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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHLPP1 Gene

protein-coding   GIFtS: 61
GCID: GC18P060382

PH Domain And Leucine Rich Repeat Protein Phosphatase 1

(Previous names: pleckstrin homology domain containing, family E (with leucine...)
(Previous symbols: PLEKHE1, PHLPP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
PH Domain And Leucine Rich Repeat Protein Phosphatase 11 2     EC 3.1.3.163 8
PHLPP1 2 3     PH Domain And Leucine Rich Repeat Protein Phosphatase1
PLEKHE11 2 3     PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 12
Pleckstrin Homology Domain Containing, Family E (With Leucine Rich
Repeats) Member 11 2
     SCN Circadian Oscillatory Protein2
Suprachiasmatic Nucleus Circadian Oscillatory Protein2 3     KIAA06063
SCOP2 3     hSCOP3
PH Domain-Containing Family E Member 12 3     Pleckstrin Homology Domain-Containing Family E Member 13

External Ids:    HGNC: 206101   Entrez Gene: 232392   Ensembl: ENSG000000819137   OMIM: 6093965   UniProtKB: O603463   

Export aliases for PHLPP1 gene to outside databases

Previous GC identifers: GC18P058535 GC18P057093


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PHLPP1 Gene:
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by
dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in
multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes
by interfering with Akt-mediated insulin signaling. (provided by RefSeq, Dec 2011)

GeneCards Summary for PHLPP1 Gene: 
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a protein-coding gene. Diseases associated with PHLPP1 include phlebotomus fever, and motion sickness, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include phospholipid binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PHLPP2.

UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346
Function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform
beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade
that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.
Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the
phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads
to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
May act as a negative regulator of K-Ras signaling in membrane rafts

Gene Wiki entry for PHLPP1 (PHLPP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.2  NT_025028.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PHLPP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PHLPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHLPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHLPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.33   Ensembl cytogenetic band:  18q21.33   HGNC cytogenetic band: 18q21.32

PHLPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLPP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P060382:  view genomic region     (about GC identifiers)

Start:
60,382,672 bp from pter      End:
60,647,666 bp from pter
Size:
264,995 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346 (See protein sequence)
Recommended Name: PH domain leucine-rich repeat-containing protein phosphatase 1  
Size: 1717 amino acids; 184672 Da
Cofactor: Binds 2 manganese ions per subunit (By similarity)
Subunit: Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity). Interacts
with AKT2, AKT3 and PRKCB isoform beta-II
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue,
expression is concentrated at the lateral membrane of epithelial cells
Sequence caution: Sequence=AAH14927.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH82244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI26278.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91980.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1A4F5 Q641Q7 Q6P4C4 Q6PJI6 Q86TN6 Q96FK2 Q9NUY1

Explore the universe of human proteins at neXtProt for PHLPP1: NX_O60346

Explore proteomics data for PHLPP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60346

  • 4/10 DME Specific Peptides for PHLPP1 (O60346) (see all 10)
     KAIITED  PPPSPGI  YNVRKGK  LHCERNQL 

    PHLPP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PHLPP1 Protein Expression
    REFSEQ proteins: NP_919431.2  
    ENSEMBL proteins: 
     ENSP00000262719   ENSP00000467279   ENSP00000383170  
    Reactome Protein details: O60346
    Human Recombinant Protein Products for PHLPP1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHLPP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    PHLPP1 for ontologies           About GeneDecksing



    PHLPP1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for PHLPP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    PPM: Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

    4 InterPro protein domains:
     IPR001932 PP2C-like
     IPR001611 Leu-rich_rpt
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O60346

    ProtoNet protein and cluster: O60346

    2 Blocks protein domains:
    IPB001611 Leucine-rich repeat signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346
    Domain: The PH domain is required for interaction with PRKCB and its dephosphorylation
    Similarity: Contains 21 LRR (leucine-rich) repeats
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 PP2C-like domain


    PHLPP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHLP1_HUMAN, O60346
    Function: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform
    beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade
    that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.
    Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the
    phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads
    to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
    May act as a negative regulator of K-Ras signaling in membrane rafts
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Enzyme regulation: Insensitive to okadaic acid

