Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PHC3 Gene

protein-coding   GIFtS: 54
GCID: GC03M169804

Polyhomeotic Homolog 3 (Drosophila)

(Previous name: polyhomeotic like 3 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polyhomeotic Homolog 3 (Drosophila)1 2     Polyhomeotic Like 3 (Drosophila)1
Early Development Regulator 31 2     HPH32
Polyhomeotic Like 31 2     Polyhomeotic-Like Protein 32
Early Development Regulatory Protein 32 3     PH33
Homolog Of Polyhomeotic 32 3     hPH33
EDR32 3     

External Ids:    HGNC: 156821   Entrez Gene: 800122   Ensembl: ENSG000001738897   UniProtKB: Q8NDX53   

Export aliases for PHC3 gene to outside databases

Previous GC identifers: GC03M167082 GC03M170863 GC03M171216 GC03M171135 GC03M171297


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PHC3 Gene:
PHC3 (polyhomeotic homolog 3 (Drosophila)) is a protein-coding gene. Diseases associated with PHC3 include acute chest syndrome, and brain cancer. An important paralog of this gene is PHC1.

UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PHC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHC3 gene promoter:
         E4BP4   Meis-1b   C/EBPalpha   CHOP-10   AREB6   CREB   HEN1   deltaCREB   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHC3 promoter sequence
   Search Chromatin IP Primers for PHC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.32

PHC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHC3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M169804:  view genomic region     (about GC identifiers)

Start:
169,804,520 bp from pter      End:
169,899,537 bp from pter
Size:
95,018 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5 (See protein sequence)
Recommended Name: Polyhomeotic-like protein 3  
Size: 983 amino acids; 106162 Da
Subunit: Component of a PRC1-like complex
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Secondary accessions: A2RRP9 Q5HYF0 Q6NSG2 Q8NFT7 Q8NFZ1 Q8TBM2 Q9H971 Q9H9I4
Alternative splicing: 7 isoforms:  Q8NDX5-1   Q8NDX5-2   Q8NDX5-3   Q8NDX5-4   Q8NDX5-5   Q8NDX5-6   Q8NDX5-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHC3: NX_Q8NDX5

Explore proteomics data for PHC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys222
  • Modification sites at PhosphoSitePlus

  • See PHC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079223.3  
    ENSEMBL proteins: 
     ENSP00000418835   ENSP00000420294   ENSP00000420271   ENSP00000419089   ENSP00000417360  
     ENSP00000418039   ENSP00000417633   ENSP00000417860   ENSP00000419899   ENSP00000418266  
     ENSP00000420713   ENSP00000418377   ENSP00000420454   ENSP00000417540  
    Reactome Protein details: Q8NDX5

    PHC3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHC3
    GenScript Custom Purified and Recombinant Proteins Services for PHC3
    Novus Biologicals PHC3 Protein
    Novus Biologicals PHC3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHC3

    PHC3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PHC3
    Novus Biologicals PHC3 Antibodies
    Abcam antibodies for PHC3
    Cloud-Clone Corp. Antibodies for PHC3
    Search ThermoFisher Antibodies for PHC3
    LSBio Antibodies in human, mouse, rat for PHC3

    PHC3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHC3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHC3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHC3
    Cloud-Clone Corp. CLIAs for PHC3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR012313 Znf_FCS

    Graphical View of Domain Structure for InterPro Entry Q8NDX5

    ProtoNet protein and cluster: Q8NDX5

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5
    Similarity: Contains 1 FCS-type zinc finger
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    PHC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHC3_HUMAN, Q8NDX5
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding ----
         
    PHC3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PHC3:
     Decreased viability with pacli  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHC3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHC3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHC3:
    hsa-mir-93-5p (MIRT027998), hsa-mir-196a-5p (MIRT026037), hsa-mir-218-5p (MIRT024226), hsa-mir-16-5p (MIRT031784), hsa-mir-103a-3p (MIRT027049)

    Block miRNA regulation of human, mouse, rat PHC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHC3 (see all 175):
    hsa-miR-124* hsa-miR-579 hsa-miR-640 hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHC3
    Predesigned siRNA for gene silencing in human, mouse, rat PHC3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHC3

    Clone
    Products:
         
    OriGene clones in human, mouse for PHC3 (see all 10)
    OriGene ORF clones in mouse, rat for PHC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHC3 (NM_024947)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHC3
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHC3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PHC3_HUMAN, Q8NDX5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--
    GO:0031519PcG protein complex IDA--

    PHC3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PHC3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PHC3
        Oxidative Stress Induced Senescence



    PHC3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PHC3: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PHC3

