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PHLDB3 Gene

protein-coding   GIFtS: 39
GCID: GC19M043983

Pleckstrin Homology-Like Domain, Family B, Member 3

  Search for PHLDB3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pleckstrin Homology-Like Domain, Family B, Member 31 2
Pleckstrin Homology-Like Domain Family B Member 32

External Ids:    HGNC: 304991   Entrez Gene: 6535832   Ensembl: ENSG000001765317   UniProtKB: Q6NSJ23   

Export aliases for PHLDB3 gene to outside databases

Previous GC identifers: GC19M048694 GC19M048677 GC19M040410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PHLDB3 Gene:
PHLDB3 (pleckstrin homology-like domain, family B, member 3) is a protein-coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is PHLDB1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHLDB3 gene promoter:
         Sp1   Tal-1   GCNF   Tal-1beta   E47   Pax-3   GCNF-1   GCNF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHLDB3 promoter sequence
   Search Chromatin IP Primers for PHLDB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHLDB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

PHLDB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLDB3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043983:  view genomic region     (about GC identifiers)

Start:
43,979,106 bp from pter      End:
44,009,087 bp from pter
Size:
29,982 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PHLB3_HUMAN, Q6NSJ2 (See protein sequence)
Recommended Name: Pleckstrin homology-like domain family B member 3  
Size: 640 amino acids; 71912 Da
Sequence caution: Sequence=BAC05082.1; Type=Erroneous termination; Positions=169; Note=Translated as Glu;
Secondary accessions: Q8N7Z4
Alternative splicing: 2 isoforms:  Q6NSJ2-1   Q6NSJ2-2   

Explore the universe of human proteins at neXtProt for PHLDB3: NX_Q6NSJ2

Explore proteomics data for PHLDB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PHLDB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_942147.3  
    ENSEMBL proteins: 
     ENSP00000292140   ENSP00000473000   ENSP00000469372   ENSP00000471158   ENSP00000473248  
     ENSP00000470976  

    PHLDB3 Human Recombinant Protein Products:

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    Novus Biologicals PHLDB3 Antibody
    Search for Antibodies for PHLDB3 at Abcam
    Cloud-Clone Corp. Antibodies for PHLDB3
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    PHLDB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PHLDB3
    Cloud-Clone Corp. CLIAs for PHLDB3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q6NSJ2

    ProtoNet protein and cluster: Q6NSJ2

    UniProtKB/Swiss-Prot: PHLB3_HUMAN, Q6NSJ2
    Domain: The PH domain mediates the binding to phosphoinositides (By similarity)
    Similarity: Contains 1 PH domain


    PHLDB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for PHLDB3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHLDB3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHLDB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHLDB3:
    hsa-mir-331-3p (MIRT043498), hsa-mir-15b-5p (MIRT046427)

    Block miRNA regulation of human, mouse, rat PHLDB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHLDB3 (see all 10):
    hsa-miR-663 hsa-miR-513a-5p hsa-miR-324-3p hsa-miR-29c hsa-miR-29a hsa-miR-1908 hsa-miR-744 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidPHLDB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHLDB3
    Predesigned siRNA for gene silencing in human, mouse, rat PHLDB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHLDB3

    Clone
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    OriGene clones in human, mouse for PHLDB3 (see all 8)
    OriGene ORF clones in mouse, rat for PHLDB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHLDB3 (NM_198850)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHLDB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDB3

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHLDB3
    Interactions:

        Search GeneGlobe Interaction Network for PHLDB3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHLDB3 (PHLB3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHLDB3 gene: 
    NM_198850.3  

    Unigene Cluster for PHLDB3:

    Pleckstrin homology-like domain, family B, member 3
    Hs.631581  [show with all ESTs]
    Unigene Representative Sequence: NM_198850
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595498 ENST00000292140(uc010eit.3 uc002own.4 uc002owo.3)
    ENST00000600660 ENST00000598849 ENST00000596141 ENST00000599242 ENST00000596902
    ENST00000594808 ENST00000601646
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHLDB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHLDB3 (see all 10):
    hsa-miR-663 hsa-miR-513a-5p hsa-miR-324-3p hsa-miR-29c hsa-miR-29a hsa-miR-1908 hsa-miR-744 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmidPHLDB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHLDB3
    Predesigned siRNA for gene silencing in human, mouse, rat PHLDB3
    Clone
    Products:
         
