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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHF19 Gene

protein-coding   GIFtS: 46
GCID: GC09M123617

PHD finger protein 19

 Explore 5 diseases affiliated with
PHF19 via our new
 Human Malady Compendium 
Biological research products
for PHF19
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
PHD Finger Protein 191 2     HPCL31
PCL31 2 3     DKFZP727G0511
MTF2L11 2     Polycomb Like 32
TDRD19B1 2     Polycomb-Like 32
Polycomb-Like Protein 32 3     Tudor Domain Containing 19B2

External Ids:    HGNC: 245661   Entrez Gene: 261472   Ensembl: ENSG000001194037   OMIM: 6097405   UniProtKB: Q5T6S33   

Export aliases for PHF19 gene to outside databases

Previous GC identifers: GC09M118994 GC09M120698 GC09M122657 GC09M093235


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PHF19_HUMAN, Q5T6S3
Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the
PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells:
acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66
or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation,
followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell
self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an
HSV-tk promoter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHF19 gene promoter:
         Nkx2-2   LCR-F1   RORalpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHF19 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q34.11

PHF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF19 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M123617:  view genomic region     (about GC identifiers)

Start:
123,617,931 bp from pter      End:
123,639,606 bp from pter
Size:
21,676 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PHF19_HUMAN, Q5T6S3 (See protein sequence)
Recommended Name: PHD finger protein 19  
Size: 580 amino acids; 65591 Da
Subunit: Associated component of the PRC2 complex. Interacts with EZH2 (via its Tudor domain). Isoform 1 interacts with
SUZ12; isoform 2 does not interact with SUZ12. Interacts with NO66
Subcellular location: Nucleus
Miscellaneous: Down-regulated in spheroid melanoma cells that display an invasive phenotype, characterized by a higher
motility, a poor proliferation rate and a gain of pluripotency gene expression. PHF19 favors the proliferation and
reduces the transmigration capacity of melanoma cell lines, 2 properties of invasive cells, suggesting that
down-regulation may participate in the switch from proliferative to invasive states in melanoma cells
(PubMed:22487681)
Sequence caution: Sequence=CAE45832.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for PHF19:
2E5Q (3D)        4BD3 (3D)    
Secondary accessions: Q32NF2 Q5T6S4 Q6N038 Q8TBL6 Q9UFS9
Alternative splicing: 3 isoforms:  Q5T6S3-1   Q5T6S3-2   Q5T6S3-3   (Contains a phosphoserine at position 166)

Explore the universe of human proteins at neXtProt for PHF19: NX_Q5T6S3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5T6S3

  • PHF19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001009936.1  NP_056466.1  

    ENSEMBL proteins: 
     ENSP00000363003   ENSP00000395938   ENSP00000404655   ENSP00000408479   ENSP00000310372  
     ENSP00000397935   ENSP00000407433  

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    Novus Biologicals PHF19 Protein
    Novus Biologicals PHF19 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PHF19

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    PHF19 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PHF19 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR025894 Mtf2_C_dom
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q5T6S3

    ProtoNet protein and cluster: Q5T6S3

    1 Blocks protein family: IPB002999 Tudor domain

    UniProtKB/Swiss-Prot: PHF19_HUMAN, Q5T6S3
    Domain: The Tudor domain recognizes and binds H3K36me3 (PubMed=23273982, PubMed:23160351, PubMed:23104054 and
    PubMed:23228662). May also bind H3K27me3, with a lower affinity (PubMed:23160351)
    Similarity: Belongs to the Polycomblike family
    Similarity: Contains 2 PHD-type zinc fingers
    Similarity: Contains 1 Tudor domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: PHF19_HUMAN, Q5T6S3
    Function: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the
    PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells:
    acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66
    or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation,
    followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell
    self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an
    HSV-tk promoter

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    hsa-miR-4328 hsa-miR-15a hsa-miR-219-5p hsa-miR-449a hsa-miR-508-3p hsa-miR-3142 hsa-miR-223 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPHF19 3' UTR sequence
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--


    PHF19 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHF19

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for PHF19 (Q5T6S33 ENSP000003630034) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    EZH2Q159103, ENSP000003201474I2D: score=1 STRING: ENSP00000320147
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    PHF19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHF19
    Search CenterWatch for drugs/clinical trials and news about PHF19 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHF19 gene (2 alternative transcripts): 
    NM_001009936.1  NM_015651.1  

    Unigene Cluster for PHF19:

    PHD finger protein 19
    Hs.460124  [show with all ESTs]
    Unigene Representative Sequence: NM_015651
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373896(uc011lyf.1 uc004bkr.2 uc004bks.1) ENST00000487555
    ENST00000462229 ENST00000464712 ENST00000467266 ENST00000453868 ENST00000474402
    ENST00000478371 ENST00000439674 ENST00000436309 ENST00000312189(uc004bkt.3)
    ENST00000456291 ENST00000419155

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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate PHF19 (see all 52):
    hsa-miR-4328 hsa-miR-15a hsa-miR-219-5p hsa-miR-449a hsa-miR-508-3p hsa-miR-3142 hsa-miR-223 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidPHF19 3' UTR sequence
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    Additional cDNA sequence: 

    AK122744.1 AK302996.1 AK303433.1 AL117477.1 BC022374.1 BC044224.1 BC108663.1 BC125076.1 
    BC125077.1 BX640713.1 

    8 DOTS entries:

    DT.97793495  DT.92434649  DT.114101  DT.101982679  DT.95352719  DT.100790941  DT.99932962  DT.97804944 

    24/211 AceView cDNA sequences (see all 211):

