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PHF14 Gene

protein-coding   GIFtS: 49
GCID: GC07P011014

PHD Finger Protein 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PHD Finger Protein 141 2
KIAA07833

External Ids:    HGNC: 222031   Entrez Gene: 96782   Ensembl: ENSG000001064437   UniProtKB: O948803   

Export aliases for PHF14 gene to outside databases

Previous GC identifers: GC07P010723 GC07P010757 GC07P010786 GC07P010980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PHF14 Gene:
PHF14 (PHD finger protein 14) is a protein-coding gene. Diseases associated with PHF14 include cerebellar disease, and dandy-walker syndrome. An important paralog of this gene is JADE2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHF14 gene promoter:
         TBP   AML1a   CBF-C   FOXL1   CBF-B   FOXJ2 (long isoform)   HFH-1   FOXJ2   ZIC2/Zic2   CP1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): PHF14 promoter sequence
   Search Chromatin IP Primers for PHF14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

PHF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF14 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P011014:  view genomic region     (about GC identifiers)

Start:
11,013,499 bp from pter      End:
11,209,250 bp from pter
Size:
195,752 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 11,067,044-11,262,833     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PHF14_HUMAN, O94880 (See protein sequence)
Recommended Name: PHD finger protein 14  
Size: 888 amino acids; 100053 Da
Sequence caution: Sequence=BAA34503.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MCZ3 B4DI82
Alternative splicing: 2 isoforms:  O94880-1   O94880-2   (Contains a phosphoserine at position 651)

Explore the universe of human proteins at neXtProt for PHF14: NX_O94880

Explore proteomics data for PHF14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys307, Lys435
  • Modification sites at PhosphoSitePlus

  • See PHF14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055475.2  
    ENSEMBL proteins: 
     ENSP00000428601   ENSP00000385795   ENSP00000398407   ENSP00000403907  

    PHF14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for PHF14
    OriGene Custom MassSpec
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    Novus Biologicals PHF14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHF14

    PHF14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for PHF14
    Cloud-Clone Corp. Antibodies for PHF14
    Search ThermoFisher Antibodies for PHF14
    LSBio Antibodies in human, mouse, rat for PHF14

    PHF14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHF14
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    GenScript Custom Assay Services for PHF14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHF14
    Cloud-Clone Corp. CLIAs for PHF14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    5 InterPro protein domains:
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry O94880

    ProtoNet protein and cluster: O94880

    UniProtKB/Swiss-Prot: PHF14_HUMAN, O94880
    Similarity: Contains 2 PHD-type zinc fingers


    PHF14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    PHF14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PHF14:
     Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Phf14):
     cellular  homeostasis/metabolism  mortality/aging  respiratory system  skeleton 

    PHF14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phf14tm1Take for PHF14

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHF14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHF14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHF14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHF14

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHF14:
    hsa-mir-183-5p (MIRT047036), hsa-mir-155-5p (MIRT020981), hsa-mir-128-3p (MIRT022055), hsa-mir-122-5p (MIRT023375)

    Block miRNA regulation of human, mouse, rat PHF14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHF14 (see all 68):
    hsa-miR-323-3p hsa-miR-4272 hsa-miR-938 hsa-miR-1243 hsa-miR-29a* hsa-miR-192* hsa-miR-130b hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidPHF14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHF14
    Predesigned siRNA for gene silencing in human, mouse, rat PHF14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHF14

    Clone
    Products:
         
    OriGene clones in human, mouse for PHF14 (see all 10)
    OriGene ORF clones in mouse, rat for PHF14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHF14 (NM_014660)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHF14
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHF14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHF14
    Interactions:

        Search GeneGlobe Interaction Network for PHF14

    3 Interacting proteins for PHF14 (O948803) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149213I2D: score=1 
    H2AFYO753673I2D: score=1 
    PCBD2Q9H0N53I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHF14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHF14 gene (2 alternative transcripts): 
    NM_001007157.1  NM_014660.3  

    Unigene Cluster for PHF14:

    PHD finger protein 14
    Hs.655688  [show with all ESTs]
    Unigene Representative Sequence: NM_014660
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521747 ENST00000403050(uc003sry.2 uc011jxi.2) ENST00000476009
    ENST00000423760(uc011jxj.2) ENST00000490957 ENST00000476774 ENST00000497851
    ENST00000481418 ENST00000470665 ENST00000498784 ENST00000489305 ENST00000493922
    ENST00000469407(uc003ssa.3) ENST00000473050 ENST00000445996
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHF14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHF14 (see all 68):
    hsa-miR-323-3p hsa-miR-4272 hsa-miR-938 hsa-miR-1243 hsa-miR-29a* hsa-miR-192* hsa-miR-130b hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidPHF14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHF14
    Predesigned siRNA for gene silencing in human, mouse, rat PHF14
    Clone
    Products:
         
    OriGene clones in human, mouse for PHF14 (see all 10)
    OriGene ORF clones in mouse, rat for PHF14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHF14 (NM_014660)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF14
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHF14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHF14
      QuantiTect SYBR Green Assays in human, mouse, rat PHF14
      QuantiFast Probe-based Assays in human, mouse, rat PHF14

