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PHF12 Gene

protein-coding   GIFtS: 53
GCID: GC17M027232

PHD Finger Protein 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PHD Finger Protein 121 2
PHD Factor 12 3
PF12
PHD Zinc Finger Transcription Factor2
KIAA15233
Pf13

External Ids:    HGNC: 208161   Entrez Gene: 576492   Ensembl: ENSG000001091187   UniProtKB: Q96QT63   

Export aliases for PHF12 gene to outside databases

Previous GC identifers: GC17M027084 GC17M027377 GC17M027378 GC17M024256 GC17M023440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PHF12 Gene:
PHF12 (PHD finger protein 12) is a protein-coding gene. Diseases associated with PHF12 include duodenum adenocarcinoma, and eaf. GO annotations related to this gene include transcription corepressor binding and phosphatidylinositol binding.

UniProtKB/Swiss-Prot: PHF12_HUMAN, Q96QT6
Function: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA.
Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May
also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA

Gene Wiki entry for PHF12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHF12 gene promoter:
         SRF   GATA-3   AP-4   CUTL1   E47   GATA-2   PPAR-alpha   MEF-2A   Hand1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHF12 promoter sequence
   Search Chromatin IP Primers for PHF12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

PHF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027232:  view genomic region     (about GC identifiers)

Start:
27,232,268 bp from pter      End:
27,278,789 bp from pter
Size:
46,522 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PHF12_HUMAN, Q96QT6 (See protein sequence)
Recommended Name: PHD finger protein 12  
Size: 1004 amino acids; 109698 Da
Subunit: Isoform 2 interacts with SIN3A in a complex composed of HDAC1, SAP30 and SIN3A. Interacts with AES
2 PDB 3D structures from and Proteopedia for PHF12:
2L9S (3D)        2LKM (3D)    
Secondary accessions: Q0VAI5 Q6ZML2 Q9BV34 Q9H7U9 Q9P205
Alternative splicing: 4 isoforms:  Q96QT6-1   Q96QT6-2   Q96QT6-3   Q96QT6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHF12: NX_Q96QT6

Explore proteomics data for PHF12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys751
  • Modification sites at PhosphoSitePlus

  • See PHF12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001028733.1  NP_001277060.1  NP_065940.1  

    ENSEMBL proteins: 
     ENSP00000329933   ENSP00000465161   ENSP00000465255   ENSP00000368157   ENSP00000467363  
     ENSP00000268756   ENSP00000463900   ENSP00000465374   ENSP00000468478   ENSP00000465017  
     ENSP00000467091   ENSP00000466695   ENSP00000467921  

    PHF12 Human Recombinant Protein Products:

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    Novus Biologicals PHF12 Lysate
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    Cloud-Clone Corp. Proteins for PHF12

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 7):
     IPR008984 SMAD_FHA_domain
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry Q96QT6

    ProtoNet protein and cluster: Q96QT6

    1 Blocks protein domain: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: PHF12_HUMAN, Q96QT6
    Domain: The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs)
    Similarity: Contains 1 FHA domain
    Similarity: Contains 2 PHD-type zinc fingers


    PHF12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHF12_HUMAN, Q96QT6
    Function: Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA.
    Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May
    also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IDA--
    GO:0001222transcription corepressor binding IEA--
    GO:0005515protein binding IPI11390640
    GO:0008270zinc ion binding IEA--
    GO:0035091phosphatidylinositol binding IDA16893883
         
    PHF12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PHF12:
     Decreased Tat-dependent transc  Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHF12
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    miRNA
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    miRTarBase miRNAs that target PHF12:
    hsa-mir-320b (MIRT036211), hsa-mir-92a-3p (MIRT049291), hsa-mir-652-3p (MIRT039475), hsa-mir-454-3p (MIRT039249), hsa-mir-221-3p (MIRT024170)

