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Aliases for PHLDA1 Gene

Aliases for PHLDA1 Gene

  • Pleckstrin Homology Like Domain Family A Member 1 2 3 5
  • T-Cell Death-Associated Gene 51 Protein 3 4
  • Apoptosis-Associated Nuclear Protein 3 4
  • Proline- And Glutamine-Rich Protein 3 4
  • Proline- And Histidine-Rich Protein 3 4
  • Proline-Histidine Rich Protein 2 3
  • PQ-Rich Protein 3 4
  • PQR Protein 3 4
  • TDAG51 3 4
  • PHRIP 3 4
  • Pleckstrin Homology-Like Domain, Family A, Member 1 2
  • Pleckstrin Homology-Like Domain Family A Member 1 3
  • DT1P1B11 3

External Ids for PHLDA1 Gene

Previous GeneCards Identifiers for PHLDA1 Gene

  • GC12M073497
  • GC12P076041
  • GC12M076137
  • GC12M074710
  • GC12M074707
  • GC12M076419

Summaries for PHLDA1 Gene

Entrez Gene Summary for PHLDA1 Gene

  • This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for PHLDA1 Gene

PHLDA1 (Pleckstrin Homology Like Domain Family A Member 1) is a Protein Coding gene. Diseases associated with PHLDA1 include Morpheaform Basal Cell Carcinoma and Juvenile Astrocytoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. An important paralog of this gene is PHLDA3.

UniProtKB/Swiss-Prot for PHLDA1 Gene

  • Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

Gene Wiki entry for PHLDA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDA1 Gene

Genomics for PHLDA1 Gene

Regulatory Elements for PHLDA1 Gene

Enhancers for PHLDA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G075819 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +210.3 210329 7.4 ATF1 PKNOX1 TBL1XR1 ZBTB40 EGR1 FOS CREM EGR2 SMARCA4 PBX2 PHLDA1 ENSG00000251893 LOC105369846 ENSG00000258091
GH12G075974 2 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +54.8 54815 10.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000258077 PHLDA1 NAP1L1 ENSG00000251893 GLIPR1 LOC100289143
GH12G075943 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.8 +88.9 88912 3.0 FOXA2 ARNT ZFP64 SIN3A ARID4B DMAP1 YY1 ZNF766 CBX5 FOS PHLDA1 GLIPR1 RN7SL734P ENSG00000258091
GH12G075950 2 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +80.6 80632 5.6 FOXA2 PKNOX1 ARNT CREB3L1 AGO1 SIN3A DMAP1 FEZF1 ZNF2 YY1 PHLDA1 GLIPR1 RN7SL734P ENSG00000258091
GH12G075749 1.4 FANTOM5 ENCODE dbSUPER 17.3 +282.5 282513 2.9 FOXA2 NFIB ZSCAN4 THRB RAD21 ZBTB40 RARA ZNF366 EGR1 RELB PHLDA1 ENSG00000251893 LOC105369846 ENSG00000258088
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PHLDA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHLDA1 Gene

Chromosome:
12
Start:
76,025,447 bp from pter
End:
76,033,932 bp from pter
Size:
8,486 bases
Orientation:
Minus strand

Genomic View for PHLDA1 Gene

Genes around PHLDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHLDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHLDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDA1 Gene

Proteins for PHLDA1 Gene

  • Protein details for PHLDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV24-PHLA1_HUMAN
    Recommended name:
    Pleckstrin homology-like domain family A member 1
    Protein Accession:
    Q8WV24
    Secondary Accessions:
    • A1A4G9
    • Q15184
    • Q2TAN2
    • Q9NZ17

    Protein attributes for PHLDA1 Gene

    Size:
    401 amino acids
    Molecular mass:
    45016 Da
    Quaternary structure:
    • Interacts with RPL14, EIF3S7 and PABPC4.
    SequenceCaution:
    • Sequence=AAH18929.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI10821.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI26426.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PHLDA1 Gene

Post-translational modifications for PHLDA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHLDA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PHLDA1 Gene

Domains & Families for PHLDA1 Gene

Protein Domains for PHLDA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PHLDA1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PHLDA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PHLDA1 Gene

Function for PHLDA1 Gene

Molecular function for PHLDA1 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
UniProtKB/Swiss-Prot Induction:
Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol ester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.