    BU739334 CD238095 AA872469 BC044224 CA426682 CR621777 AI869299 BF222587 
    BM784783 AA809060 BF732227 AI197770 AA627388 BC022374 BF886499 AA769676 
    BF102809 BE858270 AL525179 BM713184 BM784790 AL039257 AI024016 CA425642 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for PHF19 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
    SP1:                    -                                         -     -           -     -     -                 -                 -                           
    SP2:        -     -     -                                         -     -           -     -     -                 -                 -                           
    SP3:                                                                                            -                 -                 -                 -         
    SP4:                    -                                                                                                                                       
    SP5:                    -                             -                                                                                                         

    ExUns: 17b ^ 18a · 18b ^ 19a · 19b
    SP1:        -                     
    SP2:        -                     
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for PHF19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHF19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAATAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See PHF19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHF19

    SOURCE GeneReport for Unigene cluster: Hs.460124

    UniProtKB/Swiss-Prot: PHF19_HUMAN, Q5T6S3
    Tissue specificity: Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in
    placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood
    leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver
    cancers, in cell lines derived from different stages of melanoma and in glioma cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including PHF19: 
              Polycomb & Trithorax Complexes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PHF19 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf191 , 5 PHD finger protein 191, 5 87.49(n)1
    89.1(a)1
      2 (23.02 cM)5
    740161  NM_028716.41  NP_082992.11 
     348937575 
    chicken
    (Gallus gallus)
    Aves LOC7722131 PHD finger protein 19-like 77.26(n)
    83.3(a)
      772213  XM_003642306.1  XP_003642354.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    PHF196
    --
    82(a)
    59(a)
    possible ortholog
    1 ↔ 1
    AAWZ02036695(2017-22767)
    AAWZ02038044(6096-12858)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.11292 Transcribed sequence with moderate similarity to protein more 80.12(n)    BQ394264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phf131 PHD finger protein 19 68.46(n)
    69.23(a)
      560078  NM_001128526.1  NP_001121998.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pcl6
    Polycomblike
    14(a)
    1 → many
    2R(14022919-14027495)


    ENSEMBL Gene Tree for PHF19 (if available)
    TreeFam Gene Tree for PHF19 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHF19 gene
    MTF22  PHF12  
    2 SIMAP similar genes for PHF19 using alignment to 5 protein entries:     PHF19_HUMAN (see all proteins):
    PHF1    MTF2

    PHF19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/349 NCBI SNPs in PHF19 are shown (see all 349    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844497431,2
    --123617572(+) TAGCAA/GAGTCA 1 -- ds50010--------
    rs1468840281,2
    --123617824(+) CCAGAA/GGACAG 1 -- ds50010--------
    rs18371,2
    C,F,O,A,H,--123618229(-) TGTTAC/TAGTAC 1 -- ut3133Minor allele frequency- T:0.39MN EA NA NS WA CSA 4702
    rs1896815501,2
    --123618274(+) AAAGCA/GGGCCT 1 -- ut310--------
    rs1406392311,2
    --123618380(+) CCCTTC/TCACCT 1 -- ut310--------
    rs1166091711,2
    F,--123618457(+) AGCTCG/CTCTAT 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs774841211,2
    F,--123618508(+) TGTGCA/TCAGGA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs345896571,2
    C,--123618559(+) AAGATG/-GGGGG 1 -- ut311Minor allele frequency- -:0.00CSA 2
    rs59004631,2
    C--123618560(+) GGGGGG/-CATCT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1500825421,2
    --123618584(+) CTCAGA/GGACCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHF19 (123617931 - 123639606 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PHF19: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PHF19 for disorders           About GeneDecksing

    OMIM gene information: 609740    OMIM disorders: --

    5 diseases for PHF19:    About MalaCards
    rheumatoid arthritis    liver cancer    arthritis    cervicitis
    melanoma


    Export disorders for PHF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHF19 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with PHF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PubMed id 15563832)1, 2, 3 Wang S.... Zhu J. (2004)
    2. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. (PubMed id 23160351)1, 2 Brien G.L.... Bracken A.P. (2012)
    3. PHF19 and Akt control the switch between proliferative and invasive states in melanoma. (PubMed id 22487681)1, 2 Ghislin S....Alcaide-Loridan C. (2012)
    4. Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes. (PubMed id 21143197)1, 2 Boulay G....Leprince D. (2011)
    5. An H3K36 methylation-engaging Tudor motif of Polycomb-like proteins mediates PRC2 complex targeting. (PubMed id 23273982)2 Cai L....Wang G.G. (2013)
    6. Tudor domains of the PRC2 components PHF1 and PHF19 selectively bind to histone H3K36me3. (PubMed id 23228662)2 Qin S.... Min J. (2013)
    7. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. (PubMed id 23104054)2 Ballare C....Di Croce L. (2012)
    8. Hypermethylated in cancer 1 (HIC1) recruits polycomb r epressive complex 2 (PRC2) to a subset of its target genes through interaction w ith human polycomb-like (hPCL) proteins. (PubMed id 22315224)1 Boulay G....Leprince D. (2012)
    9. Meta-analysis of genome-wide association studies in c eliac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PubMed id 21383967)1 Zhernakova A....Plenge R.M. (2011)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26147 HGNC: 24566 AceView: PHF19 Ensembl:ENSG00000119403 euGenes: HUgn26147
    ECgene: PHF19 H-InvDB: PHF19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHF19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHF19 gene:
    Search GeneIP for patents involving PHF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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