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PHF10 Gene

protein-coding   GIFtS: 52
GCID: GC06M170104

PHD Finger Protein 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
PHD Finger Protein 101 2     BRG1-Associated Factor, 45-KD, A2
BAF45A2 3 5     PHD Zinc Finger Protein XAP1352
XAP1352 3     BAF45a3
BRG1-Associated Factor 45a2 3     

External Ids:    HGNC: 182501   Entrez Gene: 552742   Ensembl: ENSG000001300247   OMIM: 6130695   UniProtKB: Q8WUB83   

Export aliases for PHF10 gene to outside databases

Previous GC identifers: GC06M169719 GC06M169679 GC06M169860 GC06M169921 GC06M169845 GC06M167523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PHF10 Gene:
This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the
encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants
are derived from this gene but the full-length nature of only two of them is known. These two splice variants
encode different isoforms. A pseudogene for this gene is located on Xq28. (provided by RefSeq, Jul 2008)

GeneCards Summary for PHF10 Gene:
PHF10 (PHD finger protein 10) is a protein-coding gene. An important paralog of this gene is DPF3.

UniProtKB/Swiss-Prot: PHF10_HUMAN, Q8WUB8
Function: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural
progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural
progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling
mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from
proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of
the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes
which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and
DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the
self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays
a role regulating the activity of genes essential for dendrite growth (By similarity)

Gene Wiki entry for PHF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHF10 gene promoter:
         XBP-1   STAT5A   E4BP4   AREB6   PPAR-gamma1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHF10 promoter sequence
   Search Chromatin IP Primers for PHF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27|Xq28   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

PHF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHF10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170104:  view genomic region     (about GC identifiers)

Start:
170,104,001 bp from pter      End:
170,124,151 bp from pter
Size:
20,151 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PHF10_HUMAN, Q8WUB8 (See protein sequence)
Recommended Name: PHD finger protein 10  
Size: 498 amino acids; 56051 Da
Subunit: Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at
least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,
SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A
and actin. Interacts with ACTL6A/BAF53A, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A and PBRM1/BAF180 (By
similarity)
Caution: It is uncertain whether Met-1 or Met-89 is the initiator
Sequence caution: Sequence=AAH20954.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI10324.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK27451.1;
Type=Erroneous gene model prediction; Sequence=BAA91934.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAD96332.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAG33554.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI12316.1;
Type=Erroneous gene model prediction;
Secondary accessions: Q2YDA3 Q53HG8 Q9BXD2 Q9NV26
Alternative splicing: 3 isoforms:  Q8WUB8-1   Q8WUB8-2   Q8WUB8-3   

Explore the universe of human proteins at neXtProt for PHF10: NX_Q8WUB8

Explore proteomics data for PHF10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys168, Lys249, Lys267
  • Modification sites at PhosphoSitePlus

  • See PHF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060758.2  NP_579866.2  

    ENSEMBL proteins: 
     ENSP00000355743   ENSP00000341805  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    4 InterPro protein domains:
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD
     IPR019787 Znf_PHD-finger

    Graphical View of Domain Structure for InterPro Entry Q8WUB8

    ProtoNet protein and cluster: Q8WUB8

    1 Blocks protein domain: IPB001965 Zn-finger-like

    UniProtKB/Swiss-Prot: PHF10_HUMAN, Q8WUB8
    Similarity: Belongs to the SAYP family
    Similarity: Contains 2 PHD-type zinc fingers


    Find genes that share domains with PHF10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHF10_HUMAN, Q8WUB8
    Function: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural
    progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural
    progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling
    mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from
    proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of
    the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes
    which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and
    DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the
    self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays
    a role regulating the activity of genes essential for dendrite growth (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with PHF10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PHF10:
     Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Phf10):
     normal 

    Find genes that share phenotypes with PHF10           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHF10
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHF10_HUMAN, Q8WUB8: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0071564npBAF complex ISS--

    Find genes that share ontologies with PHF10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHF10
    Interactions:

        Search GeneGlobe Interaction Network for PHF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PHF10 (Q8WUB82, 3 ENSP000003418054) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516932, 3MINT-64353 I2D: score=5 
    SETDB1Q150472, 3MINT-64355 I2D: score=5 
    UNC119Q134322, 3MINT-64354 I2D: score=5 
    UTP14AQ9BVJ62, 3MINT-64356 I2D: score=5 
    CELSR2Q9HCU42, 3MINT-65562 I2D: score=4 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007399nervous system development IEA--

    Find genes that share ontologies with PHF10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHF10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PHF10 gene (2 alternative transcripts): 
    NM_018288.3  NM_133325.2  

    Unigene Cluster for PHF10:

