Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PHLDA1 Gene

protein-coding   GIFtS: 51
GCID: GC12M076419

Pleckstrin Homology-Like Domain, Family A, Member 1

  See PHLDA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Pleckstrin Homology-Like Domain, Family A, Member 11 2     PHRIP2 3
TDAG512 3 5     PQ-Rich Protein2 3
Proline-Histidine Rich Protein1 2     PQR Protein2 3
Apoptosis-Associated Nuclear Protein2 3     T-Cell Death-Associated Gene 51 Protein2 3
Proline- And Glutamine-Rich Protein2 3     DT1P1B112
Proline- And Histidine-Rich Protein2 3     Pleckstrin Homology-Like Domain Family A Member 12

External Ids:    HGNC: 89331   Entrez Gene: 228222   Ensembl: ENSG000001392897   OMIM: 6053355   UniProtKB: Q8WV243   

Export aliases for PHLDA1 gene to outside databases

Previous GC identifers: GC12M073497 GC12P076041 GC12M076137 GC12M074710 GC12M074707


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PHLDA1 Gene:
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play
an important role in the anti-apoptotic effects of insulin-like growth factor-1. (provided by RefSeq, Jul 2008)

GeneCards Summary for PHLDA1 Gene:
PHLDA1 (pleckstrin homology-like domain, family A, member 1) is a protein-coding gene. Diseases associated with PHLDA1 include morpheaform basal cell carcinoma. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is PHLDA3.

UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
Function: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell
death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects
of IGF1. May be involved in translational regulation

Gene Wiki entry for PHLDA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHLDA1 gene promoter:
         NF-1/L   NF-1   AML1a   FOXD1   AP-4   E47   FOXL1   FOXO4   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PHLDA1 promoter sequence
   Search Chromatin IP Primers for PHLDA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHLDA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q15

PHLDA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHLDA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M076419:  view genomic region     (about GC identifiers)

Start:
76,419,227 bp from pter      End:
76,427,712 bp from pter
Size:
8,486 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24 (See protein sequence)
Recommended Name: Pleckstrin homology-like domain family A member 1  
Size: 401 amino acids; 45016 Da
Subunit: Interacts with RPL14, EIF3S7 and PABPC4
Sequence caution: Sequence=AAH18929.3; Type=Erroneous initiation; Sequence=AAI10821.1; Type=Erroneous initiation;
Sequence=AAI26426.2; Type=Erroneous initiation;
Secondary accessions: A1A4G9 Q15184 Q2TAN2 Q9NZ17

Explore the universe of human proteins at neXtProt for PHLDA1: NX_Q8WV24

Explore proteomics data for PHLDA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PHLDA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031376.3  
    ENSEMBL proteins: 
     ENSP00000473593   ENSP00000266671  

    PHLDA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PHLDA1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHLDA1
    GenScript Custom Purified and Recombinant Proteins Services for PHLDA1
    Novus Biologicals PHLDA1 Proteins
    Novus Biologicals PHLDA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHLDA1

     
    Search eBioscience for Proteins for PHLDA1 

    PHLDA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PHLDA1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PHLDA1
    OriGene Custom Antibody Services for PHLDA1
    Novus Biologicals PHLDA1 Antibodies
    Abcam antibodies for PHLDA1
    Cloud-Clone Corp. Antibodies for PHLDA1
    Search ThermoFisher Antibodies for PHLDA1
    LSBio Antibodies in human, mouse, rat for PHLDA1

    PHLDA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHLDA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHLDA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHLDA1
    Cloud-Clone Corp. CLIAs for PHLDA1
    Search eBioscience for ELISAs for PHLDA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR001849 Pleckstrin_homology

    Graphical View of Domain Structure for InterPro Entry Q8WV24

    ProtoNet protein and cluster: Q8WV24

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
    Similarity: Contains 1 PH domain


    Find genes that share domains with PHLDA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHLA1_HUMAN, Q8WV24
    Function: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell
    death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects
    of IGF1. May be involved in translational regulation
    Induction: Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol
    ester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11369516
         
    Find genes that share ontologies with PHLDA1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Phlda1):
     immune system 

    Find genes that share phenotypes with PHLDA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Phlda1tm1Ywc for PHLDA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHLDA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHLDA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHLDA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHLDA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHLDA1:
    hsa-mir-375 (MIRT019686)

    Block miRNA regulation of human, mouse, rat PHLDA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHLDA1 (see all 80):
    hsa-miR-411* hsa-miR-548j hsa-miR-323-3p hsa-miR-361-5p hsa-miR-640 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHLDA1
    Predesigned siRNA for gene silencing in human, mouse, rat PHLDA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHLDA1

    Clone
    Products:
         
    OriGene clones in human, mouse for PHLDA1 (see all 7)
    OriGene ORF clones in mouse, rat for PHLDA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHLDA1 (NM_007350)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHLDA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDA1
    Addgene plasmids for PHLDA1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHLDA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHLDA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PHLA1_HUMAN, Q8WV24: Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with
    intracellular vesicles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    mitochondrion2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IEA--
    GO:0005886plasma membrane ----
    GO:0030659cytoplasmic vesicle membrane IEA--

