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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHF20 Gene

protein-coding   GIFtS: 55
GCID: GC20P034359

PHD finger protein 20

(Previous name: chromosome 20 open reading frame 104 )
(Previous symbol: C20orf104)
 Explore 10 diseases affiliated with
PHF20 via our new
 Human Malady Compendium 
Biological research products
for PHF20
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
PHD Finger Protein 201 2     GLEA22 3
C20orf1041 2 3     HCA582 3
TDRD20A1 2     NZF2 3
Glioma-Expressed Antigen 22 3     TZP2 3
Hepatocellular Carcinoma-Associated Antigen 582 3     Chromosome 20 Open Reading Frame 1041
Novel Zinc Finger Protein2 3     DJ1121G12.11
Transcription Factor TZP2 3     Tudor Domain Containing 20A2

External Ids:    HGNC: 160981   Entrez Gene: 512302   Ensembl: ENSG000000252937   OMIM: 6103355   UniProtKB: Q9BVI03   

Export aliases for PHF20 gene to outside databases

Previous GC identifers: GC20P033824 GC20P031137


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0
Function: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required
for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but
instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex
it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to
methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage

Gene Wiki entry for PHF20


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHF20 gene promoter:
         Egr-3   HOXA9   HOXA9B   Pbx1a   Egr-4   Meis-1b   Egr-2   Pax-4a   ATF6   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PHF20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22-q11.23   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22-q11.23

PHF20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF20 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P034359:  view genomic region     (about GC identifiers)

Start:
34,359,896 bp from pter      End:
34,538,303 bp from pter
Size:
178,408 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0 (See protein sequence)
Recommended Name: PHD finger protein 20  
Size: 1012 amino acids; 115386 Da
Subunit: Homodimer; disulfide-linked. Component of some MLL1/MLL complex, at least composed of the core components MLL,
ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L,
MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9
and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT,
WDR5 and HCFC1
Subcellular location: Nucleus
Miscellaneous: Antibodies against PHF20 are present in sera from patients with hepatocellular carcinoma, glioblastoma
and childhood medulloblastula
Sequence caution: Sequence=AAF34184.1; Type=Frameshift; Positions=260; Sequence=AAK19748.1; Type=Frameshift;
Positions=635, 653, 655;
5 PDB 3D structures from and Proteopedia for PHF20:
2LDM (3D)        3P8D (3D)        3Q1J (3D)        3QII (3D)        3SD4 (3D)    
Secondary accessions: A7E235 B2RB56 E1P5S3 Q566Q2 Q5JWY9 Q66K49 Q9BWV4 Q9BXA3 Q9BZW3 Q9H421 Q9H4J6
Q9NZ22
Alternative splicing: 2 isoforms:  Q9BVI0-1   Q9BVI0-2   (Ref.1 (AAF34184) sequence is in conflict in positions: 237:KTR->KKTS)

Explore the universe of human proteins at neXtProt for PHF20: NX_Q9BVI0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BVI0

  • PHF20 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057520.2  
    ENSEMBL proteins: 
     ENSP00000363124   ENSP00000404455   ENSP00000341900   ENSP00000363112   ENSP00000391915  
     ENSP00000413712   ENSP00000410373  

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    Uscn Proteins for PHF20

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0031965nuclear membrane IDA--


    PHF20 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PHF20


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PHF20 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR017956 AT_hook_DNA-bd_motif
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR015880 Znf_C2H2-like
     IPR019786 Zinc_finger_PHD-type_CS

    Graphical View of Domain Structure for InterPro Entry Q9BVI0

    ProtoNet protein and cluster: Q9BVI0

    2 Blocks protein families:
    IPB001965 Zn-finger-like
    IPB002999 Tudor domain


    UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0
    Domain: The Tudor domain 2 mediates reading of dimethyl-lysine residues
    Domain: The Tudor domain 1 doesn't bind dimethyl-lysine residues, due to an atypical and occluded aromatic cage
    Similarity: Contains 1 A.T hook DNA-binding domain
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 2 Tudor domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0
    Function: Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required
    for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but
    instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex
    it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to
    methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage

    miRNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043995contributes to histone acetyltransferase activity (H4-K5 specific) IDA--
    GO:0043996contributes to histone acetyltransferase activity (H4-K8 specific) IDA--
    GO:0046972contributes to histone acetyltransferase activity (H4-K16 specific) IDA--


