Aliases for PHIP Gene
External Ids for PHIP Gene
Previous HGNC Symbols for PHIP Gene
Previous GeneCards Identifiers for PHIP Gene
This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016]
GeneCards Summary for PHIP Gene
PHIP (Pleckstrin Homology Domain Interacting Protein) is a Protein Coding gene. Diseases associated with PHIP include Melanoma Metastasis and Phimosis. GO annotations related to this gene include insulin receptor binding and lysine-acetylated histone binding. An important paralog of this gene is BRWD3.
UniProtKB/Swiss-Prot for PHIP Gene
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.