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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PHF6 Gene

protein-coding GIFtS: 52
GCID: GC0XP133507

PHD finger protein 6

(Previous name: Borjeson-Forssman-Lehmann syndrome )
(Previous symbols: BFLS, BORJ)

Explore 13 diseases affiliated with
PHF6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
PHD Finger Protein 6¹ ²		PHD-Like Zinc Finger Protein² ³
BFLS¹ ² ⁵		MGC14797¹
BORJ¹ ²		Borjeson-Forssman-Lehmann Syndrome¹
CENP-31¹ ²		Centromere Protein 31²
KIAA1823¹ ³

External Ids:	HGNC: 18145¹	Entrez Gene: 84295²	Ensembl: ENSG00000156531⁷	OMIM: 300414⁵	UniProtKB: Q8IWS0³

Export aliases for PHF6 gene to outside databases

Previous GC identifers: GC00U991174 GC0XP130353 GC0XP131452 GC0XP132212 GC0XP133232 GC0XP133334 GC0XP122905

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PHF6:

This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type

zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus.

Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with

Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism,

hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears.

Alternate splicing results in multiple transcript variants, encoding different isoforms. (provided by RefSeq, Jun

2010)

UniProtKB/Swiss-Prot: PHF6_HUMAN, Q8IWS0

Function: May play a role in transcriptional regulation

Gene Wiki entry for PHF6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011786.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PHF6 gene promoter:
AML1a Sp1 FOXD3 HNF-4alpha2 POU3F2 NF-kappaB HNF-4alpha1 Sox9 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PHF6 promoter sequence

Search SABiosciences Chromatin IP Primers for PHF6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3 Ensembl cytogenetic band: Xq26.2 HGNC cytogenetic band: Xq26

PHF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF6 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP133507: view genomic region (about GC identifiers)

Start:	133,507,283 bp from pter	End:	133,562,822 bp from pter
Size:	55,540 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHF6_HUMAN, Q8IWS0 (See protein sequence)

Recommended Name: PHD finger protein 6

Size: 365 amino acids; 41290 Da

Subcellular location: Nucleus. Nucleus, nucleolus. Note=Nuclear, it particularly localizes to the nucleolus

Sequence caution: Sequence=BAB47452.1; Type=Erroneous initiation;

Secondary accessions: D3DTG3 Q5JRC7 Q5JRC8 Q96JK3 Q9BRU0

Alternative splicing: 2 isoforms: Q8IWS0-1 Q8IWS0-2 (No experimental confirmation available. Contains a phosphoserine at position 146)

Explore the universe of human proteins at neXtProt for PHF6: NX_Q8IWS0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWS0

PHF6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001015877.1 NP_115711.2 NP_115834.1

ENSEMBL proteins:

ENSP00000359839 ENSP00000329097 ENSP00000359835 ENSP00000359836 ENSP00000377831

ENSP00000394480

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	Uscn Proteins for PHF6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--

PHF6 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PHF6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PHF6 for domains About GeneDecksing

1 InterPro domain/family:

IPR001965 Znf_PHD

Graphical View of Domain Structure for InterPro Entry Q8IWS0

ProtoNet protein and cluster: Q8IWS0

UniProtKB/Swiss-Prot: PHF6_HUMAN, Q8IWS0

Similarity: Contains 2 PHD-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PHF6_HUMAN, Q8IWS0

Function: May play a role in transcriptional regulation

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

PHF6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PHF6:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PHF6

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PHF6 Browse MicroRNA Expression Plasmids
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		hsa-miR-4291 hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-4328 hsa-miR-106a hsa-miR-199a-3p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: PHF6 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PHF6

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for PHF6 (Q8IWS0³ ENSP00000329097⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106³, ENSP00000367207⁴	I2D: score=1 STRING: ENSP00000367207
LYAR	Q9NX58³, ENSP00000345917⁴	I2D: score=1 STRING: ENSP00000345917
AXIN1	ENSP00000262320⁴	STRING: ENSP00000262320
HDGF	ENSP00000357189⁴	STRING: ENSP00000357189
KNCN	ENSP00000379607⁴	STRING: ENSP00000379607