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding IPI19615732
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--
         
    PHLPP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Phlpp1):
     behavior/neurological  no phenotypic analysis 

    PHLPP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phlpp1tm1.1Saco for PHLPP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PHLPP1 
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    hsa-miR-511 hsa-miR-3622b-3p hsa-miR-4330 hsa-miR-2113 hsa-miR-4273 hsa-miR-190 hsa-miR-224 hsa-miR-3606
    SwitchGear 3'UTR luciferase reporter plasmidPHLPP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PHLPP1 About   (see all 9)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI3K/AKT Signaling in Cancer0.88
    Signaling by ERBB40.67
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5Fc epsilon receptor (FCERI) signaling
    Fc epsilon receptor (FCERI) signaling0.69
    Role of LAT2/NTAL/LAB on calcium mobilization0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/31        Reactome Pathways for PHLPP1 (see all 31)
        Signaling by EGFR in Cancer
    Negative regulation of the PI3K/AKT network
    Disease
    Signaling by ERBB2
    GAB1 signalosome


    1         Kegg Pathway  (Kegg details for PHLPP1):
        PI3K-Akt signaling pathway


    PHLPP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHLPP1

    5/26 Interacting proteins for PHLPP1 (O603462, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCRIBQ141602, 3MINT-8204981 I2D: score=3 
    CDH1P128302, 3MINT-8205015 I2D: score=1 
    AKT1P317493I2D: score=5 
    USP46P620683I2D: score=3 
    AKT2P317513I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0009649entrainment of circadian clock IEA--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    PHLPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHLPP1 (PHLP1)

    4 HMDB Compounds for PHLPP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Manganesemanganese 7439-96-5--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about PHLPP1 / PHLP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHLPP1 gene: 
    NM_194449.3  

    Unigene Cluster for PHLPP1:

    PH domain and leucine rich repeat protein phosphatase 1
    Hs.465337  [show with all ESTs]
    Unigene Representative Sequence: NM_194449
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262719 ENST00000497351 ENST00000588452 ENST00000487409 ENST00000588953
    ENST00000591386 ENST00000591106 ENST00000400316(uc021ule.1)
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    hsa-miR-511 hsa-miR-3622b-3p hsa-miR-4330 hsa-miR-2113 hsa-miR-4273 hsa-miR-190 hsa-miR-224 hsa-miR-3606
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    Additional mRNA sequence: 

    AB011178.2 AF130097.2 AK001924.1 BC010706.1 BC014927.2 BC047653.1 BC063519.1 BC082244.1 
    BC126277.1 

    10 DOTS entries:

    DT.115029  DT.100652846  DT.40294035  DT.75155785  DT.100652984  DT.95189671  DT.95195521  DT.95309269 
    DT.100752083  DT.101960639 

    24/143 AceView cDNA sequences (see all 143):

    AW518966 AI969611 BC010706 BU159555 BC014927 H63251 BM673462 AL079409 
    BU682436 BG056493 BQ213311 BF966064 BE501129 CB122648 AI860347 BX508333 
    AI702468 NM_194449 BM724138 BU192801 AB011178 AW958916 AA306570 AA364012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHLPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAATTTT
    PHLPP1 Expression
    About this image


    See PHLPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHLPP1

    SOURCE GeneReport for Unigene cluster: Hs.465337

    UniProtKB/Swiss-Prot: PHLP1_HUMAN, O60346
    Tissue specificity: In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic
    mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or
    significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous
    tissues

        SABiosciences Expression via Pathway-Focused PCR Array including PHLPP1: 
              Protein Phosphatases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLPP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PHLPP1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phlpp11 , 5 PH domain and leucine rich repeat protein phosphatase more1, 5 86.22(n)1
    89.99(a)1
      1 (49.76 cM)5
    984321  NM_133821.31  NP_598582.31 
     1061717525 
    chicken
    (Gallus gallus)
    Aves PHLPP11 PH domain and leucine rich repeat protein phosphatase more 81.05(n)
    90.01(a)
      420904  XM_418990.3  XP_418990.3 
    lizard
    (Anolis carolinensis)
    Reptilia PHLPP16
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343265.1(125236-221791)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX752400.12   -- 85.86(n)    BX752400.1 
    zebrafish
    (Danio rerio)
    Actinopterygii PHLPP16
    PH domain and leucine rich repeat protein phosphat...
    66(a)
    1 ↔ 1
    2(290248-301002)
    worm
    (Caenorhabditis elegans)
    Secernentea F43C1.16
    Protein phosphatase PHLPP-like protein
    24(a)
    1 → many
    III(4210562-4216706)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CYR1(YJL005W)4 Adenylate cyclase, required for cAMP production and more   --   10(425157-431237) 853452  NP_012529.1 


