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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHLDA1 Gene

protein-coding   GIFtS: 51
GCID: GC12M076419

pleckstrin homology-like domain, family A, member 1
 Explore 7 diseases affiliated with
PHLDA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PHLDA1    

Aliases
for PHLDA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pleckstrin Homology-Like Domain, Family A, Member 11 2     Proline- And Histidine-Rich Protein2 3
TDAG511 2 3 5     PQ-Rich Protein2 3
PHRIP1 2 3     PQR Protein2 3
DT1P1B111 2     T-Cell Death-Associated Gene 51 Protein2 3
Apoptosis-Associated Nuclear Protein2 3     Pleckstrin Homology-Like Domain Family A Member 12
Proline- And Glutamine-Rich Protein2 3     Proline-Histidine Rich Protein2

External Ids:    HGNC: 89331   Entrez Gene: 228222   Ensembl: ENSG000001392897   OMIM: 6053355   UniProtKB: Q8WV243   

Export aliases for PHLDA1 gene to outside databases

Previous GC identifers: GC12M073497 GC12P076041 GC12M076137 GC12M074710 GC12M074707


Summaries
for PHLDA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PHLDA1:
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an
important role in the anti-apoptotic effects of insulin-like growth factor-1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
Function: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell
death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of
IGF1. May be involved in translational regulation

Gene Wiki entry for PHLDA1


Genomic Views
for PHLDA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHLDA1 gene promoter:
         NF-1/L   NF-1   AML1a   FOXD1   AP-4   E47   FOXL1   FOXO4   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PHLDA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHLDA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHLDA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q15

PHLDA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLDA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M076419:  view genomic region     (about GC identifiers)

Start:
 76,419,227 bp from pter      End:
 76,427,712 bp from pter
Size:
 8,486 bases      Orientation:
 minus strand

Proteins
for PHLDA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24 (See protein sequence)
Recommended Name: Pleckstrin homology-like domain family A member 1  
Size: 401 amino acids; 45016 Da
Subunit: Interacts with RPL14, EIF3S7 and PABPC4
Subcellular location: Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular
vesicles
Sequence caution: Sequence=AAH18929.3; Type=Erroneous initiation; Sequence=AAI10821.1; Type=Erroneous initiation;
Sequence=AAI26426.2; Type=Erroneous initiation;
Secondary accessions: A1A4G9 Q15184 Q2TAN2 Q9NZ17

Explore the universe of human proteins at neXtProt for PHLDA1: NX_Q8WV24

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WV24

    • PHLDA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031376.3  
    ENSEMBL proteins: 
     ENSP00000266671  

    Human Recombinant Protein Products: 
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    Novus Biologicals PHLDA1 Proteins
    Novus Biologicals PHLDA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PHLDA1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane IDA--
    GO:0030659cytoplasmic vesicle membrane IEA--


    PHLDA1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PHLDA1

    Protein Domains /
    Families
    for PHLDA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PHLDA1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q8WV24

    ProtoNet protein and cluster: Q8WV24

    1 Blocks protein family: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
    Similarity: Contains 1 PH domain


    Function
    for PHLDA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
    Function: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell
    death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of
    IGF1. May be involved in translational regulation
    Induction: Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol ester
    (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells

    miRNA
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    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate PHLDA1 (see all 80):
    hsa-miR-411* hsa-miR-548j hsa-miR-323-3p hsa-miR-361-5p hsa-miR-640 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: PHLDA1
    OriGene siRNA: PHLDA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHLDA1

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PHLDA1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDA1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904
    GO:0005543phospholipid binding IEA--


    PHLDA1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Phlda1tm1Ywc for PHLDA1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Phlda1):
     immune system 

    PHLDA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PHLDA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHLDA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for PHLDA1 (Q8WV241, 2, 3 ENSP000002666714) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC4Q133101, 3, ENSP000003619494EBI-738731,EBI-877641 I2D: score=2 STRING: ENSP00000361949
    MDFIQ997501, 2, 3, ENSP000002303214EBI-738731,EBI-724076 MINT-68168 I2D: score=5 STRING: ENSP00000230321
    EIF3DO153711, 3, ENSP000002161904EBI-738731,EBI-353818 I2D: score=3 STRING: ENSP00000216190
    RPL14P509141, 3, ENSP000003451564EBI-738731,EBI-356746 I2D: score=3 STRING: ENSP00000345156
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66045 I2D: score=5 STRING: ENSP00000377582
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0006917induction of apoptosis IEA--
    GO:0045210FasL biosynthetic process IEA--


    PHLDA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PHLDA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHLDA1
    Search CenterWatch for drugs/clinical trials and news about PHLDA1 / PHLA1 

    Transcripts
    for PHLDA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PHLDA1 gene: 
    NM_007350.3  

    Unigene Cluster for PHLDA1:

    Pleckstrin homology-like domain, family A, member 1
    Hs.602085  [show with all ESTs]
    Unigene Representative Sequence: NM_007350
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000266671(uc001sxu.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHLDA1
    8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate PHLDA1 (see all 80):
    hsa-miR-411* hsa-miR-548j hsa-miR-323-3p hsa-miR-361-5p hsa-miR-640 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHLDA1 (see all 7)
    OriGene shRNA RFP: PHLDA1
    OriGene siRNA: PHLDA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHLDA1
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHLDA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHLDA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHLDA1

    Additional cDNA sequence: 

    AF220656.1 AK026181.1 AK304224.1 BC017756.1 BC018929.2 BC037430.1 BC039558.1 BC047362.1 
    BC065825.1 BC110820.1 BC126425.1 BC130427.1 U92983.1 Z50194.1 