    Block miRNA regulation of human, mouse, rat PHF12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHF12 (see all 25):
    hsa-miR-3607-3p hsa-miR-301a hsa-miR-20b* hsa-miR-105 hsa-miR-548a-3p hsa-miR-29a* hsa-miR-3121-3p hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidPHF12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PHF12

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    GenScript: all cDNA clones in your preferred vector (see all 2): PHF12 (NM_020889)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF12

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHF12_HUMAN, Q96QT6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016580Sin3 complex IDA--
    GO:0017053transcriptional repressor complex IDA11390640

    PHF12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHF12
    Interactions:

        GeneGlobe Interaction Network for PHF12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PHF12 (Q96QT63 ENSP000003299334) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC1Q135473, ENSP000003626494I2D: score=2 STRING: ENSP00000362649
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    MORF4L1Q9UBU83, ENSP000003313104I2D: score=2 STRING: ENSP00000331310
    SIN3AQ96ST33, ENSP000003536224I2D: score=2 STRING: ENSP00000353622
    MORF4L2Q150143I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0045892negative regulation of transcription, DNA-templated IDA11390640

    PHF12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHF12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHF12 gene (3 alternative transcripts): 
    NM_001033561.1  NM_001290131.1  NM_020889.2  

    Unigene Cluster for PHF12:

    PHD finger protein 12
    Hs.444173  [show with all ESTs]
    Unigene Representative Sequence: NM_001033561
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332830(uc010wbb.1 uc002hdg.1) ENST00000577226(uc002hdi.1)
    ENST00000589176 ENST00000582436(uc002hdh.1 uc002hdk.1) ENST00000582655
    ENST00000378879 ENST00000579036 ENST00000579563 ENST00000268756(uc002hdj.1 uc010crw.1)
    ENST00000583524 ENST00000584822 ENST00000578900 ENST00000483934 ENST00000584685
    ENST00000582853 ENST00000584236 ENST00000583747
    miRNA
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    Block miRNA regulation of human, mouse, rat PHF12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHF12 (see all 25):
    hsa-miR-3607-3p hsa-miR-301a hsa-miR-20b* hsa-miR-105 hsa-miR-548a-3p hsa-miR-29a* hsa-miR-3121-3p hsa-miR-33b
    SwitchGear 3'UTR luciferase reporter plasmidPHF12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PHF12
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PHF12 (NM_020889)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHF12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHF12
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat PHF12
      QuantiFast Probe-based Assays in human, mouse, rat PHF12

    Additional mRNA sequence: 

    AB040956.1 AK024290.1 AK291420.1 AK294056.1 AL161953.1 AY030283.1 BC001657.1 BC110882.1 
    BC121043.1 BC121044.1 

    17 DOTS entries:

    DT.435789  DT.100778707  DT.95357451  DT.91764110  DT.95216273  DT.120953679  DT.40309079  DT.91764112 
    DT.91821184  DT.92036044  DT.120953646  DT.120953662  DT.75188360  DT.86842170  DT.95331744  DT.100778706 
    DT.120953592 

    Selected AceView cDNA sequences (see all 93):

    BQ425073 BF858311 AA431150 BI258910 AI350760 AU132285 AW005510 BX093682 
    AB040956 BU526964 AK091441 AI872988 BQ877079 BQ011196 AX746984 BM847460 
    BM685437 AW062950 BI913280 AA255939 BG761572 BF338140 AK160370 BE257989 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PHF12 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:              -     -     -           -     -     -           -                                                                       -                     
    SP2:              -     -     -           -     -     -           -     -     -     -     -     -     -                                   -                     
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                    -     -           -                     
    SP5:        -     -     -     -           -     -     -           -                                                                                             

    ExUns: 18a · 18b · 18c · 18d ^ 19a · 19b · 19c · 19d ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
    SP1:                                                                              
    SP2:                                                                              
    SP3:                    -     -                       -                           
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for PHF12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTAGAGCG
    PHF12 Expression
    About this image


