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Aliases for PHF19 Gene

Aliases for PHF19 Gene

  • PHD Finger Protein 19 2 3 5
  • Tudor Domain Containing 19B 2 3
  • Polycomb-Like Protein 3 3 4
  • PCL3 3 4
  • Polycomb-Like 3 2
  • Polycomb Like 3 3
  • TDRD19B 3
  • MTF2L1 3
  • HPCL3 4

External Ids for PHF19 Gene

Previous GeneCards Identifiers for PHF19 Gene

  • GC09M118994
  • GC09M120698
  • GC09M122657
  • GC09M123617
  • GC09M093235

Summaries for PHF19 Gene

GeneCards Summary for PHF19 Gene

PHF19 (PHD Finger Protein 19) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is PHF1.

UniProtKB/Swiss-Prot for PHF19 Gene

  • Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at Lys-36 (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF19 Gene

Genomics for PHF19 Gene

Regulatory Elements for PHF19 Gene

Enhancers for PHF19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PHF19 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHF19 Gene

Chromosome:
9
Start:
120,855,651 bp from pter
End:
120,894,896 bp from pter
Size:
39,246 bases
Orientation:
Minus strand

Genomic View for PHF19 Gene

Genes around PHF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF19 Gene

Proteins for PHF19 Gene

  • Protein details for PHF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6S3-PHF19_HUMAN
    Recommended name:
    PHD finger protein 19
    Protein Accession:
    Q5T6S3
    Secondary Accessions:
    • Q32NF2
    • Q5T6S4
    • Q6N038
    • Q8TBL6
    • Q9UFS9

    Protein attributes for PHF19 Gene

    Size:
    580 amino acids
    Molecular mass:
    65591 Da
    Quaternary structure:
    • Associated component of the PRC2 complex. Interacts with EZH2 (via its Tudor domain). Isoform 1 interacts with SUZ12; isoform 2 does not interact with SUZ12. Interacts with NO66.
    Miscellaneous:
    • Down-regulated in spheroid melanoma cells that display an invasive phenotype, characterized by a higher motility, a poor proliferation rate and a gain of pluripotency gene expression. PHF19 favors the proliferation and reduces the transmigration capacity of melanoma cell lines, 2 properties of invasive cells, suggesting that down-regulation may participate in the switch from proliferative to invasive states in melanoma cells (PubMed:22487681).
    SequenceCaution:
    • Sequence=CAE45832.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHF19 Gene

    Alternative splice isoforms for PHF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF19 Gene

Proteomics data for PHF19 Gene at MOPED

Post-translational modifications for PHF19 Gene

  • Ubiquitination at Lys 554
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PHF19 (PHF19)

No data available for DME Specific Peptides for PHF19 Gene

Domains & Families for PHF19 Gene

Gene Families for PHF19 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T6S3

UniProtKB/Swiss-Prot:

PHF19_HUMAN :
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23273982, PubMed:23160351, PubMed:23104054 and PubMed:23228662). May also bind H3K27me3, with a lower affinity (PubMed:23160351).
  • Belongs to the Polycomblike family.
  • Contains 2 PHD-type zinc fingers.
Domain:
  • The Tudor domain recognizes and binds H3K36me3 (PubMed:23273982, PubMed:23160351, PubMed:23104054 and PubMed:23228662). May also bind H3K27me3, with a lower affinity (PubMed:23160351).
  • Contains 1 Tudor domain.
Family:
  • Belongs to the Polycomblike family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with PHF19: view

Function for PHF19 Gene

Molecular function for PHF19 Gene

UniProtKB/Swiss-Prot Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at Lys-36 (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
genes like me logo Genes that share phenotypes with PHF19: view

Animal Models for PHF19 Gene

MGI Knock Outs for PHF19:

Animal Model Products

miRNA for PHF19 Gene

miRTarBase miRNAs that target PHF19

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHF19 Gene

Localization for PHF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHF19 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF19 Gene COMPARTMENTS Subcellular localization image for PHF19 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PHF19 Gene

