Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PHF3 Gene

protein-coding   GIFtS: 57
GCID: GC06P064403

PHD Finger Protein 3

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
PHD Finger Protein 31 2
KIAA02443 5

External Ids:    HGNC: 89211   Entrez Gene: 234692   Ensembl: ENSG000001184827   OMIM: 6077895   UniProtKB: Q925763   

Export aliases for PHF3 gene to outside databases

Previous GC identifers: GC06P064338 GC06P064353 GC06P061536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PHF3 Gene:
This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription
factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for PHF3 Gene:
PHF3 (PHD finger protein 3) is a protein-coding gene. An important paralog of this gene is DIDO1.

Gene Wiki entry for PHF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHF3 gene promoter:
         XBP-1   Nkx2-5   Evi-1   HNF-1A   GATA-2   Egr-2   Max   GATA-6   HNF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHF3 promoter sequence
   Search Chromatin IP Primers for PHF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12   Ensembl cytogenetic band:  6q12   HGNC cytogenetic band: 6q12

PHF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P064403:  view genomic region     (about GC identifiers)

Start:
64,345,725 bp from pter      End:
64,489,229 bp from pter
Size:
143,505 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576 (See protein sequence)
Recommended Name: PHD finger protein 3  
Size: 2039 amino acids; 229481 Da
Sequence caution: Sequence=BAA13438.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PHF3:
2DME (3D)    
Secondary accessions: A3KFI8 Q14CR5 Q5CZI1 Q5T1T6 Q9NQ16 Q9UI45
Alternative splicing: 2 isoforms:  Q92576-1   Q92576-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHF3: NX_Q92576

Explore proteomics data for PHF3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys964, Lys1220
  • Modification sites at PhosphoSitePlus

  • See PHF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001277188.1  NP_001277189.1  NP_055968.1  

    ENSEMBL proteins: 
     ENSP00000424694   ENSP00000425227   ENSP00000425338   ENSP00000424078   ENSP00000262043  
     ENSP00000424994   ENSP00000422841   ENSP00000424197   ENSP00000421417   ENSP00000377048  

    PHF3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PHF3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHF3
    GenScript Custom Purified and Recombinant Proteins Services for PHF3
    Novus Biologicals PHF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHF3

     
    Search eBioscience for Proteins for PHF3 

    PHF3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PHF3
    OriGene Custom Antibody Services for PHF3
    Novus Biologicals PHF3 Antibodies
    Abcam antibodies for PHF3
    Cloud-Clone Corp. Antibodies for PHF3
    Search ThermoFisher Antibodies for PHF3
    LSBio Antibodies in human, mouse, rat for PHF3

    PHF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHF3
    Cloud-Clone Corp. CLIAs for PHF3
    Search eBioscience for ELISAs for PHF3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR001965 Znf_PHD
     IPR003618 TFIIS_cen_dom
     IPR012921 SPOC_C
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q92576

    ProtoNet protein and cluster: Q92576

    2 Blocks protein domains:
    IPB001965 Zn-finger-like
    IPB012921 SPOC


    UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 TFIIS central domain


    Find genes that share domains with PHF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with PHF3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PHF3:
     Decreased p24 protein expressi  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHF3:
    hsa-mir-101-3p (MIRT027369), hsa-mir-375 (MIRT019971), hsa-let-7e-5p (MIRT051438), hsa-mir-130b-3p (MIRT020337)

    Block miRNA regulation of human, mouse, rat PHF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHF3 (see all 35):
    hsa-miR-188-5p hsa-miR-25 hsa-miR-301a hsa-miR-374a* hsa-miR-130b hsa-miR-92b hsa-miR-301b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidPHF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHF3
    Predesigned siRNA for gene silencing in human, mouse, rat PHF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHF3

    Clone
    Products:
         
    OriGene clones in human, mouse for PHF3 (see all 5)
    OriGene ORF clones in mouse, rat for PHF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHF3 (NM_015153)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHF3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    Find genes that share ontologies with PHF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including PHF3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PHF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for PHF3 (Q925763 ENSP000002620434) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHBP352323, ENSP000003004084I2D: score=1 STRING: ENSP00000300408
    YWHAGP619813I2D: score=2 
    NR3C1P041503I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    YWHAZP631043I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0007275multicellular organismal development NAS11856869

