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Aliases for PHLDB2 Gene

Aliases for PHLDB2 Gene

  • Pleckstrin Homology Like Domain Family B Member 2 2 3
  • Pleckstrin Homology-Like Domain, Family B, Member 2 2 3 5
  • Protein LL5-Beta 3 4
  • LL5b 3 4
  • LL5 Beta 3
  • LL5beta 3

External Ids for PHLDB2 Gene

Previous GeneCards Identifiers for PHLDB2 Gene

  • GC03P112923
  • GC03P113061
  • GC03P113085
  • GC03P111451
  • GC03P108826

Summaries for PHLDB2 Gene

GeneCards Summary for PHLDB2 Gene

PHLDB2 (Pleckstrin Homology Like Domain Family B Member 2) is a Protein Coding gene. Among its related pathways are Regulation of Microtubule Cytoskeleton. An important paralog of this gene is PHLDB3.

UniProtKB/Swiss-Prot for PHLDB2 Gene

  • Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).

Gene Wiki entry for PHLDB2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDB2 Gene

Genomics for PHLDB2 Gene

Regulatory Elements for PHLDB2 Gene

Enhancers for PHLDB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PHLDB2 on UCSC Golden Path with GeneCards custom track

Promoters for PHLDB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHLDB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHLDB2 Gene

Chromosome:
3
Start:
111,732,480 bp from pter
End:
111,976,517 bp from pter
Size:
244,038 bases
Orientation:
Plus strand

Genomic View for PHLDB2 Gene

Genes around PHLDB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHLDB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHLDB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDB2 Gene

Proteins for PHLDB2 Gene

  • Protein details for PHLDB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SQ0-PHLB2_HUMAN
    Recommended name:
    Pleckstrin homology-like domain family B member 2
    Protein Accession:
    Q86SQ0
    Secondary Accessions:
    • A5PKZ3
    • Q59EA8
    • Q68CY3
    • Q6NT98
    • Q8N8U8
    • Q8NAB1
    • Q8NCU5

    Protein attributes for PHLDB2 Gene

    Size:
    1253 amino acids
    Molecular mass:
    142158 Da
    Quaternary structure:
    • Interacts with FLNC.
    SequenceCaution:
    • Sequence=AAH69194.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAD93140.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PHLDB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHLDB2 Gene

Proteomics data for PHLDB2 Gene at MOPED

Post-translational modifications for PHLDB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PHLDB2 Gene

Domains & Families for PHLDB2 Gene

Gene Families for PHLDB2 Gene

Protein Domains for PHLDB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PHLDB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86SQ0

UniProtKB/Swiss-Prot:

PHLB2_HUMAN :
  • The PH domain mediates the binding to phosphoinositides.
Domain:
  • The PH domain mediates the binding to phosphoinositides.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PHLDB2: view

Function for PHLDB2 Gene

Molecular function for PHLDB2 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).
genes like me logo Genes that share phenotypes with PHLDB2: view

Animal Model Products

miRNA for PHLDB2 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHLDB2 Gene

Localization for PHLDB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHLDB2 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHLDB2 Gene COMPARTMENTS Subcellular localization image for PHLDB2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PHLDB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 colocalizes_with focal adhesion IDA 24859005
GO:0031252 cell leading edge IDA 24859005
GO:0045180 basal cortex IDA 23940118
genes like me logo Genes that share ontologies with PHLDB2: view

Pathways & Interactions for PHLDB2 Gene

genes like me logo Genes that share pathways with PHLDB2: view

Pathways by source for PHLDB2 Gene

1 BioSystems pathway for PHLDB2 Gene

Gene Ontology (GO) - Biological Process for PHLDB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IMP 24859005
GO:0070507 regulation of microtubule cytoskeleton organization IGI 23940118
GO:1903690 negative regulation of wound healing, spreading of epidermal cells IMP 24859005
genes like me logo Genes that share ontologies with PHLDB2: view