    PHF20 for ontologies           About GeneDecksing


    6 GenomeRNAi human phenotypes for PHF20:
     G0/1 arrest  Increased G1 DNA content  Increased cell death HMECs cel  Increased cell size 
     Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Phf20):
     craniofacial  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  no phenotypic analysis 
     skeleton  vision/eye 

    PHF20 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PHF20
        Chromatin Regulation / Acetylation



    PHF20 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHF20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for PHF20 (Q9BVI02, 3 ENSP000003631244) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628052, 3MINT-2829358 MINT-2830381 MINT-2829913 I2D: score=1 
    HIST1H4CP628052, 3MINT-2829358 MINT-2830381 MINT-2829913 I2D: score=1 
    HIST1H4DP628052, 3MINT-2829358 MINT-2830381 MINT-2829913 I2D: score=1 
    HIST1H4EP628052, 3MINT-2829358 MINT-2830381 MINT-2829913 I2D: score=1 
    HIST1H4FP628052, 3MINT-2829358 MINT-2830381 MINT-2829913 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0043981histone H4-K5 acetylation IDA--
    GO:0043982histone H4-K8 acetylation IDA--
    GO:0043984histone H4-K16 acetylation IDA--


    PHF20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHF20
    Search CenterWatch for drugs/clinical trials and news about PHF20 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHF20 gene: 
    NM_016436.4  

    Unigene Cluster for PHF20:

    PHD finger protein 20
    Hs.517044  [show with all ESTs]
    Unigene Representative Sequence: BC150178
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461122 ENST00000374012(uc002xej.1 uc002xek.1) ENST00000461405
    ENST00000452270 ENST00000339089(uc002xei.1) ENST00000374000(uc002xel.1 uc010gfo.1)
    ENST00000481202 ENST00000449988 ENST00000486408 ENST00000495338 ENST00000496305
    ENST00000480940 ENST00000485604 ENST00000420233 ENST00000473943 ENST00000439301(uc002xeh.3)


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    hsa-miR-194* hsa-miR-323-3p hsa-miR-3938 hsa-miR-3146 hsa-miR-15a hsa-miR-128 hsa-miR-30d hsa-miR-3653
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    Additional cDNA sequence: 

    AF220416.1 AF258787.1 AF348207.1 AK054597.1 AK090798.1 AK097498.1 AK314503.1 AL137330.1 
    AY027523.1 AY134747.1 BC006415.1 BC015538.2 BC016948.1 BC022933.1 BC048210.1 BC062681.1 
    BC080598.1 BC093405.1 BC150178.1 

    22 DOTS entries:

    DT.100044409  DT.305771  DT.95154061  DT.100780272  DT.92472013  DT.101985494  DT.443943  DT.443988 
    DT.92472026  DT.100042229  DT.100725372  DT.92472059  DT.100774767  DT.91796016  DT.92472043  DT.120825619 
    DT.75147899  DT.75148089  DT.95329770  DT.102831124  DT.120825578  DT.120825622 

    24/204 AceView cDNA sequences (see all 204):

    BQ436139 Z43217 C21160 BQ028521 CA432348 CB139717 AY134747 AA599532 
    BF970213 BC048210 AK097498 AI081823 BM562675 BU742208 AU119982 AL137330 
    BC015538 AL040922 AI992137 AL558423 BQ642597 AI926894 CA442864 CR626103 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PHF20 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a ·
    SP1:                                                                                                                                                        -   
    SP2:                    -     -           -     -                       -     -     -                                                                           
    SP3:                    -     -     -     -                             -     -     -                                                                           
    SP4:                                                                    -     -     -                                                                           
    SP5:                    -                 -     -                                                                                                               