    Find genes that share ontologies with PHF3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PHF3 gene (3 alternative transcripts): 
    NM_001290259.1  NM_001290260.1  NM_015153.3  

    Unigene Cluster for PHF3:

    PHD finger protein 3
    Hs.348921  [show with all ESTs]
    Unigene Representative Sequence: BX648268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506783 ENST00000481385 ENST00000515594 ENST00000494284 ENST00000262043(uc010kaf.1 uc003pem.2 uc010kag.1 uc010kah.1 uc003pen.2 uc011dxs.1)
    ENST00000509876 ENST00000509330(uc003peo.3) ENST00000514822 ENST00000503248
    ENST00000505138 ENST00000420043 ENST00000393387(uc003pep.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHF3 (see all 35):
    hsa-miR-188-5p hsa-miR-25 hsa-miR-301a hsa-miR-374a* hsa-miR-130b hsa-miR-92b hsa-miR-301b hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidPHF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHF3
    Predesigned siRNA for gene silencing in human, mouse, rat PHF3
    Clone
    Products:
         
    OriGene clones in human, mouse for PHF3 (see all 5)
    OriGene ORF clones in mouse, rat for PHF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHF3 (NM_015153)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHF3
      QuantiTect SYBR Green Assays in human, mouse, rat PHF3
      QuantiFast Probe-based Assays in human, mouse, rat PHF3

    Additional mRNA sequence: 

    AF091622.1 AK025283.1 AK026492.1 AK055678.1 AK290491.1 AK298580.1 AK307869.1 AK315868.1 
    BC040583.1 BC113650.1 BC113652.1 BX648268.1 D87685.2 

    12 DOTS entries:

    DT.117158  DT.100784957  DT.101963068  DT.91769861  DT.100642944  DT.91769857  DT.100784955  DT.100039392 
    DT.100803122  DT.121382455  DT.40110212  DT.95330598 

    Selected AceView cDNA sequences (see all 221):

    BQ002812 BM722967 Z45576 AF091622 H06856 BM677428 BE502884 CD105330 
    AW513893 D60643 AI750009 BM543225 AW173458 BQ786756 BX090778 AW058298 
    BQ008111 AA214597 BX952365 AL045291 C01480 AI075779 AA767622 AA677675 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PHF3 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
    SP1:              -     -           -     -     -                                                                                                               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                -                           
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for PHF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PHF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PHF3 Expression
    About this image


    PHF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    PHF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348921

    UniProtKB/Swiss-Prot: PHF3_HUMAN, Q92576
    Tissue specificity: Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell
    lines, anaplastic astrocytomas, and astrocytomas

        Pathway & Disease-focused RT2 Profiler PCR Array including PHF3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHF3
    QuantiTect SYBR Green Assays in human, mouse, rat PHF3
    QuantiFast Probe-based Assays in human, mouse, rat PHF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PHF3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf31 , 5 PHD finger protein 31, 5 83.05(n)1
    79.62(a)1
      1 (11.45 cM)5
    2131091  NM_001081080.11  NP_001074549.11 
     308023425 
    chicken
    (Gallus gallus)
    Aves PHF31 PHD finger protein 3 68.54(n)
    62.96(a)
      428641  XM_426199.3  XP_426199.3 
    lizard
    (Anolis carolinensis)
    Reptilia PHF36
    PHD finger protein 3
    49(a)
    1 ↔ 1
    GL343266.1(322958-367707)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.301302 Xenopus laevis transcribed sequence with weak similarity more 80(n)    48021752 
    zebrafish
    (Danio rerio)
    Actinopterygii BI979202.12   -- 75.85(n)    BI979202.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pps6
    protein partner of snf
    10(a)
    1 → many
    3R(8239550-8246973)


