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Aliases for PHLDB3 Gene

Aliases for PHLDB3 Gene

  • Pleckstrin Homology Like Domain Family B Member 3 2 3
  • Pleckstrin Homology-Like Domain, Family B, Member 3 2 5

External Ids for PHLDB3 Gene

Previous GeneCards Identifiers for PHLDB3 Gene

  • GC19M048694
  • GC19M048677
  • GC19M043983
  • GC19M040410

Summaries for PHLDB3 Gene

GeneCards Summary for PHLDB3 Gene

PHLDB3 (Pleckstrin Homology Like Domain Family B Member 3) is a Protein Coding gene. GO annotations related to this gene include enzyme binding. An important paralog of this gene is PHLDB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDB3 Gene

Genomics for PHLDB3 Gene

Regulatory Elements for PHLDB3 Gene

Enhancers for PHLDB3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PHLDB3 on UCSC Golden Path with GeneCards custom track

Promoters for PHLDB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHLDB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHLDB3 Gene

43,474,341 bp from pter
43,504,935 bp from pter
30,595 bases
Minus strand

Genomic View for PHLDB3 Gene

Genes around PHLDB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHLDB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHLDB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDB3 Gene

Proteins for PHLDB3 Gene

  • Protein details for PHLDB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pleckstrin homology-like domain family B member 3
    Protein Accession:
    Secondary Accessions:
    • Q8N7Z4

    Protein attributes for PHLDB3 Gene

    640 amino acids
    Molecular mass:
    71912 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05082.1; Type=Erroneous termination; Positions=169; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHLDB3 Gene


neXtProt entry for PHLDB3 Gene

Proteomics data for PHLDB3 Gene at MOPED

Post-translational modifications for PHLDB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHLDB3 Gene

No data available for DME Specific Peptides for PHLDB3 Gene

Domains & Families for PHLDB3 Gene

Gene Families for PHLDB3 Gene

Protein Domains for PHLDB3 Gene


Suggested Antigen Peptide Sequences for PHLDB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • The PH domain mediates the binding to phosphoinositides.
  • The PH domain mediates the binding to phosphoinositides.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PHLDB3: view

Function for PHLDB3 Gene

genes like me logo Genes that share phenotypes with PHLDB3: view

Animal Model Products

CRISPR Products

miRNA for PHLDB3 Gene

miRTarBase miRNAs that target PHLDB3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHLDB3 Gene

Localization for PHLDB3 Gene

Subcellular locations from

Jensen Localization Image for PHLDB3 Gene COMPARTMENTS Subcellular localization image for PHLDB3 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PHLDB3 Gene

Pathways & Interactions for PHLDB3 Gene

SuperPathways for PHLDB3 Gene

No Data Available

Interacting Proteins for PHLDB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000292140 for PHLDB3 Gene via STRING

Gene Ontology (GO) - Biological Process for PHLDB3 Gene


No data available for Pathways by source and SIGNOR curated interactions for PHLDB3 Gene

Drugs & Compounds for PHLDB3 Gene

No Compound Related Data Available

Transcripts for PHLDB3 Gene

mRNA/cDNA for PHLDB3 Gene

(5) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PHLDB3 Gene

Pleckstrin homology-like domain, family B, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDB3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for PHLDB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHLDB3 Gene

mRNA expression in normal human tissues for PHLDB3 Gene

mRNA differential expression in normal tissues according to GTEx for PHLDB3 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.7), Skin - Sun Exposed (Lower leg) (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for PHLDB3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.0), Testis (22.6), and Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PHLDB3 Gene

SOURCE GeneReport for Unigene cluster for PHLDB3 Gene Hs.631581

genes like me logo Genes that share expression patterns with PHLDB3: view

Protein tissue co-expression partners for PHLDB3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PHLDB3 Gene

Orthologs for PHLDB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHLDB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PHLDB3 35
  • 84.92 (n)
  • 84.49 (a)
  • 82 (a)
(Canis familiaris)
Mammalia PHLDB3 35
  • 84.72 (n)
  • 82.94 (a)
  • 80 (a)
(Mus musculus)
Mammalia Phldb3 35
  • 80.97 (n)
  • 80.13 (a)
Phldb3 16
Phldb3 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Phldb3 35
  • 80.1 (n)
  • 78.74 (a)
(Monodelphis domestica)
Mammalia PHLDB3 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 2 (a)
(Pan troglodytes)
Mammalia PHLDB3 36
  • 96 (a)
(Anolis carolinensis)
Reptilia PHLDB3 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia phldb3 35
  • 55.53 (n)
  • 47.05 (a)
(Danio rerio)
Actinopterygii PHLDB3 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5004 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5769 36
  • 24 (a)
Species with no ortholog for PHLDB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDB3 Gene

Gene Tree for PHLDB3 (if available)
Gene Tree for PHLDB3 (if available)

Paralogs for PHLDB3 Gene

Paralogs for PHLDB3 Gene

genes like me logo Genes that share paralogs with PHLDB3: view

Variants for PHLDB3 Gene

Sequence variations from dbSNP and Humsavar for PHLDB3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11083711 - 43,497,227(+) GTTGC(C/T)GGAAC nc-transcript-variant, reference, missense
rs7257767 -- 43,497,193(+) CGATC(C/T)TCCTC nc-transcript-variant, reference, synonymous-codon
rs12977999 -- 43,495,009(+) tgagg(A/T)ggggc intron-variant
rs12978269 -- 43,500,267(+) GATCT(C/T)ATTAG intron-variant
rs12980205 -- 43,504,218(+) GAGAC(C/T)CCCCC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PHLDB3 Gene

Variant ID Type Subtype PubMed ID
nsv509744 CNV Insertion 20534489
nsv2502 CNV Insertion 18451855
esv2668877 CNV Deletion 23128226

Variation tolerance for PHLDB3 Gene

Residual Variation Intolerance Score: 92.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PHLDB3 Gene

Disorders for PHLDB3 Gene

Relevant External Links for PHLDB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PHLDB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHLDB3 Gene

Publications for PHLDB3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PMID: 23382074) Armour S.M. … Sinclair D.A. (Mol. Cell. Biol. 2013) 3

Products for PHLDB3 Gene

Sources for PHLDB3 Gene