    Find genes that share ontologies with PHLDA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHLDA1
    Interactions:

        Search GeneGlobe Interaction Network for PHLDA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for PHLDA1 (Q8WV241, 2, 3 ENSP000002666714) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC4Q133101, 3, ENSP000003619494EBI-738731,EBI-372844 I2D: score=2 STRING: ENSP00000361949
    MDFIQ997501, 2, 3, ENSP000002303214EBI-738731,EBI-724076 MINT-68168 I2D: score=5 STRING: ENSP00000230321
    EIF3DO153711, 3, ENSP000002161904EBI-738731,EBI-353818 I2D: score=3 STRING: ENSP00000216190
    RPL14P509141, 3, ENSP000003451564EBI-738731,EBI-356746 I2D: score=3 STRING: ENSP00000345156
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66045 I2D: score=5 STRING: ENSP00000377582
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0021879forebrain neuron differentiation IEA--
    GO:0043065positive regulation of apoptotic process IEA--
    GO:0045210FasL biosynthetic process IEA--

    Find genes that share ontologies with PHLDA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHLDA1 (PHLA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PHLDA1 gene: 
    NM_007350.3  

    Unigene Cluster for PHLDA1:

    Pleckstrin homology-like domain, family A, member 1
    Hs.602085  [show with all ESTs]
    Unigene Representative Sequence: NM_007350
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602540 ENST00000266671(uc001sxu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHLDA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHLDA1 (see all 80):
    hsa-miR-411* hsa-miR-548j hsa-miR-323-3p hsa-miR-361-5p hsa-miR-640 hsa-miR-3653 hsa-miR-3074-3p hsa-miR-550a*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHLDA1
    Predesigned siRNA for gene silencing in human, mouse, rat PHLDA1
    Clone
    Products:
         
    OriGene clones in human, mouse for PHLDA1 (see all 7)
    OriGene ORF clones in mouse, rat for PHLDA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHLDA1 (NM_007350)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHLDA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDA1
    Addgene plasmids for PHLDA1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PHLDA1
    OriGene qSTAR qPCR primer pairs in human, mouse for PHLDA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHLDA1
      QuantiTect SYBR Green Assays in human, mouse, rat PHLDA1
      QuantiFast Probe-based Assays in human, mouse, rat PHLDA1

    Additional mRNA sequence: 

    AF220656.1 AK026181.1 AK304224.1 BC017756.1 BC018929.2 BC037430.1 BC039558.1 BC047362.1 
    BC065825.1 BC110820.1 BC126425.1 BC130427.1 U92983.1 Z50194.1 

    11 DOTS entries:

    DT.210165  DT.121108819  DT.95122829  DT.100824221  DT.91771636  DT.95122855  DT.91771643  DT.121108875 
    DT.91912311  DT.95122858  DT.102823681 

    Selected AceView cDNA sequences (see all 338):

    BU172476 AW615278 CA443016 AI795908 AI418651 BQ225107 BM967163 CA423883 
    CA426740 AA242962 AI803695 AA301586 BE910525 AI356732 BG168679 AI302879 
    BG288905 BM724525 AI198210 BU631406 AL121002 W02970 AA380178 CR603389 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PHLDA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PHLDA1 Expression
    About this image


    PHLDA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Medulla Oblongata
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Paraxial Mesoderm Cells Branchial Arch 1
             Zeugopod Long Bone
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Basal Cells Respiratory Bronchioles
             Tracheal Cartilage
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
    PHLDA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHLDA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.602085

    UniProtKB/Swiss-Prot: PHLA1_HUMAN, Q8WV24
    Tissue specificity: Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic
    nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level)

        Custom PCR Arrays for PHLDA1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PHLDA1
    OriGene qSTAR qPCR primer pairs in human, mouse for PHLDA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHLDA1
    QuantiTect SYBR Green Assays in human, mouse, rat PHLDA1
    QuantiFast Probe-based Assays in human, mouse, rat PHLDA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for PHLDA1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phlda11 , 5 pleckstrin homology-like domain, family A, member 11, 5 84.69(n)1
    84.44(a)1
      10 (58.70 cM)5
    216641  NM_009344.31  NP_033370.21 
     1115062865 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.183922 Xenopus laevis transcribed sequence with weak similarity more 76.68(n)    BG814950.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phlda11 pleckstrin homology-like domain, family A, member 1 78.93(n)
    75.2(a)
      449990  NM_001006011.1  NP_001006011.1 


    ENSEMBL Gene Tree for PHLDA1 (if available)
    TreeFam Gene Tree for PHLDA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PHLDA1 gene
    PHLDA32  PHLDA22  
    1 SIMAP similar gene for PHLDA1 using alignment to 3 protein entries:     PHLA1_HUMAN (see all proteins):
    PHLDA3