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

PHF6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PHF6 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PHF6
1 Novoseek chemical compound relationship for PHF6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	30.6	2	15994862 (1), 12415272 (1)

Search CenterWatch for drugs/clinical trials and news about PHF6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PHF6 gene (3 alternative transcripts):

NM_001015877.1 NM_032335.3 NM_032458.2

Unigene Cluster for PHF6:

PHD finger protein 6

Hs.356501 [show with all ESTs]

Unigene Representative Sequence: NM_032458

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370803(uc004exj.3 uc011mvk.2) ENST00000332070(uc004exk.3)

ENST00000370799(uc004exi.3) ENST00000370800(uc004exh.3 uc010nrr.3)

ENST00000394292 ENST00000416404

miRNA Products:		OriGene 3'-UTR Clone (see all 3): PHF6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHF6
		8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate PHF6 (see all 65):
		hsa-miR-4291 hsa-miR-520e hsa-miR-302d hsa-miR-429 hsa-miR-4328 hsa-miR-106a hsa-miR-199a-3p hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: PHF6 3' UTR sequence

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Additional cDNA sequence:

AB058726.1 AK290095.1 AK303369.1 AK303647.1 AY157622.1 BC005994.1

6 DOTS entries:

DT.70104413 DT.100784977 DT.95163967 DT.95340051 DT.100796081 DT.40195494

24/170 AceView cDNA sequences (see all 170):

AA295831 CB163101 NM_032458 BQ268349 AA281329 AI520918 AI651414 AA761743

BG122271 AA714133 AA258886 AI961656 AA035532 BQ771811 CD723980 BM907433

AL600580 BE766296 CD237909 AY157622 BE463652 BX280276 AL600645 AI218919

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PHF6 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12
SP1:									-																		-
SP2:									-																		-
SP3:									-
SP4:
SP5:									-				-

ECgene alternative splicing isoforms for PHF6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PHF6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATGTATAT

About this image

PHF6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Kidney

Lung

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PHF6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PHF6

SOURCE GeneReport for Unigene cluster: Hs.356501

UniProtKB/Swiss-Prot: PHF6_HUMAN, Q8IWS0

Tissue specificity: Ubiquitously expressed

SABiosciences Expression via Pathway-Focused PCR Array including PHF6:

Epigenetic Chromatin Remodeling Factors in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PHF6 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Phf6^{1 , 5}	PHD finger protein 6^{1, 5}	92.49(n)¹ 97.53(a)¹		X (29.28 cM)⁵ 70998¹ NM_027642.1¹ NP_081918.1¹ 52912266⁵
chicken (Gallus gallus)	Aves	PHF6¹	PHD finger protein 6	84.57(n) 89.59(a)		422235 XM_420223.3 XP_420223.2
lizard (Anolis carolinensis)	Reptilia	PHF6⁶	--	87(a)	1 ↔ 1	GL343761.1(209206-215074)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12568²	Xenopus laevis transcribed sequence with weak similarity more	79.11(n)		BX853085.1
zebrafish (Danio rerio)	Actinopterygii	wufa22g03²	wufa22g03	74.36(n)		327070 BC044163.1

ENSEMBL Gene Tree for PHF6 (if available)
TreeFam Gene Tree for PHF6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PHF6 gene

