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Aliases for PHF11 Gene

Aliases for PHF11 Gene

  • PHD Finger Protein 11 2 3 5
  • BRCA1 C-Terminus-Associated Protein 3 4
  • Renal Carcinoma Antigen NY-REN-34 3 4
  • IgE Responsiveness (Atopic) 2 3
  • BCAP 3 4
  • NY-REN-34 3
  • NYREN34 3
  • IGHER 3
  • IGEL 3
  • IGER 3
  • APY 3

External Ids for PHF11 Gene

Previous GeneCards Identifiers for PHF11 Gene

  • GC13P049006
  • GC13P047868
  • GC13P048968
  • GC13P050069
  • GC13P030863

Summaries for PHF11 Gene

Entrez Gene Summary for PHF11 Gene

  • This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for PHF11 Gene

PHF11 (PHD Finger Protein 11) is a Protein Coding gene. Diseases associated with PHF11 include asthma and atopic dermatitis. An important paralog of this gene is PHF6.

UniProtKB/Swiss-Prot for PHF11 Gene

  • Positive regulator of Th1-type cytokine gene expression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF11 Gene

Genomics for PHF11 Gene

Regulatory Elements for PHF11 Gene

Promoters for PHF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHF11 Gene

Chromosome:
13
Start:
49,495,610 bp from pter
End:
49,528,987 bp from pter
Size:
33,378 bases
Orientation:
Plus strand

Genomic View for PHF11 Gene

Genes around PHF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF11 Gene

Proteins for PHF11 Gene

  • Protein details for PHF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIL8-PHF11_HUMAN
    Recommended name:
    PHD finger protein 11
    Protein Accession:
    Q9UIL8
    Secondary Accessions:
    • Q5W0A4
    • Q5W0A6
    • Q9Y5A2

    Protein attributes for PHF11 Gene

    Size:
    331 amino acids
    Molecular mass:
    37582 Da
    Quaternary structure:
    • Interacts with BRCA1 and RELA.
    SequenceCaution:
    • Sequence=AAD42871.1; Type=Frameshift; Positions=226, 253; Evidence={ECO:0000305}; Sequence=AAH17212.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PHF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF11 Gene

Proteomics data for PHF11 Gene at MOPED

Post-translational modifications for PHF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PHF11 Gene

Domains & Families for PHF11 Gene

Gene Families for PHF11 Gene

Protein Domains for PHF11 Gene

Suggested Antigen Peptide Sequences for PHF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIL8

UniProtKB/Swiss-Prot:

PHF11_HUMAN :
  • Contains 1 PHD-type zinc finger.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with PHF11: view

Function for PHF11 Gene

Molecular function for PHF11 Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of Th1-type cytokine gene expression.
genes like me logo Genes that share phenotypes with PHF11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PHF11 Gene

Localization for PHF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF11 Gene COMPARTMENTS Subcellular localization image for PHF11 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for PHF11 Gene

Pathways & Interactions for PHF11 Gene

SuperPathways for PHF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PHF11: view

No data available for Pathways by source and SIGNOR curated interactions for PHF11 Gene

Drugs & Compounds for PHF11 Gene

No Compound Related Data Available

Transcripts for PHF11 Gene

Unigene Clusters for PHF11 Gene

PHD finger protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHF11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for PHF11 Gene

GeneLoc Exon Structure for
PHF11
ECgene alternative splicing isoforms for
PHF11

Expression for PHF11 Gene

mRNA expression in normal human tissues for PHF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHF11 Gene

This gene is overexpressed in Pancreas (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PHF11 Gene



SOURCE GeneReport for Unigene cluster for PHF11 Gene Hs.369039

mRNA Expression by UniProt/SwissProt for PHF11 Gene

Q9UIL8-PHF11_HUMAN
Tissue specificity: Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta.
genes like me logo Genes that share expression patterns with PHF11: view

Protein tissue co-expression partners for PHF11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PHF11 Gene

Orthologs for PHF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PHF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PHF11 35
  • 82.18 (n)
  • 73.27 (a)
-- 36
  • 54 (a)
OneToMany
PHF11 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PHF11 35
  • 81.03 (n)
  • 70.39 (a)
PHF11 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf11b 35
  • 74.06 (n)
  • 58.06 (a)
Phf11d 16
Gm6904 36
  • 58 (a)
OneToMany
Phf11a 36
  • 49 (a)
OneToMany
Phf11b 36
  • 53 (a)
OneToMany
Phf11c 36
  • 47 (a)
OneToMany
Phf11d 36
  • 50 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PHF11 35
  • 99.5 (n)
  • 99.4 (a)
PHF11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf11 35
  • 66.37 (n)
  • 52.19 (a)
oppossum
(Monodelphis domestica)
Mammalia PHF11 36
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHF11 35
  • 60.29 (n)
  • 44.49 (a)
PHF11 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF11 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii phf11 36
  • 15 (a)
OneToOne
Species with no ortholog for PHF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF11 Gene

ENSEMBL:
Gene Tree for PHF11 (if available)
TreeFam:
Gene Tree for PHF11 (if available)

Paralogs for PHF11 Gene

Paralogs for PHF11 Gene

(2) SIMAP similar genes for PHF11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHF11: view

Variants for PHF11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PHF11 Gene

Q9UIL8-PHF11_HUMAN
Variation in PHF11 seems to be associated with propensity to childhood atopic dermatitis and asthma.

Sequence variations from dbSNP and Humsavar for PHF11 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs2980 -- 49,526,937(-) CAAGC(A/G)GAGGG intron-variant, downstream-variant-500B
rs2981 -- 49,526,958(-) TCTCA(C/T)CAAGC intron-variant, downstream-variant-500B
rs3033 -- 49,528,856(-) TGGGA(A/G)TGTGA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs942870 -- 49,523,843(+) TCATA(C/T)AGTTA intron-variant
rs1046295 -- 49,528,674(+) TTACC(A/G)TTTCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PHF11 Gene

Variant ID Type Subtype PubMed ID
nsv523648 CNV Gain 19592680
nsv900070 CNV Loss 21882294
esv2319655 CNV Deletion 18987734
esv2747396 CNV Deletion 23290073
nsv519181 CNV Loss 19592680
nsv826637 CNV Loss 20364138

Variation tolerance for PHF11 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHF11 Gene

HapMap Linkage Disequilibrium report
PHF11
Human Gene Mutation Database (HGMD)
PHF11

Disorders for PHF11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PHF11 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
atopic dermatitis
  • eczema
- elite association - COSMIC cancer census association via MalaCards
Search PHF11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PHF11

Genetic Association Database (GAD)
PHF11
Human Genome Epidemiology (HuGE) Navigator
PHF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHF11
genes like me logo Genes that share disorders with PHF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHF11 Gene

Publications for PHF11 Gene

  1. Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis. (PMID: 15674390) Jang N. … Jones G. (Genes Immun. 2005) 3 4 23 48 67
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3
  3. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. (PMID: 12754510) Zhang Y. … Cookson W.O.C.M. (Nat. Genet. 2003) 3 23
  4. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PHF11 Gene

Sources for PHF11 Gene

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