    11 DOTS entries:

    DT.210165  DT.121108819  DT.95122829  DT.100824221  DT.91771636  DT.95122855  DT.91771643  DT.121108875 
    DT.91912311  DT.95122858  DT.102823681 

    24/338 AceView cDNA sequences (see all 338):

    CA425441 CA425605 BU620908 BC017756 CA426740 AA995175 AI371462 CR603389 
    AI198210 CD105221 CR607629 CK903903 BU623177 BG283676 AI926866 BX111936 
    BU631406 BQ006990 BM724525 AL121002 AA307019 AA242962 CK299866 BM967163 

    GeneLoc Exon Structure


    Expression
    for PHLDA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHLDA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PHLDA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/25 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 25) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Paraxial Mesoderm CellsBone, Skeletal Muscle
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    LungRespiratory BronchiolesBasal CellsLung
    LungTracheal CartilageChondrocytesLung
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BoneZeugopod Long BoneBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Secondary follicles (Primary Cell)Ovary, Reproductive System
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See PHLDA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHLDA1

    SOURCE GeneReport for Unigene cluster: Hs.602085

    UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
    Tissue specificity: Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi,
    and progressively reduced expressed in primary and metastatic melanomas (at protein level)

        SABiosciences Custom PCR Arrays for PHLDA1
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    In Situ
    Assay Products:     
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    Orthologs
    for PHLDA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PHLDA1 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Phlda11 , 5 pleckstrin homology-like domain, family A, member 11, 5 87.37(n)1
    89.43(a)1    		   10 (58.70 cM)5
    216641  NM_009344.31  NP_033370.21 
     1115062865 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.183922 Xenopus laevis transcribed sequence with weak similarity more 76.68(n)    BG814950.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii phlda16
    		 pleckstrin homology-like domain, family A, member ...
    		 66(a)
    		 1 ↔ 1
    		 4(2210472-2211508)


    ENSEMBL Gene Tree for PHLDA1 (if available)
    TreeFam Gene Tree for PHLDA1 (if available) 

    Paralogs
    for PHLDA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHLDA1 gene
    PHLDA32  PHLDA22  
    1 SIMAP similar gene for PHLDA1 using alignment to 2 protein entries:     PHLA1_HUMAN (see all proteins):
    PHLDA3

    PHLDA1 for paralogs           About GeneDecksing



    Genomic Variants
    for PHLDA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/180 NCBI SNPs in PHLDA1 are shown (see all 180)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1391626691,2
    		--76418907(+) AAGAGA/GCATAA 1 -- ds50010--------
    rs733854411,2
    		C,--76419174(+) TTCACG/AGGAAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs746207941,2
    		C,F,--76419228(+) CAGGTC/TGGTTG 1 -- ut311Minor allele frequency- T:0.07WA 118
    rs1472300791,2
    		--76419241(+) TCAATA/GGATAA 1 -- ut310--------
    rs764373001,2
    		F,--76419312(+) CATCTA/CAGAGA 1 -- ut311Minor allele frequency- C:0.04NA 120
    rs1869786111,2
    		--76419350(+) AAAAAA/GTTCAT 1 -- ut310--------
    rs1406109351,2
    		--76419370(+) GGTGTA/GTAAAG 1 -- ut310--------
    rs1444702551,2
    		--76419454(+) ACCTCG/TGAATG 1 -- ut310--------
    rs795452531,2
    		--76419458(+) CGGAAC/TGTAAC 1 -- ut310--------
    rs1476441291,2
    		--76419515(+) ACTCC-/CTGTTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHLDA1 (76419227 - 76427712 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PHLDA1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHLDA1
    DNA2.0 Custom Variant and Variant Library Synthesis for PHLDA1

    Disorders / Diseases
    for PHLDA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PHLDA1 for disorders           About GeneDecksing

    OMIM gene information: 605335    OMIM disorders: --

    7 diseases for PHLDA1:    About MalaCards
    intractable epilepsy    hyperhomocysteinemia    homocysteine    melanoma
    breast cancer    atherosclerosis    neuronitis

    1 Novoseek disease relationship for PHLDA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.0112 14 17211533 (6), 12384558 (1), 18641796 (1), 18597688 (1)


    Export disorders for PHLDA1 gene to outside databases

    Publications
    for PHLDA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHLDA1 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with PHLDA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. (PubMed id 12384558)1, 2, 3, 9 Neef R.... Johnson J.P. (2002)
    2. TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. (PubMed id 15037619)1, 3, 9 Toyoshima Y....LeRoith D. (2004)
    3. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. (PubMed id 12738777)1, 2, 9 Hossain G.S.... Austin R.C. (2003)
    4. Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. (PubMed id 11369516)1, 2, 9 Hinz T.... Kabelitz D. (2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping. (PubMed id 10894922)1, 2 Kuske M.D. and Johnson J.P. (2000)
    7. Down-regulation of PHLDA1 gene expression is associated with breast cancer progression. (PubMed id 17211533)1, 9 Nagai M.A....Soares F.A. (2007)
    8. TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy. (PubMed id 17870236)1, 9 Xi Z.Q....Wang X.F. (2007)
    9. Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-7 breast cancer cells. (PubMed id 18641796)1, 9 Marchiori A.C....Nagai M.A. (2008)
    10. Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells. (PubMed id 15002043)1, 9 Oberg H.H....Kabelitz D. (2004)

    External Searches for PHLDA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing PHLDA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22822 HGNC: 8933 AceView: PHLDA1 Ensembl:ENSG00000139289 euGenes: HUgn22822
    ECgene: PHLDA1 H-InvDB: PHLDA1

    Other Databases showing PHLDA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PHLDA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHLDA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PHLDA1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for PHLDA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PHLDA1 gene:
    Search GeneIP for patents involving PHLDA1

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