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Aliases for PHC3 Gene

Aliases for PHC3 Gene

  • Polyhomeotic Homolog 3 (Drosophila) 2 3
  • Early Development Regulatory Protein 3 3 4
  • Early Development Regulator 3 2 3
  • Homolog Of Polyhomeotic 3 3 4
  • Polyhomeotic Like 3 2 3
  • HPH3 3 4
  • EDR3 3 4
  • Polyhomeotic Like 3 (Drosophila) 2
  • Polyhomeotic-Like Protein 3 3
  • PH3 4

External Ids for PHC3 Gene

Previous GeneCards Identifiers for PHC3 Gene

  • GC03M167082
  • GC03M170863
  • GC03M171216
  • GC03M171135
  • GC03M171297
  • GC03M169804

Summaries for PHC3 Gene

GeneCards Summary for PHC3 Gene

PHC3 (Polyhomeotic Homolog 3 (Drosophila)) is a Protein Coding gene. Diseases associated with PHC3 include acute chest syndrome. Among its related pathways are Cellular Senescence and Cellular Senescence. An important paralog of this gene is SAMD7.

UniProtKB/Swiss-Prot for PHC3 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Wiki entry for PHC3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHC3 Gene

Genomics for PHC3 Gene

Regulatory Elements for PHC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PHC3 Gene

Start:
170,086,732 bp from pter
End:
170,181,749 bp from pter
Size:
95,018 bases
Orientation:
Minus strand

Genomic View for PHC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHC3 Gene

Proteins for PHC3 Gene

  • Protein details for PHC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDX5-PHC3_HUMAN
    Recommended name:
    Polyhomeotic-like protein 3
    Protein Accession:
    Q8NDX5
    Secondary Accessions:
    • A2RRP9
    • Q5HYF0
    • Q6NSG2
    • Q8NFT7
    • Q8NFZ1
    • Q8TBM2
    • Q9H971
    • Q9H9I4

    Protein attributes for PHC3 Gene

    Size:
    983 amino acids
    Molecular mass:
    106162 Da
    Quaternary structure:
    • Component of a PRC1-like complex.
    Miscellaneous:
    • The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes

    Three dimensional structures from OCA and Proteopedia for PHC3 Gene

    Alternative splice isoforms for PHC3 Gene

neXtProt entry for PHC3 Gene

Proteomics data for PHC3 Gene at MOPED

Post-translational modifications for PHC3 Gene

  • Ubiquitination at Lys222
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PHC3 Gene

Domains for PHC3 Gene

Gene Families for PHC3 Gene

HGNC:
  • SAMD :Sterile alpha motif (SAM) domain containing

Protein Domains for PHC3 Gene

Suggested Antigen Peptide Sequences for PHC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NDX5

UniProtKB/Swiss-Prot:

PHC3_HUMAN :
  • Q8NDX5
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Similarity:
  • Contains 1 FCS-type zinc finger.
genes like me logo Genes that share domains with PHC3: view

Function for PHC3 Gene

Molecular function for PHC3 Gene

UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for PHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with PHC3: view

Phenotypes for PHC3 Gene

genes like me logo Genes that share phenotypes with PHC3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHC3 Gene

Localization for PHC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHC3 Gene COMPARTMENTS Subcellular localization image for PHC3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for PHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0015629 actin cytoskeleton IDA --
GO:0031519 PcG protein complex IDA 21282530
GO:0035102 PRC1 complex IDA 12167701
genes like me logo Genes that share ontologies with PHC3: view

Pathways for PHC3 Gene

genes like me logo Genes that share pathways with PHC3: view

Pathways by source for PHC3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Complexes in human,mouse,rat

Gene Ontology (GO) - Biological Process for PHC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0016925 protein sumoylation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with PHC3: view

Transcripts for PHC3 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PHC3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PHC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHC3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: - - - -
SP3: -

Relevant External Links for PHC3 Gene

GeneLoc Exon Structure for
PHC3
ECgene alternative splicing isoforms for
PHC3

Expression for PHC3 Gene

mRNA expression in normal human tissues for PHC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHC3 Gene

SOURCE GeneReport for Unigene cluster for PHC3 Gene Hs.529592

genes like me logo Genes that share expressions with PHC3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHC3 Gene

Orthologs for PHC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHC3 35
  • 99.87 (n)
  • 99.8 (a)
PHC3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHC3 35
  • 94.07 (n)
  • 96.78 (a)
PHC3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHC3 35
  • 95.37 (n)
  • 97.59 (a)
PHC3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phc3 35
  • 88.94 (n)
  • 93.04 (a)
Phc3 16
Phc3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHC3 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHC3 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phc3 35
  • 89.13 (n)
  • 94.32 (a)
chicken
(Gallus gallus)
Aves PHC3 35
  • 79.04 (n)
  • 80.37 (a)
PHC3 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHC3 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phc3 35
  • 65.8 (n)
  • 63.25 (a)
zebrafish
(Danio rerio)
Actinopterygii phc3 36
  • 42 (a)
OneToMany
PHC3 (2 of 2) 36
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ph-d 36
  • 14 (a)
ManyToMany
ph-p 36
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for PHC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHC3 Gene

ENSEMBL:
Gene Tree for PHC3 (if available)
TreeFam:
Gene Tree for PHC3 (if available)

Paralogs for PHC3 Gene

Paralogs for PHC3 Gene

genes like me logo Genes that share paralogs with PHC3: view

Variants for PHC3 Gene

Sequence variations from dbSNP and Humsavar for PHC3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs879161 -- 170,094,327(-) AAGCC(C/T)TGTGT utr-variant-3-prime
rs888507 -- 170,093,251(-) GAATC(C/G)TTAGA utr-variant-3-prime
rs1052228 -- 170,095,566(-) AAAAA(C/G)ATTGT utr-variant-3-prime
rs1052229 -- 170,095,308(-) TCATG(A/T)TCCAG utr-variant-3-prime
rs1273546 -- 170,149,561(+) gtgat(C/T)ctcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHC3 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER Inversion 18451855
esv2668922 CNV Deletion 23128226

Relevant External Links for PHC3 Gene

HapMap Linkage Disequilibrium report
PHC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHC3 Gene

Disorders for PHC3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PHC3 Gene including...

Search for PHC3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for PHC3 Gene

genes like me logo Genes that share disorders with PHC3: view

No data available for UniProtKB/Swiss-Prot for PHC3 Gene

Publications for PHC3 Gene

  1. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family. (PMID: 12384788) Tonkin E. … Strachan T. (Hum. Genet. 2002) 2 3 4 23
  2. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PMID: 12167701) Levine S.S. … Kingston R.E. (Mol. Cell. Biol. 2002) 2 3 4
  3. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PHC3 Gene

Sources for PHC3 Gene

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