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Aliases for PHLDB3 Gene

Aliases for PHLDB3 Gene

  • Pleckstrin Homology-Like Domain, Family B, Member 3 2 3

External Ids for PHLDB3 Gene

Previous GeneCards Identifiers for PHLDB3 Gene

  • GC19M048694
  • GC19M048677
  • GC19M043983
  • GC19M040410

Summaries for PHLDB3 Gene

GeneCards Summary for PHLDB3 Gene

PHLDB3 (Pleckstrin Homology-Like Domain, Family B, Member 3) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is PHLDB2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDB3 Gene

Genomics for PHLDB3 Gene

Regulatory Elements for PHLDB3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHLDB3 Gene

Start:
43,474,954 bp from pter
End:
43,504,935 bp from pter
Size:
29,982 bases
Orientation:
Minus strand

Genomic View for PHLDB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHLDB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDB3 Gene

Proteins for PHLDB3 Gene

  • Protein details for PHLDB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NSJ2-PHLB3_HUMAN
    Recommended name:
    Pleckstrin homology-like domain family B member 3
    Protein Accession:
    Q6NSJ2
    Secondary Accessions:
    • Q8N7Z4

    Protein attributes for PHLDB3 Gene

    Size:
    640 amino acids
    Molecular mass:
    71912 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05082.1; Type=Erroneous termination; Positions=169; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHLDB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHLDB3 Gene

Proteomics data for PHLDB3 Gene at MOPED

Post-translational modifications for PHLDB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHLDB3 Gene

No data available for DME Specific Peptides for PHLDB3 Gene

Domains for PHLDB3 Gene

Gene Families for PHLDB3 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for PHLDB3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PHLDB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NSJ2

UniProtKB/Swiss-Prot:

PHLB3_HUMAN :
  • Q6NSJ2
Domain:
  • The PH domain mediates the binding to phosphoinositides.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PHLDB3: view

Function for PHLDB3 Gene

Gene Ontology (GO) - Molecular Function for PHLDB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with PHLDB3: view

Phenotypes for PHLDB3 Gene

GenomeRNAi human phenotypes for PHLDB3:
genes like me logo Genes that share phenotypes with PHLDB3: view

Animal Model Products

CRISPR Products

miRNA for PHLDB3 Gene

miRTarBase miRNAs that target PHLDB3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHLDB3 Gene

Localization for PHLDB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHLDB3 Gene COMPARTMENTS Subcellular localization image for PHLDB3 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PHLDB3 Gene

Pathways for PHLDB3 Gene

SuperPathways for PHLDB3 Gene

No Data Available

Interacting Proteins for PHLDB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000292140%0d%0a9606.ENSP00000212015%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000292140 for PHLDB3 Gene via STRING

Gene Ontology (GO) - Biological Process for PHLDB3 Gene

None

No data available for Pathways by source for PHLDB3 Gene

Transcripts for PHLDB3 Gene

mRNA/cDNA for PHLDB3 Gene

(6) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PHLDB3 Gene

Pleckstrin homology-like domain, family B, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHLDB3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDB3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for PHLDB3 Gene

GeneLoc Exon Structure for
PHLDB3
ECgene alternative splicing isoforms for
PHLDB3

Expression for PHLDB3 Gene

mRNA expression in normal human tissues for PHLDB3 Gene

mRNA differential expression in normal tissues according to GTEx for PHLDB3 Gene

This gene is overexpressed in Esophagus - Mucosa (4.7), Skin - Sun Exposed (Lower leg) (4.4), and Skin - Not Sun Exposed (Suprapubic) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PHLDB3 Gene

SOURCE GeneReport for Unigene cluster for PHLDB3 Gene Hs.631581

genes like me logo Genes that share expressions with PHLDB3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PHLDB3 Gene

Orthologs for PHLDB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHLDB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHLDB3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHLDB3 35
  • 84.92 (n)
  • 84.49 (a)
PHLDB3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHLDB3 35
  • 84.72 (n)
  • 82.94 (a)
PHLDB3 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phldb3 35
  • 80.97 (n)
  • 80.13 (a)
Phldb3 16
Phldb3 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHLDB3 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 2 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Phldb3 35
  • 80.1 (n)
  • 78.74 (a)
lizard
(Anolis carolinensis)
Reptilia PHLDB3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phldb3 35
  • 55.53 (n)
  • 47.05 (a)
zebrafish
(Danio rerio)
Actinopterygii PHLDB3 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5004 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5769 36
  • 24 (a)
OneToMany
Species with no ortholog for PHLDB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDB3 Gene

ENSEMBL:
Gene Tree for PHLDB3 (if available)
TreeFam:
Gene Tree for PHLDB3 (if available)

Paralogs for PHLDB3 Gene

Paralogs for PHLDB3 Gene

Selected SIMAP similar genes for PHLDB3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PHLDB3: view

Variants for PHLDB3 Gene

Sequence variations from dbSNP and Humsavar for PHLDB3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1055099 -- 43,475,437(+) GCGGC(G/T)GTCAC synonymous-codon, reference
rs1125030 -- 43,495,482(-) ACCTG(G/T)CACCT intron-variant
rs1125031 -- 43,495,280(-) TTCTC(A/C/T)GAGCC synonymous-codon, reference, nc-transcript-variant
rs1133929 -- 43,479,588(-) GCCCC(A/G)CCCAC reference, synonymous-codon, intron-variant, nc-transcript-variant
rs2305374 -- 43,479,562(+) TTCGC(A/G/T)GGCCT missense, reference, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PHLDB3 Gene

Variant ID Type Subtype PubMed ID
nsv509744 CNV Insertion 20534489
nsv2502 CNV Insertion 18451855
esv2668877 CNV Deletion 23128226

Relevant External Links for PHLDB3 Gene

HapMap Linkage Disequilibrium report
PHLDB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHLDB3 Gene

Disorders for PHLDB3 Gene

No disorders were found for PHLDB3 Gene.

No data available for UniProtKB/Swiss-Prot for PHLDB3 Gene

Publications for PHLDB3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Viral immune modulators perturb the human molecular network by common and unique strategies. (PMID: 22810585) Pichlmair A. … Superti-Furga G. (Nature 2012) 3
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PMID: 23382074) Armour S.M. … Sinclair D.A. (Mol. Cell. Biol. 2013) 3

Products for PHLDB3 Gene

Sources for PHLDB3 Gene

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