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Aliases for PHF14 Gene

Aliases for PHF14 Gene

  • PHD Finger Protein 14 2 3 5
  • KIAA0783 4

External Ids for PHF14 Gene

Previous GeneCards Identifiers for PHF14 Gene

  • GC07P010723
  • GC07P010757
  • GC07P010786
  • GC07P010980
  • GC07P011014

Summaries for PHF14 Gene

GeneCards Summary for PHF14 Gene

PHF14 (PHD Finger Protein 14) is a Protein Coding gene. An important paralog of this gene is BRD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF14 Gene

Genomics for PHF14 Gene

Regulatory Elements for PHF14 Gene

Enhancers for PHF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F010998 0.4 ENCODE 16.8 +41.2 41225 0.5 CREB1 HMBOX1 CREM PHF14 NDUFA4 GC07P010991 RPL23AP52
GH07F010934 0.6 ENCODE 10.9 -23.4 -23384 0.2 ELF3 CBX3 SIN3A ZBTB40 RAD21 ZNF335 GATA4 THAP11 SMAD5 CBFB PHF14 NDUFA4 GC07M010895
GH07F010930 0.2 ENCODE 10.9 -26.8 -26768 1.0 ZNF512 SPI1 PHF14 NDUFA4 GC07M010895
GH07F011211 0.5 ENCODE 10.5 +254.4 254386 0.7 GATAD2A CTCF ZNF654 TRIM22 REST RAD21 TEAD3 SMC3 ZNF143 NDUFA4 PHF14 LOC105375153 GC07M011257
GH07F011212 0.2 ENCODE 10.5 +255.3 255329 1.1 TFAP4 HLF PPARG NR2F2 ZNF217 POLR2A SMARCA4 CEBPA TCF7L2 EZH2 NDUFA4 PHF14 LOC105375153 GC07M011257
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PHF14 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHF14 Gene

Chromosome:
7
Start:
10,957,892 bp from pter
End:
11,169,828 bp from pter
Size:
211,937 bases
Orientation:
Plus strand

Genomic View for PHF14 Gene

Genes around PHF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF14 Gene

Proteins for PHF14 Gene

  • Protein details for PHF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94880-PHF14_HUMAN
    Recommended name:
    PHD finger protein 14
    Protein Accession:
    O94880
    Secondary Accessions:
    • A7MCZ3
    • B4DI82

    Protein attributes for PHF14 Gene

    Size:
    888 amino acids
    Molecular mass:
    100053 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34503.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF14 Gene

Post-translational modifications for PHF14 Gene

  • Ubiquitination at Lys 307 and Lys 435
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHF14 Gene

Domains & Families for PHF14 Gene

Gene Families for PHF14 Gene

Suggested Antigen Peptide Sequences for PHF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94880

UniProtKB/Swiss-Prot:

PHF14_HUMAN :
  • Contains 1 C2HC pre-PHD-type zinc finger.
Similarity:
  • Contains 1 C2HC pre-PHD-type zinc finger.
  • Contains 3 PHD-type zinc fingers.
genes like me logo Genes that share domains with PHF14: view

Function for PHF14 Gene

Gene Ontology (GO) - Molecular Function for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHF14: view
genes like me logo Genes that share phenotypes with PHF14: view

Animal Models for PHF14 Gene

MGI Knock Outs for PHF14:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHF14 Gene

Localization for PHF14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF14 Gene COMPARTMENTS Subcellular localization image for PHF14 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PHF14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHF14 Gene

Pathways & Interactions for PHF14 Gene

SuperPathways for PHF14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0048286 lung alveolus development IEA --
GO:0072201 negative regulation of mesenchymal cell proliferation IEA --
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IEA --
genes like me logo Genes that share ontologies with PHF14: view

No data available for Pathways by source and SIGNOR curated interactions for PHF14 Gene

Transcripts for PHF14 Gene

Unigene Clusters for PHF14 Gene

PHD finger protein 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF14 Gene

No ASD Table

Relevant External Links for PHF14 Gene

GeneLoc Exon Structure for
PHF14
ECgene alternative splicing isoforms for
PHF14

Expression for PHF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PHF14 Gene

Protein differential expression in normal tissues from HIPED for PHF14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.2), Retina (8.8), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHF14 Gene



Protein tissue co-expression partners for PHF14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHF14 Gene:

PHF14

SOURCE GeneReport for Unigene cluster for PHF14 Gene:

Hs.655688
genes like me logo Genes that share expression patterns with PHF14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHF14 Gene

Orthologs for PHF14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PHF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF14 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia PHF14 34 35
  • 94.25 (n)
cow
(Bos Taurus)
Mammalia PHF14 34 35
  • 93.91 (n)
rat
(Rattus norvegicus)
Mammalia Phf14 34
  • 91.71 (n)
mouse
(Mus musculus)
Mammalia Phf14 34 16 35
  • 91.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PHF14 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF14 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHF14 34 35
  • 84.59 (n)
lizard
(Anolis carolinensis)
Reptilia PHF14 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phf14 34
  • 76.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11349 34
zebrafish
(Danio rerio)
Actinopterygii phf14 34 35
  • 72.81 (n)
wufb80h09 34
fruit fly
(Drosophila melanogaster)
Insecta CG15439 35
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea phf-14 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 35
  • 15 (a)
OneToMany
Species where no ortholog for PHF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHF14 Gene

ENSEMBL:
Gene Tree for PHF14 (if available)
TreeFam:
Gene Tree for PHF14 (if available)

Paralogs for PHF14 Gene

Paralogs for PHF14 Gene

(2) SIMAP similar genes for PHF14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PHF14: view

Variants for PHF14 Gene

Sequence variations from dbSNP and Humsavar for PHF14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10085512 -- 11,108,589(+) TCAAT(C/T)AGCAA intron-variant
rs10085765 -- 10,976,887(+) GCTTA(A/G)ATTTG intron-variant
rs10215147 -- 11,026,738(+) ttttt(A/T)aaatt intron-variant
rs10226402 -- 11,023,774(+) agtga(C/G)ctgag intron-variant
rs10226792 -- 11,166,625(+) ATCTA(C/T)TACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF14 Gene

Variant ID Type Subtype PubMed ID
dgv405n21 CNV gain 19592680
dgv6266n100 CNV loss 25217958
esv2752140 CNV gain 17911159
esv3571637 CNV loss 25503493
esv3612203 CNV loss 21293372
esv3891050 CNV gain 25118596
esv3891051 CNV loss 25118596
nsv1019888 CNV gain 25217958
nsv1029882 CNV loss 25217958
nsv1030035 CNV gain 25217958
nsv1031075 CNV loss 25217958
nsv1137574 CNV deletion 24896259
nsv428162 CNV loss 18775914
nsv477386 CNV novel sequence insertion 20440878
nsv606187 CNV gain 21841781
nsv606194 CNV loss 21841781
nsv606195 CNV gain 21841781
nsv606196 CNV loss 21841781
nsv819766 CNV gain 19587683
nsv830901 CNV gain 17160897
nsv970446 CNV duplication 23825009

Variation tolerance for PHF14 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF14 Gene

Disorders for PHF14 Gene

Relevant External Links for PHF14

Human Genome Epidemiology (HuGE) Navigator
PHF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHF14

No disorders were found for PHF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHF14 Gene

Publications for PHF14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Filtering genetic variants and placing informative priors based on putative biological function. (PMID: 26866982) Friedrichs S. … Bailey J.N. (BMC Genet. 2016) 3 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for PHF14 Gene

Sources for PHF14 Gene

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