    ExUns: 20b ^ 21a · 21b ^ 22
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PHF20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHF20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAGGGGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PHF20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHF20

    SOURCE GeneReport for Unigene cluster: Hs.517044

    UniProtKB/Swiss-Prot: PHF20_HUMAN, Q9BVI0
    Tissue specificity: Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in
    brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell
    lines while it is not expressed in the respective normal tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PHF20 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves PHF201 PHD finger protein 20 70.03(n)
    66.47(a)
      419131  XM_003642447.1  XP_003642495.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHF206
    --
    66(a)
    1 ↔ 1
    4(134639745-134673562)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.177572 Xenopus laevis transcribed sequence with moderate similarity more 78.9(n)    BG814107.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phf20b1 PHD finger protein 20, b 54.57(n)
    47.52(a)
      445482  NM_001004114.1  NP_001004114.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MBD-R26
    MBD-R2
    13(a)
    1 → many
    3R(8177865-8182024)


    ENSEMBL Gene Tree for PHF20 (if available)
    TreeFam Gene Tree for PHF20 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHF20 gene
    PHF20L12  
    1 SIMAP similar gene for PHF20 using alignment to 6 protein entries:     PHF20_HUMAN (see all proteins):
    PHF20L1

    PHF20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2827 NCBI SNPs in PHF20 are shown (see all 2827    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388382551,2
    --34357992(+) TTTCAC/TCATGT 1 -- us2k10--------
    rs761842291,2
    --34358269(+) GGATTC/TGCTGG 1 -- us2k10--------
    rs1463423751,2
    --34358282(+) GAGGCC/TTGTAA 1 -- us2k10--------
    rs286852741,2
    C,F,--34358527(+) AAATAT/CAAAAA 1 -- us2k1 tfbs31Minor allele frequency- C:0.10NA 120
    rs1485270131,2
    --34358652(+) ACTCCA/CGTCTG 1 -- us2k10--------
    rs1812302361,2
    --34358653(+) CTCCCA/GTCTGG 1 -- us2k10--------
    rs1421685801,2
    --34358669(+) AGAGCA/GAGACT 1 -- us2k10--------
    rs1863071671,2
    --34358777(+) AGACCA/CGCCTG 1 -- us2k10--------
    rs1917737081,2
    --34358794(+) ATCGTC/GAAACT 1 -- us2k10--------
    rs1507609611,2
    --34358922(+) GACTGC/TGCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHF20 (34359896 - 34538303 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PHF20
         1 CNV: 5135

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHF20
    DNA2.0 Custom Variant and Variant Library Synthesis for PHF20

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PHF20 for disorders           About GeneDecksing

    OMIM gene information: 610335    OMIM disorders: --

    10 diseases for PHF20:    About MalaCards
    hepatocellular carcinoma    carcinoma    childhood medulloblastoma    gastroparesis
    ileus    medulloblastoma    prostatic hypertrophy    lung cancer
    glioblastoma    prostatitis

    3 diseases from the University of Copenhagen DISEASES database for PHF20:
    Gastroparesis     Large cell medulloblastoma     Ileus

    Export disorders for PHF20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHF20 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with PHF20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls. (PubMed id 11703362)1, 2, 9 Fischer U....Meese E. (2001)
    2. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)1, 2, 9 Behrends U.... Mautner J. (2003)
    3. PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. (PubMed id 22864287)1, 2 Cui G.... Mer G. (2012)
    4. Crystal structures of the Tudor domains of human PHF20 reveal novel structural variations on the Royal Family of proteins. (PubMed id 22449972)1, 2 Adams-Cioaba M.A....Min J. (2012)
    5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2 Wang Y....Chen W.-F. (2002)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51230 HGNC: 16098 AceView: C20orf104 Ensembl:ENSG00000025293 euGenes: HUgn51230
    ECgene: PHF20 H-InvDB: PHF20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHF20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHF20 gene:
    Search GeneIP for patents involving PHF20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    Advanced Cell Diagnostics
    About This Section

     
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     Regulatory tfbs in PHF20 promoter
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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