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Aliases for PHF14 Gene

Aliases for PHF14 Gene

  • PHD Finger Protein 14 2 3
  • KIAA0783 4

External Ids for PHF14 Gene

Previous GeneCards Identifiers for PHF14 Gene

  • GC07P010723
  • GC07P010757
  • GC07P010786
  • GC07P010980
  • GC07P011014

Summaries for PHF14 Gene

GeneCards Summary for PHF14 Gene

PHF14 (PHD Finger Protein 14) is a Protein Coding gene. Diseases associated with PHF14 include dandy-walker syndrome. An important paralog of this gene is BRPF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF14 Gene

Genomics for PHF14 Gene

Regulatory Elements for PHF14 Gene

Genomic Location for PHF14 Gene

Start:
10,973,872 bp from pter
End:
11,169,623 bp from pter
Size:
195,752 bases
Orientation:
Plus strand

Genomic View for PHF14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF14 Gene

Proteins for PHF14 Gene

  • Protein details for PHF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94880-PHF14_HUMAN
    Recommended name:
    PHD finger protein 14
    Protein Accession:
    O94880
    Secondary Accessions:
    • A7MCZ3
    • B4DI82

    Protein attributes for PHF14 Gene

    Size:
    888 amino acids
    Molecular mass:
    100053 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34503.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PHF14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF14 Gene

Proteomics data for PHF14 Gene at MOPED

Post-translational modifications for PHF14 Gene

  • Ubiquitination at Lys307 and Lys435
  • Modification sites at PhosphoSitePlus

Other Protein References for PHF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PHF14 Gene

Domains for PHF14 Gene

Gene Families for PHF14 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Protein Domains for PHF14 Gene

Suggested Antigen Peptide Sequences for PHF14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94880

UniProtKB/Swiss-Prot:

PHF14_HUMAN :
  • O94880
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with PHF14: view

Function for PHF14 Gene

Gene Ontology (GO) - Molecular Function for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PHF14: view

Phenotypes for PHF14 Gene

genes like me logo Genes that share phenotypes with PHF14: view

Animal Models for PHF14 Gene

MGI Knock Outs for PHF14:

miRNA for PHF14 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PHF14 Gene

Localization for PHF14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF14 Gene COMPARTMENTS Subcellular localization image for PHF14 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PHF14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PHF14 Gene

Pathways for PHF14 Gene

SuperPathways for PHF14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0008285 negative regulation of cell proliferation --
GO:0048286 lung alveolus development IEA --
GO:0072201 negative regulation of mesenchymal cell proliferation --
GO:2000584 negative regulation of platelet-derived growth factor receptor-alpha signaling pathway IEA --
genes like me logo Genes that share ontologies with PHF14: view

No data available for Pathways by source for PHF14 Gene

Transcripts for PHF14 Gene

Unigene Clusters for PHF14 Gene

PHD finger protein 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHF14 Gene

No ASD Table

Relevant External Links for PHF14 Gene

GeneLoc Exon Structure for
PHF14
ECgene alternative splicing isoforms for
PHF14

Expression for PHF14 Gene

mRNA expression in normal human tissues for PHF14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHF14 Gene

SOURCE GeneReport for Unigene cluster for PHF14 Gene Hs.655688

genes like me logo Genes that share expressions with PHF14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHF14 Gene

Orthologs for PHF14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PHF14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF14 35
  • 99.66 (n)
  • 100 (a)
PHF14 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHF14 35
  • 93.91 (n)
  • 96.59 (a)
PHF14 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHF14 35
  • 94.25 (n)
  • 95.98 (a)
PHF14 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf14 35
  • 91.08 (n)
  • 96.24 (a)
Phf14 16
Phf14 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF14 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF14 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf14 35
  • 91.71 (n)
  • 96.24 (a)
chicken
(Gallus gallus)
Aves PHF14 35
  • 84.59 (n)
  • 95.1 (a)
PHF14 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF14 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11349 35
tropical clawed frog
(Silurana tropicalis)
Amphibia phf14 35
  • 76.65 (n)
  • 84.53 (a)
zebrafish
(Danio rerio)
Actinopterygii phf14 35
  • 72.81 (n)
  • 82 (a)
phf14 36
  • 70 (a)
OneToOne
wufb80h09 35
fruit fly
(Drosophila melanogaster)
Insecta CG15439 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea phf-14 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 36
  • 15 (a)
OneToMany
Species with no ortholog for PHF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHF14 Gene

ENSEMBL:
Gene Tree for PHF14 (if available)
TreeFam:
Gene Tree for PHF14 (if available)

Paralogs for PHF14 Gene

Paralogs for PHF14 Gene

Selected SIMAP similar genes for PHF14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PHF14: view

Variants for PHF14 Gene

Sequence variations from dbSNP and Humsavar for PHF14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs182594 -- 11,005,495(-) AGAAA(C/G)AGTGA intron-variant
rs190074 -- 10,974,321(-) ACTAA(A/G)GAATC utr-variant-5-prime, nc-transcript-variant
rs191984 -- 11,075,701(-) ttgga(A/T)atatg intron-variant
rs218965 -- 10,982,937(-) TGAGA(C/T)GCAGA synonymous-codon, reference, intron-variant
rs218966 - 10,982,603(-) TCTCC(C/T)TTTTC reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF14 Gene

Variant ID Type Subtype PubMed ID
nsv887600 CNV Gain 21882294
esv2752140 CNV Gain 17911159
nsv887601 CNV Gain 21882294
nsv819766 CNV Gain 19587683
dgv7185n71 CNV Loss 21882294
nsv428162 CNV Loss 18775914
nsv830901 CNV Gain 17160897
dgv405n21 CNV Gain 19592680

Relevant External Links for PHF14 Gene

HapMap Linkage Disequilibrium report
PHF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHF14 Gene

Disorders for PHF14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PHF14 Gene including...

Search for PHF14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PHF14 Gene

Relevant External Links for PHF14

Human Genome Epidemiology (HuGE) Navigator
PHF14
genes like me logo Genes that share disorders with PHF14: view

No data available for UniProtKB/Swiss-Prot for PHF14 Gene

Publications for PHF14 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity. (PMID: 17158748) Ouararhni K. … Hamiche A. (Genes Dev. 2006) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for PHF14 Gene

Sources for PHF14 Gene

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