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Aliases for PHF21B Gene

Aliases for PHF21B Gene

  • PHD Finger Protein 21B 2 3
  • PHD Finger Protein 4 2 3
  • KIAA1661 4
  • BHC80L 3
  • PHF4 3

External Ids for PHF21B Gene

Previous HGNC Symbols for PHF21B Gene

  • PHF4

Previous GeneCards Identifiers for PHF21B Gene

  • GC22M043598
  • GC22M045277
  • GC22M028224

Summaries for PHF21B Gene

GeneCards Summary for PHF21B Gene

PHF21B (PHD Finger Protein 21B) is a Protein Coding gene. An important paralog of this gene is PHF21A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF21B Gene

Genomics for PHF21B Gene

Regulatory Elements for PHF21B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHF21B Gene

Start:
44,881,162 bp from pter
End:
45,009,999 bp from pter
Size:
128,838 bases
Orientation:
Minus strand

Genomic View for PHF21B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHF21B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF21B Gene

Proteins for PHF21B Gene

  • Protein details for PHF21B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK2-PF21B_HUMAN
    Recommended name:
    PHD finger protein 21B
    Protein Accession:
    Q96EK2
    Secondary Accessions:
    • B0QYW3
    • B0QYW4
    • B3KRU4
    • B7Z4F8
    • Q5TFL2
    • Q6ICC0

    Protein attributes for PHF21B Gene

    Size:
    531 amino acids
    Molecular mass:
    57455 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PHF21B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF21B Gene

Proteomics data for PHF21B Gene at MOPED

Post-translational modifications for PHF21B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHF21B Gene

No data available for DME Specific Peptides for PHF21B Gene

Domains for PHF21B Gene

Gene Families for PHF21B Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Protein Domains for PHF21B Gene

Graphical View of Domain Structure for InterPro Entry

Q96EK2

UniProtKB/Swiss-Prot:

PF21B_HUMAN :
  • Q96EK2
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PHF21B: view

Function for PHF21B Gene

Gene Ontology (GO) - Molecular Function for PHF21B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PHF21B: view

Phenotypes for PHF21B Gene

GenomeRNAi human phenotypes for PHF21B:
genes like me logo Genes that share phenotypes with PHF21B: view

Animal Model Products

CRISPR Products

miRNA for PHF21B Gene

miRTarBase miRNAs that target PHF21B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHF21B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHF21B Gene

Localization for PHF21B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF21B Gene COMPARTMENTS Subcellular localization image for PHF21B gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PHF21B Gene

Pathways for PHF21B Gene

SuperPathways for PHF21B Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PHF21B Gene

Gene Ontology (GO) - Biological Process for PHF21B Gene

None

No data available for Pathways by source for PHF21B Gene

Transcripts for PHF21B Gene

Unigene Clusters for PHF21B Gene

PHD finger protein 21B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHF21B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF21B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7:
SP8: -
SP9:

ExUns: 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for PHF21B Gene

GeneLoc Exon Structure for
PHF21B
ECgene alternative splicing isoforms for
PHF21B

Expression for PHF21B Gene

mRNA expression in normal human tissues for PHF21B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHF21B Gene

This gene is overexpressed in Pituitary (11.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PHF21B Gene

SOURCE GeneReport for Unigene cluster for PHF21B Gene Hs.254097

genes like me logo Genes that share expressions with PHF21B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PHF21B Gene

Orthologs for PHF21B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PHF21B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF21B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHF21B 35
  • 91.21 (n)
  • 91.82 (a)
PHF21B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHF21B 35
  • 92.65 (n)
  • 93.32 (a)
PHF21B 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf21b 35
  • 88.2 (n)
  • 88.68 (a)
Phf21b 16
Phf21b 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF21B 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF21B 36
  • 24 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf21b 35
  • 88.07 (n)
  • 88.48 (a)
chicken
(Gallus gallus)
Aves PHF21B 35
  • 76.88 (n)
  • 78.88 (a)
PHF21B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF21B 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12693 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495715 35
  • 73.32 (n)
  • 71.52 (a)
Str.16953 35
zebrafish
(Danio rerio)
Actinopterygii CABZ01111990.1 36
  • 47 (a)
OneToMany
PHF21B (2 of 2) 36
  • 53 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RCO1 36
  • 7 (a)
OneToMany
Species with no ortholog for PHF21B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF21B Gene

ENSEMBL:
Gene Tree for PHF21B (if available)
TreeFam:
Gene Tree for PHF21B (if available)

Paralogs for PHF21B Gene

Paralogs for PHF21B Gene

Selected SIMAP similar genes for PHF21B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHF21B: view

Variants for PHF21B Gene

Sequence variations from dbSNP and Humsavar for PHF21B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs129447 -- 44,941,265(+) GGTCC(A/C)CGCAG intron-variant
rs129448 -- 44,941,331(+) ACTTC(A/G)GGGGC intron-variant
rs131988 -- 45,010,161(+) GCACG(C/G)TCGCC upstream-variant-2KB
rs131989 -- 45,011,237(+) AACAG(C/T)GCTTT upstream-variant-2KB
rs131990 -- 45,011,536(+) AAAAA(A/C)AAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PHF21B Gene

Variant ID Type Subtype PubMed ID
nsv9919 CNV Gain+Loss 18304495
nsv915289 CNV Loss 21882294
nsv915290 CNV Loss 21882294
esv2724375 CNV Deletion 23290073
esv1949381 CNV Deletion 18987734
esv2724376 CNV Deletion 23290073
dgv786e201 CNV Deletion 23290073
esv2724378 CNV Deletion 23290073
esv2661257 CNV Deletion 23128226
esv2724379 CNV Deletion 23290073
esv2724380 CNV Deletion 23290073
esv2724381 CNV Deletion 23290073
esv2724382 CNV Deletion 23290073
esv2724383 CNV Deletion 23290073
esv1006365 CNV Deletion 20482838
esv1527783 CNV Deletion 17803354
esv4033 CNV Deletion 18987735
esv2724385 CNV Deletion 23290073
esv7819 CNV Loss 19470904
nsv915291 CNV Loss 21882294
dgv5003n71 CNV Loss 21882294
nsv191258 CNV Insertion 16902084
nsv471209 CNV Loss 18288195
nsv191598 CNV Insertion 16902084
dgv775n67 CNV Gain 20364138
nsv513594 CNV Insertion 21212237
esv2499028 CNV Insertion 19546169
esv2457019 CNV Deletion 19546169

Relevant External Links for PHF21B Gene

HapMap Linkage Disequilibrium report
PHF21B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF21B Gene

Disorders for PHF21B Gene

Relevant External Links for PHF21B

Genetic Association Database (GAD)
PHF21B
Human Genome Epidemiology (HuGE) Navigator
PHF21B
genes like me logo Genes that share disorders with PHF21B: view

No data available for UniProtKB/Swiss-Prot for PHF21B Gene

Publications for PHF21B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PHF21B Gene

Sources for PHF21B Gene

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