Aliases for PHIP Gene
External Ids for PHIP Gene
Previous HGNC Symbols for PHIP Gene
Previous GeneCards Identifiers for PHIP Gene
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PHIP Gene
PHIP (Pleckstrin Homology Domain Interacting Protein) is a Protein Coding gene. GO annotations related to this gene include insulin receptor binding and lysine-acetylated histone binding. An important paralog of this gene is BRWD3.
UniProtKB/Swiss-Prot for PHIP Gene
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.