    Additional mRNA sequence: 

    AB018326.1 AK123522.1 AK294419.1 AK295461.1 BC104657.1 BC152414.1 NR_033435.1 NR_033436.1 

    18 DOTS entries:

    DT.413333  DT.91768933  DT.101971111  DT.100783802  DT.91768948  DT.97785932  DT.91701618  DT.91768922 
    DT.95331551  DT.91768894  DT.99958539  DT.100783799  DT.40231059  DT.95101233  DT.97789068  DT.75112469 
    DT.91768899  DT.95282971 

    Selected AceView cDNA sequences (see all 258):

    BG676461 F06945 CA945229 BG191233 AA666080 CK825072 CR625297 AL539735 
    BX436777 BG217248 Z40033 BM836200 AA600172 BX410332 AA253408 BM834437 
    AW161419 CB177184 BU624382 BM141867 BP376167 BP380289 AA036826 BF514779 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHF14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PHF14 Expression
    About this image

    PHF14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHF14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655688
        Custom PCR Arrays for PHF14
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHF14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHF14
    QuantiTect SYBR Green Assays in human, mouse, rat PHF14
    QuantiFast Probe-based Assays in human, mouse, rat PHF14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PHF14 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf141 , 5 PHD finger protein 141, 5 91.08(n)1
    96.24(a)1
      6 (5.01 cM)5
    757251  NM_001168382.11  NP_001161854.11 
     119078095 
    chicken
    (Gallus gallus)
    Aves PHF141 PHD finger protein 14 84.59(n)
    95.1(a)
      420583  NM_001012856.1  NP_001012874.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHF146
    PHD finger protein 14
    78(a)
    1 ↔ 1
    6(25016686-25161330)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.113492 Xenopus laevis transcribed sequence with moderate similarity more 77.19(n)    BX852734.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb80h092 wufb80h09 77.25(n)   323076  57057816 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154396
    --
    29(a)
    1 ↔ 1
    2L(4449289-4453004)
    worm
    (Caenorhabditis elegans)
    Secernentea phf-146
    Protein PHF-14 (phf-14) mRNA, complete cds
    25(a)
    1 ↔ 1
    V(17871401-17879923) WBGene00013339
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTO16
    Subunit of the NuA3 histone acetyltransferase comp...
    15(a)
    1 → many
    XVI(631515-633761) YPR031W


    ENSEMBL Gene Tree for PHF14 (if available)
    TreeFam Gene Tree for PHF14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHF14 gene
    JADE22  BRD12  BRPF12  MLLT102  JADE32  JADE12  MLLT62  BRPF32  
    2 SIMAP similar genes for PHF14 using alignment to 3 protein entries:     PHF14_HUMAN (see all proteins):
    MLL/AF10 fusion    AF10

    PHF14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHF14 (see all 4174)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs664978591,2
    C--11011562(+) AGACTT/-TTTTT 3 -- us2k11Minor allele frequency- -:0.00NA 2
    rs132340461,2
    C,F--11011612(+) GGCTGA/GAATGC 3 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1440870671,2
    C--11011622(+) CAGTGA/GCGTGA 3 -- us2k10--------
    rs1930791361,2
    --11011639(+) CTCACG/TGCAAC 3 -- us2k10--------
    rs1509667471,2
    C--11011808(+) TCCACA/CCGCCT 3 -- us2k10--------
    rs1407603431,2
    --11011843(+) CAGGCA/GTGAGC 3 -- us2k10--------
    rs1857187971,2
    --11011859(+) CACCCA/GGCAGT 3 -- us2k10--------
    rs1897933101,2
    --11011886(+) AACTAC/GGTGTT 3 -- us2k10--------
    rs1146759921,2
    C,F--11011947(+) TAGAAA/GTTAGT 3 -- us2k11Minor allele frequency- G:0.02WA 118
    rs69453721,2
    C,F,A,H--11012074(+) CATAGA/GTAAGA 3 -- us2k1 tfbs3107Minor allele frequency- G:0.34EA NS NA PA EU CA WA CSA 6439

    HapMap Linkage Disequilibrium report for PHF14 (11013499 - 11209250 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PHF14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428162CNV Loss18775914
    dgv7185n71CNV Loss21882294
    nsv887600CNV Gain21882294
    nsv819766CNV Gain19587683
    dgv405n21CNV Gain19592680
    esv2752140CNV Gain17911159
    nsv830901CNV Gain17160897
    nsv887601CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHF14
    DNA2.0 Custom Variant and Variant Library Synthesis for PHF14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for PHF14:    
    About MalaCards
    cerebellar disease    dandy-walker syndrome    leukemia

    1 disease from the University of Copenhagen DISEASES database for PHF14:
    Dandy-Walker syndrome

    PHF14 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: PHF14 (1 document)

    Export disorders for PHF14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHF14 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PHF14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9678 HGNC: 22203 AceView: PHF14 Ensembl:ENSG00000106443 euGenes: HUgn9678
    ECgene: PHF14 H-InvDB: PHF14

    (According to HUGE)
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    HUGE: KIAA0783

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PHF14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PHF14 gene:
    Search GeneIP for patents involving PHF14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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