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PHLPP1 Gene

protein-coding   GIFtS: 61
GCID: GC18P060382

PH Domain And Leucine Rich Repeat Protein Phosphatase 1

(Previous names: pleckstrin homology domain containing, family E (with leucine...)
(Previous symbols: PLEKHE1, PHLPP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PH Domain And Leucine Rich Repeat Protein Phosphatase 11 2     EC 3.1.3.163 8
PHLPP1 2 3     KIAA06063 5
PLEKHE11 2 3     PH Domain And Leucine Rich Repeat Protein Phosphatase1
SCOP2 3 5     PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 12
Pleckstrin Homology Domain Containing, Family E (With Leucine Rich
Repeats) Member 11 2
     SCN Circadian Oscillatory Protein2
Suprachiasmatic Nucleus Circadian Oscillatory Protein2 3     hSCOP3
PH Domain-Containing Family E Member 12 3     Pleckstrin Homology Domain-Containing Family E Member 13

External Ids:    HGNC: 206101   Entrez Gene: 232392   Ensembl: ENSG000000819137   OMIM: 6093965   UniProtKB: O603463   

Export aliases for PHLPP1 gene to outside databases

Previous GC identifers: GC18P058535 GC18P057093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PHLPP1 Gene:
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by
dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in
multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes
by interfering with Akt-mediated insulin signaling. (provided by RefSeq, Dec 2011)

GeneCards Summary for PHLPP1 Gene:
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a protein-coding gene. Diseases associated with PHLPP1 include phlebotomus fever, and motion sickness. GO annotations related to this gene include phospholipid binding and phosphoprotein phosphatase activity. An important paralog of this gene is PHLPP2.

UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346
Function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform
beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade
that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.
Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the
phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads
to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
May act as a negative regulator of K-Ras signaling in membrane rafts

Gene Wiki entry for PHLPP1 (PHLPP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010966.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for PHLPP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PHLPP1 promoter sequence
   Search Chromatin IP Primers for PHLPP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHLPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.32

PHLPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLPP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P060382:  view genomic region     (about GC identifiers)

Start:
60,382,672 bp from pter      End:
60,647,666 bp from pter
Size:
264,995 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346 (See protein sequence)
Recommended Name: PH domain leucine-rich repeat-containing protein phosphatase 1  
Size: 1717 amino acids; 184672 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity). Interacts
with AKT2, AKT3 and PRKCB isoform beta-II
Sequence caution: Sequence=AAH14927.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH82244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI26278.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91980.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1A4F5 Q641Q7 Q6P4C4 Q6PJI6 Q86TN6 Q96FK2 Q9NUY1

Explore the universe of human proteins at neXtProt for PHLPP1: NX_O60346

Explore proteomics data for PHLPP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys246, Lys1146
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PHLPP1 (O60346) (see all 10)
     KAIITED  PPPSPGI  YNVRKGK  LHCERNQL 


    See PHLPP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_919431.2  
    ENSEMBL proteins: 
     ENSP00000262719   ENSP00000467279   ENSP00000383170  
    Reactome Protein details: O60346

    PHLPP1 Human Recombinant Protein Products:

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    PHLPP1 Assay Products:

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    Cloud-Clone Corp. CLIAs for PHLPP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    4 InterPro protein domains:
     IPR001932 PP2C-like_dom
     IPR001611 Leu-rich_rpt
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O60346

    ProtoNet protein and cluster: O60346

    2 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346
    Domain: The PH domain is required for interaction with PRKCB and its dephosphorylation
    Similarity: Contains 21 LRR (leucine-rich) repeats
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PP2C-like domain


    PHLPP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHLP1_HUMAN, O60346
    Function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform
    beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade
    that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.
    Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the
    phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads
    to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
    May act as a negative regulator of K-Ras signaling in membrane rafts
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Enzyme regulation: Insensitive to okadaic acid

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding IPI18162466
    GO:0046872metal ion binding IEA--
         
    PHLPP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Phlpp1):
     behavior/neurological  no phenotypic analysis 

    PHLPP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phlpp1tm1.1Saco for PHLPP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHLPP1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHLPP1

    miRNA
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    miRTarBase miRNAs that target PHLPP1:
    hsa-mir-1307-3p (MIRT035820), hsa-mir-331-3p (MIRT019235), hsa-mir-484 (MIRT041846), hsa-mir-877-5p (MIRT037351), hsa-mir-190a-5p (MIRT021082)

