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Aliases for PHF11 Gene

Aliases for PHF11 Gene

  • PHD Finger Protein 11 2 3 5
  • BRCA1 C-Terminus-Associated Protein 3 4
  • Renal Carcinoma Antigen NY-REN-34 3 4
  • IgE Responsiveness (Atopic) 2 3
  • BCAP 3 4
  • NY-REN-34 3
  • NYREN34 3
  • IGHER 3
  • IGEL 3
  • IGER 3
  • APY 3

External Ids for PHF11 Gene

Previous GeneCards Identifiers for PHF11 Gene

  • GC13P049006
  • GC13P047868
  • GC13P048968
  • GC13P050069
  • GC13P030863

Summaries for PHF11 Gene

Entrez Gene Summary for PHF11 Gene

  • This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for PHF11 Gene

PHF11 (PHD Finger Protein 11) is a Protein Coding gene. Diseases associated with PHF11 include Ige Responsiveness, Atopic and Asthma. An important paralog of this gene is PHF6.

UniProtKB/Swiss-Prot for PHF11 Gene

  • Positive regulator of Th1-type cytokine gene expression.

Additional gene information for PHF11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF11 Gene

Genomics for PHF11 Gene

GeneHancer (GH) Regulatory Elements for PHF11 Gene

Promoters and enhancers for PHF11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I049494 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 564.2 +2.1 2084 6.6 HDGF PKNOX1 FOXA2 ARID4B DMAP1 ZNF2 IRF4 YY1 ZNF207 ZNF143 PHF11 SETDB2 TRIM13 KCNRG EBPL ARL11 RCBTB1 GC13P049390
GH13I049442 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 23.8 -50.0 -49984 5.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SETDB2 CAB39L PHF11 ARL11 EBPL SNRPGP14 GC13P049390
GH13I049640 Enhancer 1.3 FANTOM5 Ensembl ENCODE 20.8 +147.0 146978 3.2 HDAC1 ZNF133 TCF12 USF2 CEBPB ZNF148 ZFP69B SMARCA4 IKZF1 STAT3 PHF11 RCBTB1 ARL11 EBPL KPNA3 SETDB2 CAB39L LOC105370205 GC13M049652
GH13I049400 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11 -94.1 -94077 1.2 HDAC1 NCOA1 CBFA2T3 DPF2 REST ZBTB40 ZNF217 CTBP1 JUND GATA3 CAB39L PHF11 MLNR GC13P049390 GC13P049413
GH13I049529 Enhancer 0.9 Ensembl ENCODE dbSUPER 19.9 +35.2 35164 1.7 POLR2A CBFA2T3 RUNX3 SPI1 PHF11 RCBTB1 GC13P049390
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PHF11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PHF11 gene promoter:

Genomic Locations for PHF11 Gene

Genomic Locations for PHF11 Gene
33,378 bases
Plus strand

Genomic View for PHF11 Gene

Genes around PHF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF11 Gene

Proteins for PHF11 Gene

  • Protein details for PHF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    PHD finger protein 11
    Protein Accession:
    Secondary Accessions:
    • Q5W0A4
    • Q5W0A6
    • Q9Y5A2

    Protein attributes for PHF11 Gene

    331 amino acids
    Molecular mass:
    37582 Da
    Quaternary structure:
    • Interacts with BRCA1 and RELA.
    • Sequence=AAD42871.1; Type=Frameshift; Positions=226, 253; Evidence={ECO:0000305}; Sequence=AAH17212.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PHF11 Gene


neXtProt entry for PHF11 Gene

Post-translational modifications for PHF11 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PHF11 Gene

Domains & Families for PHF11 Gene

Gene Families for PHF11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PHF11 Gene

Suggested Antigen Peptide Sequences for PHF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PHF11: view

No data available for UniProtKB/Swiss-Prot for PHF11 Gene

Function for PHF11 Gene

Molecular function for PHF11 Gene

UniProtKB/Swiss-Prot Function:
Positive regulator of Th1-type cytokine gene expression.

