Aliases for PHLPP1 Gene
- PH Domain And Leucine Rich Repeat Protein Phosphatase 1 2 3
- SCOP 3 4 6
- Pleckstrin Homology Domain Containing, Family E (With Leucine Rich Repeats) Member 1 2 3
- Suprachiasmatic Nucleus Circadian Oscillatory Protein 3 4
- PH Domain-Containing Family E Member 1 3 4
- EC 22.214.171.124 4 64
- KIAA0606 4 6
- PLEKHE1 3 4
External Ids for PHLPP1 Gene
Previous Symbols for PHLPP1 Gene
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
GeneCards Summary for PHLPP1 Gene
PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with PHLPP1 include obesity. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include phospholipid binding and phosphoprotein phosphatase activity. An important paralog of this gene is PHLPP2.
UniProtKB/Swiss-Prot for PHLPP1 Gene
Protein phosphatase that mediates dephosphorylation of Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II and Ser-657 of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of Ser-473 of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.