    PHD finger protein 10
    Hs.435933  [show with all ESTs]
    Unigene Representative Sequence: AJ420510
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366780 ENST00000339209(uc011egy.2 uc011egz.2) ENST00000480008(uc011eha.1)
    ENST00000464779
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    Additional mRNA sequence: 

    AJ420510.1 AK001837.1 AK222612.1 AK296349.1 AL133094.1 BC020954.2 BC110323.1 CR457273.1 

    7 DOTS entries:

    DT.95275389  DT.95275392  DT.454952  DT.455377  DT.318602  DT.91705141  DT.100788680 

    Selected AceView cDNA sequences (see all 243):

    AA478403 AA504303 CR604749 AW629767 BQ888852 Z28776 Z38644 AW513720 
    AL133094 AA422129 AA321065 BM668319 Z32896 CF147451 CA394663 BM715004 
    AA788754 NM_018288 AI420793 AA343469 CB109716 CD106952 BM976384 CD722230 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PHF10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                                                        -     -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PHF10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATAAAAG
    PHF10 Expression
    About this image

    PHF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435933
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PHF10 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phf101 , 5 PHD finger protein 101, 5 91.73(n)1
    96.31(a)1
      17 (8.95 cM)5
    720571  NM_024250.41  NP_077212.31 
     149450095 
    chicken
    (Gallus gallus)
    Aves PHF101 PHD finger protein 10 85.18(n)
    91.86(a)
      100857350  XM_003640957.2  XP_003641005.2 
    lizard
    (Anolis carolinensis)
    Reptilia PHF106
    PHD finger protein 10
    90(a)
    1 ↔ 1
    5(774577-796637)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167822 Xenopus laevis transcribed sequence with moderate similarity more 82.11(n)    BX851578.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc662332 hypothetical protein MGC66233 77.54(n)   393628  AY398397.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta e(y)36
    enhancer of yellow 3
    6(a)
    many ↔ many
    X(19521982-19532385)
    worm
    (Caenorhabditis elegans)
    Secernentea phf-101 phf-10 47.57(n)
    38.29(a)
      3565141  NM_001047648.2  NP_001041113.1 


    ENSEMBL Gene Tree for PHF10 (if available)
    TreeFam Gene Tree for PHF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHF10 gene
    DPF32  DPF22  DPF12  
    1 SIMAP similar gene for PHF10 using alignment to 1 protein entry:     PHF10_HUMAN:
    AF-9/MLL fusion

    Find genes that share paralogs with PHF10           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for PHF10
    PGOHUM00000246295 PGOHUM00000242098


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHF10 (see all 359)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494110611,2
    C--170107283(+) TCTCC-/TGTA  
            
    TGTAT
    2 -- int10--------
    rs1896688881,2
    --170107301(+) TTATAA/CCCTGC 2 -- int10--------
    rs1816500161,2
    --170107420(+) TTCCTA/CTACCT 2 -- int10--------
    rs1867899521,2
    --170107623(+) CTGGCA/GTAGTA 2 -- int10--------
    rs2017641411,2
    C--170107639(+) CTAAT-/TAATCTT 2 -- int10--------
    rs11274891,2
    C,F,O,H--170107702(-) CTCCTG/ATGAGG 2 -- int1 ese319Minor allele frequency- A:0.23MN NS EA NA WA CSA 2523
    rs1148777021,2
    F--170108139(+) AGACCA/CATGGA 2 -- int11Minor allele frequency- C:0.01WA 118
    rs1920920201,2
    --170108176(+) GACAAC/TCAGTT 2 -- int10--------
    rs1508672401,2
    --170108212(+) CAGAGG/TATCAC 2 -- int10--------
    rs1834399041,2
    --170108225(+) TTGACA/GAGAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for PHF10 (170104001 - 170124151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PHF10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830872CNV Loss17160897
    esv24038CNV Loss19812545
    nsv887011CNV Loss21882294
    nsv887010CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHF10
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 613069    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PHF10:
    Visceral leishmaniasis

    Find genes that share disorders with PHF10           About GenesLikeMe


    Export disorders for PHF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHF10 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with PHF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28. (PubMed id 11827455)1, 2, 3 Aradhya S....Nelson D.L. (Genomics 2002)
    2. PHF10 is required for cell proliferation in normal and SV40- immortalized human fibroblast cells. (PubMed id 20068294)1, 2 Banga S.S.... Ozer H.L. (Cytogenet. Genome Res. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PubMed id 23400010)1 Del-Aguila J.L....Boerwinkle E. (Pharmacogenomics J. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-I_B RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (J. Biol. Chem. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55274 HGNC: 18250 AceView: PHF10 Ensembl:ENSG00000130024 euGenes: HUgn55274
    ECgene: PHF10 H-InvDB: PHF10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PHF10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PHF10 gene:
    Search GeneIP for patents involving PHF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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