    OriGene clones in human, mouse for PHLDB3 (see all 8)
    OriGene ORF clones in mouse, rat for PHLDB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHLDB3 (NM_198850)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHLDB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDB3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PHLDB3
    OriGene qSTAR qPCR primer pairs in human, mouse for PHLDB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat PHLDB3
      QuantiTect SYBR Green Assays in human, mouse, rat PHLDB3
      QuantiFast Probe-based Assays in human, mouse, rat PHLDB3

    Additional mRNA sequence: 

    AK097512.1 BC007947.2 BC029299.1 BC070094.1 BC157852.1 BC171853.1 

    7 DOTS entries:

    DT.441786  DT.92028370  DT.75189764  DT.70104807  DT.121500814  DT.75142990  DT.99998416 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PHLDB3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                          -                           
    SP2:                                                                          -     -                     
    SP3:                                                                          -     -                     
    SP4:        -                                                                                             
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for PHLDB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHLDB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCATTTGGA
    PHLDB3 Expression
    About this image

    PHLDB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHLDB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631581
        Custom PCR Arrays for PHLDB3
    Primer
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    OriGene qPCR primer pairs and template standards for PHLDB3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PHLDB3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phldb31 , 5 pleckstrin homology-like domain, family B, member 31, 5 80.97(n)1
    80.13(a)1
      7 (11.80 cM)5
    2329701  NM_001102613.11  NP_001096083.11 
     246113285 
    lizard
    (Anolis carolinensis)
    Reptilia PHLDB36
    pleckstrin homology-like domain, family B, member ...
    40(a)
    1 ↔ 1
    LGf(1027776-1073014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia phldb31 pleckstrin homology-like domain, family B, member 3 55.53(n)
    47.05(a)
      100491291  XM_002939142.2  XP_002939188.2 
    zebrafish
    (Danio rerio)
    Actinopterygii PHLDB36
    pleckstrin homology-like domain, family B, member ...
    47(a)
    1 ↔ 1
    16(58344912-58350917) ENSDARG00000091016
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50046
    --
    10(a)
    1 → many
    X(17001626-17030021)


    ENSEMBL Gene Tree for PHLDB3 (if available)
    TreeFam Gene Tree for PHLDB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHLDB3 gene
    PHLDB12  PHLDB22  
    5 SIMAP similar genes for PHLDB3 using alignment to 7 protein entries:     PHLB3_HUMAN (see all proteins):
    DKFZp434G227    DKFZp313N0632    PHLDB1    KIAA0638    PHLDB2

    PHLDB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHLDB3 (see all 767)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809068921,2
    --43978774(+) GCTGAC/TTAAGG 1 -- ds50010--------
    rs1145735261,2
    --43978787(+) AGGAGC/GGGGGC 1 -- ds50010--------
    rs104156831,2
    C,F--43978798(+) caggcG/Atggtg 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1509031981,2
    C--43978870(+) AGTTGA/GAGACC 1 -- ds50010--------
    rs1862349051,2
    --43978939(+) AGGGAA/GGAAAA 1 -- ds50010--------
    rs72538561,2
    C,F,H--43979015(+) AGCAGC/TCGGTC 1 -- ds500124Minor allele frequency- T:0.15NS EA NA WA CSA 2487
    rs735507031,2
    C,F--43979161(+) GGCTGT/AGGGAC 1 -- ds50012Minor allele frequency- A:0.09WA 120
    rs1397792721,2
    --43979248(+) CCACAA/GCAGCA 1 -- ds50010--------
    rs116721191,2
    C,F,H--43979348(+) GGCAGG/AGCCTT 1 -- ut313Minor allele frequency- A:0.08NA EA 242
    rs1914757801,2
    --43979376(+) TCGGGA/GGCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHLDB3 (43979106 - 44009087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PHLDB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668877CNV Deletion23128226
    nsv2502CNV Insertion18451855
    nsv509744CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHLDB3
    DNA2.0 Custom Variant and Variant Library Synthesis for PHLDB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHLDB3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PHLDB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    5. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    9. Purification of CpG islands using a methylated DNA binding column. (PubMed id 8012384)1 Cross S.H.... Bird A.P. (Nat. Genet. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 653583 HGNC: 30499 Ensembl:ENSG00000176531 euGenes: HUgn653583 ECgene: PHLDB3
    H-InvDB: PHLDB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PHLDB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PHLDB3 gene:
    Search GeneIP for patents involving PHLDB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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