    ENSEMBL Gene Tree for PHF3 (if available)
    TreeFam Gene Tree for PHF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PHF3 gene
    DIDO12  SPOCD12  
    3 SIMAP similar genes for PHF3 using alignment to 9 protein entries:     PHF3_HUMAN (see all proteins):
    TCEA2    PHF8    SPOCD1

    Find genes that share paralogs with PHF3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PHF3 (see all 1419)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913037051,2
    --64354622(+) TTTTTA/TTAAAA 1 -- us2k10--------
    rs790497651,2
    F--64354623(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.14WA 118
    rs1836199881,2
    --64354624(+) TTTTTA/TAAAAA 1 -- us2k10--------
    rs1894903231,2
    --64354625(+) TTTTAA/TAAAAA 1 -- us2k10--------
    rs1163735291,2
    F--64354662(+) AAAAAT/CGAACA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1930677361,2
    --64354672(+) AGATTC/TGTGAA 1 -- us2k10--------
    rs754703171,2
    F--64354727(+) GGTATG/CCACCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1853884281,2
    --64354741(+) CTTTTC/GCAGTT 1 -- us2k10--------
    rs567136541,2
    C--64354793(+) TTGGA-/TTTTTT 1 -- us2k10--------
    rs1161616011,2
    F--64354803(+) TTTTTT/GTTTTT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for PHF3 (64345725 - 64489229 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PHF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830674CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): PHF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHF3
    DNA2.0 Custom Variant and Variant Library Synthesis for PHF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607789    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PHF3:
    Alcohol dependence

    Find genes that share disorders with PHF3           About GenesLikeMe

    Genetic Association Database (GAD): PHF3
    Human Genome Epidemiology (HuGE) Navigator: PHF3 (1 document)

    Export disorders for PHF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PHF3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with PHF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PHF3 expression is frequently reduced in glioma. (PubMed id 11856869)1, 2, 3, 9 Fischer U.... Meese E. (Cytogenet. Cell Genet. 2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    7. PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme. (PubMed id 11464277)1, 9 Struss A.K....Meese E. (Oncogene 2001)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence. (PubMed id 23324950)1 Zuo L....Luo X. (J. Hum. Genet. 2013)
    10. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23469 HGNC: 8921 AceView: PHF3 Ensembl:ENSG00000118482 euGenes: HUgn23469
    ECgene: PHF3 H-InvDB: PHF3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0244

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PHF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PHF3 gene:
    Search GeneIP for patents involving PHF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PHF3   OriGene RNAi products in human, mouse, rat for PHF3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PHF3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PHF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for PHF3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PHF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHF3   OriGene Custom Protein Services for PHF3  

     
     
     Block miRNA regulation of human, mouse, rat PHF3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PHF3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHF3 Predesigned siRNA for gene silencing in human, mouse, rat PHF3
     QuantiFast Probe-based Assays in human, mouse, rat PHF3 QuantiTect SYBR Green Assays in human, mouse, rat PHF3
     PCR Arrays including human, mouse, rat PHF3 Search Chromatin IP Primers for PHF3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHF3  Search GeneGlobe Interaction Network for PHF3
     Regulatory tfbs in PHF3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PHF3 GenScript cDNA clones with any tag delivered in your preferred vector for PHF3
     GenScript Custom Assay Services for PHF3 GenScript Custom overexpressing Cell Line Services for PHF3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PHF3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PHF3 antibodies
     PHF3 lysates
     Antibodies for PHF3
     See all of Abcam's Antibodies, Kits and Proteins for PHF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PHF3
     Antibodies for PHF3
     ELISAs for PHF3
     CLIAs for PHF3



     Browse ESI BIO Cell Lines and PureStem Progenitors for PHF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF3
     SwitchGear 3'UTR luciferase reporter plasmids for PHF3
     SwitchGear Promoter luciferase reporter plasmids for PHF3
     Search ThermoFisher Antibodies for PHF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHF3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHF3
     LSBio Antibodies in human, mouse, rat for PHF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PHF3
      Search eBioscience for proteins for PHF3
      Search eBioscience for elisas for PHF3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHF3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4