    ENSEMBL Gene Tree for PHLPP1 (if available)
    TreeFam Gene Tree for PHLPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHLPP1 gene
    PHLPP22  
    4 SIMAP similar genes for PHLPP1 using alignment to 2 protein entries:     PHLP1_HUMAN (see all proteins):
    PHLPPL    PHLPP2    LRRC1    FLII

    PHLPP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4800 SNPs in PHLPP1 are shown (see all 4800)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1868951121,2
    --60234813(+) TATCAC/TTCTTG 1 -- us2k10--------
    rs734650391,2
    C,F--60234925(+) TAAATG/TAAAAT 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1423381461,2
    --60234950(+) GGAATA/GTAAAA 1 -- us2k10--------
    rs1486910071,2
    C--60234969(+) AGAAA-/TATT  
            
    TATTT
    1 -- us2k10--------
    rs1905529121,2
    --60235096(+) CTTTAC/TTGAGG 1 -- us2k10--------
    rs713525871,2
    C,F--60235165(+) AATCCG/AGATTT 1 -- us2k15Minor allele frequency- A:0.09NA WA 244
    rs1828273751,2
    --60235276(+) CACCCC/TCACTA 1 -- us2k10--------
    rs749128411,2
    C,F--60235296(+) AAAAAA/GTGAGC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1466314401,2
    --60235361(+) ATCACC/TTGGGC 1 -- us2k10--------
    rs1878617851,2
    --60235368(+) GGGCCA/CGAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHLPP1 (60382672 - 60632672 bp, first 250kb of PHLPP1)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PHLPP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659096CNV Deletion23128226
    esv2665321CNV Deletion23128226
    esv2384564CNV Deletion18987734
    esv2717197CNV Deletion23290073
    esv267732CNV Insertion20981092
    nsv525821CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609396    OMIM disorders: --

    19 diseases for PHLPP1:    About MalaCards
    phlebotomus fever    motion sickness    obesity    prostate cancer, progression of
    narcolepsy    chronic lymphocytic leukemia    acute lymphoblastic leukemia    insulin resistance
    lymphoblastic leukemia    glioblastoma    prostate cancer    colon cancer
    leukemia    prostatitis    retinitis    colorectal cancer
    lung cancer    breast cancer    neuronitis


    PHLPP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PHLPP1
    Human Genome Epidemiology (HuGE) Navigator: PHLPP1 (3 documents)

    Export disorders for PHLPP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHLPP1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with PHLPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (PubMed id 15808505)1, 2, 3, 9 Gao T.... Newton A.C. (2005)
    2. The phosphatase PHLPP controls the cellular levels of protein kinase C. (PubMed id 18162466)1, 2, 9 Gao T....Newton A.C. (2008)
    3. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. (PubMed id 19079341)1, 2, 9 Liu J.... Gao T. (2009)
    4. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (PubMed id 17386267)1, 2, 9 Brognard J.... Newton A.C. (2007)
    5. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)1, 2 Nusbaum C.... Lander E.S. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    9. SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. (PubMed id 10570941)1, 3 Shimizu K....Nagai K. (1999)
    10. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23239 HGNC: 20610 AceView: PLEKHE1 Ensembl:ENSG00000081913 euGenes: HUgn23239
    ECgene: PHLPP1 Kegg: 23239 H-InvDB: PHLPP1

    (According to HUGE)
    About This Section
    HUGE: KIAA0606

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHLPP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PHLPP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHLPP1 gene:
    Search GeneIP for patents involving PHLPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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