Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PHC2 Gene

protein-coding   GIFtS: 57
GCID: GC01M033789

Polyhomeotic Homolog 2 (Drosophila)

(Previous names: early development regulator 2 (homolog of polyhomeotic 2),...)
(Previous symbol: EDR2)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Polyhomeotic Homolog 2 (Drosophila)1 2     HPH22
EDR21 2 3     Polyhomeotic 22
Early Development Regulator 2 (Homolog Of Polyhomeotic 2)1 2     Polyhomeotic-Like 22
Early Development Regulatory Protein 22 3     Polyhomeotic-Like Protein 22
PH22 3     hPH23
Polyhomeotic-Like 2 (Drosophila)1     

External Ids:    HGNC: 31831   Entrez Gene: 19122   Ensembl: ENSG000001346867   OMIM: 6029795   UniProtKB: Q8IXK03   

Export aliases for PHC2 gene to outside databases

Previous GC identifers: GC01M032845 GC01M033215 GC01M033291 GC01M033458 GC01M033561 GC01M031905


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PHC2 Gene:
In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is
responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric,
chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein
'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of
human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for PHC2 Gene:
PHC2 (polyhomeotic homolog 2 (Drosophila)) is a protein-coding gene. An important paralog of this gene is PHC1.

UniProtKB/Swiss-Prot: PHC2_HUMAN, Q8IXK0
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PHC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHC2 gene promoter:
         NF-1/L   C/EBPbeta   NF-1   p53   LUN-1   CUTL1   POU3F2   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHC2 promoter sequence
   Search Chromatin IP Primers for PHC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p34.3

PHC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHC2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M033789:  view genomic region     (about GC identifiers)

Start:
33,789,224 bp from pter      End:
33,896,653 bp from pter
Size:
107,430 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PHC2_HUMAN, Q8IXK0 (See protein sequence)
Recommended Name: Polyhomeotic-like protein 2  
Size: 858 amino acids; 90713 Da
Subunit: Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2.
Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and
with MAPKAPK2
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Sequence caution: Sequence=AAH68573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH92492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI13956.1;
Type=Erroneous gene model prediction;
Secondary accessions: A1L4Q1 D3DPR2 Q2TAL3 Q5T0C1 Q6NUJ6 Q6ZQR1 Q8N306 Q8TAG8 Q96BL4 Q9Y4Y7
Alternative splicing: 5 isoforms:  Q8IXK0-1   Q8IXK0-2   Q8IXK0-3   Q8IXK0-4   Q8IXK0-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHC2: NX_Q8IXK0

Explore proteomics data for PHC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PHC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004418.2  NP_932157.1  

    ENSEMBL proteins: 
     ENSP00000362517   ENSP00000362521   ENSP00000257118   ENSP00000389436   ENSP00000391440  
     ENSP00000362515  
    Reactome Protein details: Q8IXK0

    PHC2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for PHC2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHC2
    GenScript Custom Purified and Recombinant Proteins Services for PHC2
    Novus Biologicals PHC2 Proteins
    Novus Biologicals PHC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHC2

     
    Search eBioscience for Proteins for PHC2 

    PHC2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PHC2
    Novus Biologicals PHC2 Antibodies
    Abcam antibodies for PHC2
    Cloud-Clone Corp. Antibodies for PHC2
    Search ThermoFisher Antibodies for PHC2
    LSBio Antibodies in human, mouse, rat for PHC2

    PHC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHC2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHC2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHC2
    Cloud-Clone Corp. CLIAs for PHC2
    Search eBioscience for ELISAs for PHC2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SAMD: Sterile alpha motif (SAM) domain containing

    4 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR012313 Znf_FCS

    Graphical View of Domain Structure for InterPro Entry Q8IXK0

    ProtoNet protein and cluster: Q8IXK0

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: PHC2_HUMAN, Q8IXK0
    Domain: HD1 motif interacts with SAM domain of PHC1
    Similarity: Contains 1 FCS-type zinc finger
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Find genes that share domains with PHC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHC2_HUMAN, Q8IXK0
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI10976766
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding ----
         
