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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHIP Gene

protein-coding   GIFtS: 51
GCID: GC06M079644

pleckstrin homology domain interacting protein


(Previous symbol: WDR11)
 Explore 4 diseases affiliated with
PHIP via our new
 Human Malady Compendium 
Biological research products
for PHIP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Pleckstrin Homology Domain Interacting Protein1 2     IRS-1 PH Domain-Binding Protein2 3
WDR111 2 3     WD Repeat-Containing Protein 112 3
BRWD21 2     FLJ207051
DCAF141 2     DDB1 And CUL4 Associated Factor 142
Ndrp1     PH-Interacting Protein2

External Ids:    HGNC: 156731   Entrez Gene: 550232   Ensembl: ENSG000001462477   OMIM: 6128705   UniProtKB: Q8WWQ03   

Export aliases for PHIP gene to outside databases

Previous GC identifers: GC06M079593 GC06M079645 GC06M079707 GC06M076837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PHIP:
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin
signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 (PubMed
11018022); Podcheko et al., 2007 (PubMed 17636024)).(supplied by OMIM, Jun 2009)

UniProtKB/Swiss-Prot: PHIP_HUMAN, Q8WWQ0
Function: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell
proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1
phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHIP gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHIP promoter sequence
   Search SABiosciences Chromatin IP Primers for PHIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q14

PHIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHIP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M079644:  view genomic region     (about GC identifiers)

Start:
79,644,136 bp from pter      End:
79,788,011 bp from pter
Size:
143,876 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHIP_HUMAN, Q8WWQ0 (See protein sequence)
Recommended Name: PH-interacting protein  
Size: 1821 amino acids; 206689 Da
Subunit: Interacts with IRS1 and IRS2 (By similarity). Interacts (via bromo domain) with acetylated lysine residues on
histone H1.4, histone H3 and H4 (in vitro)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH21905.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=BAC11417.1; Type=Frameshift; Positions=1648;
1 PDB 3D structure from and Proteopedia for PHIP:
3MB3 (3D)    
Secondary accessions: B2RPK4 Q05CQ9 Q5VVH4 Q66I29 Q69YV1 Q8NBZ5 Q96H52 Q96ME2 Q9H261

Explore the universe of human proteins at neXtProt for PHIP: NX_Q8WWQ0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WWQ0

  • PHIP Protein expression data from MOPED and PaxDb:    About this image 
    PHIP Protein Expression
    REFSEQ proteins: NP_060404.3  
    ENSEMBL proteins: 
     ENSP00000275034  

    Human Recombinant Protein Products for PHIP: 
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    Novus Biologicals PHIP Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PHIP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus ISS--

    PHIP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PHIP


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PHIP for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR019775 WD40_repeat_CS
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q8WWQ0

    ProtoNet protein and cluster: Q8WWQ0

    1 Blocks protein family: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: PHIP_HUMAN, Q8WWQ0
    Similarity: Contains 2 bromo domains
    Similarity: Contains 8 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHIP_HUMAN, Q8WWQ0
    Function: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell
    proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1
    phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding NAS11018022
    GO:0005515protein binding IPI11018022
    GO:0070577histone acetyl-lysine binding IDA--
         
    PHIP for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Phip):
     adipose tissue  cardiovascular system  cellular  growth/size  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle  respiratory system 

    PHIP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PHIP 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHIP:
    hsa-mir-1 (MIRT005277)

    OriGene 3'-UTR Clone: PHIP
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHIP
    8/178 QIAGEN miScript miRNA Assays for microRNAs that regulate PHIP (see all 178):
    hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-605 hsa-miR-138-2* hsa-miR-519a hsa-miR-3916 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHIP (see all 3)
    Browse OriGene siRNA
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    Sirion Biotech Custom design and validation of potent shRNA sequences against PHIP 

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of PHIP 
    Sirion Biotech Customized adenovirus for potent knockdown of PHIP

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHIP (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHIP 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/15 Interacting proteins for PHIP (Q8WWQ02, 3 ENSP000002750344) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STMN4Q9H1692, 3, ENSP000003425384MINT-65452 I2D: score=5 STRING: ENSP00000342538
    ENSG00000258947Q135093I2D: score=2 
    TUBB3Q135093I2D: score=2 
    IRS2Q9Y4H23, ENSP000003650164I2D: score=1 STRING: ENSP00000365016
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation ISS--
    GO:0006606protein import into nucleus IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0008286insulin receptor signaling pathway NAS11018022

    PHIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHIP
    Search CenterWatch for drugs/clinical trials and news about PHIP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHIP gene: 
    NM_017934.5  

    Unigene Clusters for PHIP:

    Pleckstrin homology domain interacting protein
    Hs.511817  [show with all ESTs], Hs.606356  [show with all ESTs]
    Unigene Representative Sequences: NM_017934, BC036479
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479165(uc003pio.4) ENST00000275034(uc003piq.3 uc003pir.3 uc011dyp.2)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHIP
    8/178 QIAGEN miScript miRNA Assays for microRNAs that regulate PHIP (see all 178):
    hsa-miR-411* hsa-miR-579 hsa-miR-106a hsa-miR-605 hsa-miR-138-2* hsa-miR-519a hsa-miR-3916 hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHIP (see all 3)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHIP
    Sirion Biotech Custom design and validation of potent shRNA sequences against PHIP 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PHIP (NM_017934)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHIP 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHIP

    Additional cDNA sequence: BC036479.1 

    23 DOTS entries:

    DT.97858748  DT.444138  DT.97840245  DT.40311328  DT.101971611  DT.95170404  DT.97785958  DT.312165 
    DT.75124657  DT.65287333  DT.100822283  DT.91760815  DT.100018230  DT.431427  DT.95227509  DT.121387444 
    DT.121387525  DT.121387539  DT.40126062  DT.91747939  DT.99984478  DT.75177627  DT.92063679 

    24/340 AceView cDNA sequences (see all 340):

    AA227922 BM712905 AW300284 AA703383 AL161957 BQ434222 CB161685 CB178010 
    BF435299 AA580782 BX442062 AI028398 CA867032 AA926991 CB123709 BC064611 
    BX282637 AA772410 BM718690 AA379329 BM973446 AI494192 AA455237 BM833936 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PHIP    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                       -                             -                                                                     
    SP2:                                      -                             -                                                                     
    SP3:                                                                    -                                                                     
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for PHIP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACAGTGAT
    PHIP Expression
    About this image
    See PHIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHIP

    SOURCE GeneReport for Unigene clusters: Hs.511817 Hs.606356

    UniProtKB/Swiss-Prot: PHIP_HUMAN, Q8WWQ0
    Tissue specificity: Expressed in myeloma and epidermoid carcinoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including PHIP: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PHIP gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PHIP1 pleckstrin homology domain interacting protein 81.75(n)
    88.32(a)
      421854  XM_003640997.1  XP_003641045.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHIP6
    --
    83(a)
    1 ↔ 1
    1(199680233-199762047)
    zebrafish
    (Danio rerio)
    Actinopterygii phip1 pleckstrin homology domain interacting protein 64.48(n)
    70.54(a)
      569727  XM_693129.5  XP_698221.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta BRWD36
    BRWD3
    28(a)
    possible ortholog
    3R(20144741-20154341)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G494301 WD40/YVTN repeat and Bromo-WDR9-I-like domain-containing more 47.43(n)
    35.16(a)
      835003  NM_124320.2  NP_199754.2 
    rice
    (Oryza sativa)
    Liliopsida --
    WD domain, G-beta repeat domain containing protein...
    17(a)
    1 → many
    3(10865216-10881763)


    ENSEMBL Gene Tree for PHIP (if available)
    TreeFam Gene Tree for PHIP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHIP gene
    TAF52  BRWD12  TAF5L2  BRWD32  
    4 SIMAP similar genes for PHIP using alignment to 2 protein entries:     PHIP_HUMAN (see all proteins):
    BRWD3    BRWD1    POC1B    WDR83

    PHIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2382 NCBI SNPs in PHIP are shown (see all 2382    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386224541,2
    --79643677(+) GCTTTC/TGACAT 1 -- ds50010--------
    rs1879639601,2
    --79643750(+) CTATTC/TACTTG 1 -- ds50010--------
    rs1406385631,2
    --79643757(+) CTTGAA/GCATTT 1 -- ds50010--------
    rs1153633951,2
    F--79643901(+) CTATCT/ATATAT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1458051771,2
    --79643984(+) ACAGAC/TAGAAT 1 -- ds50010--------
    rs1384584151,2
    --79643990(+) AGAATA/GAGATT 1 -- ds50010--------
    rs1812680981,2
    --79644054(+) TGCTGC/TTGGAA 1 -- ds50010--------
    rs1420202101,2
    --79644289(+) TGGCCG/TCAAGA 1 -- ut310--------
    rs1853356651,2
    --79644487(+) AAGCTC/GTGAGA 1 -- ut310--------
    rs1901295161,2
    --79644491(+) TCTGAG/TATACG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHIP (79644136 - 79788011 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PHIP
         1 Indel: 59366
    Human Gene Mutation Database (HGMD): PHIP

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHIP
    DNA2.0 Custom Variant and Variant Library Synthesis for PHIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PHIP for disorders           About GeneDecksing

    OMIM gene information: 612870    OMIM disorders: --

    4 diseases for PHIP:    About MalaCards
    legg-calve-perthes disease    pancreatitis    myeloma    carcinoma

    1 disease from the University of Copenhagen DISEASES database for PHIP:
    Legg-Calve-Perthes Disease

    Export disorders for PHIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHIP gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with PHIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. (PubMed id 11018022)1, 2, 3 Farhang-Fallah J.... Rozakis-Adcock M. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Histone recognition and large-scale structural analysis of the human bromodomain family. (PubMed id 22464331)2 Filippakopoulos P.... Knapp S. (2012)
    4. Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis. (PubMed id 22511720)1 De Semir D....Kashani-Sabet M. (2012)
    5. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55023 HGNC: 15673 AceView: PHIP Ensembl:ENSG00000146247 euGenes: HUgn55023
    ECgene: PHIP H-InvDB: PHIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHIP gene:
    Search GeneIP for patents involving PHIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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