Aliases
for PHF16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| PHD Finger Protein 161 2 3 | | KIAA02151 3 | | JADE32 3 | | Protein Jade-32 |
| External Ids: | HGNC: 229821 | Entrez Gene: 97672 | Ensembl: ENSG000001022217 | OMIM: 3006185 | UniProtKB: Q926133 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n337672 | |
Export aliases for PHF16 gene to outside databasesPrevious GC identifers: GC0XP045598 GC0XP045817 GC0XP046528 GC0XP046656 GC0XP044482
Summaries
for PHF16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PHF16:
This gene is part of a gene cluster on chromosome Xp11.23. The encoded protein contains a zinc finger motif often foundin transcriptional regulators, however, its exact function is not known. Alternative splicing results in multipletranscript variants encoding the same protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: JADE3_HUMAN, Q92613Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activitytoward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo
Gene Wiki entry for PHF16
|
Genomic Views
for PHF16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PHF16 gene promoter:
E2F-3a E2F-4 E2F-5 E2F E2F-1 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PHF16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHF16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.23 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.3PHF16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP046771: view genomic region
(about GC identifiers)
Start:
|
46,771,711 bp from pter |
End:
|
46,920,641 bp from pter |
Size:
|
148,931 bases |
Orientation:
|
plus strand |
|
Proteins
for PHF16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JADE3_HUMAN, Q92613 (See
protein sequence)Recommended Name: Protein Jade-3 Size: 823 amino acids; 93808 Da
Subunit: Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 andPHF17
Sequence caution: Sequence=BAA13205.2; Type=Erroneous initiation;
Secondary accessions: Q6IE79Explore the universe of human proteins at neXtProt for PHF16: NX_Q92613
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92613
PHF16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001070913.1 NP_055550.1
ENSEMBL proteins: ENSP00000391009 ENSP00000218343 ENSP00000400584 ENSP00000380373
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000123 | histone acetyltransferase complex |
IDA | 16387653 |
PHF16 for ontologies About GeneDecksing
PHF16 Antibody Products:
Assay Products for PHF16: |
Protein
Domains /
Families
for PHF16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PHF16 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q92613ProtoNet protein and cluster: Q92613 UniProtKB/Swiss-Prot: JADE3_HUMAN, Q92613Similarity: Belongs to the JADE familySimilarity: Contains 1 PHD-type zinc finger |
Function
for PHF16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: JADE3_HUMAN, Q92613Function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activitytoward histone H3 and is responsible for the bulk of histone H4 acetylation in vivoInduction: By estradiol in estrogen-responsive breast cancer cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHF16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHF16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PHF16 (NM_001077445) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PHF16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF16 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
PHF16 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PHF16:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Phf16):
PHF16 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PHF16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PHF16
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for PHF16 (Q926133 ENSP000002183434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
PHF16 for ontologies About GeneDecksing
|
Drugs & Compounds
for PHF16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PHF16
Search CenterWatch for drugs/clinical trials and news about PHF16 / JADE3
|
Transcripts
for PHF16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PHF16 gene (2 alternative transcripts): NM_001077445.1 NM_014735.3 Unigene Cluster for PHF16: PHD finger protein 16 Hs.371977 [show with all ESTs]Unigene Representative Sequence: D869694 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000424392 ENST00000218343(uc004dgy.3) ENST00000455411 ENST00000397189(uc004dgx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHF16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHF16 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PHF16 (NM_001077445) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PHF16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF16 |
Additional cDNA sequence: AF127774.1 AK291220.1 BC113880.1 BC114487.1 D86969.1 4 DOTS entries: DT.413585 DT.97838422 DT.121289853 DT.100745292 1 AceView cDNA sequence: AL703879
GeneLoc Exon Structure
|
Expression
for PHF16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PHF16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTCAATT
About this image
See PHF16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PHF16
SOURCE GeneReport for Unigene cluster: Hs.371977
UniProtKB/Swiss-Prot: JADE3_HUMAN, Q92613Tissue specificity: Ubiquitously expressed, with highest levels in placenta and uterus
SABiosciences Custom PCR Arrays for PHF16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHF16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHF16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHF16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHF16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF16 |
Orthologs
for PHF16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PHF16 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PHF161 |
PHD finger protein 16 |
74.58(n)
74.58(a) |
|
418674 XM_416870.3 XP_416870.3 |
lizard
(Anolis carolinensis) |
Reptilia |
PHF166 |
-- |
71(a) |
1 ↔ 1 |
3(112070077-112087934) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.5662 |
Transcribed sequence with moderate similarity to protein more |
77.81(n) |
|
AL864925.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
jade32 |
jade3 protein |
77.72(n) |
|
387595 BC045468.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rno6 |
rhinoceros |
6(a) |
1 → many |
3L(187207-199762) |
worm
(Caenorhabditis elegans) |
Secernentea |
phf-156 |
Protein PHF-15, isoform b |
18(a) |
1 → many |
III(3322961-3331717) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G147406 |
RING/FYVE/PHD zinc finger-containing protein |
21(a) |
1 → many |
3(4952004-4953423) |
rice
(Oryza sativa) |
Liliopsida |
-- |
PHD-finger domain containing protein, putative, ex... |
12(a) |
1 → many |
1(4430532-4432679) |
ENSEMBL Gene Tree for PHF16 (if available)
TreeFam Gene Tree for PHF16 (if available) |
Paralogs
for PHF16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PHF16 gene
- PHF172 BRPF12 BRD12 MLLT102 PHF142 PHF152 MLLT62 BRPF32
2 SIMAP similar genes for PHF16 using alignment to 3 protein entries: JADE3_HUMAN (see all proteins):PHF17 PHF15
PHF16 for paralogs About GeneDecksing
|
Genomic Variants
for PHF16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
|
|
|
