Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHF3 Gene

protein-coding   GIFtS: 56
GCID: GC06P064403

PHD Finger Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
PHD Finger Protein 31 2
KIAA02443 5

External Ids:    HGNC: 89211   Entrez Gene: 234692   Ensembl: ENSG000001184827   OMIM: 6077895   UniProtKB: Q925763   

Export aliases for PHF3 gene to outside databases

Previous GC identifers: GC06P064338 GC06P064353 GC06P061536


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PHF3 Gene: 
PHF3 (PHD finger protein 3) is a protein-coding gene. Diseases associated with PHF3 include anaplastic astrocytoma, and astrocytoma. GO annotations related to this gene include molecular_function and zinc ion binding. An important paralog of this gene is DIDO1.

Gene Wiki entry for PHF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007299.13  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHF3 gene promoter:
         XBP-1   Nkx2-5   Evi-1   HNF-1A   GATA-2   Egr-2   Max   GATA-6   HNF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12   Ensembl cytogenetic band:  6q12   HGNC cytogenetic band: 6q12

PHF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P064403:  view genomic region     (about GC identifiers)

Start:
64,345,725 bp from pter      End:
64,489,229 bp from pter
Size:
143,505 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576 (See protein sequence)
Recommended Name: PHD finger protein 3  
Size: 2039 amino acids; 229481 Da
Sequence caution: Sequence=BAA13438.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PHF3:
2DME (3D)    
Secondary accessions: A3KFI8 Q14CR5 Q5CZI1 Q5T1T6 Q9NQ16 Q9UI45
Alternative splicing: 2 isoforms:  Q92576-1   Q92576-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHF3: NX_Q92576

Explore proteomics data for PHF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92576

  • PHF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PHF3 Protein Expression
    REFSEQ proteins: NP_055968.1  
    ENSEMBL proteins: 
     ENSP00000424694   ENSP00000425227   ENSP00000425338   ENSP00000424078   ENSP00000262043  
     ENSP00000424994   ENSP00000422841   ENSP00000424197   ENSP00000421417   ENSP00000377048  

    Human Recombinant Protein Products for PHF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PHF3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PHF3
    GenScript Custom Purified and Recombinant Proteins Services for PHF3
    Novus Biologicals PHF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHF3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    PHF3 for ontologies           About GeneDecksing



    PHF3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PHF3
    GenScript Custom Superior Antibodies Services for PHF3
    Novus Biologicals PHF3 Antibodies
    Abcam antibodies for PHF3
    Cloud-Clone Corp. Antibodies for PHF3 
    Search ThermoFisher Antibodies for PHF3
    LSBio Antibodies in human, mouse, rat for PHF3 

    Assay Products for PHF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHF3 
    Cloud-Clone Corp. CLIAs for PHF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5/8 InterPro protein domains (see all 8):
     IPR001965 Znf_PHD
     IPR003618 TFIIS_cen_dom
     IPR012921 SPOC_C
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q92576

    ProtoNet protein and cluster: Q92576

    2 Blocks protein domains:
    IPB001965 Zn-finger-like
    IPB012921 SPOC


    UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 TFIIS central domain


    PHF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    PHF3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PHF3:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PHF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PHF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHF3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHF3
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PHF3 (see all 35):
    hsa-miR-188-5p hsa-miR-25 hsa-miR-301a hsa-miR-374a* hsa-miR-130b hsa-miR-92b hsa-miR-301b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidPHF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PHF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHF3
    Sirion Biotech Customized adenovirus for overexpression of PHF3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PHF3 (see all 5)
    OriGene ORF clones in mouse, rat for PHF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHF3 (NM_015153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHF3
    Search LifeMap BioReagents cell lines for PHF3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHF3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for PHF3 (Q925763 ENSP000002620434) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHBP352323, ENSP000003004084I2D: score=1 STRING: ENSP00000300408
    YWHAGP619813I2D: score=2 
    NR3C1P041503I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    YWHAZP631043I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development NAS11856869

    PHF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHF3

    Search CenterWatch for drugs/clinical trials and news about PHF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHF3 gene: 
    NM_015153.2  

    Unigene Cluster for PHF3:

    PHD finger protein 3
    Hs.348921  [show with all ESTs]
    Unigene Representative Sequence: BX648268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506783 ENST00000481385 ENST00000515594 ENST00000494284 ENST00000262043(uc010kaf.1 uc003pem.2 uc010kag.1 uc010kah.1 uc003pen.2 uc011dxs.1)
    ENST00000509876 ENST00000509330(uc003peo.3) ENST00000514822 ENST00000503248
    ENST00000505138 ENST00000420043 ENST00000393387(uc003pep.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHF3
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PHF3 (see all 35):
    hsa-miR-188-5p hsa-miR-25 hsa-miR-301a hsa-miR-374a* hsa-miR-130b hsa-miR-92b hsa-miR-301b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidPHF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PHF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHF3
    Clone
    Products:
         
    OriGene clones in human, mouse for PHF3 (see all 5)
    OriGene ORF clones in mouse, rat for PHF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHF3 (NM_015153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF3

    Additional mRNA sequence: 

    AF091622.1 AK025283.1 AK026492.1 AK055678.1 AK290491.1 AK298580.1 AK307869.1 AK315868.1 
    BC040583.1 BC113650.1 BC113652.1 BX648268.1 D87685.2 

    12 DOTS entries:

    DT.117158  DT.100784957  DT.101963068  DT.91769861  DT.100642944  DT.91769857  DT.100784955  DT.100039392 
    DT.100803122  DT.121382455  DT.40110212  DT.95330598 

    24/221 AceView cDNA sequences (see all 221):

