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Aliases for PHC2 Gene

Aliases for PHC2 Gene

  • Polyhomeotic Homolog 2 2 3 5
  • Early Development Regulator 2 (Homolog Of Polyhomeotic 2) 2 3
  • Early Development Regulatory Protein 2 3 4
  • HPH2 3 4
  • EDR2 3 4
  • PH2 3 4
  • Polyhomeotic Homolog 2 (Drosophila) 2
  • Polyhomeotic-Like 2 (Drosophila) 2
  • Polyhomeotic-Like Protein 2 3
  • Polyhomeotic-Like 2 3
  • Polyhomeotic 2 3

External Ids for PHC2 Gene

Previous HGNC Symbols for PHC2 Gene

  • EDR2

Previous GeneCards Identifiers for PHC2 Gene

  • GC01M032845
  • GC01M033215
  • GC01M033291
  • GC01M033458
  • GC01M033561
  • GC01M033789
  • GC01M031905
  • GC01M033325
  • GC01M033326
  • GC01M033328

Summaries for PHC2 Gene

Entrez Gene Summary for PHC2 Gene

  • In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PHC2 Gene

PHC2 (Polyhomeotic Homolog 2) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Metabolism of proteins. GO annotations related to this gene include sequence-specific DNA binding and identical protein binding. An important paralog of this gene is PHC3.

UniProtKB/Swiss-Prot for PHC2 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Wiki entry for PHC2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHC2 Gene

Genomics for PHC2 Gene

Regulatory Elements for PHC2 Gene

Enhancers for PHC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G033336 2 FANTOM5 Ensembl ENCODE dbSUPER 37.7 +87.3 87316 15.1 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PHC2 A3GALT2 ENSG00000225313 TRIM62 RNF19B PIR53170 RN7SKP16
GH01G033361 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.6 +66.4 66351 7.0 PKNOX1 ATF1 ZNF493 ZFP64 ZNF133 SIN3A ARID4B FEZF1 ZNF2 ZNF48 PHC2 ZBTB8B A3GALT2 FNDC5 ZSCAN20 LOC101929464 GC01M033371
GH01G033381 1.3 Ensembl ENCODE dbSUPER 26.7 +47.5 47527 4.0 PKNOX1 TFAP4 ZNF175 MAX CEBPG TEAD3 FOSL1 ZBTB48 FOS MAFK PHC2 A3GALT2 TRIM62 GC01M033371 LOC101929464
GH01G033330 1.3 Ensembl ENCODE dbSUPER 25.8 +98.1 98135 5.8 SOX13 SAP130 ARID4B MAX ZBTB40 THRB ZNF48 RARA YY1 TEAD3 PHC2 A3GALT2 ENSG00000225313 TRIM62 RN7SKP16 MIR3605
GH01G033386 1.2 Ensembl ENCODE dbSUPER 26.3 +41.9 41922 4.8 BHLHE40 ZSCAN4 MAFG REST RAD51 ZNF316 MAFF POLR2A SMARCA4 FOS PHC2 A3GALT2 TRIM62 GC01M033371 LOC101929464
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PHC2 on UCSC Golden Path with GeneCards custom track

Promoters for PHC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000004522 -90 1401 ARNT SIN3A ZNF48 GLIS2 ELK1 ZNF143 FOS NFYC REST ZNF623

Genomic Location for PHC2 Gene

Chromosome:
1
Start:
33,323,623 bp from pter
End:
33,431,052 bp from pter
Size:
107,430 bases
Orientation:
Minus strand

Genomic View for PHC2 Gene

Genes around PHC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHC2 Gene

Proteins for PHC2 Gene

  • Protein details for PHC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXK0-PHC2_HUMAN
    Recommended name:
    Polyhomeotic-like protein 2
    Protein Accession:
    Q8IXK0
    Secondary Accessions:
    • A1L4Q1
    • A8KA40
    • D3DPR2
    • Q2TAL3
    • Q5T0C1
    • Q6NUJ6
    • Q6ZQR1
    • Q8N306
    • Q8TAG8
    • Q96BL4
    • Q9Y4Y7

    Protein attributes for PHC2 Gene

    Size:
    858 amino acids
    Molecular mass:
    90713 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.
    Miscellaneous:
    • The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
    SequenceCaution:
    • Sequence=AAH68573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH92492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PHC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHC2 Gene

Post-translational modifications for PHC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PHC2 Gene

Domains & Families for PHC2 Gene

Gene Families for PHC2 Gene

Protein Domains for PHC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXK0

UniProtKB/Swiss-Prot:

