticActivity:
O-phosphoethanolamine + H(2)O = ethanolamine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphocholine + H(2)O = choline + phosphate.
UniProtKB/Swiss-Prot Function:
Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

Enzyme Numbers (IUBMB) for PHOSPHO1 Gene

genes like me logo Genes that share phenotypes with PHOSPHO1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PHOSPHO1

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PHOSPHO1 Gene

Localization for PHOSPHO1 Gene

Subcellular locations from

Jensen Localization Image for PHOSPHO1 Gene COMPARTMENTS Subcellular localization image for PHOSPHO1 gene
Compartment Confidence
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PHOSPHO1 Gene

Pathways & Interactions for PHOSPHO1 Gene

genes like me logo Genes that share pathways with PHOSPHO1: view

Pathways by source for PHOSPHO1 Gene

Interacting Proteins for PHOSPHO1 Gene

Gene Ontology (GO) - Biological Process for PHOSPHO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0008152 metabolic process IEA --
GO:0030500 regulation of bone mineralization IEA --
GO:0035630 bone mineralization involved in bone maturation IEA,IBA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PHOSPHO1: view

No data available for SIGNOR curated interactions for PHOSPHO1 Gene

Drugs & Compounds for PHOSPHO1 Gene

(5) Drugs for PHOSPHO1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Target, product of 139
Ethanolamine Experimental Pharma 0
O-Phosphoethanolamine Experimental Pharma 0
Phosphocholine Experimental Pharma 0
Magnesium Nutra 0

(3) Additional Compounds for PHOSPHO1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with PHOSPHO1: view

Transcripts for PHOSPHO1 Gene

Unigene Clusters for PHOSPHO1 Gene

Phosphatase, orphan 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHOSPHO1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5
SP2: - - -
SP3: -

Relevant External Links for PHOSPHO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHOSPHO1 Gene

mRNA expression in normal human tissues for PHOSPHO1 Gene

mRNA differential expression in normal tissues according to GTEx for PHOSPHO1 Gene

This gene is overexpressed in Whole Blood (x38.3) and Testis (x8.9).

Protein differential expression in normal tissues from HIPED for PHOSPHO1 Gene

This gene is overexpressed in Liver, secretome (40.6) and Heart (27.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PHOSPHO1 Gene

SOURCE GeneReport for Unigene cluster for PHOSPHO1 Gene Hs.405607

mRNA Expression by UniProt/SwissProt for PHOSPHO1 Gene

Tissue specificity: Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.
genes like me logo Genes that share expression patterns with PHOSPHO1: view

Protein tissue co-expression partners for PHOSPHO1 Gene

Primer Products

Orthologs for PHOSPHO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHOSPHO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PHOSPHO1 35
  • 91.21 (n)
  • 91.73 (a)
  • 88 (a)
(Canis familiaris)
Mammalia PHOSPHO1 35
  • 92.78 (n)
  • 94.16 (a)
  • 70 (a)
(Mus musculus)
Mammalia Phospho1 35
  • 88.14 (n)
  • 92.89 (a)
Phospho1 16
Phospho1 36
  • 88 (a)
(Pan troglodytes)
Mammalia PHOSPHO1 35
  • 99.54 (n)
  • 99.32 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Phospho1 35
  • 87.77 (n)
  • 90.66 (a)
(Monodelphis domestica)
Mammalia PHOSPHO1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia PHOSPHO1 36
  • 72 (a)
(Gallus gallus)
Aves PHOSPHO1 35
  • 65.86 (n)
  • 61.69 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia PHOSPHO1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia phospho1 35
  • 56.82 (n)
  • 56.12 (a)
(Danio rerio)
Actinopterygii phospho1 35
  • 60.03 (n)
  • 53.25 (a)
phospho1 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12237 36
  • 24 (a)
CG14212 36
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PS2 35
  • 41.22 (n)
  • 32.14 (a)
(Oryza sativa)
Liliopsida Os01g0720400 35
  • 52.25 (n)
  • 36.94 (a)
Species with no ortholog for PHOSPHO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHOSPHO1 Gene

Gene Tree for PHOSPHO1 (if available)
Gene Tree for PHOSPHO1 (if available)

Paralogs for PHOSPHO1 Gene

Paralogs for PHOSPHO1 Gene

(1) SIMAP similar genes for PHOSPHO1 Gene using alignment to 5 proteins: Pseudogenes for PHOSPHO1 Gene

genes like me logo Genes that share paralogs with PHOSPHO1: view

Variants for PHOSPHO1 Gene

Sequence variations from dbSNP and Humsavar for PHOSPHO1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs605256 -- 49,228,993(-) GAGTT(G/T)TGTGT intron-variant
rs617182 -- 49,229,912(-) CAATT(C/T)TCCCA intron-variant
rs850527 -- 49,228,768(-) ctgtc(A/G)cccag intron-variant
rs850528 -- 49,228,722(-) agttc(C/T)gcctc intron-variant
rs850529 -- 49,228,599(-) gttag(A/C)cagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHOSPHO1 Gene

Variant ID Type Subtype PubMed ID
nsv2074 CNV Insertion 18451855

Variation tolerance for PHOSPHO1 Gene

Gene Damage Index Score: 1.69; 32.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PHOSPHO1 Gene

Disorders for PHOSPHO1 Gene

Relevant External Links for PHOSPHO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PHOSPHO1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHOSPHO1 Gene

Publications for PHOSPHO1 Gene

  1. Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene. (PMID: 12464021) Houston B. … Farquharson C. (Anim. Genet. 2002) 2 3 4 67
  2. PHOSPHO1 -- a novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage. (PMID: 15050893) Houston B. … Farquharson C. (Bone 2004) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Role of bone-type tissue-nonspecific alkaline phosphatase and PHOSPO1 in vascular calcification. (PMID: 24533943) Bobryshev Y.V. … Chistiakov D.A. (Curr. Pharm. Des. 2014) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for PHOSPHO1 Gene

Sources for PHOSPHO1 Gene