    Selected Interacting proteins for PHC3 (Q8NDX52, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF2Q994962, 3MINT-8010325 MINT-8010390 I2D: score=2 
    CBX2Q147812, 3MINT-8010325 MINT-8010390 I2D: score=1 
    BMI1P352262, 3MINT-8010325 I2D: score=2 
    PCGF2P352272, 3MINT-8010390 I2D: score=1 
    CBX4O002572MINT-8010325 MINT-8010390
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--

    PHC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PHC3 gene: 
    NM_024947.3  

    Unigene Cluster for PHC3:

    Polyhomeotic homolog 3 (Drosophila)
    Hs.529592  [show with all ESTs]
    Unigene Representative Sequence: NM_024947
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484068 ENST00000495893 ENST00000494943(uc010hws.1 uc003fgl.2)
    ENST00000467570(uc011bpq.1 uc011bpr.1) ENST00000486042 ENST00000484931
    ENST00000497171 ENST00000479467(uc003fgm.2) ENST00000466189 ENST00000475729
    ENST00000474275(uc003fgo.1) ENST00000472330 ENST00000465896 ENST00000497658(uc003fgp.3 uc003fgq.3)
    ENST00000481639 ENST00000491258 ENST00000490723
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHC3 (see all 175):
    hsa-miR-124* hsa-miR-579 hsa-miR-640 hsa-miR-520f hsa-miR-106a hsa-miR-138-2* hsa-miR-519a hsa-miR-4275
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHC3
    Predesigned siRNA for gene silencing in human, mouse, rat PHC3
    Clone
    Products:
         
    OriGene clones in human, mouse for PHC3 (see all 10)
    OriGene ORF clones in mouse, rat for PHC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHC3 (NM_024947)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHC3
      QuantiTect SYBR Green Assays in human, mouse, rat PHC3
      QuantiFast Probe-based Assays in human, mouse, rat PHC3

    Additional mRNA sequence: 

    AF380154.1 AF444193.1 AJ320486.3 AK022791.1 AK023029.1 AK093027.1 AK095225.1 AK300151.1 
    AK304411.1 BC022325.1 BC026001.1 BC070164.1 BC112944.1 BC131772.1 EF560717.1 

    15 DOTS entries:

    DT.97837426  DT.97774911  DT.75180698  DT.422499  DT.40261189  DT.100747176  DT.100736556  DT.120885288 
    DT.91889250  DT.406575  DT.100746203  DT.120885286  DT.204393  DT.91660475  DT.91816052 

    Selected AceView cDNA sequences (see all 129):

    H95610 AI275052 BE858742 AA278956 AA810014 BM678950 AV710124 AK022791 
    NM_024947 CB158879 BG779367 AI418979 AI339026 AI680172 AA306889 AI560883 
    AV715725 AJ320486 AF380154 AW274510 CD678195 CA433106 BQ023311 Z40983 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PHC3    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                            
    SP2:                                -     -     -     -                                                         
    SP3:              -                                                                                             


    ECgene alternative splicing isoforms for PHC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PHC3 expression in normal human tissues (normalized intensities)      PHC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGTCTGGA
    PHC3 Expression
    About this image


    PHC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    PHC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529592
        Pathway & Disease-focused RT2 Profiler PCR Array including PHC3: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHC3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHC3
    QuantiTect SYBR Green Assays in human, mouse, rat PHC3
    QuantiFast Probe-based Assays in human, mouse, rat PHC3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PHC3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phc31 , 5 polyhomeotic-like 3 (Drosophila)1, 5 88.94(n)1
    93.04(a)1
      3 (14.36 cM)5
    2419151  NM_001165954.11  NP_001159426.11 
     308993715 
    chicken
    (Gallus gallus)
    Aves PHC31 polyhomeotic homolog 3 (Drosophila) 79.04(n)
    80.37(a)
      429159  XM_004943489.1  XP_004943546.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHC36
    polyhomeotic homolog 3 (Drosophila)
    74(a)
    1 ↔ 1
    3(7700903-7776389)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia phc31 polyhomeotic homolog 3 (Drosophila) 65.8(n)
    63.25(a)
      100496983  XM_004914423.1  XP_004914480.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phc36
    PHC3 (2 of 2)6
    polyhomeotic homolog 3 (Drosophila)
    42(a)
    27(a)
    1 ↔ many
    1 ↔ many
    2(37145094-37168609) ENSDARG00000074604
    24(27176043-27226283) ENSDARG00000079167
    fruit fly
    (Drosophila melanogaster)
    Insecta ph-d6
    ph-p6
    polyhomeotic proximal
    14(a)
    14(a)
    many ↔ many
    many ↔ many
    X(2010899-2017164)
    X(2020243-2030888)


