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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHLPP2 Gene

protein-coding   GIFtS: 55
GCID: GC16M071674

PH domain and leucine rich repeat protein phosphatase 2

(Previous name: PH domain and leucine rich repeat protein phosphatase-like...)
(Previous symbol: PHLPPL)
 Explore 2 diseases affiliated with
PHLPP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PHLPP2    

Aliases
for PHLPP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
PH Domain And Leucine Rich Repeat Protein Phosphatase 21 2     PH Domain And Leucine Rich Repeat Protein Phosphatase-Like1
PHLPPL1 2 3 5     PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 22
KIAA09311 3     PHLPP-Like1
EC 3.1.3.163 8     PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase-Like3

External Ids:    HGNC: 291491   Entrez Gene: 230352   Ensembl: ENSG000000401997   OMIM: 6110665   UniProtKB: Q6ZVD83   

Export aliases for PHLPP2 gene to outside databases

Previous GC identifers: GC16M070236 GC16M057446


Summaries
for PHLPP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PHLP2_HUMAN, Q6ZVD8
Function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II
and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that
primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation
of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3.
Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell
proliferation and may act as a tumor suppressor

Gene Wiki entry for PHLPP2 (PHLPPL)


Genomic Views
for PHLPP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PHLPP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PHLPP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHLPP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHLPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

PHLPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLPP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M071674:  view genomic region     (about GC identifiers)

Start:
 71,671,738 bp from pter      End:
 71,758,604 bp from pter
Size:
 86,867 bases      Orientation:
 minus strand

Proteins
for PHLPP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PHLP2_HUMAN, Q6ZVD8 (See protein sequence)
Recommended Name: PH domain leucine-rich repeat-containing protein phosphatase 2  
Size: 1323 amino acids; 146751 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Interacts with AKT1, AKT3 and PRKCB isoform beta-II
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue,
expression is concentrated in the cytoplasm and nucleus
Sequence caution: Sequence=BAA76775.2; Type=Erroneous initiation; Sequence=BAA91943.1; Type=Erroneous initiation;
Secondary accessions: A1L374 Q9NV17 Q9Y2E3
Alternative splicing: 3 isoforms:  Q6ZVD8-1   Q6ZVD8-2   Q6ZVD8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHLPP2: NX_Q6ZVD8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZVD8

    • 4/7 DME Specific Peptides for PHLPP2 (Q6ZVD8) (see all 7)
     KAIITED  YNVRKGK  VEVEVDIHC  SDNGLDSDD 

    PHLPP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055835.2  
    ENSEMBL proteins: 
     ENSP00000458660   ENSP00000456572   ENSP00000457991   ENSP00000377159   ENSP00000454519  
     ENSP00000353610   ENSP00000445781   ENSP00000348611  
    Reactome Protein details: Q6ZVD8
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: PHLPP2
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    Novus Biologicals PHLPP2 Lysate
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    Uscn Proteins for PHLPP2

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001917photoreceptor inner segment IEA--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0016020membrane ----
    GO:0042622photoreceptor outer segment membrane IEA--


    PHLPP2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PHLPP2

    Protein Domains /
    Families
    for PHLPP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PHLPP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001932 PP2C-like
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q6ZVD8

    ProtoNet protein and cluster: Q6ZVD8

    UniProtKB/Swiss-Prot: PHLP2_HUMAN, Q6ZVD8
    Similarity: Contains 22 LRR (leucine-rich) repeats
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PP2C-like domain


    Function
    for PHLPP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PHLP2_HUMAN, Q6ZVD8
    Function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II
    and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that
    primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation
    of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3.
    Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell
    proliferation and may act as a tumor suppressor
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=4.13 mM for p-nitrophenyl phosphate;

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
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    8/118 QIAGEN miScript miRNA Assays for microRNAs that regulate PHLPP2 (see all 118):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-134 hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene shRNA RFP: PHLPP2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PHLPP2

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004721phosphoprotein phosphatase activity ----
    GO:0004722protein serine/threonine phosphatase activity IEA--
    GO:0046872metal ion binding IEA--


