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Aliases for PHLPP1 Gene

Aliases for PHLPP1 Gene

  • PH Domain And Leucine Rich Repeat Protein Phosphatase 1 2 3
  • SCOP 3 4 6
  • Pleckstrin Homology Domain Containing, Family E (With Leucine Rich Repeats) Member 1 2 3
  • Suprachiasmatic Nucleus Circadian Oscillatory Protein 3 4
  • PH Domain-Containing Family E Member 1 3 4
  • EC 3.1.3.16 4 64
  • KIAA0606 4 6
  • PLEKHE1 3 4
  • PHLPP 3 4
  • PH Domain Leucine-Rich Repeat-Containing Protein Phosphatase 1 3
  • Pleckstrin Homology Domain-Containing Family E Member 1 4
  • PH Domain And Leucine Rich Repeat Protein Phosphatase 2
  • SCN Circadian Oscillatory Protein 3
  • HSCOP 4

External Ids for PHLPP1 Gene

Previous Symbols for PHLPP1 Gene

  • PLEKHE1
  • PHLPP

Summaries for PHLPP1 Gene

Entrez Gene Summary for PHLPP1 Gene

  • This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

GeneCards Summary for PHLPP1 Gene

PHLPP1 (PH Domain And Leucine Rich Repeat Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with PHLPP1 include obesity. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include phospholipid binding and phosphoprotein phosphatase activity. An important paralog of this gene is PHLPP2.

UniProtKB/Swiss-Prot for PHLPP1 Gene

  • Protein phosphatase that mediates dephosphorylation of Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II and Ser-657 of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of Ser-473 of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

Gene Wiki entry for PHLPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLPP1 Gene

Genomics for PHLPP1 Gene

Genomic Location for PHLPP1 Gene

Start:
62,715,439 bp from pter
End:
62,980,443 bp from pter
Size:
265,005 bases
Orientation:
Plus strand

Genomic View for PHLPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLPP1 Gene

No data available for Regulatory Elements for PHLPP1 Gene

Proteins for PHLPP1 Gene

  • Protein details for PHLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60346-PHLP1_HUMAN
    Recommended name:
    PH domain leucine-rich repeat-containing protein phosphatase 1
    Protein Accession:
    O60346
    Secondary Accessions:
    • A1A4F5
    • Q641Q7
    • Q6P4C4
    • Q6PJI6
    • Q86TN6
    • Q96FK2
    • Q9NUY1

    Protein attributes for PHLPP1 Gene

    Size:
    1717 amino acids
    Molecular mass:
    184672 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
    Quaternary structure:
    • Interacts with the nucleotide free form of K-Ras (KRAS) via its LRR repeats (By similarity). Interacts with AKT2, AKT3 and PRKCB isoform beta-II.
    SequenceCaution:
    • Sequence=AAH14927.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH82244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI26278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for PHLPP1 Gene

Proteomics data for PHLPP1 Gene at MOPED

Post-translational modifications for PHLPP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys246 and Lys1146

Other Protein References for PHLPP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PHLPP1 Gene

Gene Families for PHLPP1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • PPM :Serine/threonine phosphatases / Protein phosphatases, Mg2+/Mn2+ dependent

Protein Domains for PHLPP1 Gene

UniProtKB/Swiss-Prot:

PHLP1_HUMAN
Domain:
  • The PH domain is required for interaction with PRKCB and its dephosphorylation:
    • O60346
  • Contains 1 PH domain.:
    • O60346
  • Contains 1 PPM-type phosphatase domain.:
    • O60346
Similarity:
  • Contains 21 LRR (leucine-rich) repeats.:
    • O60346
genes like me logo Genes that share domains with PHLPP1: view

Function for PHLPP1 Gene

Molecular function for PHLPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Insensitive to okadaic acid.
UniProtKB/Swiss-Prot Function: Protein phosphatase that mediates dephosphorylation of Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II and Ser-657 of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of Ser-473 of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

Enzyme Numbers (IUBMB) for PHLPP1 Gene

Gene Ontology (GO) - Molecular Function for PHLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 18162466
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHLPP1: view

Phenotypes for PHLPP1 Gene

genes like me logo Genes that share phenotypes with PHLPP1: view

Animal Models for PHLPP1 Gene

MGI Knock Outs for PHLPP1:

miRNA for PHLPP1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PHLPP1 Gene

Localization for PHLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHLPP1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated at the lateral membrane of epithelial cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHLPP1 Gene COMPARTMENTS Subcellular localization image for PHLPP1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PHLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PHLPP1: view

Pathways for PHLPP1 Gene

genes like me logo Genes that share pathways with PHLPP1: view

Pathways by source for PHLPP1 Gene

Gene Ontology (GO) - Biological Process for PHLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0009649 entrainment of circadian clock IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with PHLPP1: view