    Find genes that share ontologies with PHC2           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Phc2):
     cellular  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     hearing/vestibular/ear  immune system  limbs/digits/tail  mortality/aging  reproductive system 
     skeleton 

    Find genes that share phenotypes with PHC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Phc2tm1Hko for PHC2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHC2:
    hsa-mir-7-5p (MIRT025770), hsa-mir-744-5p (MIRT037714), hsa-mir-373-3p (MIRT002500), hsa-mir-192-5p (MIRT026403), hsa-mir-124-3p (MIRT022596), hsa-mir-155-5p (MIRT001526)

    Block miRNA regulation of human, mouse, rat PHC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHC2 (see all 58):
    hsa-miR-579 hsa-miR-4254 hsa-miR-3194-5p hsa-miR-128 hsa-miR-155 hsa-miR-330-3p hsa-miR-4309 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmidPHC2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHC2
    Predesigned siRNA for gene silencing in human, mouse, rat PHC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHC2

    Clone
    Products:
         
    OriGene clones in human, mouse for PHC2 (see all 15)
    OriGene ORF clones in mouse, rat for PHC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PHC2 (NM_004427)
    Sino Biological Human cDNA Clone for PHC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PHC2_HUMAN, Q8IXK0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0031519PcG protein complex IDA--
    GO:0035102PRC1 complex IDA12167701

    Find genes that share ontologies with PHC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for PHC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81


    Find genes that share SuperPaths with PHC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for PHC2
        Oxidative Stress Induced Senescence


        Pathway & Disease-focused RT2 Profiler PCR Arrays including PHC2: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PHC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PHC2 (Q8IXK01, 2, 3 ENSP000002571184) via UniProtKB, MINT, STRING, and/or I2D (see all 133)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235107Q065872, 3, ENSP000003964394MINT-8010325 MINT-8010390 I2D: score=2 STRING: ENSP00000396439
    RING1Q065872, 3, ENSP000003637874MINT-8010325 MINT-8010390 I2D: score=2 STRING: ENSP00000363787
    ENSG00000206287Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    ENSG00000226788Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    ENSG00000228520Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with PHC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PHC2 gene (2 alternative transcripts): 
    NM_004427.3  NM_198040.2  

    Unigene Cluster for PHC2:

    Polyhomeotic homolog 2 (Drosophila)
    Hs.524271  [show with all ESTs]
    Unigene Representative Sequence: NM_198040
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485928(uc001bxf.1) ENST00000373418(uc001bxe.1) ENST00000373422
    ENST00000257118(uc001bxg.1 uc009vuh.1) ENST00000467894 ENST00000486897
    ENST00000493483 ENST00000473158 ENST00000459964 ENST00000468406 ENST00000484692
    ENST00000431992(uc001bxh.1) ENST00000419414 ENST00000373416(uc001bxi.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHC2 (see all 58):
    hsa-miR-579 hsa-miR-4254 hsa-miR-3194-5p hsa-miR-128 hsa-miR-155 hsa-miR-330-3p hsa-miR-4309 hsa-miR-525-3p
    SwitchGear 3'UTR luciferase reporter plasmidPHC2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHC2
    Predesigned siRNA for gene silencing in human, mouse, rat PHC2
    Clone
    Products:
         
    OriGene clones in human, mouse for PHC2 (see all 15)
    OriGene ORF clones in mouse, rat for PHC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PHC2 (NM_004427)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHC2
      QuantiTect SYBR Green Assays in human, mouse, rat PHC2
      QuantiFast Probe-based Assays in human, mouse, rat PHC2

    Additional mRNA sequence: 