    Block miRNA regulation of human, mouse, rat PHLPP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHLPP1 (see all 17):
    hsa-miR-511 hsa-miR-3622b-3p hsa-miR-4330 hsa-miR-2113 hsa-miR-4273 hsa-miR-190 hsa-miR-224 hsa-miR-3606
    SwitchGear 3'UTR luciferase reporter plasmidPHLPP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PHLPP1

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLPP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHLP1_HUMAN, O60346: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue,
    expression is concentrated at the lateral membrane of epithelial cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    PHLPP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PHLPP1 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PI-3K cascade
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    GAB1 signalosome0.93
    Role of LAT2/NTAL/LAB on calcium mobilization0.80
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI-3K cascade0.88
    Signaling by ERBB40.66
    2Signaling by FGFR
    Signaling by FGFR0.91
    DAP12 interactions0.89
    Signaling by FGFR in disease0.91
    Signaling by PDGF0.87
    Downstream signaling of activated FGFR0.91
    Signaling by EGFR0.83
    Downstream signal transduction0.90
    Signaling by EGFR in Cancer0.82
    3Downstream Signaling Events Of B Cell Receptor (BCR)
    Downstream Signaling Events Of B Cell Receptor (BCR)0.79
    Signaling by the B Cell Receptor (BCR)0.79
    4Signaling by GPCR
    Signal Transduction0.58
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PHLPP1
        Negative regulation of the PI3K/AKT network


    1 Kegg Pathway  (Kegg details for PHLPP1):
        PI3K-Akt signaling pathway


    PHLPP1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PHLPP1: 
              Protein Phosphatases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PHLPP1

    Selected Interacting proteins for PHLPP1 (O603461, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCRIBQ141601, 2, 3EBI-2511516,EBI-357345 MINT-8204981 I2D: score=3 
    CDH1P128302, 3MINT-8205015 I2D: score=1 
    AKT1P317493I2D: score=5 
    USP46P620683I2D: score=3 
    AKT2P317513I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009649entrainment of circadian clock IEA--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    PHLPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHLPP1 (PHLP1)

    4 HMDB Compounds for PHLPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHLPP1 gene: 
    NM_194449.3  

    Unigene Cluster for PHLPP1:

    PH domain and leucine rich repeat protein phosphatase 1
    Hs.465337  [show with all ESTs]
    Unigene Representative Sequence: NM_194449
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262719 ENST00000497351 ENST00000588452 ENST00000487409 ENST00000588953
    ENST00000591386 ENST00000591106 ENST00000400316(uc021ule.1)
    miRNA
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    hsa-miR-511 hsa-miR-3622b-3p hsa-miR-4330 hsa-miR-2113 hsa-miR-4273 hsa-miR-190 hsa-miR-224 hsa-miR-3606
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      QuantiFast Probe-based Assays in human, mouse, rat PHLPP1

    Additional mRNA sequence: 

    AB011178.2 AF130097.2 AK001924.1 BC010706.1 BC014927.2 BC047653.1 BC063519.1 BC082244.1 
    BC126277.1 

    10 DOTS entries:

    DT.115029  DT.100652846  DT.40294035  DT.75155785  DT.100652984  DT.95189671  DT.95195521  DT.95309269 
    DT.100752083  DT.101960639 

    Selected AceView cDNA sequences (see all 143):

    AW518966 AI969611 BC010706 BM677804 BG740290 BU159555 BC014927 H63251 
    BM673462 AL079409 BU682436 BG056493 BQ213311 BF966064 BE501129 CB122648 
    AI860347 BX508333 AI702468 NM_194449 BM724138 BU192801 AB011178 AW958916 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHLPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAATTTT
    PHLPP1 Expression
    About this image

    PHLPP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHLPP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465337

    UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346
    Tissue specificity: In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic
    mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or
    significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous
    tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including PHLPP1: 
              Protein Phosphatases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLPP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PHLPP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phlpp11 , 5 PH domain and leucine rich repeat protein phosphatase more1, 5 86.09(n)1
    89.69(a)1
      1 (49.76 cM)5
    984321  NM_133821.31  NP_598582.31 
     1061717525 
    chicken
    (Gallus gallus)
    Aves PHLPP11 PH domain and leucine rich repeat protein phosphatase more 81.26(n)
    89.92(a)
      420904  XM_418990.4  XP_418990.4 
    lizard
    (Anolis carolinensis)
    Reptilia PHLPP16
    PH domain and leucine rich repeat protein phosphat...
    86(a)
    1 ↔ 1
    GL343265.1(125236-221791)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX752400.12   -- 85.86(n)    BX752400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii PHLPP16
    PH domain and leucine rich repeat protein phosphat...
    68(a)
    1 ↔ 1
    2(290242-301021) ENSDARG00000078694
    fruit fly
    (Drosophila melanogaster)
    Insecta Phlpp6
    PH domain leucine-rich repeat protein phosphatase
    20(a)
    1 → many
    2L(19059647-19063049)
    worm
    (Caenorhabditis elegans)
    Secernentea F43C1.16
    Protein F43C1.1 (F43C1.1) mRNA, complete cds
    25(a)
    1 → many
    III(4210562-4216706) WBGene00009647
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYR1(YJL005W)4 Adenylate cyclase, required for cAMP production and more   --   10(425157-431237) 853452  NP_012529.1 


    ENSEMBL Gene Tree for PHLPP1 (if available)
    TreeFam Gene Tree for PHLPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHLPP1 gene
    PHLPP22  
    4 SIMAP similar genes for PHLPP1 using alignment to 2 protein entries:     PHLP1_HUMAN (see all proteins):
    PHLPPL    PHLPP2    LRRC1    FLII

    PHLPP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHLPP1 (see all 4800)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868951121,2
    --60234813(+) TATCAC/TTCTTG 1 -- us2k10--------
    rs734650391,2
    C,F--60234925(+) TAAATG/TAAAAT 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1423381461,2
    --60234950(+) GGAATA/GTAAAA 1 -- us2k10--------
    rs1486910071,2
    C--60234969(+) AGAAA-/TATT  
            
    TATTT
    1 -- us2k10--------
    rs1905529121,2
    --60235096(+) CTTTAC/TTGAGG 1 -- us2k10--------
    rs713525871,2
    C,F--60235165(+) AATCCG/AGATTT 1 -- us2k15Minor allele frequency- A:0.09NA WA 244
    rs1828273751,2
    --60235276(+) CACCCC/TCACTA 1 -- us2k10--------
    rs749128411,2
    C,F--60235296(+) AAAAAA/GTGAGC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1466314401,2
    --60235361(+) ATCACC/TTGGGC 1 -- us2k10--------
    rs1878617851,2
    --60235368(+) GGGCCA/CGAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHLPP1 (60382672 - 60632672 bp, first 250kb of PHLPP1)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PHLPP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659096CNV Deletion23128226
    esv2665321CNV Deletion23128226
    esv2384564CNV Deletion18987734
    esv2717197CNV Deletion23290073
    esv267732CNV Insertion20981092
    nsv525821CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHLPP1
    DNA2.0 Custom Variant and Variant Library Synthesis for PHLPP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609396    OMIM disorders: --

    19 diseases for PHLPP1:    
    About MalaCards
    phlebotomus fever    motion sickness    obesity    narcolepsy
    diabetic nephropathy    insulin resistance    huntington's disease    lymphoblastic leukemia
    chronic lymphocytic leukemia    prostate cancer    prostatitis    leukemia
    retinitis    pancreatic cancer    colorectal cancer    lung cancer
    pancreatitis    breast cancer    neuronitis


    PHLPP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PHLPP1
    Human Genome Epidemiology (HuGE) Navigator: PHLPP1 (3 documents)

    Export disorders for PHLPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHLPP1 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with PHLPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (PubMed id 15808505)1, 2, 3, 9 Gao T.... Newton A.C. (Mol. Cell 2005)
    2. The phosphatase PHLPP controls the cellular levels of protein kinase C. (PubMed id 18162466)1, 2, 9 Gao T.... Newton A.C. (J. Biol. Chem. 2008)
    3. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. (PubMed id 19079341)1, 2, 9 Liu J.... Gao T. (Oncogene 2009)
    4. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (PubMed id 17386267)1, 2, 9 Brognard J.... Newton A.C. (Mol. Cell 2007)
    5. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. (PubMed id 10570941)1, 3 Shimizu K....Nagai K. (FEBS Lett. 1999)
    10. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23239 HGNC: 20610 AceView: PLEKHE1 Ensembl:ENSG00000081913 euGenes: HUgn23239
    ECgene: PHLPP1 Kegg: 23239 H-InvDB: PHLPP1

    (According to HUGE)
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    HUGE: KIAA0606

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PHLPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PHLPP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PHLPP1 gene:
    Search GeneIP for patents involving PHLPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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