    PHF12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Eye (Sensory Organs)
             Retina
    PHF12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHF12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444173
        Custom PCR Arrays for PHF12
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    QuantiFast Probe-based Assays in human, mouse, rat PHF12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHF12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PHF12 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf121 , 5 PHD finger protein 121, 5 94.42(n)1
    96.01(a)1
      11 (46.74 cM)5
    2684481  NM_174852.31  NP_777277.21 
     779827545 
    chicken
    (Gallus gallus)
    Aves PHF121 PHD finger protein 12 79.5(n)
    81.92(a)
      417580  XM_415826.4  XP_415826.4 
    lizard
    (Anolis carolinensis)
    Reptilia PHF126
    PHD finger protein 12
    69(a)
    1 ↔ 1
    GL344282.1(12583-35160)
    African clawed frog
    (Xenopus laevis)
    Amphibia phf12-prov2 PHD finger protein 12 77.4(n)    BC043787.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phf12b1 PHD finger protein 12b 61.04(n)
    58.99(a)
      325296  XM_002664624.3  XP_002664670.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG38156
    --
    31(a)
    1 ↔ 1
    X(6189424-6193006)


    ENSEMBL Gene Tree for PHF12 (if available)
    TreeFam Gene Tree for PHF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHF12 gene
    3 SIMAP similar genes for PHF12 using alignment to 13 protein entries:     PHF12_HUMAN (see all proteins):
    AIRE    BPTF    PHF21A

    PHF12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHF12 (see all 878)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467602911,2
    --27232610(+) ACAGCC/TAGAAA 1 -- ut310--------
    rs1884670151,2
    --27232727(+) GTAGCA/GATCTT 1 -- ut310--------
    rs2013076711,2
    --27233194(+) TAGCCA/GCCAGT 1 -- ut310--------
    rs1999538611,2
    C--27233221(+) GGAGCA/GCAGCA 2 R C mis10--------
    rs1433547871,2
    C--27233280(+) CCTGCA/GGCAGG 2 P L mis11Minor allele frequency- G:0.00NA 4544
    rs1416862591,2
    C,F--27233312(+) TTGGTC/TGCAAA 2 A syn12Minor allele frequency- T:0.00NA EU 5871
    rs2018451651,2
    --27233408(+) CCACTA/GCCCCC 2 G syn10--------
    rs2013308941,2
    --27233420(+) ATCAAA/GCTCGA 2 S syn10--------
    rs2004412511,2
    --27233472(+) GGGCCC/TGGGAA 2 Q R mis10--------
    rs1440980311,2
    --27233631(+) ATTCCA/GACTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for PHF12 (27232268 - 27278789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PHF12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833408CNV Loss17160897
    nsv457719CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHF12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for PHF12:    
    About MalaCards
    duodenum adenocarcinoma    eaf    adenocarcinoma    hiv-1
    alzheimer's disease


    PHF12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PHF12
    Human Genome Epidemiology (HuGE) Navigator: PHF12 (2 documents)

    Export disorders for PHF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHF12 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with PHF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pf1, a novel PHD zinc finger protein that links the TLE corepressor to the mSin3A-histone deacetylase complex. (PubMed id 11390640)1, 2, 3 Yochum G.S. and Ayer D.E. (Mol. Cell. Biol. 2001)
    2. The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding. (PubMed id 16893883)1, 2 Kaadige M.R. and Ayer D.E. (J. Biol. Chem. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and transducin-like enhancer of Split. (PubMed id 12391155)1, 9 Yochum G.S. and Ayer D.E. (Mol. Cell. Biol. 2002)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57649 HGNC: 20816 AceView: PHF12 Ensembl:ENSG00000109118 euGenes: HUgn57649
    ECgene: PHF12 H-InvDB: PHF12

    (According to HUGE)
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    HUGE: KIAA1523

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PHF12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PHF12 gene:
    Search GeneIP for patents involving PHF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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