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Aliases for PHLDA3 Gene

Aliases for PHLDA3 Gene

  • Pleckstrin Homology Like Domain Family A Member 3 2 3
  • Pleckstrin Homology-Like Domain, Family A, Member 3 2 3 5
  • TDAG51/Ipl Homolog 1 3 4
  • TIH1 3 4
  • Pleckstrin Homology-Like Domain, Family A, Member 2 3
  • Pleckstrin Homology-Like Domain 2
  • Member 2 2
  • Family A 2

External Ids for PHLDA3 Gene

Previous GeneCards Identifiers for PHLDA3 Gene

  • GC01M199137
  • GC01M196871
  • GC01M197901
  • GC01M198722
  • GC01M198166
  • GC01M199701
  • GC01M172600

Summaries for PHLDA3 Gene

GeneCards Summary for PHLDA3 Gene

PHLDA3 (Pleckstrin Homology Like Domain Family A Member 3) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-4,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is PHLDA1.

UniProtKB/Swiss-Prot for PHLDA3 Gene

  • p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDA3 Gene

Genomics for PHLDA3 Gene

Regulatory Elements for PHLDA3 Gene

Promoters for PHLDA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHLDA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHLDA3 Gene

Chromosome:
1
Start:
201,464,383 bp from pter
End:
201,469,237 bp from pter
Size:
4,855 bases
Orientation:
Minus strand

Genomic View for PHLDA3 Gene

Genes around PHLDA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHLDA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHLDA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDA3 Gene

Proteins for PHLDA3 Gene

  • Protein details for PHLDA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5J5-PHLA3_HUMAN
    Recommended name:
    Pleckstrin homology-like domain family A member 3
    Protein Accession:
    Q9Y5J5
    Secondary Accessions:
    • B2R5A4
    • Q53HD6
    • Q8NBW9

    Protein attributes for PHLDA3 Gene

    Size:
    127 amino acids
    Molecular mass:
    13891 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • PHLDA3 genomic locus is frequently observed in primary lung cancers, suggesting a role in tumor suppression.

neXtProt entry for PHLDA3 Gene

Proteomics data for PHLDA3 Gene at MOPED

Post-translational modifications for PHLDA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHLDA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PHLDA3 (PHLDA3)

No data available for DME Specific Peptides for PHLDA3 Gene

Domains & Families for PHLDA3 Gene

Protein Domains for PHLDA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PHLDA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5J5

UniProtKB/Swiss-Prot:

PHLA3_HUMAN :
  • The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.
  • Belongs to the PHLDA3 family.
Domain:
  • The PH domain binds phosphoinositides with a broad specificity. It competes with the PH domain of AKT1 and directly interferes with AKT1 binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), preventing AKT1 association to membrane lipids and subsequent activation of AKT1 signaling.
  • Contains 1 PH domain.
Family:
  • Belongs to the PHLDA3 family.
genes like me logo Genes that share domains with PHLDA3: view

No data available for Gene Families for PHLDA3 Gene

Function for PHLDA3 Gene

Molecular function for PHLDA3 Gene

GENATLAS Biochemistry:
pleckstrin homology domain,family A,member 3,TDAG51/Ip1 homology 1 (TIH1),putatively involved in FAS (APT1) expression and apoptosis
UniProtKB/Swiss-Prot Function:
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
UniProtKB/Swiss-Prot Induction:
By p53/TP53; expression is directly activated by TP53. TP53 phosphorylation on Ser-15 is required to activate the PHLDA3 promoter.

Gene Ontology (GO) - Molecular Function for PHLDA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 19203586
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 19203586
genes like me logo Genes that share ontologies with PHLDA3: view
genes like me logo Genes that share phenotypes with PHLDA3: view

Animal Models for PHLDA3 Gene

MGI Knock Outs for PHLDA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PHLDA3

miRNA for PHLDA3 Gene

miRTarBase miRNAs that target PHLDA3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHLDA3 Gene

Localization for PHLDA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHLDA3 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHLDA3 Gene COMPARTMENTS Subcellular localization image for PHLDA3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 2
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PHLDA3 Gene

