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Aliases for PHLDA1 Gene

Aliases for PHLDA1 Gene

  • Pleckstrin Homology-Like Domain, Family A, Member 1 2 3
  • TDAG51 3 4 6
  • T-Cell Death-Associated Gene 51 Protein 3 4
  • Apoptosis-Associated Nuclear Protein 3 4
  • Proline- And Glutamine-Rich Protein 3 4
  • Proline- And Histidine-Rich Protein 3 4
  • Proline-Histidine Rich Protein 2 3
  • PQ-Rich Protein 3 4
  • PQR Protein 3 4
  • PHRIP 3 4
  • Pleckstrin Homology-Like Domain Family A Member 1 3
  • DT1P1B11 3

External Ids for PHLDA1 Gene

Previous GeneCards Identifiers for PHLDA1 Gene

  • GC12M073497
  • GC12P076041
  • GC12M076137
  • GC12M074710
  • GC12M074707
  • GC12M076419

Summaries for PHLDA1 Gene

Entrez Gene Summary for PHLDA1 Gene

  • This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

GeneCards Summary for PHLDA1 Gene

PHLDA1 (Pleckstrin Homology-Like Domain, Family A, Member 1) is a Protein Coding gene. Diseases associated with PHLDA1 include morpheaform basal cell carcinoma. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is PHLDA2.

UniProtKB/Swiss-Prot for PHLDA1 Gene

  • Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

Gene Wiki entry for PHLDA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHLDA1 Gene

Genomics for PHLDA1 Gene

Regulatory Elements for PHLDA1 Gene

Genomic Location for PHLDA1 Gene

Start:
76,025,447 bp from pter
End:
76,033,932 bp from pter
Size:
8,486 bases
Orientation:
Minus strand

Genomic View for PHLDA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHLDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHLDA1 Gene

Proteins for PHLDA1 Gene

  • Protein details for PHLDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV24-PHLA1_HUMAN
    Recommended name:
    Pleckstrin homology-like domain family A member 1
    Protein Accession:
    Q8WV24
    Secondary Accessions:
    • A1A4G9
    • Q15184
    • Q2TAN2
    • Q9NZ17

    Protein attributes for PHLDA1 Gene

    Size:
    401 amino acids
    Molecular mass:
    45016 Da
    Quaternary structure:
    • Interacts with RPL14, EIF3S7 and PABPC4.
    SequenceCaution:
    • Sequence=AAH18929.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI10821.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI26426.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PHLDA1 Gene

Proteomics data for PHLDA1 Gene at MOPED

Post-translational modifications for PHLDA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHLDA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PHLDA1 Gene

Domains for PHLDA1 Gene

Protein Domains for PHLDA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PHLDA1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV24

UniProtKB/Swiss-Prot:

PHLA1_HUMAN :
  • Q8WV24
Domain:
  • Contains 1 PH domain.
genes like me logo Genes that share domains with PHLDA1: view

No data available for Gene Families for PHLDA1 Gene

Function for PHLDA1 Gene

Molecular function for PHLDA1 Gene

UniProtKB/Swiss-Prot Function: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
UniProtKB/Swiss-Prot Induction: Induced by homocysteine and other endoplasmic reticulum stress-inducing reagents. Induced by phorbol ester (TPA)/ionomycin, and stimulation of the T-cell receptor (TCR) complex in T-cells.

Gene Ontology (GO) - Molecular Function for PHLDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11369516
genes like me logo Genes that share ontologies with PHLDA1: view

Phenotypes for PHLDA1 Gene

MGI mutant phenotypes for PHLDA1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with PHLDA1: view

Animal Models for PHLDA1 Gene

MGI Knock Outs for PHLDA1:

miRNA for PHLDA1 Gene

miRTarBase miRNAs that target PHLDA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PHLDA1 Gene

Localization for PHLDA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHLDA1 Gene

Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHLDA1 Gene COMPARTMENTS Subcellular localization image for PHLDA1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
mitochondrion 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PHLDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with PHLDA1: view

