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Aliases for PHIP Gene

Aliases for PHIP Gene

  • Pleckstrin Homology Domain Interacting Protein 2 3
  • DDB1 And CUL4 Associated Factor 14 2 3
  • IRS-1 PH Domain-Binding Protein 3 4
  • WD Repeat-Containing Protein 11 3 4
  • WDR11 3 4
  • PH-Interacting Protein 3
  • DCAF14 3
  • BRWD2 3
  • Ndrp 3

External Ids for PHIP Gene

Previous Symbols for PHIP Gene

  • WDR11

Summaries for PHIP Gene

Entrez Gene Summary for PHIP Gene

  • PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PHIP Gene

PHIP (Pleckstrin Homology Domain Interacting Protein) is a Protein Coding gene. Diseases associated with PHIP include legg-calve-perthes disease. GO annotations related to this gene include insulin receptor binding and lysine-acetylated histone binding. An important paralog of this gene is BRWD3.

UniProtKB/Swiss-Prot for PHIP Gene

  • Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHIP Gene

Genomics for PHIP Gene

Genomic Location for PHIP Gene

Start:
78,934,419 bp from pter
End:
79,078,294 bp from pter
Size:
143,876 bases
Orientation:
Minus strand

Genomic View for PHIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHIP Gene

Regulatory Elements for PHIP Gene

Proteins for PHIP Gene

  • Protein details for PHIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWQ0-PHIP_HUMAN
    Recommended name:
    PH-interacting protein
    Protein Accession:
    Q8WWQ0
    Secondary Accessions:
    • A7J992
    • B2RPK4
    • Q05CQ9
    • Q5VVH4
    • Q66I29
    • Q69YV1
    • Q8NBZ5
    • Q96H52
    • Q96ME2
    • Q9H261

    Protein attributes for PHIP Gene

    Size:
    1821 amino acids
    Molecular mass:
    206689 Da
    Quaternary structure:
    • Interacts with IRS1 and IRS2 (By similarity). Interacts (via bromo domain) with acetylated lysine residues on histone H1.4, histone H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=AAH21905.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAC11417.1; Type=Frameshift; Positions=1648; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHIP Gene

neXtProt entry for PHIP Gene

Proteomics data for PHIP Gene at MOPED

Post-translational modifications for PHIP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys65, Lys400, Lys1005, Lys1032, Lys1150, Lys1393, Lys1528, Lys1542, and Lys1736

Other Protein References for PHIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PHIP Gene

Domains for PHIP Gene

Gene Families for PHIP Gene

HGNC:
  • WDR :WD repeat domain containing
  • DCAF :DDB1 and CUL4 associated factors

UniProtKB/Swiss-Prot:

PHIP_HUMAN
Domain:
  • Contains 2 bromo domains.:
    • Q8WWQ0
Similarity:
  • Contains 8 WD repeats.:
    • Q8WWQ0
genes like me logo Genes that share domains with PHIP: view

Function for PHIP Gene

Molecular function for PHIP Gene

UniProtKB/Swiss-Prot Function: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.

Gene Ontology (GO) - Molecular Function for PHIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding NAS 11018022
GO:0005515 protein binding IPI 11018022
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with PHIP: view
genes like me logo Genes that share phenotypes with PHIP: view

miRNA for PHIP Gene

miRTarBase miRNAs that target PHIP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHIP Gene

Localization for PHIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHIP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHIP Gene COMPARTMENTS Subcellular localization image for PHIP gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PHIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PHIP: view

Pathways for PHIP Gene

SuperPathways for PHIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation ISS --
GO:0006606 protein import into nucleus IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008284 positive regulation of cell proliferation ISS --
GO:0008286 insulin receptor signaling pathway NAS 11018022
genes like me logo Genes that share ontologies with PHIP: view

No data available for Pathways by source for PHIP Gene

Transcripts for PHIP Gene

Unigene Clusters for PHIP Gene

Pleckstrin homology domain interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHIP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for PHIP Gene

GeneLoc Exon Structure for
PHIP
ECgene alternative splicing isoforms for
PHIP

Expression for PHIP Gene

mRNA expression in normal human tissues for PHIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PHIP Gene

SOURCE GeneReport for Unigene cluster for PHIP Gene Hs.511817

mRNA Expression by UniProt/SwissProt for PHIP Gene

Q8WWQ0-PHIP_HUMAN
Tissue specificity: Expressed in myeloma and epidermoid carcinoma cell lines.
genes like me logo Genes that share expressions with PHIP: view

Orthologs for PHIP Gene

This gene was present in the common ancestor of animals.

Orthologs for PHIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHIP 36
  • 99.29 (n)
  • 99.33 (a)
PHIP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHIP 36
  • 93.78 (n)
  • 96.08 (a)
PHIP 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHIP 36
  • 93.98 (n)
  • 95.83 (a)
PHIP 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phip 36
  • 90.32 (n)
  • 94.95 (a)
Phip 16
Phip 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHIP 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 67 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Phip 36
  • 88.91 (n)
  • 93.46 (a)
chicken
(Gallus gallus)
Aves PHIP 36
  • 81.41 (n)
  • 87.98 (a)
PHIP 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHIP 37
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phip 36
  • 73.9 (n)
  • 78.79 (a)
zebrafish
(Danio rerio)
Actinopterygii phip 36
  • 64.64 (n)
  • 70.17 (a)
phip 37
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002030 36
  • 50.42 (n)
  • 49.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta BRWD3 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for PHIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHIP Gene

ENSEMBL:
Gene Tree for PHIP (if available)
TreeFam:
Gene Tree for PHIP (if available)

Paralogs for PHIP Gene

Paralogs for PHIP Gene

Selected SIMAP similar genes for PHIP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PHIP: view

Variants for PHIP Gene

Sequence variations from dbSNP and Humsavar for PHIP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs946022 -- 78,962,416(+) AGGTA(G/T)TATTT intron-variant
rs1056958 -- 78,946,787(-) GTTTT(C/T)ATAAA reference, missense
rs1056959 -- 78,946,759(-) AAGGA(A/G)GAAGA missense, reference
rs1056960 -- 78,946,061(-) CTACT(C/T)CTTCA missense, reference
rs1135076 -- 78,946,017(-) TCTGC(A/G)ATACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for PHIP Gene

Variant ID Type Subtype PubMed ID
esv2675407 CNV Deletion 23128226
nsv830705 CNV Gain 17160897
nsv819945 CNV Loss 19587683
nsv518477 CNV Gain 19592680
esv270820 CNV Insertion 20981092
esv274137 CNV Insertion 20981092

Relevant External Links for PHIP Gene

HapMap Linkage Disequilibrium report
PHIP
Human Gene Mutation Database (HGMD)
PHIP

Disorders for PHIP Gene

(1) University of Copenhagen DISEASES for PHIP Gene

genes like me logo Genes that share disorders with PHIP: view

No data available for UniProtKB/Swiss-Prot for PHIP Gene

Publications for PHIP Gene

  1. Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. (PMID: 11018022) Farhang-Fallah J. … Rozakis-Adcock M. (J. Biol. Chem. 2000) 2 3 4
  2. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival. (PMID: 17636024) Podcheko A. … Rozakis-Adcock M. (Mol. Cell. Biol. 2007) 3 4
  5. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 3 4

Products for PHIP Gene

Sources for PHIP Gene

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