    AJ242730.1 AJ419231.1 AK056429.1 AK128821.1 AK292905.1 AK294426.1 BC015450.1 BC018602.1 
    BC028396.1 BC029269.1 BC068573.1 BC092492.1 BC110863.1 BC130630.1 BC144121.1 

    Selected DOTS entries (see all 27):

    DT.100827013  DT.85104654  DT.100827014  DT.100827022  DT.101985100  DT.91763220  DT.100827012  DT.91887374 
    DT.100827021  DT.121459675  DT.97860476  DT.121459663  DT.40119465  DT.410333  DT.421145  DT.91763214 
    DT.121459639  DT.91763217  DT.92042827  DT.100000645  DT.100827008  DT.102840210  DT.121459677  DT.410330 

    Selected AceView cDNA sequences (see all 645):

    BM772838 BE671429 BG236100 BU168232 BM765774 CR597056 BM765602 AU280429 
    BM843702 BM784154 BM766102 BM741417 CA424578 BM771661 AI697348 AI002703 
    AI339880 BM694718 BQ720551 BQ070982 AI281288 BM916208 BM771680 BM842933 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PHC2 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^
    SP1:                                                              -     -     -     -     -     -     -                 -                                       
    SP2:                                                                                      -     -     -           -     -                                       
    SP3:                                                                                      -     -     -                 -                                       
    SP4:                                                                                      -     -     -           -                                             
    SP5:                                                                                      -     -     -                 -                                       

    ExUns: 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25a · 25b
    SP1:        -                 -     -               
    SP2:        -                 -                     
    SP3:        -                 -     -               
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for PHC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PHC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTCAGGG
    PHC2 Expression
    About this image


    PHC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
    PHC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524271
        Pathway & Disease-focused RT2 Profiler PCR Arrays including PHC2: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHC2
    QuantiTect SYBR Green Assays in human, mouse, rat PHC2
    QuantiFast Probe-based Assays in human, mouse, rat PHC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PHC2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phc21 , 5 polyhomeotic-like 2 (Drosophila)1, 5 86.75(n)1
    87.1(a)1
      4 (62.12 cM)5
    543831  NM_018774.41  NP_061244.11 
     1286547385 
    chicken
    (Gallus gallus)
    Aves PHC21 polyhomeotic homolog 2 (Drosophila) 76.94(n)
    79.11(a)
      100857390  XM_003642542.2  XP_003642590.2 
    lizard
    (Anolis carolinensis)
    Reptilia PHC26
    polyhomeotic homolog 2 (Drosophila)
    71(a)
    1 ↔ 1
    AAWZ02039448(1974-7779)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ073537.12   -- 81.15(n)    BJ073537.1 
    zebrafish
    (Danio rerio)
    Actinopterygii edr22 early development regulator 2 (homolog of polyhomeotic more 76.41(n)   171465  AB064940.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ph-d6
    ph-p6
    polyhomeotic proximal
    13(a)
    13(a)
    many ↔ many
    many ↔ many
    X(2010899-2017164)
    X(2020243-2030888)


    ENSEMBL Gene Tree for PHC2 (if available)
    TreeFam Gene Tree for PHC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PHC2 gene
    PHC12  PHC32  SAMD72  SAMD112  
    4 SIMAP similar genes for PHC2 using alignment to 5 protein entries:     PHC2_HUMAN (see all proteins):
    HPH1    SAMD13    HPH2    DKFZp686A1782