PHF11²

1 SIMAP similar gene for PHF6 using alignment to 4 protein entries: PHF6_HUMAN (see all proteins):

G2E3

PHF6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104894918^1,2	C	pathogenic	133547953(+)	`ACTGCA/GTATAT`	6	H R	mis¹		0	--	--	--	--
rs104894917^1,2	C	pathogenic	133547967(+)	`ATGCCA/GAGAAG`	6	K E	mis¹		0	--	--	--	--
rs104894919^1,2	C	pathogenic	133549085(+)	`CATCAA/GGAGCA`	6	R G	mis¹		0	--	--	--	--
rs111563242^1,2	C	--	133505436(+)	`GATATT/CTCCCT`	3	--	us2k¹		1		NA	1
rs185112895^1,2		--	133505467(+)	`TTCCTC/TTCCAC`	3	--	us2k¹		0	--	--	--	--
rs189925824^1,2		--	133505556(+)	`GGCTGG/TGTCTT`	3	--	us2k¹		0	--	--	--	--
rs12853392^1,2	C,H	--	133505570(+)	`TACTGT/GTGTGT`	3	--	us2k¹ tfbs³		6		NS EA NA	422
rs182607258^1,2		--	133505641(+)	`TGTAAC/TACAGC`	3	--	us2k¹		0	--	--	--	--
rs186840707^1,2		--	133505715(+)	`GCAGGA/GATTGA`	3	--	us2k¹		0	--	--	--	--
rs112112694^1,2	C	--	133505717(+)	`AGGGAC/TTGAGT`	3	--	us2k¹		1		CSA	1

HapMap Linkage Disequilibrium report for PHF6 (133507283 - 133562822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PHF6
1 CNV: 52932
Human Gene Mutation Database (HGMD): PHF6

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHF6

DNA2.0 Custom Variant and Variant Library Synthesis for PHF6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PHF6 for disorders           About GeneDecksing

OMIM gene information: 300414
OMIM disorders: 301900
UniProtKB/Swiss-Prot: PHF6_HUMAN, Q8IWS0

Defects in PHF6 are the cause of Boerjeson-Forssman-Lehmann syndrome (BFLS) [MIM:301900]; also known as

Boerjeson-Forssman syndrome (BORJ). BFLS is a X-linked recessive disorder characterized by moderate to severe mental

retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue

of the face, narrow palpebral fissure and large but not deformed ears

13 diseases for PHF6: About MalaCards

borjeson-forssman-lehmann syndrome mental retardation epilepsy hypogonadism obesity

pituitary hormone deficiency intellectual disability acute lymphoblastic leukemia lymphoblastic leukemia

acute myeloid leukemia gynecomastia myeloid leukemia microcephaly

leukemia

3 diseases from the University of Copenhagen DISEASES database for PHF6:

Borjeson-Forssman-Lehmann syndrome Intellectual disability Gynecomastia

2 Novoseek disease relationships for PHF6 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
borjeson-forssman-lehmann syndrome	98.1	5	15994862 (2), 14756673 (1), 15580208 (1), 12415272 (1)
obesity	41.3	1	17698420 (1)

Export disorders for PHF6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PHF6 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with PHF6)

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Mutations in PHF6 are associated with Boerjeson-Forssman-Lehmann syndrome. (PubMed id 12415272)^{1, 2, 3, 9} Lower K.M....Gecz J. (2002)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
A novel PHF6 mutation results in enhanced exon skipping and mild Borjeson-Forssman-Lehmann syndrome. (PubMed id 15466013)^{1, 3} Vallee D....Picketts D.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
Mutation screening in Borjeson-Forssman-Lehmann syndrome: identification of a novel de novo PHF6 mutation in a female patient. (PubMed id 15994862)^{1, 9} Crawford J....Gecz J. (2006)
The clinical picture of the Borjeson-Forssman-Lehmann syndrome in males and heterozygous females with PHF6 mutations. (PubMed id 14756673)^{1, 9} Turner G....Partington M. (2004)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Somatic mutation of PHF6 gene in T-cell acute lymphobl atic leukemia, acute myelogenous leukemia and hepatocellular carcinoma. (PubMed id 21736506)¹ Yoo N.J....Lee S.H. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84295	HGNC: 18145	AceView: PHF6	Ensembl:ENSG00000156531	euGenes: HUgn84295
ECgene: PHF6	H-InvDB: PHF6

(According to HUGE)
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HUGE: KIAA1823

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PHF6	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PHF6

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Patent Information for PHF6 gene:
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