Pathways for PHLDA1 Gene

SuperPathways for PHLDA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHLDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0021879 forebrain neuron differentiation IEA --
GO:0043065 positive regulation of apoptotic process IEA --
GO:0045210 FasL biosynthetic process IEA --
genes like me logo Genes that share ontologies with PHLDA1: view

No data available for Pathways by source for PHLDA1 Gene

Transcripts for PHLDA1 Gene

mRNA/cDNA for PHLDA1 Gene

Unigene Clusters for PHLDA1 Gene

Pleckstrin homology-like domain, family A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHLDA1 Gene

No ASD Table

Relevant External Links for PHLDA1 Gene

GeneLoc Exon Structure for
PHLDA1
ECgene alternative splicing isoforms for
PHLDA1

Expression for PHLDA1 Gene

mRNA expression in normal human tissues for PHLDA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHLDA1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHLDA1 Gene

SOURCE GeneReport for Unigene cluster for PHLDA1 Gene Hs.602085

mRNA Expression by UniProt/SwissProt for PHLDA1 Gene

Q8WV24-PHLA1_HUMAN
Tissue specificity: Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).
genes like me logo Genes that share expressions with PHLDA1: view

Orthologs for PHLDA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PHLDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHLDA1 35
  • 96.26 (n)
  • 96.51 (a)
PHLDA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHLDA1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHLDA1 35
  • 89.71 (n)
  • 89.26 (a)
PHLDA1 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phlda1 35
  • 84.69 (n)
  • 84.44 (a)
Phlda1 16
Phlda1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHLDA1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phlda1 35
  • 86.55 (n)
  • 87.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18392 35
tropical clawed frog
(Silurana tropicalis)
Amphibia phlda1 35
  • 80.27 (n)
  • 88 (a)
zebrafish
(Danio rerio)
Actinopterygii phlda1 35
  • 78.93 (n)
  • 75.2 (a)
phlda1 36
  • 67 (a)
OneToOne
Species with no ortholog for PHLDA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHLDA1 Gene

ENSEMBL:
Gene Tree for PHLDA1 (if available)
TreeFam:
Gene Tree for PHLDA1 (if available)

Paralogs for PHLDA1 Gene

Paralogs for PHLDA1 Gene

Selected SIMAP similar genes for PHLDA1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PHLDA1: view

Variants for PHLDA1 Gene

Sequence variations from dbSNP and Humsavar for PHLDA1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1046922 -- 76,026,872(-) TCTCA(A/T)GTCAT utr-variant-3-prime
rs1433369 -- 76,030,373(+) CTGTT(C/T)CTTCC intron-variant
rs2082529 -- 76,033,699(+) CAATG(C/T)CTGAC upstream-variant-2KB
rs3048373 -- 76,033,769(+) CTCTT(-/AAT/AATTT)GTTAT upstream-variant-2KB
rs3747549 -- 76,031,696(-) GCTTT(C/T)CCCCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PHLDA1 Gene

Variant ID Type Subtype PubMed ID
nsv518190 CNV Loss 19592680

Relevant External Links for PHLDA1 Gene

HapMap Linkage Disequilibrium report
PHLDA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHLDA1 Gene

Disorders for PHLDA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PHLDA1 Gene including...

Search for PHLDA1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for PHLDA1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0.0112 9
genes like me logo Genes that share disorders with PHLDA1: view

No data available for UniProtKB/Swiss-Prot for PHLDA1 Gene

Publications for PHLDA1 Gene

  1. Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation. (PMID: 12384558) Neef R. … Johnson J.P. (Cancer Res. 2002) 2 3 4 23
  2. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocysteinemia. (PMID: 12738777) Hossain G.S. … Austin R.C. (J. Biol. Chem. 2003) 3 4 23
  3. Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product. (PMID: 11369516) Hinz T. … Kabelitz D. (Cell. Signal. 2001) 3 4 23
  4. TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival. (PMID: 15037619) Toyoshima Y. … LeRoith D. (J. Biol. Chem. 2004) 2 3 23
  5. A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation. (PMID: 15315823) Meier-Noorden M. … Hinz T. (Gene 2004) 3 23

Products for PHLDA1 Gene

Sources for PHLDA1 Gene

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