    PHLPP2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for PHLPP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PIP3 activates AKT signaling
    8/9 pathways (see all 9)
    		PIP3 activates AKT signaling1.00
    		PI3K/AKT activation0.97
    		PI3K/AKT Signaling in Cancer1.00
    		GAB1 signalosome0.96
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    		PI3K events in ERBB4 signaling1.00
    		Signaling by ERBB40.67
    3Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    4Signaling by the B Cell Receptor (BCR)
    		Signaling by the B Cell Receptor (BCR)1.00
    		Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5Negative regulation of the PI3K/AKT network
    		Negative regulation of the PI3K/AKT network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/29        Reactome Pathways for PHLPP2 (see all 29)
        Signaling by EGFR in Cancer
    Negative regulation of the PI3K/AKT network
    Disease
    Signaling by ERBB2
    GAB1 signalosome



    PHLPP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHLPP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/19 Interacting proteins for PHLPP2 (Q6ZVD82, 3 ENSP000003486114) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZRP153113, ENSP000003389344I2D: score=2 STRING: ENSP00000338934
    RDXP352413, ENSP000003428304I2D: score=2 STRING: ENSP00000342830
    SLC9A3R1O147453, ENSP000002626134I2D: score=2 STRING: ENSP00000262613
    SNX27Q96L923, ENSP000003578364I2D: score=2 STRING: ENSP00000357836
    USP1O947823, ENSP000003435264I2D: score=2 STRING: ENSP00000343526
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IEA--


    PHLPP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PHLPP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHLPP2

    4 HMDB Compounds for PHLPP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    Search CenterWatch for drugs/clinical trials and news about PHLPP2 / PHLP2 

    Transcripts
    for PHLPP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PHLPP2 gene: 
    NM_015020.2  

    Unigene Cluster for PHLPP2:

    PH domain and leucine rich repeat protein phosphatase 2
    Hs.709458  [show with all ESTs]
    Unigene Representative Sequence: AB023148
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568004(uc002fav.3) ENST00000564884 ENST00000568954 ENST00000393524(uc010cgf.3)
    ENST00000567016 ENST00000538126(uc002fay.1) ENST00000574977 ENST00000360429
    ENST00000540628 ENST00000356272(uc002fax.3)

    miRNA
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    8/118 QIAGEN miScript miRNA Assays for microRNAs that regulate PHLPP2 (see all 118):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-128 hsa-miR-134 hsa-miR-200a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: PHLPP2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHLPP2
    Clone
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    Additional cDNA sequence: 

    AB023148.2 AK001661.1 AK001854.1 BC035267.1 BC129927.1 BC129983.1 BX647823.1 BX648157.1 
    BX648394.1 

    7 DOTS entries:

    DT.120688457  DT.95319756  DT.315922  DT.95357742  DT.91785894  DT.91955431  DT.100736839 

    24/100 AceView cDNA sequences (see all 100):

    BU624944 BU521957 CB158518 AU132858 F12258 BG718350 BC035267 AA621801 
    AI953756 AA625418 AA613593 BU192608 BM728870 AA237080 BE766007 BG621271 
    AL602100 BM850683 AB023148 W00412 Z45505 AU135447 AK001854 AI743368 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PHLPP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                                                                                            
    SP2:                                                                    -                                       


    ECgene alternative splicing isoforms for PHLPP2

    Expression
    for PHLPP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHLPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCAGCAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See PHLPP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHLPP2

    SOURCE GeneReport for Unigene cluster: Hs.709458

    UniProtKB/Swiss-Prot: PHLP2_HUMAN, Q6ZVD8
    Tissue specificity: In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic
    mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly
    decreased in 80% of tested tumors (at protein level)

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    In Situ
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    Orthologs
    for PHLPP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PHLPP2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Phlpp21 , 5 PH domain and leucine rich repeat protein phosphatase more1, 5 86.99(n)1
    90.91(a)1    		   8 (57.33 cM)5
    2446501  NM_001122594.21  NP_001116066.21 
     1098685425 
    chicken
    (Gallus gallus)    		 Aves PHLPP21 PH domain and leucine rich repeat protein phosphatase more 73.76(n)
    79.17(a)    		   415881  XM_414238.3  XP_414238.3 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.183142 Transcribed sequence with weak similarity to protein more 71.66(n)    BX759989.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003328951 PH domain leucine-rich repeat-containing protein phosphatase more 63.82(n)
    64.52(a)    		   100332895  XM_002664099.2  XP_002664145.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Phlpp6
    		 PH domain leucine-rich repeat protein phosphatase
    		 15(a)
    		 1 → many
    		 2L(19059647-19063049)
    worm
    (Caenorhabditis elegans)    		 Secernentea F43C1.11 Protein F43C1.1 40.75(n)
    32.93(a)    		   185690  NM_065444.2  NP_497845.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G393906
    AT3G475706
    (see all 7)    		 leucine-rich repeat protein kinase-like protein
    putative LRR receptor-like serine/threonine-protei...
    (see all 7)    		 6(a)
    14(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 5(15763715-15765469)
    3(17527507-17530929)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 95)    		 expressed protein
    (see all 95)    		 9(a)
    8(a)
    (see all 95)    		 many ↔ many
    many ↔ many
    (see all 95)    		 11(27908076-27915246)
    1(28665264-28667061)


