Aliases for PHIP Gene
External Ids for PHIP Gene
Previous Symbols for PHIP Gene
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PHIP Gene
PHIP (Pleckstrin Homology Domain Interacting Protein) is a Protein Coding gene. Diseases associated with PHIP include legg-calve-perthes disease. GO annotations related to this gene include insulin receptor binding and lysine-acetylated histone binding. An important paralog of this gene is BRWD3.
UniProtKB/Swiss-Prot for PHIP Gene
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.