Phenotypes From GWAS Catalog for PHF11 Gene

Gene Ontology (GO) - Molecular Function for PHF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHF11: view
genes like me logo Genes that share phenotypes with PHF11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PHF11 Gene

Localization for PHF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHF11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHF11 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PHF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with PHF11: view

Pathways & Interactions for PHF11 Gene

SuperPathways for PHF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with PHF11: view

No data available for Pathways by source and SIGNOR curated interactions for PHF11 Gene

Drugs & Compounds for PHF11 Gene

No Compound Related Data Available

Transcripts for PHF11 Gene

Unigene Clusters for PHF11 Gene

PHD finger protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHF11 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - - -
SP4: - - - -

Relevant External Links for PHF11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PHF11 Gene

This gene is overexpressed in Pancreas (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PHF11 Gene

Protein tissue co-expression partners for PHF11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHF11 Gene:


SOURCE GeneReport for Unigene cluster for PHF11 Gene:


mRNA Expression by UniProt/SwissProt for PHF11 Gene:

Tissue specificity: Highly expressed in T and B-cells, as well as natural killer and mature dendritic cells. Expressed at higher levels in Th1 as compared to Th2 cells. Expressed at low levels in all normal tissues tested, including lung, testis, small intestine, breast, liver and placenta.

Evidence on tissue expression from TISSUES for PHF11 Gene

  • Stomach(4.4)
genes like me logo Genes that share expression patterns with PHF11: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHF11 Gene

Orthologs for PHF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PHF11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PHF11 33 34
  • 99.5 (n)
(Bos Taurus)
Mammalia PHF11 33 34
  • 82.18 (n)
-- 34
  • 54 (a)
(Canis familiaris)
Mammalia PHF11 33 34
  • 81.03 (n)
(Mus musculus)
Mammalia Phf11b 33 34
  • 74.06 (n)
Gm6904 34
  • 58 (a)
Phf11d 16 34
  • 50 (a)
Phf11a 34
  • 49 (a)
Phf11c 34
  • 47 (a)
(Rattus norvegicus)
Mammalia Phf11 33
  • 66.37 (n)
(Monodelphis domestica)
Mammalia PHF11 34
  • 41 (a)
(Gallus gallus)
Aves PHF11 33 34
  • 60.29 (n)
(Anolis carolinensis)
Reptilia PHF11 34
  • 39 (a)
(Danio rerio)
Actinopterygii phf11 34
  • 15 (a)
Species where no ortholog for PHF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF11 Gene

Gene Tree for PHF11 (if available)
Gene Tree for PHF11 (if available)

Paralogs for PHF11 Gene

Paralogs for PHF11 Gene

(2) SIMAP similar genes for PHF11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHF11: view

Variants for PHF11 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PHF11 Gene

Variation in PHF11 seems to be associated with propensity to childhood atopic dermatitis and asthma.

Sequence variations from dbSNP and Humsavar for PHF11 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000155730 -- 49,507,288(+) T/C intron_variant
rs1000438651 -- 49,507,114(+) C/G intron_variant
rs1000469548 -- 49,505,986(+) TTCTTCTTC/TTCTTC intron_variant
rs1000474463 -- 49,526,804(+) A/T intron_variant
rs1000659871 -- 49,494,553(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PHF11 Gene

Variant ID Type Subtype PubMed ID
dgv3139n54 CNV loss 21841781
esv2319655 CNV deletion 18987734
esv2747396 CNV deletion 23290073
esv3550445 CNV deletion 23714750
nsv1148044 CNV deletion 26484159
nsv519181 CNV loss 19592680
nsv523648 CNV gain 19592680
nsv561613 CNV loss 21841781
nsv826637 CNV loss 20364138

Variation tolerance for PHF11 Gene

Residual Variation Intolerance Score: 73.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PHF11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for PHF11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PHF11 Gene - From: HGMD, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ige responsiveness, atopic
  • iger
  • asthma, susceptibility to
  • eczema
dermatitis, atopic
  • atod
- elite association - COSMIC cancer census association via MalaCards
Search PHF11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for PHF11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PHF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHF11 Gene

Publications for PHF11 Gene

  1. Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis. (PMID: 15674390) Jang N … Jones G (Genes and immunity 2005) 3 4 22 44 58
  2. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. (PMID: 12754510) Zhang Y … Cookson WO (Nature genetics 2003) 3 4 22 44 58
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 2 3 4 58
  4. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 2 3 4 58
  5. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. (PMID: 21348951) Parsa A … Liggett SB (Clinical and translational science 2011) 3 44 58

Products for PHF11 Gene

Sources for PHF11 Gene

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