    ENSEMBL Gene Tree for PHLPP2 (if available)
    TreeFam Gene Tree for PHLPP2 (if available) 

    Paralogs
    for PHLPP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHLPP2 gene
    PHLPP12  
    4 SIMAP similar genes for PHLPP2 using alignment to 5 protein entries:     PHLP2_HUMAN (see all proteins):
    PHLPPL    PHLPP1    LRRC57    LRRC28

    PHLPP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PHLPP2
    PGOHUM00000248884


    Genomic Variants
    for PHLPP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1234 NCBI SNPs in PHLPP2 are shown (see all 1234)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1122261571,2
    		C,--71678415(+) GTGACC/G/TGGCTT 1 -- ds50010--------
    rs1166381051,2
    		F,--71678456(+) AGAACT/CGTGGA 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1465331611,2
    		--71678508(+) TCAATA/CAGGAC 1 -- ds50010--------
    rs1834658481,2
    		--71678598(+) TAAAGC/TAAAAA 1 -- ds50010--------
    rs37526811,2
    		C,F,H,--71678663(-) AAGCTG/ATGAGT 1 -- ds500126Minor allele frequency- A:0.49EA NS NA WA 4230
    rs1502096881,2
    		--71678675(+) GCAGTA/GTCAGG 1 -- ds50010--------
    rs72046081,2
    		C,F,A,H,--71678679(+) TGTCAC/GGGAAT 1 -- ds500128Minor allele frequency- G:0.15NA NS EA WA CSA EU 3066
    rs287128761,2
    		C,F,--71678762(+) TTCTAC/GAAACA 1 -- ds50013Minor allele frequency- G:0.20WA 122
    rs1457783481,2
    		--71678827(+) CTCCAC/TTTTAA 1 -- ds50010--------
    rs740272731,2
    		C,--71678860(+) CACTTC/TATTTT 1 -- ut311Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for PHLPP2 (71671738 - 71758604 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PHLPP2: --
    Human Gene Mutation Database (HGMD): PHLPP2

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PHLPP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PHLPP2 for disorders           About GeneDecksing

    OMIM gene information: 611066    OMIM disorders: --

    2 diseases for PHLPP2:    About MalaCards
    colon cancer    colorectal cancer

    Human Genome Epidemiology (HuGE) Navigator: PHLPP2 (1 document)

    Export disorders for PHLPP2 gene to outside databases

    Publications
    for PHLPP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHLPP2 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with PHLPP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (PubMed id 17386267)1, 2, 3 Brognard J.... Newton A.C. (2007)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    5. Ras-associating domain proteins: a new class of cyclic nucleotide-gated channel modulators. (PubMed id 22183406)1 Gupta V.K....Rajala R.V. (2012)
    6. PHLPP-mediated dephosphorylation of S6K1 inhibits pro tein translation and cell growth. (PubMed id 21986499)1 Liu J....Gao T. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Purinergic receptor-mediated rapid depletion of nucle ar phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases. (PubMed id 20605778)1 Mistafa O....Stenius U. (2010)
    9. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. (PubMed id 20513427)1 Qiao M....Pardee A.B. (2010)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

    External Searches for PHLPP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing PHLPP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23035 HGNC: 29149 AceView: KIAA0931 Ensembl:ENSG00000040199 euGenes: HUgn23035
    ECgene: PHLPP2 H-InvDB: PHLPP2

    Other Databases showing PHLPP2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0931

    Specialized Databases showing PHLPP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHLPP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PHLPP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PHLPP2 gene:
    Search GeneIP for patents involving PHLPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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