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Aliases for PHF14 Gene

Aliases for PHF14 Gene

  • PHD Finger Protein 14 2 3 5
  • KIAA0783 4

External Ids for PHF14 Gene

Previous GeneCards Identifiers for PHF14 Gene

  • GC07P010723
  • GC07P010757
  • GC07P010786
  • GC07P010980
  • GC07P011014

Summaries for PHF14 Gene

GeneCards Summary for PHF14 Gene

PHF14 (PHD Finger Protein 14) is a Protein Coding gene. An important paralog of this gene is BRPF3.

Additional gene information for PHF14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF14 Gene

Genomics for PHF14 Gene

Regulatory Elements for PHF14 Gene

Enhancers for PHF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H010972 1.1 ENCODE 11.1 +16.0 16007 2.7 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 FOS SP3 SP5 MXD4 NDUFA4 PHF14 GC07P010991
GH07H010998 0.5 ENCODE 16.8 +41.2 41225 0.5 CREB1 HMBOX1 CREM PHF14 NDUFA4 GC07P010991 RPL23AP52
GH07H011211 0.7 ENCODE 10.6 +254.4 254386 0.7 GATAD2A CTCF ZNF654 HINFP TRIM22 REST RAD21 TEAD3 SMC3 ZNF143 NDUFA4 PHF14 LOC105375153 GC07M011257
GH07H011212 0.7 ENCODE 10.6 +255.3 255329 1.1 CTCF TFAP4 HLF MNT DPF2 FOXA1 ZNF217 NFIL3 CTBP1 GATA3 NDUFA4 PHF14 LOC105375153 GC07M011257
GH07H010889 0.7 ENCODE 10.5 -68.4 -68424 0.2 CTCF ZNF654 TRIM22 MAX REST RAD21 CC2D1A ZNF143 SMC3 RCOR1 PHF14 GC07P010879 GC07P010901
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PHF14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PHF14 Gene

Genomic Locations for PHF14 Gene
211,937 bases
Plus strand

Genomic View for PHF14 Gene

Genes around PHF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF14 Gene

Proteins for PHF14 Gene

  • Protein details for PHF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PHD finger protein 14
    Protein Accession:
    Secondary Accessions:
    • A7MCZ3
    • B4DI82

    Protein attributes for PHF14 Gene

    888 amino acids
    Molecular mass:
    100053 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34503.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHF14 Gene


neXtProt entry for PHF14 Gene

Post-translational modifications for PHF14 Gene

  • Ubiquitination at Lys307 and Lys435
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHF14 Gene

Domains & Families for PHF14 Gene

Gene Families for PHF14 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PHF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PHF14: view

No data available for UniProtKB/Swiss-Prot for PHF14 Gene

Function for PHF14 Gene

Phenotypes From GWAS Catalog for PHF14 Gene

Gene Ontology (GO) - Molecular Function for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHF14: view
genes like me logo Genes that share phenotypes with PHF14: view

Animal Models for PHF14 Gene

MGI Knock Outs for PHF14:

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHF14 Gene

Localization for PHF14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHF14 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PHF14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PHF14 Gene

Pathways & Interactions for PHF14 Gene

SuperPathways for PHF14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0048286 lung alveolus development IEA --
GO:0072201 negative regulation of mesenchymal cell proliferation IEA --
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IEA --
genes like me logo Genes that share ontologies with PHF14: view

No data available for Pathways by source and SIGNOR curated interactions for PHF14 Gene

Drugs & Compounds for PHF14 Gene

No Compound Related Data Available

Transcripts for PHF14 Gene

Unigene Clusters for PHF14 Gene

PHD finger protein 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF14 Gene

No ASD Table

Relevant External Links for PHF14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHF14 Gene

Protein differential expression in normal tissues from HIPED for PHF14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.2), Retina (8.8), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHF14 Gene

Protein tissue co-expression partners for PHF14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHF14 Gene:


SOURCE GeneReport for Unigene cluster for PHF14 Gene:


Evidence on tissue expression from TISSUES for PHF14 Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with PHF14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHF14 Gene

Orthologs for PHF14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PHF14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PHF14 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia PHF14 33 34
  • 94.25 (n)
(Bos Taurus)
Mammalia PHF14 33 34
  • 93.91 (n)
(Rattus norvegicus)
Mammalia Phf14 33
  • 91.71 (n)
(Mus musculus)
Mammalia Phf14 33 16 34
  • 91.08 (n)
(Ornithorhynchus anatinus)
Mammalia PHF14 34
  • 84 (a)
(Monodelphis domestica)
Mammalia PHF14 34
  • 71 (a)
(Gallus gallus)
Aves PHF14 33 34
  • 84.59 (n)
(Anolis carolinensis)
Reptilia PHF14 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia phf14 33
  • 76.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11349 33
(Danio rerio)
Actinopterygii phf14 33 34
  • 72.81 (n)
wufb80h09 33
fruit fly
(Drosophila melanogaster)
Insecta CG15439 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea phf-14 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 34
  • 15 (a)
Species where no ortholog for PHF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHF14 Gene

Gene Tree for PHF14 (if available)
Gene Tree for PHF14 (if available)

Paralogs for PHF14 Gene

Paralogs for PHF14 Gene

(2) SIMAP similar genes for PHF14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PHF14: view

Variants for PHF14 Gene

Sequence variations from dbSNP and Humsavar for PHF14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000001124 -- 10,994,497(+) CAGAA(A/G)TTTGT intron-variant
rs1000018324 -- 11,119,506(+) TCATT(A/G)TGAAA intron-variant
rs1000030385 -- 11,174,345(+) GTCTC(A/G)ATCTC intron-variant
rs1000038310 -- 11,063,264(+) GAAGG(G/T)TAAGT intron-variant, utr-variant-3-prime
rs1000059116 -- 11,003,778(+) TATGT(A/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF14 Gene

Variant ID Type Subtype PubMed ID
nsv970446 CNV duplication 23825009
nsv830901 CNV gain 17160897
nsv819766 CNV gain 19587683
nsv606196 CNV loss 21841781
nsv606195 CNV gain 21841781
nsv606194 CNV loss 21841781
nsv606187 CNV gain 21841781
nsv477386 CNV novel sequence insertion 20440878
nsv428162 CNV loss 18775914
nsv1137574 CNV deletion 24896259
nsv1031075 CNV loss 25217958
nsv1030035 CNV gain 25217958
nsv1029882 CNV loss 25217958
nsv1019888 CNV gain 25217958
esv3891051 CNV loss 25118596
esv3891050 CNV gain 25118596
esv3612203 CNV loss 21293372
esv3571637 CNV loss 25503493
esv2752140 CNV gain 17911159
dgv6266n100 CNV loss 25217958
dgv405n21 CNV gain 19592680

Variation tolerance for PHF14 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF14 Gene

Disorders for PHF14 Gene

Relevant External Links for PHF14

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PHF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHF14 Gene

Publications for PHF14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for PHF14 Gene

Sources for PHF14 Gene

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