Pathways & Interactions for PHF19 Gene

genes like me logo Genes that share pathways with PHF19: view

Pathways by source for PHF19 Gene

1 Cell Signaling Technology pathway for PHF19 Gene

Gene Ontology (GO) - Biological Process for PHF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0019827 stem cell population maintenance IEA --
GO:0040029 regulation of gene expression, epigenetic TAS --
GO:0048863 stem cell differentiation IEA --
GO:0061087 positive regulation of histone H3-K27 methylation IEA,IMP 23104054
genes like me logo Genes that share ontologies with PHF19: view

No data available for SIGNOR curated interactions for PHF19 Gene

Drugs & Compounds for PHF19 Gene

No Compound Related Data Available

Transcripts for PHF19 Gene

Unigene Clusters for PHF19 Gene

PHD finger protein 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHF19 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6:
SP7: -
SP8:
SP9: -
SP10:

ExUns: 17b ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PHF19 Gene

GeneLoc Exon Structure for
PHF19
ECgene alternative splicing isoforms for
PHF19

Expression for PHF19 Gene

mRNA expression in normal human tissues for PHF19 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHF19 Gene



SOURCE GeneReport for Unigene cluster for PHF19 Gene Hs.460124

mRNA Expression by UniProt/SwissProt for PHF19 Gene

Q5T6S3-PHF19_HUMAN
Tissue specificity: Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines.
genes like me logo Genes that share expression patterns with PHF19: view

Protein tissue co-expression partners for PHF19 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PHF19 Gene

Orthologs for PHF19 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PHF19 35
  • 92.13 (n)
  • 97.07 (a)
PHF19 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf19 35
  • 87.49 (n)
  • 89.1 (a)
Phf19 16
Phf19 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf19 35
  • 88.12 (n)
  • 89.62 (a)
dog
(Canis familiaris)
Mammalia PHF19 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF19 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF19 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHF19 35
  • 77.32 (n)
  • 83.3 (a)
PHF19 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF19 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phf19 35
  • 70.39 (n)
  • 76.34 (a)
Str.1129 35
zebrafish
(Danio rerio)
Actinopterygii phf13 35
  • 68.46 (n)
  • 69.23 (a)
phf19 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pcl 35
  • 48.65 (n)
  • 35.03 (a)
Pcl 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6624 36
  • 41 (a)
OneToMany
Species with no ortholog for PHF19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF19 Gene

ENSEMBL:
Gene Tree for PHF19 (if available)
TreeFam:
Gene Tree for PHF19 (if available)

Paralogs for PHF19 Gene

Paralogs for PHF19 Gene

(2) SIMAP similar genes for PHF19 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHF19: view

Variants for PHF19 Gene

Sequence variations from dbSNP and Humsavar for PHF19 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs881310 -- 120,891,320(-) TGGAC(C/T)AAGTT intron-variant
rs881375 -- 120,890,620(+) AAACA(C/T)GTCTT intron-variant
rs914842 -- 120,856,693(-) TCATT(C/T)GGTTC nc-transcript-variant, utr-variant-3-prime
rs1056567 -- 120,869,767(-) CAGAG(C/T)CTGAG intron-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-3-prime
rs7847628 -- 120,868,947(+) GCCCC(A/G)CCTCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PHF19 Gene

Variant ID Type Subtype PubMed ID
nsv893809 CNV Gain 21882294

Variation tolerance for PHF19 Gene

Residual Variation Intolerance Score: 24.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF19 Gene

Human Gene Mutation Database (HGMD)
PHF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF19 Gene

Disorders for PHF19 Gene

Relevant External Links for PHF19

Genetic Association Database (GAD)
PHF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHF19

No disorders were found for PHF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHF19 Gene

Publications for PHF19 Gene

  1. A novel human homologue of Drosophila polycomblike gene is up- regulated in multiple cancers. (PMID: 15563832) Wang S. … Zhu J. (Gene 2004) 2 3 4 67
  2. MicroRNA-195-5p acts as an anti-oncogene by targeting PHF19 in hepatocellular carcinoma. (PMID: 25955388) Xu H. … Wang Q. (Oncol. Rep. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for PHF19 Gene

Sources for PHF19 Gene

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