PHLDB3 Gene
protein-coding GIFtS: 40
GCID: GC19M043983
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pleckstrin homology-like domain, family B, member 3
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Aliases
for PHLDB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pleckstrin Homology-Like Domain, Family B, Member 31 2 | | FLJ401931 | | Pleckstrin Homology-Like Domain Family B Member 32 |
Export aliases for PHLDB3 gene to outside databasesPrevious GC identifers: GC19M048694 GC19M048677 GC19M040410 |
Summaries
for PHLDB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PHLDB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PHLDB3 gene promoter:
Sp1 Tal-1 GCNF Tal-1beta E47 Pax-3 GCNF-1 GCNF-2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PHLDB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHLDB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.31PHLDB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M043983: view genomic region
(about GC identifiers)
Start:
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43,979,255 bp from pter |
End:
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44,009,087 bp from pter |
Size:
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29,833 bases |
Orientation:
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minus strand |
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Proteins
for PHLDB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PHLB3_HUMAN, Q6NSJ2 (See
protein sequence)Recommended Name: Pleckstrin homology-like domain family B member 3 Size: 640 amino acids; 71912 Da
Sequence caution: Sequence=BAC05082.1; Type=Erroneous termination; Positions=169; Note=Translated as Glu;
Secondary accessions: Q8N7Z4Alternative splicing: 2 isoforms: Q6NSJ2-1 Q6NSJ2-2 Explore the universe of human proteins at neXtProt for PHLDB3: NX_Q6NSJ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NSJ2
PHLDB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_942147.3
ENSEMBL proteins: ENSP00000292140
Human Recombinant Protein Products:
PHLDB3 Antibody Products:
Assay Products for PHLDB3: |
Protein
Domains /
Families
for PHLDB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PHLDB3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6NSJ2ProtoNet protein and cluster: Q6NSJ2 UniProtKB/Swiss-Prot: PHLB3_HUMAN, Q6NSJ2Domain: The PH domain mediates the binding to phosphoinositides (By similarity)Similarity: Contains 1 PH domain |
Function
for PHLDB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHLDB3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHLDB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PHLDB3 (NM_198850) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PHLDB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDB3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005543 | phospholipid binding |
IEA | -- |
PHLDB3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PHLDB3:
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Pathways & Interactions
for PHLDB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHLDB3
|
Drugs & Compounds
for PHLDB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PHLDB3
Search CenterWatch for drugs/clinical trials and news about PHLDB3 / PHLB3
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Transcripts
for PHLDB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PHLDB3 gene: NM_198850.3 Unigene Cluster for PHLDB3: Pleckstrin homology-like domain, family B, member 3 Hs.631581 [show with all ESTs]Unigene Representative Sequence: NM_1988501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000292140(uc010eit.3 uc002own.4 uc002owo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHLDB3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHLDB3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PHLDB3 (NM_198850) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PHLDB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDB3 |
Additional cDNA sequence: AK097512.1 BC007947.2 BC029299.1 BC070094.1 BC157852.1 BC171853.1 7 DOTS entries: DT.441786 DT.92028370 DT.75189764 DT.70104807 DT.121500814 DT.75142990 DT.99998416
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PHLDB3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PHLDB3
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Expression
for PHLDB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PHLDB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCATTTGGA
About this image
See PHLDB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PHLDB3
SOURCE GeneReport for Unigene cluster: Hs.631581
SABiosciences Custom PCR Arrays for PHLDB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHLDB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PHLDB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHLDB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHLDB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDB3 |
Orthologs
for PHLDB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PHLDB3 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for PHLDB3 (if available)
TreeFam Gene Tree for PHLDB3 (if available) |
Paralogs
for PHLDB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PHLDB3 gene
- PHLDB12 PHLDB22
5 SIMAP similar genes for PHLDB3 using alignment to 7 protein entries: PHLB3_HUMAN (see all proteins):DKFZp434G227 DKFZp313N0632 PHLDB1 KIAA0638 PHLDB2
PHLDB3 for paralogs About GeneDecksing
|
Genomic Variants
for PHLDB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PHLDB3 (43979255 - 44009087 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PHLDB3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHLDB3 |
|
Disorders
/ Diseases
for PHLDB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PHLDB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PHLDB3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with PHLDB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Purification of CpG islands using a methylated DNA binding column. (PubMed id 8012384)1 Cross S.H.... Bird A.P. (1994)
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External Searches for PHLDB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing PHLDB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PHLDB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PHLDB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PHLDB3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for PHLDB3 gene:
Search GeneIP for patents involving PHLDB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PHLDB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PHLDB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHLDB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHLDB3 | | | OriGene Protein Over-expression Lysate for PHLDB3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PHLDB3 | | OriGene 3'-UTR Clone for PHLDB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHLDB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHLDB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PHLDB3 | | OriGene Custom Protein Services for PHLDB3 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PHLDB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHLDB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHLDB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHLDB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHLDB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHLDB3 |
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 |  |  |  | |
| | | | Search Tocris compounds for PHLDB3 |
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 | | | PHLDB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDB3 |
|  |  |  | | | | ThermoFisher Antibody for PHLDB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDB3 |
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