    Find genes that share paralogs with PHC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PHC2 (see all 1084)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484050591,2
    --33788728(+) ACTTAC/TGCCTC 2 -- ds50010--------
    rs1921637651,2
    --33788754(+) TTCTCA/CTTCTT 2 -- ds50010--------
    rs1843719601,2
    --33788874(+) TCTATC/TGAGAG 2 -- ds50010--------
    rs1888285731,2
    --33788875(+) CTATCA/GAGAGG 2 -- ds50010--------
    rs75427771,2
    C,F,H--33788884(+) GGTGTG/ATGCTG 2 -- ds500121Minor allele frequency- A:0.12NS EA NA 2470
    rs1812567751,2
    C--33788916(+) CTGCCC/GCAGGT 2 -- ds50010--------
    rs726582291,2
    C,F--33788930(+) CAGAGG/ACTGCT 2 -- ds50012Minor allele frequency- A:0.16NA EA 240
    rs726582321,2
    C,F--33788977(+) GGTAGG/CGGGGC 2 -- ds50012Minor allele frequency- C:0.16NA EA 240
    rs770436641,2
    C,F--33789021(+) CCAAGG/AGACAC 2 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1164862531,2
    C,F--33789118(+) GCCATC/ACACTT 2 -- ds50011Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for PHC2 (33789224 - 33896653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PHC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658876CNV Deletion23128226
    esv1384773CNV Insertion17803354
    nsv871813CNV Loss21882294
    nsv522364CNV Loss19592680
    nsv516693CNV Loss19592680
    nsv834613CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHC2
    DNA2.0 Custom Variant and Variant Library Synthesis for PHC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602979    OMIM disorders: --


    Find genes that share disorders with PHC2           About GenesLikeMe

    Genetic Association Database (GAD): PHC2
    Human Genome Epidemiology (HuGE) Navigator: PHC2 (1 document)

    Export disorders for PHC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PHC2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with PHC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PubMed id 9121482)1, 2, 3, 9 Gunster M.J.... Otte A.P. (Mol. Cell. Biol. 1997)
    2. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family. (PubMed id 12384788)1, 2, 3, 9 Tonkin E.... Strachan T. (Hum. Genet. 2002)
    3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)1, 2 Vandamme J.... Angrand P.O. (Mol. Cell. Proteomics 2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N.... Peters G. (PLoS ONE 2009)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (Nature 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. P66(ShcA) interacts with MAPKAP kinase 2 and regulates its activity. (PubMed id 15094067)1, 2 Yannoni Y.M.... Lin L.L. (FEBS Lett. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1912 HGNC: 3183 AceView: PHC2 Ensembl:ENSG00000134686 euGenes: HUgn1912
    ECgene: PHC2 H-InvDB: PHC2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PHC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PHC2 gene:
    Search GeneIP for patents involving PHC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PHC2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PHC2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PHC2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PHC2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PHC2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHC2   OriGene Custom Protein Services for PHC2  

     
     
     Block miRNA regulation of human, mouse, rat PHC2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PHC2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHC2 Predesigned siRNA for gene silencing in human, mouse, rat PHC2
     QuantiFast Probe-based Assays in human, mouse, rat PHC2 QuantiTect SYBR Green Assays in human, mouse, rat PHC2
     PCR Arrays including human, mouse, rat PHC2 Search Chromatin IP Primers for PHC2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHC2  GeneGlobe Interaction Network for PHC2
     Regulatory tfbs in PHC2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PHC2 GenScript cDNA clones with any tag delivered in your preferred vector for PHC2
     GenScript Custom Assay Services for PHC2 GenScript Custom overexpressing Cell Line Services for PHC2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PHC2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for PHC2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PHC2 antibodies
     PHC2 proteins
     PHC2 lysates
     Antibodies for PHC2
     See all of Abcam's Antibodies, Kits and Proteins for PHC2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PHC2
     Antibodies for PHC2
     ELISAs for PHC2
     CLIAs for PHC2



     Browse ESI BIO Cell Lines and PureStem Progenitors for PHC2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC2
     SwitchGear 3'UTR luciferase reporter plasmids for PHC2
     SwitchGear Promoter luciferase reporter plasmids for PHC2
     Search ThermoFisher Antibodies for PHC2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHC2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHC2
     LSBio Antibodies in human, mouse, rat for PHC2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for PHC2
      Search eBioscience for proteins for PHC2
      Search eBioscience for elisas for PHC2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHC2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4