Aliases for PHF19 Gene
External Ids for PHF19 Gene
Previous GeneCards Identifiers for PHF19 Gene
GeneCards Summary for PHF19 Gene
PHF19 (PHD Finger Protein 19) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase I Transcription. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF1.
UniProtKB/Swiss-Prot for PHF19 Gene
Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at Lys-36 (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.