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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHLDA3 Gene

protein-coding   GIFtS: 50
GCID: GC01M201434

Pleckstrin Homology-Like Domain, Family A, Member 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pleckstrin Homology-Like Domain, Family A, Member 31 2     Member 21
TIH12 3 5     Pleckstrin Homology-Like Domain1
TDAG51/Ipl Homolog 12 3     Pleckstrin Homology-Like Domain Family A Member 32
Family A1     Pleckstrin Homology-Like Domain, Family A, Member 22

External Ids:    HGNC: 89341   Entrez Gene: 236122   Ensembl: ENSG000001743077   OMIM: 6070545   UniProtKB: Q9Y5J53   

Export aliases for PHLDA3 gene to outside databases

Previous GC identifers: GC01M199137 GC01M196871 GC01M197901 GC01M198722 GC01M198166 GC01M199701 GC01M172600


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PHLDA3 Gene: 
PHLDA3 (pleckstrin homology-like domain, family A, member 3) is a protein-coding gene. Diseases associated with PHLDA3 include germ cell tumors, and lung cancer, and among its related super-pathways are Cell Cycle / Checkpoint Control. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is PHLDA1.

UniProtKB/Swiss-Prot: PHLA3_HUMAN, Q9Y5J5
Function: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to
membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to
p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may
explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHLDA3 gene promoter:
         GR   GR-beta   HSF1 (long)   NF-kappaB   HSF1short   GR-alpha   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHLDA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHLDA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHLDA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q31

PHLDA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLDA3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M201434:  view genomic region     (about GC identifiers)

Start:
201,434,620 bp from pter      End:
201,438,365 bp from pter
Size:
3,746 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PHLA3_HUMAN, Q9Y5J5 (See protein sequence)
Recommended Name: Pleckstrin homology-like domain family A member 3  
Size: 127 amino acids; 13891 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein
Miscellaneous: PHLDA3 genomic locus is frequently observed in primary lung cancers, suggesting a role in tumor
suppression
Secondary accessions: B2R5A4 Q53HD6 Q8NBW9

Explore the universe of human proteins at neXtProt for PHLDA3: NX_Q9Y5J5

Explore proteomics data for PHLDA3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5J5

  • PHLDA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PHLDA3 Protein Expression
    REFSEQ proteins: NP_036528.1  
    ENSEMBL proteins: 
     ENSP00000356280   ENSP00000356278  

    Human Recombinant Protein Products for PHLDA3: 
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    Cloud-Clone Corp. Proteins for PHLDA3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA19203586
    GO:0043231intracellular membrane-bounded organelle IDA--

    PHLDA3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y5J5

    ProtoNet protein and cluster: Q9Y5J5

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PHLA3_HUMAN, Q9Y5J5
    Domain: The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and
    directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol
    3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1
    signaling
    Similarity: Belongs to the PHLDA3 family
    Similarity: Contains 1 PH domain


    PHLDA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHLA3_HUMAN, Q9Y5J5
    Function: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to
    membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to
    p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may
    explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor
    Induction: By p53/TP53; expression is directly activated by TP53. TP53 phosphorylation on 'Ser-15' is required to
    activate the PHLDA3 promoter

         Genatlas biochemistry entry for PHLDA3:
    pleckstrin homology domain,family A,member 3,TDAG51/Ip1 homology 1 (TIH1),putatively involved in FAS (APT1)
    expression and apoptosis

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ----
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA19203586
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA19203586
    GO:0010314phosphatidylinositol-5-phosphate binding IDA19203586
         
    PHLDA3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Phlda3):
     embryogenesis 

    PHLDA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phlda3tm1Bty for PHLDA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PHLDA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PHLDA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHLDA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHLDA3 

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PHLDA3 (see all 19):
    hsa-miR-185* hsa-miR-15a hsa-miR-548s hsa-miR-424 hsa-miR-195 hsa-miR-761 hsa-miR-15b hsa-miR-203
    SwitchGear 3'UTR luciferase reporter plasmidPHLDA3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PHLDA3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    2PI3K / Akt Signaling
    PI3K / Akt Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for PHLDA3
        Apoptosis and Autophagy
    PI3K / Akt Signaling
    DNA Damage



    PHLDA3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHLDA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/101 Interacting proteins for PHLDA3 (Q9Y5J53 ENSP000003562784) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5LO759643, ENSP000003006884I2D: score=2 STRING: ENSP00000300688
    CCDC47Q96A333, ENSP000002257264I2D: score=2 STRING: ENSP00000225726
    PDXDC1Q6P9963, ENSP000003228074I2D: score=2 STRING: ENSP00000322807
    XPO4Q9C0E23, ENSP000002553054I2D: score=2 STRING: ENSP00000255305
    ARCN1P484443, ENSP000002640284I2D: score=1 STRING: ENSP00000264028
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009653anatomical structure morphogenesis TAS10594239
    GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA19203586
    GO:0043065positive regulation of apoptotic process IDA19203586
    GO:0051898negative regulation of protein kinase B signaling cascade IDA19203586

    PHLDA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHLDA3 (PHLA3)

    Search CenterWatch for drugs/clinical trials and news about PHLDA3 / PHLA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHLDA3 gene: 
    NM_012396.3  

    Unigene Cluster for PHLDA3:

    Pleckstrin homology-like domain, family A, member 3
    Hs.268557  [show with all ESTs]
    Unigene Representative Sequence: BM554089
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367311(uc001gwq.3) ENST00000485436 ENST00000497057 ENST00000367309

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PHLDA3 (see all 19):
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    SwitchGear 3'UTR luciferase reporter plasmidPHLDA3 3' UTR sequence
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    Additional mRNA sequence: 

    AF151100.1 AK075179.1 AK222644.1 AK312115.1 BC014390.1 BC068273.1 NR_073080.1 

    11 DOTS entries:

    DT.210869  DT.100818395  DT.100818391  DT.91770478  DT.97859503  DT.100818392  DT.100818393  DT.102825138 
    DT.121367175  DT.95154308  DT.95154310 

    24/195 AceView cDNA sequences (see all 195):

    BM760786 BG104388 BM831586 BE302779 BM762469 BG288084 BE857481 BG751548 
    CR605205 BU196508 CR622274 BM849812 CF127462 BC014390 CR608565 CD105325 
    BM843027 BM840101 BQ638307 BQ718261 BF337564 CR592160 BU190249 CR621810 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PHLDA3    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                -                     
    SP2:        -                                             
    SP3:                          -     -                     
    SP4:                                                      


    ECgene alternative splicing isoforms for PHLDA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHLDA3 expression in normal human tissues (normalized intensities)      PHLDA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCCCCA
    PHLDA3 Expression
    About this image


    PHLDA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Heart Tube
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Adipose (Muscoskeletal System)
             adipose tissue   
     
     Amnion (Extraembryonic Tissues)
             amniotic fluid   

     -- (Integumentary System)
             SKIN   

    See PHLDA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHLDA3

    SOURCE GeneReport for Unigene cluster: Hs.268557

    UniProtKB/Swiss-Prot: PHLA3_HUMAN, Q9Y5J5
    Tissue specificity: Widely expressed with lowest expression in liver and spleen

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PHLDA3 gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phlda31 , 5 pleckstrin homology-like domain, family A, member 31, 5 94.4(n)1
    100(a)1
      1 (59.26 cM)5
    272801  NM_013750.21  NP_038778.11 
     1357661195 
    chicken
    (Gallus gallus)
    Aves LOC1008592831 pleckstrin homology-like domain family A member 3-like 80.73(n)
    77.06(a)
      100859283  XM_003642734.1  XP_003642782.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHLDA36
    Uncharacterized protein
    55(a)
    1 ↔ 1
    4(131522121-131522549)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208732 Xenopus laevis transcribed sequence 80.3(n)    BQ897374.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phlda31 pleckstrin homology-like domain, family A, member 3 61.06(n)
    53.27(a)
      368779  NM_001002455.1  NP_001002455.1 


    ENSEMBL Gene Tree for PHLDA3 (if available)
    TreeFam Gene Tree for PHLDA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHLDA3 gene
    PHLDA12  PHLDA22  
    2 SIMAP similar genes for PHLDA3 using alignment to 1 protein entry:     PHLA3_HUMAN:
    PHLDA2    PHLDA1

    PHLDA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in PHLDA3 are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5948441,2
    C,F,A--201434160(-) GAATTA/TGAGAC 2 -- ds50016Minor allele frequency- T:0.33NA CSA 12
    rs6056441,2
    C,F,A--201434199(-) ACTTTA/GGGAGG 2 -- ds50015Minor allele frequency- G:0.20NA 10
    rs1845916931,2
    --201434374(+) AGCAGA/GGGCAG 2 -- ds50010--------
    rs1889564751,2
    --201434409(+) TCATAC/GGGACT 2 -- ds50010--------
    rs1815299021,2
    --201434549(+) ATTGGA/GAGATT 2 -- ds50010--------
    rs1379030871,2
    C--201434602(+) GCAAAG/TAATTT 2 -- ds50010--------
    rs1850465661,2
    --201434604(+) AAAGAA/GTTTCA 2 -- ds50010--------
    rs1407962661,2
    --201434721(+) AACACC/TGCAGT 2 -- ut31 nc-transcript-variant0--------
    rs10535921,2
    C,F,A,H--201434740(-) CTCTAC/TGCATC 2 -- ut31 nc-transcript-variantese321Minor allele frequency- T:0.44MN NS EA NA WA CSA 2055
    rs1906017831,2
    --201434799(+) AAAAGA/GACCTA 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for PHLDA3 (201434620 - 201438365 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PHLDA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832326CNV Loss17160897
    nsv832315CNV Loss17160897
    nsv467961CNV Gain19166990
    nsv470776CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607054    OMIM disorders: --

    2 diseases for PHLDA3:    About MalaCards
    germ cell tumors    lung cancer


    PHLDA3 for disorders           About GeneDecksing


    Export disorders for PHLDA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHLDA3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with PHLDA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. (PubMed id 19203586)1, 2 Kawase T.... Taya Y. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. (PubMed id 10594239)1, 2 Frank D....Tycko B. (1999)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Expressional and mutational analysis of PHLDA3 gene i n common human cancers. (PubMed id 21753719)1 Yoo N.J....Lee S.H. (2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23612 HGNC: 8934 AceView: PHLDA3 Ensembl:ENSG00000174307 euGenes: HUgn23612
    ECgene: PHLDA3 H-InvDB: PHLDA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHLDA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHLDA3 gene:
    Search GeneIP for patents involving PHLDA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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