Pathways & Interactions for PHLDA3 Gene

SuperPathways for PHLDA3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHLDA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 10594239
GO:0051898 negative regulation of protein kinase B signaling IDA 19203586
genes like me logo Genes that share ontologies with PHLDA3: view

No data available for Pathways by source and SIGNOR curated interactions for PHLDA3 Gene

Drugs & Compounds for PHLDA3 Gene

No Compound Related Data Available

Transcripts for PHLDA3 Gene

Unigene Clusters for PHLDA3 Gene

Pleckstrin homology-like domain, family A, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDA3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for PHLDA3 Gene

GeneLoc Exon Structure for
PHLDA3
ECgene alternative splicing isoforms for
PHLDA3

Expression for PHLDA3 Gene

mRNA expression in normal human tissues for PHLDA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHLDA3 Gene

This gene is overexpressed in Bone (13.6), Nasopharynx (8.9), Frontal cortex (8.9), Esophagus (7.7), and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHLDA3 Gene



SOURCE GeneReport for Unigene cluster for PHLDA3 Gene Hs.268557

mRNA Expression by UniProt/SwissProt for PHLDA3 Gene

Q9Y5J5-PHLA3_HUMAN
Tissue specificity: Widely expressed with lowest expression in liver and spleen.
genes like me logo Genes that share expression patterns with PHLDA3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for PHLDA3 Gene

Orthologs for PHLDA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PHLDA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHLDA3 35
  • 100 (n)
  • 100 (a)
PHLDA3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phlda3 16
Phlda3 36
  • 98 (a)
OneToOne
Phlda3 35
  • 94.4 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PHLDA3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHLDA3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phlda3 35
  • 94.4 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves PHLDA3 36
  • 70 (a)
OneToOne
LOC100859283 35
  • 80.73 (n)
  • 77.06 (a)
lizard
(Anolis carolinensis)
Reptilia PHLDA3 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20873 35
zebrafish
(Danio rerio)
Actinopterygii phlda3 36
  • 43 (a)
OneToOne
phlda3 35
  • 61.11 (n)
  • 52.78 (a)
Species with no ortholog for PHLDA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDA3 Gene

ENSEMBL:
Gene Tree for PHLDA3 (if available)
TreeFam:
Gene Tree for PHLDA3 (if available)

Paralogs for PHLDA3 Gene

Paralogs for PHLDA3 Gene

(2) SIMAP similar genes for PHLDA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PHLDA3: view

Variants for PHLDA3 Gene

Sequence variations from dbSNP and Humsavar for PHLDA3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35383942 - 201,468,704(+) GCTTC(C/T)GCTTC nc-transcript-variant, reference, missense
rs594844 -- 201,465,032(-) GAATT(A/T)GAGAC downstream-variant-500B, utr-variant-3-prime
rs637743 -- 201,467,698(-) ATCCA(A/G)CTCCT intron-variant
rs1256930 -- 201,468,349(-) TGAGG(A/T)CAAGG nc-transcript-variant, utr-variant-3-prime
rs1053582 -- 201,465,941(-) GGGGA(G/T)CTGGC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PHLDA3 Gene

Variant ID Type Subtype PubMed ID
nsv467961 CNV Gain 19166990
nsv470776 CNV Gain 18288195
nsv832315 CNV Loss 17160897
nsv832326 CNV Loss 17160897

Variation tolerance for PHLDA3 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHLDA3 Gene

HapMap Linkage Disequilibrium report
PHLDA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHLDA3 Gene

Disorders for PHLDA3 Gene

Relevant External Links for PHLDA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHLDA3

No disorders were found for PHLDA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHLDA3 Gene

Publications for PHLDA3 Gene

  1. PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. (PMID: 19203586) Kawase T. … Taya Y. (Cell 2009) 3 4 67
  2. Low PHLDA3 expression in oesophageal squamous cell carcinomas is associated with poor prognosis. (PMID: 25667479) Muroi H. … Kato H. (Anticancer Res. 2015) 3
  3. PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors. (PMID: 24912192) Ohki R. … Nakagama H. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for PHLDA3 Gene

Sources for PHLDA3 Gene

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