    Find genes that share paralogs with PHLDA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PHLDA1 (see all 211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391626691,2
    C--76418907(+) AAGAGA/GCATAA 1 -- ds50010--------
    rs733854411,2
    C,F--76419174(+) TTCACG/AGGAAC 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs746207941,2
    C,F--76419228(+) CAGGTC/TGGTTG 1 -- ut311Minor allele frequency- T:0.07WA 118
    rs1472300791,2
    C--76419241(+) TCAATA/GGATAA 1 -- ut310--------
    rs764373001,2
    C,F--76419312(+) CATCTA/CAGAGA 1 -- ut311Minor allele frequency- C:0.04NA 120
    rs1869786111,2
    --76419350(+) AAAAAA/GTTCAT 1 -- ut310--------
    rs1406109351,2
    --76419370(+) GGTGTA/GTAAAG 1 -- ut310--------
    rs1444702551,2
    --76419454(+) ACCTCG/TGAATG 1 -- ut310--------
    rs795452531,2
    C--76419458(+) CGGAAC/TGTAAC 1 -- ut310--------
    rs1476441291,2
    C--76419515(+) ACTCC-/CTGTTGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHLDA1 (76419227 - 76427712 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PHLDA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518190CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHLDA1
    DNA2.0 Custom Variant and Variant Library Synthesis for PHLDA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605335    OMIM disorders: --

    1 disease for PHLDA1:    
    About MalaCards
    morpheaform basal cell carcinoma


    Find genes that share disorders with PHLDA1           About GenesLikeMe

    1 Novoseek inferred disease relationship for PHLDA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0.0112 14 17211533 (6), 12384558 (1), 18641796 (1), 18597688 (1)


    Export disorders for PHLDA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PHLDA1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with PHLDA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. (PubMed id 12384558)1, 2, 3, 9 Neef R.... Johnson J.P. (Cancer Res. 2002)
    2. TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. (PubMed id 15037619)1, 3, 9 Toyoshima Y....LeRoith D. (J. Biol. Chem. 2004)
    3. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocysteinemia. (PubMed id 12738777)1, 2, 9 Hossain G.S.... Austin R.C. (J. Biol. Chem. 2003)
    4. Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. (PubMed id 11369516)1, 2, 9 Hinz T.... Kabelitz D. (Cell. Signal. 2001)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping. (PubMed id 10894922)1, 2 Kuske M.D. and Johnson J.P. (Cytogenet. Cell Genet. 2000)
    7. Down-regulation of PHLDA1 gene expression is associated with breast cancer progression. (PubMed id 17211533)1, 9 Nagai M.A....Soares F.A. (Breast Cancer Res. Treat. 2007)
    8. TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy. (PubMed id 17870236)1, 9 Xi Z.Q....Wang X.F. (Neurosci. Lett. 2007)
    9. Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-7 breast cancer cells. (PubMed id 18641796)1, 9 Marchiori A.C....Nagai M.A. (Braz. J. Med. Biol. Res. 2008)
    10. Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells. (PubMed id 15002043)1, 9 Oberg H.H....Kabelitz D. (Cell Death Differ. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 22822 HGNC: 8933 AceView: PHLDA1 Ensembl:ENSG00000139289 euGenes: HUgn22822
    ECgene: PHLDA1 H-InvDB: PHLDA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PHLDA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PHLDA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PHLDA1 gene:
    Search GeneIP for patents involving PHLDA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PHLDA1
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PHLDA1   OriGene RNAi products in human, mouse, rat for PHLDA1  
     OriGene qPCR primer pairs and template standards for PHLDA1   OriGene Protein Over-expression Lysate for PHLDA1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PHLDA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PHLDA1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PHLDA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHLDA1   OriGene Custom Protein Services for PHLDA1  

     
     
     Block miRNA regulation of human, mouse, rat PHLDA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PHLDA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHLDA1 Predesigned siRNA for gene silencing in human, mouse, rat PHLDA1
     QuantiFast Probe-based Assays in human, mouse, rat PHLDA1 QuantiTect SYBR Green Assays in human, mouse, rat PHLDA1
     Custom PCR Arrays for PHLDA1 Search Chromatin IP Primers for PHLDA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHLDA1  Search GeneGlobe Interaction Network for PHLDA1
     Regulatory tfbs in PHLDA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PHLDA1 GenScript cDNA clones with any tag delivered in your preferred vector for PHLDA1
     GenScript Custom Assay Services for PHLDA1 GenScript Custom overexpressing Cell Line Services for PHLDA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PHLDA1 (PHLA1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PHLDA1 antibodies
     PHLDA1 proteins
     PHLDA1 lysates
     Antibodies for PHLDA1
     See all of Abcam's Antibodies, Kits and Proteins for PHLDA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PHLDA1
     Antibodies for PHLDA1
     ELISAs for PHLDA1
     CLIAs for PHLDA1



     Browse ESI BIO Cell Lines and PureStem Progenitors for PHLDA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHLDA1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PHLDA1
     SwitchGear Promoter luciferase reporter plasmids for PHLDA1
     Search ThermoFisher Antibodies for PHLDA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHLDA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHLDA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHLDA1
     LSBio Antibodies in human, mouse, rat for PHLDA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for PHLDA1
      Search eBioscience for proteins for PHLDA1
      Search eBioscience for elisas for PHLDA1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHLDA1 gene at Home site.
    Version: 3.12.216 30 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4