No data available for SIGNOR curated interactions for PHLDB2 Gene

Drugs & Compounds for PHLDB2 Gene

No Compound Related Data Available

Transcripts for PHLDB2 Gene

Unigene Clusters for PHLDB2 Gene

Pleckstrin homology-like domain, family B, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDB2 Gene

No ASD Table

Relevant External Links for PHLDB2 Gene

GeneLoc Exon Structure for
PHLDB2
ECgene alternative splicing isoforms for
PHLDB2

Expression for PHLDB2 Gene

mRNA expression in normal human tissues for PHLDB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHLDB2 Gene

This gene is overexpressed in Synovial fluid (23.5) and Placenta (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHLDB2 Gene



SOURCE GeneReport for Unigene cluster for PHLDB2 Gene Hs.603252

genes like me logo Genes that share expression patterns with PHLDB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PHLDB2 Gene

Orthologs for PHLDB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHLDB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PHLDB2 35
  • 89.65 (n)
  • 90.66 (a)
PHLDB2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHLDB2 35
  • 82.26 (n)
  • 82.86 (a)
PHLDB2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phldb2 35
  • 85.76 (n)
  • 87.34 (a)
Phldb2 16
Phldb2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PHLDB2 35
  • 99.5 (n)
  • 99.42 (a)
PHLDB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phldb2 35
  • 82.93 (n)
  • 84.73 (a)
oppossum
(Monodelphis domestica)
Mammalia PHLDB2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHLDB2 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHLDB2 35
  • 73.79 (n)
  • 75.98 (a)
PHLDB2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHLDB2 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC570807 35
  • 58.18 (n)
  • 57.46 (a)
wufc31d06 35
PHLDB2 (1 of 2) 36
  • 43 (a)
OneToMany
PHLDB2 (2 of 2) 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5004 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5769 36
  • 34 (a)
OneToMany
Species with no ortholog for PHLDB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDB2 Gene

ENSEMBL:
Gene Tree for PHLDB2 (if available)
TreeFam:
Gene Tree for PHLDB2 (if available)

Paralogs for PHLDB2 Gene

Paralogs for PHLDB2 Gene

genes like me logo Genes that share paralogs with PHLDB2: view

Variants for PHLDB2 Gene

Sequence variations from dbSNP and Humsavar for PHLDB2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3749298 - 111,953,978(+) TCCCT(C/T)CCTCA reference, missense
rs13077 -- 111,974,707(+) ACAAG(C/T)TATTT utr-variant-3-prime
rs712507 -- 111,936,542(+) GATTA(C/T)GTCAG intron-variant
rs712508 -- 111,938,981(+) TTTTG(G/T)ATTTT intron-variant
rs712509 -- 111,939,443(-) GACAC(A/C/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHLDB2 Gene

Variant ID Type Subtype PubMed ID
nsv460821 CNV Gain 19166990
nsv3947 CNV Insertion 18451855
nsv829676 CNV Gain 17160897
esv2635192 CNV Insertion 19546169
esv2668352 CNV Deletion 23128226
esv2725775 CNV Deletion 23290073
esv2725776 CNV Deletion 23290073
esv2725777 CNV Deletion 23290073
esv1055295 CNV Deletion 17803354
esv1320651 CNV Insertion 17803354

Variation tolerance for PHLDB2 Gene

Residual Variation Intolerance Score: 15% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PHLDB2 Gene

Disorders for PHLDB2 Gene

Relevant External Links for PHLDB2

Genetic Association Database (GAD)
PHLDB2
Human Genome Epidemiology (HuGE) Navigator
PHLDB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHLDB2

No disorders were found for PHLDB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHLDB2 Gene

Publications for PHLDB2 Gene

  1. LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin. (PMID: 12376540) Paranavitane V. … Stephens L. (J. Biol. Chem. 2003) 2 3 4 67
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for PHLDB2 Gene

Sources for PHLDB2 Gene

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