Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHF3 Gene

protein-coding   GIFtS: 52
GCID: GC06P064403

PHD finger protein 3

 Explore 3 diseases affiliated with
PHF3 via our new
 Human Malady Compendium 
Biological research products
for PHF3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
PHD Finger Protein 31 2
KIAA02443 5

External Ids:    HGNC: 89211   Entrez Gene: 234692   Ensembl: ENSG000001184827   OMIM: 6077895   UniProtKB: Q925763   

Export aliases for PHF3 gene to outside databases

Previous GC identifers: GC06P064338 GC06P064353 GC06P061536


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for PHF3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHF3 gene promoter:
         XBP-1   Nkx2-5   Evi-1   HNF-1A   GATA-2   Egr-2   Max   GATA-6   HNF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12   Ensembl cytogenetic band:  6q12   HGNC chromosome: 6

PHF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P064403:  view genomic region     (about GC identifiers)

Start:
64,345,725 bp from pter      End:
64,489,229 bp from pter
Size:
143,505 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576 (See protein sequence)
Recommended Name: PHD finger protein 3  
Size: 2039 amino acids; 229481 Da
Sequence caution: Sequence=BAA13438.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PHF3:
2DME (3D)    
Secondary accessions: A3KFI8 Q14CR5 Q5CZI1 Q5T1T6 Q9NQ16 Q9UI45
Alternative splicing: 2 isoforms:  Q92576-1   Q92576-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHF3: NX_Q92576

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92576

  • PHF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055968.1  
    ENSEMBL proteins: 
     ENSP00000424694   ENSP00000425227   ENSP00000425338   ENSP00000424078   ENSP00000262043  
     ENSP00000424994   ENSP00000422841   ENSP00000424197   ENSP00000421417   ENSP00000377048  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PHF3
    OriGene Custom Protein Services for PHF3 
    GenScript Custom Purified and Recombinant Proteins Services for PHF3
    Novus Biologicals PHF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PHF3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--


    PHF3 for ontologies           About GeneDecksing



    PHF3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PHF3 
    GenScript Custom Superior Antibodies Services for PHF3
    Novus Biologicals PHF3 Antibodies
    Search for Antibodies for PHF3 at Abcam  
    Uscn Antibodies for PHF3
    Search ThermoFisher Antibodies for PHF3

    Assay Products for PHF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHF3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PHF3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PHF3 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001965 Znf_PHD
     IPR003618 TFIIS_cen_dom
     IPR012921 SPOC_C
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q92576

    ProtoNet protein and cluster: Q92576

    2 Blocks protein families:
    IPB001965 Zn-finger-like
    IPB012921 SPOC


    UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 TFIIS central domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PHF3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHF3
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PHF3 (see all 35):
    hsa-miR-188-5p hsa-miR-25 hsa-miR-301a hsa-miR-374a* hsa-miR-130b hsa-miR-92b hsa-miR-301b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidPHF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHF3 (see all 7)
    OriGene shRNA RFP: PHF3
    OriGene siRNA: PHF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHF3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHF3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHF3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PHF3 (NM_015153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHF3
    Search LifeMap BioReagents cell lines for PHF3

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008270zinc ion binding IEA--


    PHF3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PHF3:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHF3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/6 Interacting proteins for PHF3 (Q925763 ENSP000002620434) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHBP352323, ENSP000003004084I2D: score=1 STRING: ENSP00000300408
    YWHAGP619813I2D: score=2 
    NR3C1P041503I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    YWHAZP631043I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development NAS11856869


    PHF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHF3
    Search CenterWatch for drugs/clinical trials and news about PHF3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHF3 gene: 
    NM_015153.2  

    Unigene Cluster for PHF3:

    PHD finger protein 3
    Hs.348921  [show with all ESTs]
    Unigene Representative Sequence: BX648268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506783 ENST00000481385 ENST00000515594 ENST00000494284 ENST00000262043(uc010kaf.1 uc003pem.2 uc010kag.1 uc010kah.1 uc003pen.2 uc011dxs.1)
    ENST00000509876 ENST00000509330(uc003peo.3) ENST00000514822 ENST00000503248
    ENST00000505138 ENST00000420043 ENST00000393387(uc003pep.1)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PHF3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHF3
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate PHF3 (see all 35):
    hsa-miR-188-5p hsa-miR-25 hsa-miR-301a hsa-miR-374a* hsa-miR-130b hsa-miR-92b hsa-miR-301b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidPHF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHF3 (see all 7)
    OriGene shRNA RFP: PHF3
    OriGene siRNA: PHF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHF3
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHF3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHF3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PHF3 (NM_015153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHF3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF3

    Additional cDNA sequence: 

    AF091622.1 AK025283.1 AK026492.1 AK055678.1 AK290491.1 AK298580.1 AK307869.1 AK315868.1 
    BC040583.1 BC113650.1 BC113652.1 BX648268.1 D87685.2 

    12 DOTS entries:

    DT.117158  DT.100784957  DT.101963068  DT.91769861  DT.100642944  DT.91769857  DT.100784955  DT.100039392 
    DT.100803122  DT.121382455  DT.40110212  DT.95330598 

    24/221 AceView cDNA sequences (see all 221):

