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Aliases for PHLDB1 Gene

Aliases for PHLDB1 Gene

  • Pleckstrin Homology Like Domain Family B Member 1 2 3
  • Pleckstrin Homology-Like Domain, Family B, Member 1 2 3 5
  • Protein LL5-Alpha 3 4
  • LL5A 3 4
  • Pleckstrin Homology-Like Domain Family B Member 1 Variant 3 3
  • Pleckstrin Homology-Like Domain Family B Member 1 Variant 4 3
  • LL5alpha 3
  • KIAA0638 4

External Ids for PHLDB1 Gene

Previous GeneCards Identifiers for PHLDB1 Gene

  • GC11P118014
  • GC11P117982
  • GC11P118478
  • GC11P114414

Summaries for PHLDB1 Gene

GeneCards Summary for PHLDB1 Gene

PHLDB1 (Pleckstrin Homology Like Domain Family B Member 1) is a Protein Coding gene. An important paralog of this gene is PHLDB2.

Gene Wiki entry for PHLDB1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDB1 Gene

Genomics for PHLDB1 Gene

Regulatory Elements for PHLDB1 Gene

Promoters for PHLDB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHLDB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHLDB1 Gene

Chromosome:
11
Start:
118,606,439 bp from pter
End:
118,658,038 bp from pter
Size:
51,600 bases
Orientation:
Plus strand

Genomic View for PHLDB1 Gene

Genes around PHLDB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHLDB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHLDB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDB1 Gene

Proteins for PHLDB1 Gene

  • Protein details for PHLDB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UU1-PHLB1_HUMAN
    Recommended name:
    Pleckstrin homology-like domain family B member 1
    Protein Accession:
    Q86UU1
    Secondary Accessions:
    • B0YJ63
    • B0YJ64
    • O75133
    • Q4KMF8
    • Q8TEQ2

    Protein attributes for PHLDB1 Gene

    Size:
    1377 amino acids
    Molecular mass:
    151162 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31613.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84896.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHLDB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHLDB1 Gene

Proteomics data for PHLDB1 Gene at MOPED

Post-translational modifications for PHLDB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PHLDB1 Gene

Domains & Families for PHLDB1 Gene

Gene Families for PHLDB1 Gene

Protein Domains for PHLDB1 Gene

Suggested Antigen Peptide Sequences for PHLDB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UU1

UniProtKB/Swiss-Prot:

PHLB1_HUMAN :
  • The PH domain mediates the binding to phosphoinositides.
Domain:
  • The PH domain mediates the binding to phosphoinositides.
  • Contains 1 FHA domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PHLDB1: view

Function for PHLDB1 Gene

genes like me logo Genes that share phenotypes with PHLDB1: view

Animal Model Products

miRNA for PHLDB1 Gene

miRTarBase miRNAs that target PHLDB1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHLDB1 Gene

Localization for PHLDB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHLDB1 Gene COMPARTMENTS Subcellular localization image for PHLDB1 gene
Compartment Confidence
nucleus 4
cytosol 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PHLDB1 Gene

Pathways & Interactions for PHLDB1 Gene

SuperPathways for PHLDB1 Gene

No Data Available

Interacting Proteins for PHLDB1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354498%0d%0a9606.ENSP00000380921%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000358081%0d%0a
Selected Interacting proteins: Q86UU1-PHLB1_HUMAN ENSP00000354498 for PHLDB1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PHLDB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010470 regulation of gastrulation IMP 23940118
GO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP 23940118
genes like me logo Genes that share ontologies with PHLDB1: view

No data available for Pathways by source and SIGNOR curated interactions for PHLDB1 Gene

Drugs & Compounds for PHLDB1 Gene

No Compound Related Data Available

Transcripts for PHLDB1 Gene

Unigene Clusters for PHLDB1 Gene

Pleckstrin homology-like domain, family B, member 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c ^
SP1:
SP2: - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: - - -
SP10: -
SP11:
SP12:
SP13:
SP14: -
SP15: -
SP16:
SP17:
SP18:
SP19:

ExUns: 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b
SP1: - -
SP2: - - - - - - - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8: - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:

Relevant External Links for PHLDB1 Gene

GeneLoc Exon Structure for
PHLDB1
ECgene alternative splicing isoforms for
PHLDB1

Expression for PHLDB1 Gene

mRNA expression in normal human tissues for PHLDB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHLDB1 Gene

This gene is overexpressed in Adrenal (23.5), Gallbladder (10.2), and Cervix (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHLDB1 Gene



SOURCE GeneReport for Unigene cluster for PHLDB1 Gene Hs.504062

genes like me logo Genes that share expression patterns with PHLDB1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PHLDB1 Gene

Orthologs for PHLDB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHLDB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PHLDB1 35
  • 90.29 (n)
  • 95.83 (a)
PHLDB1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHLDB1 35
  • 84.48 (n)
  • 88.24 (a)
PHLDB1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phldb1 35
  • 87.41 (n)
  • 93.93 (a)
Phldb1 16
Phldb1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PHLDB1 35
  • 99.62 (n)
  • 99.7 (a)
PHLDB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phldb1 35
  • 87.49 (n)
  • 94.62 (a)
oppossum
(Monodelphis domestica)
Mammalia PHLDB1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHLDB1 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHLDB1 35
  • 72.32 (n)
  • 74.01 (a)
PHLDB1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHLDB1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phldb1 35
  • 63.82 (n)
  • 66.22 (a)
Str.7477 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14334 35
zebrafish
(Danio rerio)
Actinopterygii LOC570275 35
  • 63.04 (n)
  • 63.61 (a)
phldb1a 36
  • 43 (a)
OneToMany
phldb1b 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5004 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5769 36
  • 31 (a)
OneToMany
Species with no ortholog for PHLDB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDB1 Gene

ENSEMBL:
Gene Tree for PHLDB1 (if available)
TreeFam:
Gene Tree for PHLDB1 (if available)

Paralogs for PHLDB1 Gene

Paralogs for PHLDB1 Gene

genes like me logo Genes that share paralogs with PHLDB1: view

Variants for PHLDB1 Gene

Sequence variations from dbSNP and Humsavar for PHLDB1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17748 -- 118,657,714(+) CTGTA(C/T)AGTGT nc-transcript-variant, utr-variant-3-prime
rs475597 -- 118,626,360(-) TATAC(A/C)AAGAA intron-variant
rs476398 -- 118,626,283(-) CTCCC(A/C)ATGTA intron-variant
rs497554 -- 118,647,996(+) TAGAA(C/T)GGAGG nc-transcript-variant, reference, missense
rs498872 -- 118,606,652(-) CTTGG(C/T)CCAGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PHLDB1 Gene

Variant ID Type Subtype PubMed ID
dgv1319n71 CNV Loss 21882294
nsv832283 CNV Loss 17160897
nsv898415 CNV Loss 21882294
esv25329 CNV Loss 19812545
nsv527864 CNV Loss 19592680
esv2675396 CNV Deletion 23128226

Variation tolerance for PHLDB1 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHLDB1 Gene

HapMap Linkage Disequilibrium report
PHLDB1
Human Gene Mutation Database (HGMD)
PHLDB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHLDB1 Gene

Disorders for PHLDB1 Gene

Relevant External Links for PHLDB1

Genetic Association Database (GAD)
PHLDB1
Human Genome Epidemiology (HuGE) Navigator
PHLDB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHLDB1

No disorders were found for PHLDB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHLDB1 Gene

Publications for PHLDB1 Gene

  1. Identification and characterization of human LL5A gene and mouse Ll5a gene in silico. (PMID: 14532993) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 4 23 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. Three SNPs in chromosome 11q23.3 are independently associated with systemic lupus erythematosus in Asians. (PMID: 24001599) Zhang J. … Yang W. (Hum. Mol. Genet. 2014) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for PHLDB1 Gene

Sources for PHLDB1 Gene

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