    AA677675 BQ006841 BP363344 AA262208 D87685 BE348440 AF091622 BQ786756 
    BU618450 AI750009 BQ008111 AI760480 CD678713 C01480 BQ641710 BP368338 
    BM722967 BX090778 BM669675 AU124429 AW058298 NM_015153 AL045291 BF515631 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PHF3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:              -     -           -     -     -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                -                           
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PHF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHF3 expression in normal human tissues (normalized intensities)      PHF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PHF3 Expression
    About this image


    PHF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Hypothalamus
             brain/midbrain   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow cd34+   
     
     Cartilage (Muscoskeletal System)
             fetal cartilage   
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Breast (Uncategorized)
             breast lobular cells   

    See PHF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHF3

    SOURCE GeneReport for Unigene cluster: Hs.348921

    UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576
    Tissue specificity: Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell
    lines, anaplastic astrocytomas, and astrocytomas

        SABiosciences Expression via Pathway-Focused PCR Array including PHF3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHF3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PHF3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf31 , 5 PHD finger protein 31, 5 83.08(n)1
    79.57(a)1
      1 (11.45 cM)5
    2131091  NM_001081080.11  NP_001074549.11 
     308023425 
    chicken
    (Gallus gallus)
    Aves PHF31 PHD finger protein 3 68.57(n)
    63.11(a)
      428641  XM_426199.2  XP_426199.2 
    lizard
    (Anolis carolinensis)
    Reptilia PHF36
    Uncharacterized protein
    52(a)
    1 ↔ 1
    GL343266.1(322958-367707)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.301302 Xenopus laevis transcribed sequence with weak similarity more 80(n)    48021752 
    zebrafish
    (Danio rerio)
    Actinopterygii BI979202.12   -- 75.85(n)    BI979202.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pps6
    protein partner of snf
    10(a)
    1 → many
    3R(8239550-8246973)


    ENSEMBL Gene Tree for PHF3 (if available)
    TreeFam Gene Tree for PHF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHF3 gene
    DIDO12  SPOCD12  
    3 SIMAP similar genes for PHF3 using alignment to 9 protein entries:     PHF3_HUMAN (see all proteins):
    TCEA2    PHF8    SPOCD1

    PHF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1419 SNPs in PHF3 are shown (see all 1419)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913037051,2
    --64354622(+) TTTTTA/TTAAAA 1 -- us2k10--------
    rs790497651,2
    F--64354623(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1836199881,2
    --64354624(+) TTTTTA/TAAAAA 1 -- us2k10--------
    rs1894903231,2
    --64354625(+) TTTTAA/TAAAAA 1 -- us2k10--------
    rs1163735291,2
    F--64354662(+) AAAAAT/CGAACA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1930677361,2
    --64354672(+) AGATTC/TGTGAA 1 -- us2k10--------
    rs754703171,2
    F--64354727(+) GGTATG/CCACCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1853884281,2
    --64354741(+) CTTTTC/GCAGTT 1 -- us2k10--------
    rs567136541,2
    C--64354793(+) TTGGA-/TTTTTT 1 -- us2k10--------
    rs1161616011,2
    F--64354803(+) TTTTTT/GTTTTT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for PHF3 (64345725 - 64489229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PHF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830674CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): PHF3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PHF3
    DNA2.0 Custom Variant and Variant Library Synthesis for PHF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607789    OMIM disorders: --

    5 diseases for PHF3:    About MalaCards
    anaplastic astrocytoma    astrocytoma    alcohol dependence    glioblastoma
    alcoholism

    1 disease from the University of Copenhagen DISEASES database for PHF3:
    Alcohol dependence

    PHF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PHF3
    Human Genome Epidemiology (HuGE) Navigator: PHF3 (1 document)

    Export disorders for PHF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHF3 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with PHF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHF3 expression is frequently reduced in glioma. (PubMed id 11856869)1, 2, 3, 9 Fischer U.... Meese E. (2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    7. PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme. (PubMed id 11464277)1, 9 Struss A.K....Meese E. (2001)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23469 HGNC: 8921 AceView: PHF3 Ensembl:ENSG00000118482 euGenes: HUgn23469
    ECgene: PHF3 H-InvDB: PHF3

    (According to HUGE)
    About This Section
    HUGE: KIAA0244

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHF3 gene:
    Search GeneIP for patents involving PHF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PHF3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PHF3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PHF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for PHF3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PHF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHF3   OriGene Custom Protein Services for PHF3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PHF3
     QIAGEN SeqTarget long-range PCR primers for resequencing PHF3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHF3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF3
     GenScript Custom Purified and Recombinant Proteins Services for PHF3 GenScript cDNA clones with any tag delivered in your preferred vector for PHF3
     GenScript Custom Assay Services for PHF3 GenScript Custom Superior Antibodies Services for PHF3
     GenScript Custom overexpressing Cell Line Services for PHF3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PHF3 promoter
     Search Chromatin IP Primers for PHF3
     RT2 qPCR Primer Assay in human, mouse, rat PHF3
     Search GNC Networks for PHF3
     SABiosciences PCR Arrays including human, mouse, rat PHF3
     Search Tocris compounds for PHF3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PHF3 antibodies
     PHF3 lysates
     Antibodies for PHF3
     See all of Abcam's Antibodies, Kits and Proteins for PHF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PHF3
     Antibodies for PHF3
     ELISAs for PHF3
     CLIAs for PHF3
     Search LifeMap BioReagents cell lines for PHF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3
     SwitchGear 3'UTR luciferase reporter plasmids for PHF3
     SwitchGear Promoter luciferase reporter plasmids for PHF3
     Search ThermoFisher Antibodies for PHF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PHF3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PHF3
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of PHF3
     LSBio Antibodies in human, mouse, rat for PHF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHF3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4