    ENSEMBL Gene Tree for PHC3 (if available)
    TreeFam Gene Tree for PHC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PHC3 gene
    PHC12  PHC22  SAMD72  SAMD112  
    Selected SIMAP similar genes for PHC3 using alignment to 12 protein entries:     PHC3_HUMAN (see all proteins) (see all similar genes):
    HPH1    ZNF546    AURA2    SPATS2L    ZNF254    SAMD13
    TCF4    CRCP    FKBP3    ZNF28    ZNF564    ZNF737
    ZNF738    NF2    ZNF547    ZNF212    SAMD11    CHID1

    PHC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PHC3 (see all 1862)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414502951,2
    C--169804890(+) CAGATC/TTGTTA 1 -- int10--------
    rs2017672221,2
    --169804975(+) GAGAA-/AATAATAA 1 -- int10--------
    rs679972011,2
    C--169805004(+) CACAT-/TT    
       
    /TTCT
    TCTAT
    1 -- int10--------
    rs1453194141,2
    C--169805086(+) ATCAGC/GGTGTG 1 -- int10--------
    rs1845483831,2
    --169805242(+) TTACAC/TTCTTT 1 -- int10--------
    rs790987321,2
    C,F--169805447(+) AAACAA/GTATAA 1 -- ut311Minor allele frequency- G:0.03NA 120
    rs1881847131,2
    --169805460(+) AAATGA/CTCCTG 1 -- ut310--------
    rs1476409841,2
    --169805597(+) TTTAAC/TAGTTA 1 -- ut310--------
    rs774683551,2
    C,F--169805832(+) CACCAA/CTCTAG 1 -- ut311Minor allele frequency- C:0.04EA 120
    rs76150391,2
    C,F,H--169806170(+) AAGACG/AACAAA 1 -- ut3119Minor allele frequency- A:0.12EA NS WA NA CSA 2104

    HapMap Linkage Disequilibrium report for PHC3 (169804520 - 169899537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PHC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668922CNV Deletion23128226
    nsv7356OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHC3
    DNA2.0 Custom Variant and Variant Library Synthesis for PHC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    3 diseases for PHC3:    About MalaCards
    acute chest syndrome    brain cancer    osteosarcoma

    1 disease from the University of Copenhagen DISEASES database for PHC3:
    Acute chest syndrome

    PHC3 for disorders           About GeneDecksing


    Export disorders for PHC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PHC3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with PHC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family. (PubMed id 12384788)1, 2, 3, 9 Tonkin E.... Strachan T. (Hum. Genet. 2002)
    2. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2, 3 Levine S.S....Kingston R.E. (Mol. Cell. Biol. 2002)
    3. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N.... Peters G. (PLoS ONE 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Human polyhomeotic homolog 3 (PHC3) sterile alpha motif (SAM) linker allows open-ended polymerization of PHC3 SAM. (PubMed id 22724443)1 Robinson A.K....Kim C.A. (Biochemistry 2012)
    9. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (Mol. Cell 2012)
    10. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80012 HGNC: 15682 AceView: PHC3 Ensembl:ENSG00000173889 euGenes: HUgn80012
    ECgene: PHC3 H-InvDB: PHC3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PHC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PHC3 gene:
    Search GeneIP for patents involving PHC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PHC3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PHC3  
     OriGene qSTAR qPCR primer pairs in human, mouse for PHC3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PHC3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHC3   OriGene Custom Protein Services for PHC3  

     
     
     Block miRNA regulation of human, mouse, rat PHC3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PHC3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHC3 Predesigned siRNA for gene silencing in human, mouse, rat PHC3
     QuantiFast Probe-based Assays in human, mouse, rat PHC3 QuantiTect SYBR Green Assays in human, mouse, rat PHC3
     PCR Arrays including human, mouse, rat PHC3 Search Chromatin IP Primers for PHC3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHC3  Search GeneGlobe Interaction Network for PHC3
     Regulatory tfbs in PHC3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PHC3 GenScript cDNA clones with any tag delivered in your preferred vector for PHC3
     GenScript Custom Assay Services for PHC3 GenScript Custom overexpressing Cell Line Services for PHC3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PHC3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PHC3 antibodies
     PHC3 proteins
     PHC3 lysates
     Antibodies for PHC3
     See all of Abcam's Antibodies, Kits and Proteins for PHC3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PHC3
     Antibodies for PHC3
     ELISAs for PHC3
     CLIAs for PHC3



     Browse ESI BIO Cell Lines and PureStem Progenitors for PHC3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PHC3
     SwitchGear Promoter luciferase reporter plasmids for PHC3
     Search ThermoFisher Antibodies for PHC3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHC3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHC3
     LSBio Antibodies in human, mouse, rat for PHC3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHC3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4