Gene Ontology (GO) - Molecular Function for PHLDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11369516
genes like me logo Genes that share ontologies with PHLDA1: view
genes like me logo Genes that share phenotypes with PHLDA1: view

Animal Models for PHLDA1 Gene

MGI Knock Outs for PHLDA1:

Animal Model Products

CRISPR Products

miRNA for PHLDA1 Gene

miRTarBase miRNAs that target PHLDA1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHLDA1 Gene

Localization for PHLDA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHLDA1 Gene

Cytoplasm. Cytoplasmic vesicle. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles. {ECO:0000269 PubMed:12738777}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHLDA1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PHLDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with PHLDA1: view

Pathways & Interactions for PHLDA1 Gene

genes like me logo Genes that share pathways with PHLDA1: view

Pathways by source for PHLDA1 Gene

Gene Ontology (GO) - Biological Process for PHLDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006915 apoptotic process IEA --
GO:0045210 FasL biosynthetic process IEA --
genes like me logo Genes that share ontologies with PHLDA1: view

No data available for SIGNOR curated interactions for PHLDA1 Gene

Drugs & Compounds for PHLDA1 Gene

No Compound Related Data Available

Transcripts for PHLDA1 Gene

mRNA/cDNA for PHLDA1 Gene

Unigene Clusters for PHLDA1 Gene

Pleckstrin homology-like domain, family A, member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDA1 Gene

No ASD Table

Relevant External Links for PHLDA1 Gene

GeneLoc Exon Structure for
PHLDA1
ECgene alternative splicing isoforms for
PHLDA1

Expression for PHLDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHLDA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHLDA1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.7).

Protein differential expression in normal tissues from HIPED for PHLDA1 Gene

This gene is overexpressed in Ovary (40.2), Breast (19.3), and Bone (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHLDA1 Gene



Protein tissue co-expression partners for PHLDA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PHLDA1 Gene:

PHLDA1

SOURCE GeneReport for Unigene cluster for PHLDA1 Gene:

Hs.602085

mRNA Expression by UniProt/SwissProt for PHLDA1 Gene:

Q8WV24-PHLA1_HUMAN
Tissue specificity: Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).

Evidence on tissue expression from TISSUES for PHLDA1 Gene

  • Nervous system(4.6)
  • Skin(2.9)
  • Kidney(2.2)
  • Liver(2.2)
  • Intestine(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with PHLDA1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PHLDA1 Gene

Orthologs for PHLDA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PHLDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHLDA1 34 35
  • 96.26 (n)
dog
(Canis familiaris)
Mammalia PHLDA1 34 35
  • 89.71 (n)
cow
(Bos Taurus)
Mammalia PHLDA1 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phlda1 34
  • 86.55 (n)
mouse
(Mus musculus)
Mammalia Phlda1 34 16 35
  • 84.69 (n)
oppossum
(Monodelphis domestica)
Mammalia PHLDA1 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phlda1 34
  • 80.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18392 34
zebrafish
(Danio rerio)
Actinopterygii phlda1 34 35
  • 78.93 (n)
Species where no ortholog for PHLDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDA1 Gene

ENSEMBL:
Gene Tree for PHLDA1 (if available)
TreeFam:
Gene Tree for PHLDA1 (if available)

Paralogs for PHLDA1 Gene

Paralogs for PHLDA1 Gene

(1) SIMAP similar genes for PHLDA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PHLDA1: view

Variants for PHLDA1 Gene

Sequence variations from dbSNP and Humsavar for PHLDA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000247900 -- 76,032,375(+) TTTCT(C/G)GACCC upstream-variant-2KB
rs1000328085 -- 76,030,950(+) CACCG(A/G)AAGTC reference, synonymous-codon
rs1000450902 -- 76,026,788(+) CTAAA(C/T)GGATT utr-variant-3-prime
rs1000457790 -- 76,026,826(+) TTCAT(C/T)ATGAT utr-variant-3-prime
rs1000875582 -- 76,030,757(+) CTGGG(A/G)TTGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PHLDA1 Gene

Variant ID Type Subtype PubMed ID
nsv518190 CNV loss 19592680

Variation tolerance for PHLDA1 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHLDA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHLDA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHLDA1 Gene

Disorders for PHLDA1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PHLDA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
morpheaform basal cell carcinoma
  • basal cell carcinoma, morphea
juvenile astrocytoma
  • pediatric astrocytoma
infundibulocystic basal cell carcinoma
  • skin infundibulocystic basal cell carcinoma
aggressive digital papillary adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PHLDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHLDA1
genes like me logo Genes that share disorders with PHLDA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHLDA1 Gene

Publications for PHLDA1 Gene

  1. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. (PMID: 12384558) Neef R. … Johnson J.P. (Cancer Res. 2002) 2 3 4 22 64
  2. TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. (PMID: 15037619) Toyoshima Y. … LeRoith D. (J. Biol. Chem. 2004) 2 3 22 64
  3. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocysteinemia. (PMID: 12738777) Hossain G.S. … Austin R.C. (J. Biol. Chem. 2003) 3 4 22 64
  4. Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. (PMID: 11369516) Hinz T. … Kabelitz D. (Cell. Signal. 2001) 3 4 22 64
  5. Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-7 breast cancer cells. (PMID: 18641796) Marchiori A.C. … Nagai M.A. (Braz. J. Med. Biol. Res. 2008) 3 22 64

Products for PHLDA1 Gene

Sources for PHLDA1 Gene

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