Compounds for PHLPP1 Gene

(4) HMDB Compounds for PHLPP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Manganese
  • manganese
7439-96-5
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with PHLPP1: view

Transcripts for PHLPP1 Gene

Unigene Clusters for PHLPP1 Gene

PH domain and leucine rich repeat protein phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHLPP1 Gene

No ASD Table

Relevant External Links for PHLPP1 Gene

GeneLoc Exon Structure for
PHLPP1
ECgene alternative splicing isoforms for
PHLPP1

Expression for PHLPP1 Gene

mRNA expression in normal human tissues for PHLPP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHLPP1 Gene

SOURCE GeneReport for Unigene cluster for PHLPP1 Gene Hs.465337

mRNA Expression by UniProt/SwissProt for PHLPP1 Gene

O60346-PHLP1_HUMAN
Tissue specificity: In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 78% of tested tumors (at protein level). Ubiquitously expressed in non-cancerous tissues.
genes like me logo Genes that share expressions with PHLPP1: view

Orthologs for PHLPP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PHLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHLPP1 36
  • 99.36 (n)
  • 99.24 (a)
PHLPP1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHLPP1 36
  • 84.89 (n)
  • 89.34 (a)
PHLPP1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHLPP1 36
  • 87.39 (n)
  • 90.11 (a)
PHLPP1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phlpp1 36
  • 86.09 (n)
  • 89.69 (a)
Phlpp1 16
Phlpp1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHLPP1 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHLPP1 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phlpp1 36
  • 85.78 (n)
  • 88.96 (a)
chicken
(Gallus gallus)
Aves PHLPP1 36
  • 81.26 (n)
  • 89.92 (a)
PHLPP1 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHLPP1 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497530 36
  • 72.77 (n)
  • 78.05 (a)
zebrafish
(Danio rerio)
Actinopterygii PHLPP1 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Phlpp 37
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F43C1.1 37
  • 25 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CYR1 37
  • 12 (a)
OneToMany
CYR1 39
Species with no ortholog for PHLPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHLPP1 Gene

ENSEMBL:
Gene Tree for PHLPP1 (if available)
TreeFam:
Gene Tree for PHLPP1 (if available)

Paralogs for PHLPP1 Gene

Paralogs for PHLPP1 Gene

Selected SIMAP similar genes for PHLPP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PHLPP1: view

Variants for PHLPP1 Gene

Sequence variations from dbSNP and Humsavar for PHLPP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs167381 -- 62,720,136(-) ATGTC(C/T)GATTT intron-variant
rs186268 -- 62,746,605(-) TACTC(C/T)TGTCT intron-variant
rs306211 -- 62,744,785(-) TTATA(A/C)TAGTA intron-variant
rs306212 -- 62,757,121(-) ATACA(A/G)TGTTG intron-variant
rs306226 -- 62,732,296(-) gtaaa(C/T)gagca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHLPP1 Gene

Variant ID Type Subtype PubMed ID
esv2717197 CNV Deletion 23290073
esv2384564 CNV Deletion 18987734
esv267732 CNV Insertion 20981092
esv2659096 CNV Deletion 23128226
nsv525821 CNV Loss 19592680
esv2665321 CNV Deletion 23128226

Relevant External Links for PHLPP1 Gene

HapMap Linkage Disequilibrium report
PHLPP1

Disorders for PHLPP1 Gene

(1) MalaCards Diseases for PHLPP1 Gene

Search for PHLPP1 Gene in MalaCards »

Relevant External Links for PHLPP1

Genetic Association Database (GAD)
PHLPP1
Human Genome Epidemiology (HuGE) Navigator
PHLPP1
genes like me logo Genes that share disorders with PHLPP1: view

No data available for UniProtKB/Swiss-Prot for PHLPP1 Gene

Publications for PHLPP1 Gene

  1. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. (PMID: 15808505) Gao T. … Newton A.C. (Mol. Cell 2005) 2 3 4 23
  2. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. (PMID: 17386267) Brognard J. … Newton A.C. (Mol. Cell 2007) 3 4 23
  3. The phosphatase PHLPP controls the cellular levels of protein kinase C. (PMID: 18162466) Gao T. … Newton A.C. (J. Biol. Chem. 2008) 3 4 23
  4. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. (PMID: 19079341) Liu J. … Gao T. (Oncogene 2009) 3 4 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PHLPP1 Gene

  • antibodies-online peptides for PHLPP1
  • antibodies-online antibodies for PHLPP1
  • antibodies-online kits for PHLPP1

Sources for PHLPP1 Gene

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