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Aliases for PHF3 Gene

Aliases for PHF3 Gene

  • PHD Finger Protein 3 2 3 5
  • KIAA0244 4

External Ids for PHF3 Gene

Previous GeneCards Identifiers for PHF3 Gene

  • GC06P064338
  • GC06P064353
  • GC06P064403
  • GC06P061536

Summaries for PHF3 Gene

Entrez Gene Summary for PHF3 Gene

  • This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for PHF3 Gene

PHF3 (PHD Finger Protein 3) is a Protein Coding gene. Diseases associated with PHF3 include Alcohol Dependence. An important paralog of this gene is DIDO1.

Gene Wiki entry for PHF3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF3 Gene

Genomics for PHF3 Gene

Regulatory Elements for PHF3 Gene

Enhancers for PHF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F063569 1.2 ENCODE 27.4 -62.7 -62663 7.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 PHF3 LGSN ENSG00000236345 ENSG00000266680 GC06M063587
GH06F063676 1.3 FANTOM5 Ensembl ENCODE 14.6 +41.4 41350 1.5 SOX13 TFAP4 SAP130 ZNF384 CEBPG RAD21 HBP1 YY1 SLC30A9 HNF4G PHF3 GC06M063647 GC06P063737
GH06F063634 1.1 ENCODE 16.9 +0.7 730 3.8 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PHF3 GC06M063647
GH06F063352 1.6 FANTOM5 Ensembl ENCODE 11.1 -282.9 -282899 1.8 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B ZNF48 YY1 ZNF143 ZNF207 FOS PHF3 ENSG00000236345 LGSN GC06M063389 GC06M063390 GC06M063391 GC06M063310
GH06F063597 1.3 Ensembl ENCODE 12.1 -37.2 -37239 1.5 HDGF CREB3L1 ARID4B ZNF48 ZNF2 YY1 ZNF207 ZNF143 MXD4 REST PHF3 ENSG00000236345 GC06M063595 GC06M063602
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PHF3 on UCSC Golden Path with GeneCards custom track

Promoters for PHF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001219618 798 2801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for PHF3 Gene

Chromosome:
6
Start:
63,635,802 bp from pter
End:
63,779,336 bp from pter
Size:
143,535 bases
Orientation:
Plus strand

Genomic View for PHF3 Gene

Genes around PHF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF3 Gene

Proteins for PHF3 Gene

  • Protein details for PHF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92576-PHF3_HUMAN
    Recommended name:
    PHD finger protein 3
    Protein Accession:
    Q92576
    Secondary Accessions:
    • A3KFI8
    • Q14CR5
    • Q5CZI1
    • Q5T1T6
    • Q9NQ16
    • Q9UI45

    Protein attributes for PHF3 Gene

    Size:
    2039 amino acids
    Molecular mass:
    229481 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13438.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHF3 Gene

    Alternative splice isoforms for PHF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF3 Gene

Post-translational modifications for PHF3 Gene

  • Ubiquitination at Lys 964 and Lys 1220
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHF3 Gene

Domains & Families for PHF3 Gene

Gene Families for PHF3 Gene

Suggested Antigen Peptide Sequences for PHF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q92576

UniProtKB/Swiss-Prot:

PHF3_HUMAN :
  • Contains 1 TFIIS central domain.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 1 TFIIS central domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PHF3: view

Function for PHF3 Gene

Gene Ontology (GO) - Molecular Function for PHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHF3: view
genes like me logo Genes that share phenotypes with PHF3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHF3 Gene

Localization for PHF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHF3 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for PHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PHF3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHF3 Gene

Pathways & Interactions for PHF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organism development NAS 11856869
genes like me logo Genes that share ontologies with PHF3: view

No data available for Pathways by source and SIGNOR curated interactions for PHF3 Gene

Transcripts for PHF3 Gene

Unigene Clusters for PHF3 Gene

PHD finger protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
SP1: - - - - -
SP2:
SP3: -
SP4: -
SP5:
SP6: - - - -
SP7:
SP8:
SP9: - -
SP10: - -
SP11: - - - - - -
SP12:
SP13: - - - - - - - -
SP14:

ExUns: 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PHF3 Gene

GeneLoc Exon Structure for
PHF3
ECgene alternative splicing isoforms for
PHF3

Expression for PHF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PHF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHF3 Gene

This gene is overexpressed in Blymphocyte (15.1), CD8 Tcells (9.4), Peripheral blood mononuclear cells (8.9), and Liver (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHF3 Gene



Protein tissue co-expression partners for PHF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHF3 Gene:

PHF3

SOURCE GeneReport for Unigene cluster for PHF3 Gene:

Hs.348921

mRNA Expression by UniProt/SwissProt for PHF3 Gene:

Q92576-PHF3_HUMAN
Tissue specificity: Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.
genes like me logo Genes that share expression patterns with PHF3: view

Primer Products

No data available for mRNA differential expression in normal tissues for PHF3 Gene

Orthologs for PHF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF3 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia PHF3 34 35
  • 91.38 (n)
cow
(Bos Taurus)
Mammalia PHF3 34 35
  • 87.69 (n)
rat
(Rattus norvegicus)
Mammalia Phf3 34
  • 83.19 (n)
mouse
(Mus musculus)
Mammalia Phf3 34 16 35
  • 83.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PHF3 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF3 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHF3 34 35
  • 68.54 (n)
lizard
(Anolis carolinensis)
Reptilia PHF3 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phf3 34
  • 59.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30130 34
zebrafish
(Danio rerio)
Actinopterygii phf3 35
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pps 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for PHF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF3 Gene

ENSEMBL:
Gene Tree for PHF3 (if available)
TreeFam:
Gene Tree for PHF3 (if available)

Paralogs for PHF3 Gene

Paralogs for PHF3 Gene

(3) SIMAP similar genes for PHF3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PHF3: view

Variants for PHF3 Gene

Sequence variations from dbSNP and Humsavar for PHF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1045943 -- 63,714,895(+) TGAAA(A/C)CTATT utr-variant-3-prime
rs10485358 -- 63,676,159(-) CTTAA(A/G)CCTTG intron-variant
rs1050512 -- 63,714,281(+) ATTAC(C/T)ATATA utr-variant-3-prime
rs10645572 -- 63,649,079(+) AAATC(-/TTAT)TTATT intron-variant
rs10651586 -- 63,637,637(+) TTCCT(-/TCA)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF3 Gene

Variant ID Type Subtype PubMed ID
esv3429676 CNV insertion 20981092
nsv1146820 CNV insertion 26484159
nsv830674 CNV gain+loss 17160897

Variation tolerance for PHF3 Gene

Residual Variation Intolerance Score: 0.512% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.45; 71.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF3 Gene

Human Gene Mutation Database (HGMD)
PHF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF3 Gene

Disorders for PHF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PHF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alcohol dependence
  • alcohol dependence, protection against
- elite association - COSMIC cancer census association via MalaCards
Search PHF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PHF3

Genetic Association Database (GAD)
PHF3
Human Genome Epidemiology (HuGE) Navigator
PHF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHF3
genes like me logo Genes that share disorders with PHF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHF3 Gene

Publications for PHF3 Gene

  1. PHF3 expression is frequently reduced in glioma. (PMID: 11856869) Fischer U. … Meese E. (Cytogenet. Cell Genet. 2001) 2 3 4 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64

Products for PHF3 Gene

Sources for PHF3 Gene

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