    BM669675 BX952365 BQ025398 BE348440 BU902331 BX474566 AA214597 BX648268 
    BP368338 AI750009 D60643 BM698892 BQ229564 AL045291 BM722967 BQ006841 
    AL700412 AI760480 CD105330 AU140645 D87685 AI075779 BP363344 BU629343 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PHF3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:              -     -           -     -     -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                -                           
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PHF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    PHF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PHF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHF3

    SOURCE GeneReport for Unigene cluster: Hs.348921

    UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576
    Tissue specificity: Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines,
    anaplastic astrocytomas, and astrocytomas

        SABiosciences Expression via Pathway-Focused PCR Array including PHF3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHF3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHF3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PHF3 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PHF31 PHD finger protein 3 68.57(n)
    63.11(a)
      428641  XM_426199.2  XP_426199.2 
    lizard
    (Anolis carolinensis)
    Reptilia PHF36
    --
    48(a)
    1 ↔ 1
    GL343266.1(322981-367707)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.301302 Xenopus laevis transcribed sequence with weak similarity more 80(n)    48021752 
    zebrafish
    (Danio rerio)
    Actinopterygii BI979202.12   -- 75.85(n)    BI979202.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pps6
    protein partner of snf
    12(a)
    possible ortholog
    3R(8239550-8246973)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G255206
    AT2G256406
    (see all 4)
    SPOC dand transcription elongation factor S-II dom...
    SPOC domain / Transcription elongation factor S-II...
    (see all 4)
    14(a)
    14(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    5(8885088-8889620)
    2(10910498-10913969)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    transcription factor S-II, central domain containi...
    SPOC domain containing protein, putative, expresse...
    (see all 3)
    13(a)
    12(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(6083116-6089638)
    6(23441842-23448456)


    ENSEMBL Gene Tree for PHF3 (if available)
    TreeFam Gene Tree for PHF3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHF3 gene
    DIDO12  SPOCD12  
    3 SIMAP similar genes for PHF3 using alignment to 9 protein entries:     PHF3_HUMAN (see all proteins):
    TCEA2    PHF8    SPOCD1

    PHF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1133 NCBI SNPs in PHF3 are shown (see all 1133    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913037051,2
    --64354622(+) TTTTTA/TTAAAA 1 -- us2k10--------
    rs790497651,2
    F,--64354623(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1836199881,2
    --64354624(+) TTTTTA/TAAAAA 1 -- us2k10--------
    rs1894903231,2
    --64354625(+) TTTTAA/TAAAAA 1 -- us2k10--------
    rs1163735291,2
    F,--64354662(+) AAAAAT/CGAACA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1930677361,2
    --64354672(+) AGATTC/TGTGAA 1 -- us2k10--------
    rs754703171,2
    F,--64354727(+) GGTATG/CCACCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1853884281,2
    --64354741(+) CTTTTC/GCAGTT 1 -- us2k10--------
    rs567136541,2
    C--64354793(+) TTGGA-/TTTTTT 1 -- us2k10--------
    rs1161616011,2
    F,--64354803(+) TTTTTT/GTTTTT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for PHF3 (64345725 - 64489229 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PHF3: --
    Human Gene Mutation Database (HGMD): PHF3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHF3
    DNA2.0 Custom Variant and Variant Library Synthesis for PHF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PHF3 for disorders           About GeneDecksing

    OMIM gene information: 607789    OMIM disorders: --

    3 diseases for PHF3:    About MalaCards
    anaplastic astrocytoma    astrocytoma    glioblastoma

    Human Genome Epidemiology (HuGE) Navigator: PHF3 (1 document)

    Export disorders for PHF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHF3 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with PHF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHF3 expression is frequently reduced in glioma. (PubMed id 11856869)1, 2, 3, 9 Fischer U.... Meese E. (2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    7. PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme. (PubMed id 11464277)1, 9 Struss A.K....Meese E. (2001)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23469 HGNC: 8921 AceView: PHF3 Ensembl:ENSG00000118482 euGenes: HUgn23469
    ECgene: PHF3 H-InvDB: PHF3

    (According to HUGE)
    About This Section
    HUGE: KIAA0244

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHF3 gene:
    Search GeneIP for patents involving PHF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PHF3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHF3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHF3  
     OriGene Protein Over-expression Lysate for PHF3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PHF3   OriGene 3'-UTR Clone for PHF3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHF3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHF3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHF3   OriGene Custom Protein Services for PHF3  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PHF3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHF3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHF3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF3
     GenScript Custom Purified and Recombinant Proteins Services for PHF3 GenScript cDNA clones with any tag delivered in your preferred vector for PHF3
     GenScript Custom Assay Services for PHF3 GenScript Custom Superior Antibodies Services for PHF3
     GenScript Custom overexpressing Cell Line Services for PHF3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PHF3 promoter
     Search Chromatin IP Primers for PHF3
     RT2 qPCR Primer Assay in human, mouse, rat PHF3
     Search GNC Networks for PHF3
     SABiosciences PCR Arrays including human, mouse, rat PHF3
     Search Tocris compounds for PHF3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PHF3 antibodies
     PHF3 lysates
     Search for Antibodies for PHF3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for PHF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PHF3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PHF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3
     SwitchGear 3'UTR luciferase reporter plasmids for PHF3
     SwitchGear Promoter luciferase reporter plasmids for PHF3
     Search ThermoFisher Antibodies for PHF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHF3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4