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Aliases for PHF24 Gene

Aliases for PHF24 Gene

  • PHD Finger Protein 24 2 3 5
  • KIAA1045 2 3 4

External Ids for PHF24 Gene

Previous HGNC Symbols for PHF24 Gene

  • KIAA1045

Summaries for PHF24 Gene

GeneCards Summary for PHF24 Gene

PHF24 (PHD Finger Protein 24) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF24 Gene

Genomics for PHF24 Gene

Regulatory Elements for PHF24 Gene

Enhancers for PHF24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F034982 1 Ensembl ENCODE 12.3 +173.2 173161 2.4 PKNOX1 MIER1 HLF MAX MIER2 REST IKZF1 MYC SPI1 FANCG PHF24 CCL19 ARHGEF39 PIR62069 DNAJB5
GH09F034899 0.2 ENCODE 11.4 +89.7 89709 0.2 CTCF ZNF654 PKNOX1 MAX TRIM22 REST RAD21 RFX5 ZNF143 ZNF580 PHF24 VCP FANCG ENSG00000234181 PIGO STOML2 CCL19 FAM205C GLULP4
GH09F034999 0.8 Ensembl ENCODE 10.9 +191.0 190989 3.0 HDAC1 PKNOX1 GATA2 ETV6 FOS CREM ZBTB11 CEBPB JUNB ELF1 VCP FANCG C9orf131 PHF24 ENSG00000234181 PIGO STOML2 ENSG00000279489 GC09P034997
GH09F034743 0.8 Ensembl ENCODE 10.4 -64.8 -64809 2.5 PKNOX1 IKZF1 FOS CCL21 CCL19 PHF24 FAM205A
GH09F035025 0.9 Ensembl ENCODE 10.4 +217.2 217233 4.1 ATF1 CBX3 PKNOX1 PTRF ZNF766 CREM JUNB ZEB2 REST HDAC8 FANCG CCDC107 PIGO TPM2 DNAJB5 SPAG8 PHF24 STOML2 ENSG00000234181 CREB3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PHF24 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHF24 Gene

Chromosome:
9
Start:
34,810,040 bp from pter
End:
34,982,544 bp from pter
Size:
172,505 bases
Orientation:
Plus strand

Genomic View for PHF24 Gene

Genes around PHF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF24 Gene

Proteins for PHF24 Gene

  • Protein details for PHF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPV7-PHF24_HUMAN
    Recommended name:
    PHD finger protein 24
    Protein Accession:
    Q9UPV7
    Secondary Accessions:
    • B7Z253
    • Q58FE9
    • Q5T662

    Protein attributes for PHF24 Gene

    Size:
    400 amino acids
    Molecular mass:
    45192 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHF24 Gene

neXtProt entry for PHF24 Gene

Post-translational modifications for PHF24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PHF24 Gene

Domains & Families for PHF24 Gene

Gene Families for PHF24 Gene

Suggested Antigen Peptide Sequences for PHF24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPV7

UniProtKB/Swiss-Prot:

PHF24_HUMAN :
  • Contains 1 PHD-type zinc finger.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PHF24: view

Function for PHF24 Gene

Gene Ontology (GO) - Molecular Function for PHF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHF24: view
genes like me logo Genes that share phenotypes with PHF24: view

Animal Models for PHF24 Gene

MGI Knock Outs for PHF24:

Animal Model Products

miRNA for PHF24 Gene

miRTarBase miRNAs that target PHF24

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHF24 Gene

Localization for PHF24 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PHF24 Gene

Pathways & Interactions for PHF24 Gene

SuperPathways for PHF24 Gene

No Data Available

Interacting Proteins for PHF24 Gene

Gene Ontology (GO) - Biological Process for PHF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0032228 regulation of synaptic transmission, GABAergic IEA --
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA --
genes like me logo Genes that share ontologies with PHF24: view

No data available for Pathways by source and SIGNOR curated interactions for PHF24 Gene

Transcripts for PHF24 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF24 Gene

No ASD Table

Relevant External Links for PHF24 Gene

GeneLoc Exon Structure for
PHF24
ECgene alternative splicing isoforms for
PHF24

Expression for PHF24 Gene

NURSA nuclear receptor signaling pathways regulating expression of PHF24 Gene:

PHF24
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PHF24 Gene

Orthologs for PHF24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PHF24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1045 34 35
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia KIAA1045 34 35
  • 90.92 (n)
cow
(Bos Taurus)
Mammalia KIAA1045 34 35
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia RGD1559864 34
  • 88.5 (n)
mouse
(Mus musculus)
Mammalia N28178 34 35
  • 88.15 (n)
Phf24 16
oppossum
(Monodelphis domestica)
Mammalia KIAA1045 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA1045 34 35
  • 73.45 (n)
lizard
(Anolis carolinensis)
Reptilia KIAA1045 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1045 34
  • 67.34 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC558943 34
  • 60.93 (n)
si:ch211-269m17.1 35
  • 53 (a)
OneToOne
Species where no ortholog for PHF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF24 Gene

ENSEMBL:
Gene Tree for PHF24 (if available)
TreeFam:
Gene Tree for PHF24 (if available)

Paralogs for PHF24 Gene

No data available for Paralogs for PHF24 Gene

Variants for PHF24 Gene

Sequence variations from dbSNP and Humsavar for PHF24 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs374394658 Uncertain significance 34,971,540(+) GGAGC(A/G)GCTCC nc-transcript-variant, reference, missense
rs10114126 -- 34,851,382(+) gactc(C/T)gtggg intron-variant
rs10115293 -- 34,900,796(+) taaaa(A/T)cggtt intron-variant
rs10116097 -- 34,966,612(+) AAATA(A/G)TTAAA intron-variant
rs10116102 -- 34,966,648(+) TGAAT(A/G)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF24 Gene

Variant ID Type Subtype PubMed ID
dgv12660n54 CNV gain 21841781
dgv3984n106 CNV deletion 24896259
esv21645 CNV loss 19812545
nsv1077100 CNV deletion 25765185
nsv1125318 OTHER inversion 24896259
nsv824912 CNV gain 20364138

Variation tolerance for PHF24 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHF24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF24 Gene

Disorders for PHF24 Gene

Relevant External Links for PHF24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHF24

No disorders were found for PHF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHF24 Gene

Publications for PHF24 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PMID: 20213681) Suzuki T. … Utsumi T. (Proteomics 2010) 4 64
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for PHF24 Gene

Sources for PHF24 Gene

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