Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PHF7 Gene

Aliases for PHF7 Gene

  • PHD Finger Protein 7 2 3 5
  • Testis Development Protein NYD-SP6 3 4
  • Testicular Secretory Protein Li 34 3
  • HSPC045 3
  • HSPC226 3
  • NYD-SP6 3

External Ids for PHF7 Gene

Previous GeneCards Identifiers for PHF7 Gene

  • GC03P051537
  • GC03P051697
  • GC03P052300
  • GC03P052402
  • GC03P052419

Summaries for PHF7 Gene

Entrez Gene Summary for PHF7 Gene

  • Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for PHF7 Gene

PHF7 (PHD Finger Protein 7) is a Protein Coding gene. An important paralog of this gene is G2E3.

UniProtKB/Swiss-Prot for PHF7 Gene

  • May play a role in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF7 Gene

Genomics for PHF7 Gene

Regulatory Elements for PHF7 Gene

Promoters for PHF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHF7 Gene

Chromosome:
3
Start:
52,410,558 bp from pter
End:
52,423,641 bp from pter
Size:
13,084 bases
Orientation:
Plus strand

Genomic View for PHF7 Gene

Genes around PHF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF7 Gene

Proteins for PHF7 Gene

  • Protein details for PHF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWX1-PHF7_HUMAN
    Recommended name:
    PHD finger protein 7
    Protein Accession:
    Q9BWX1
    Secondary Accessions:
    • K4DI82

    Protein attributes for PHF7 Gene

    Size:
    381 amino acids
    Molecular mass:
    43767 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PHF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF7 Gene

Proteomics data for PHF7 Gene at MOPED

Post-translational modifications for PHF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PHF7 Gene

Domains & Families for PHF7 Gene

Gene Families for PHF7 Gene

Protein Domains for PHF7 Gene

Suggested Antigen Peptide Sequences for PHF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWX1

UniProtKB/Swiss-Prot:

PHF7_HUMAN :
  • Contains 1 PHD-type zinc finger.
Similarity:
  • Contains 1 PHD-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PHF7: view

Function for PHF7 Gene

Molecular function for PHF7 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis.
genes like me logo Genes that share phenotypes with PHF7: view

Animal Model Products

miRNA for PHF7 Gene

miRTarBase miRNAs that target PHF7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHF7 Gene

Localization for PHF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF7 Gene COMPARTMENTS Subcellular localization image for PHF7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for PHF7 Gene

Pathways & Interactions for PHF7 Gene

SuperPathways for PHF7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PHF7 Gene

Drugs & Compounds for PHF7 Gene

No Compound Related Data Available

Transcripts for PHF7 Gene

Unigene Clusters for PHF7 Gene

PHD finger protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHF7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - -
SP6: -
SP7: - -
SP8: - - - -
SP9:
SP10:

Relevant External Links for PHF7 Gene

GeneLoc Exon Structure for
PHF7
ECgene alternative splicing isoforms for
PHF7

Expression for PHF7 Gene

mRNA expression in normal human tissues for PHF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHF7 Gene

This gene is overexpressed in Testis (x45.4).

Protein differential expression in normal tissues from HIPED for PHF7 Gene

This gene is overexpressed in Blymphocyte (32.9), Nasal epithelium (17.4), and Tlymphocyte (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PHF7 Gene



SOURCE GeneReport for Unigene cluster for PHF7 Gene Hs.372719

mRNA Expression by UniProt/SwissProt for PHF7 Gene

Q9BWX1-PHF7_HUMAN
Tissue specificity: Highly expressed in Sertoli cells, but not in germ cells in adult testis. Expression in embryonic testis is 30-times lower. Highly expressed in colon, spleen, white blood cells, pancreas, lung, liver, placenta and brain. Detected at lower levels in thymus, small intestine, ovary and kidney.
genes like me logo Genes that share expression patterns with PHF7: view

Protein tissue co-expression partners for PHF7 Gene

Primer Products

In Situ Assay Products

Orthologs for PHF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PHF7 35
  • 89.76 (n)
  • 85.3 (a)
PHF7 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHF7 35
  • 92.65 (n)
  • 91.08 (a)
PHF7 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf7 35
  • 86.38 (n)
  • 84.64 (a)
Phf7 16
Phf7 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PHF7 35
  • 99.48 (n)
  • 99.21 (a)
PHF7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf7 35
  • 84.21 (n)
  • 81.58 (a)
oppossum
(Monodelphis domestica)
Mammalia PHF7 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF7 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750143 35
  • 51.24 (n)
  • 47.06 (a)
-- 36
  • 39 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 38 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002929 35
  • 47.39 (n)
  • 40.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9576 36
  • 20 (a)
ManyToMany
pie 36
  • 18 (a)
ManyToMany
Species with no ortholog for PHF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PHF7 Gene

ENSEMBL:
Gene Tree for PHF7 (if available)
TreeFam:
Gene Tree for PHF7 (if available)

Paralogs for PHF7 Gene

Paralogs for PHF7 Gene

(3) SIMAP similar genes for PHF7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PHF7: view

Variants for PHF7 Gene

Sequence variations from dbSNP and Humsavar for PHF7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035957 A breast cancer sample
rs498778 -- 52,419,877(+) AGAGG(C/T)TTCCA reference, synonymous-codon
rs1088266 -- 52,419,441(+) ttttt(C/T)ttttt intron-variant
rs1088267 -- 52,419,492(+) tggca(C/T)gatct intron-variant
rs2109557 -- 52,414,897(+) AGGCT(A/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF7 Gene

Variant ID Type Subtype PubMed ID
nsv876789 CNV Loss 21882294
nsv834696 CNV Loss 17160897
nsv834697 CNV Loss 17160897
dgv5137n71 CNV Loss 21882294

Variation tolerance for PHF7 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF7 Gene

HapMap Linkage Disequilibrium report
PHF7
Human Gene Mutation Database (HGMD)
PHF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF7 Gene

Disorders for PHF7 Gene

Relevant External Links for PHF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHF7

No disorders were found for PHF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHF7 Gene

Publications for PHF7 Gene

  1. NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis. (PMID: 11829468) Xiao J. … Sha J.H. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for PHF7 Gene

Sources for PHF7 Gene

Back to Top

Content