PHC2_HUMAN :
  • HD1 motif interacts with SAM domain of PHC1.
Domain:
  • HD1 motif interacts with SAM domain of PHC1.
genes like me logo Genes that share domains with PHC2: view

Function for PHC2 Gene

Molecular function for PHC2 Gene

UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for PHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 10976766
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 16169070
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PHC2: view
genes like me logo Genes that share phenotypes with PHC2: view

Animal Models for PHC2 Gene

MGI Knock Outs for PHC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHC2 Gene

Localization for PHC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHC2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA,IDA 21282530
GO:0005654 nucleoplasm TAS,IDA --
GO:0031519 PcG protein complex IDA 21282530
GO:0035102 PRC1 complex IDA 12167701
genes like me logo Genes that share ontologies with PHC2: view

Pathways & Interactions for PHC2 Gene

genes like me logo Genes that share pathways with PHC2: view

Gene Ontology (GO) - Biological Process for PHC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with PHC2: view

No data available for SIGNOR curated interactions for PHC2 Gene

Drugs & Compounds for PHC2 Gene

No Compound Related Data Available

Transcripts for PHC2 Gene

Unigene Clusters for PHC2 Gene

Polyhomeotic homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10: - -
SP11: -
SP12: -
SP13:
SP14:
SP15: - -

ExUns: 21 ^ 22a · 22b · 22c ^ 23 ^ 24 ^ 25a · 25b
SP1: - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for PHC2 Gene

GeneLoc Exon Structure for
PHC2
ECgene alternative splicing isoforms for
PHC2

Expression for PHC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHC2 Gene

This gene is overexpressed in Whole Blood (x9.3).

Protein differential expression in normal tissues from HIPED for PHC2 Gene

This gene is overexpressed in Retina (19.7), Fetal heart (7.9), Peripheral blood mononuclear cells (6.7), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHC2 Gene



Protein tissue co-expression partners for PHC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PHC2 Gene:

PHC2

SOURCE GeneReport for Unigene cluster for PHC2 Gene:

Hs.524271

Evidence on tissue expression from TISSUES for PHC2 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Skin(3.9)
  • Lung(3.5)
  • Pancreas(3.2)
  • Intestine(2.7)
genes like me logo Genes that share expression patterns with PHC2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHC2 Gene

Orthologs for PHC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHC2 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia PHC2 34 35
  • 91.01 (n)
cow
(Bos Taurus)
Mammalia PHC2 34 35
  • 90.91 (n)
rat
(Rattus norvegicus)
Mammalia Phc2 34
  • 87.48 (n)
mouse
(Mus musculus)
Mammalia Phc2 34 16 35
  • 86.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PHC2 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHC2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHC2 34 35
  • 76.94 (n)
lizard
(Anolis carolinensis)
Reptilia PHC2 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii phc2a 34 35
  • 58.79 (n)
phc2b 35
  • 47 (a)
OneToMany
edr2 34
fruit fly
(Drosophila melanogaster)
Insecta ph-d 35
  • 13 (a)
ManyToMany
ph-p 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for PHC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHC2 Gene

ENSEMBL:
Gene Tree for PHC2 (if available)
TreeFam:
Gene Tree for PHC2 (if available)

Paralogs for PHC2 Gene

Paralogs for PHC2 Gene

(4) SIMAP similar genes for PHC2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PHC2: view

Variants for PHC2 Gene

Sequence variations from dbSNP and Humsavar for PHC2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000021276 -- 33,330,841(+) CCTAA(C/T)CTGTA intron-variant
rs1000034975 -- 33,324,358(+) TGCAG(A/C)GGGTG nc-transcript-variant, utr-variant-3-prime
rs1000074697 -- 33,375,287(+) CCCAC(C/T)AGACC intron-variant
rs1000086727 -- 33,324,102(+) GAAGC(A/G)CCGTC nc-transcript-variant, utr-variant-3-prime
rs1000103987 -- 33,333,162(+) GGTGT(G/T)CCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PHC2 Gene

Variant ID Type Subtype PubMed ID
esv1384773 CNV insertion 17803354
esv2658876 CNV deletion 23128226
esv3585684 CNV loss 21293372
nsv1130953 CNV deletion 24896259
nsv1142758 CNV deletion 24896259
nsv476125 CNV novel sequence insertion 20440878
nsv516693 CNV loss 19592680
nsv522364 CNV loss 19592680
nsv545963 CNV loss 21841781
nsv834613 CNV gain 17160897

Variation tolerance for PHC2 Gene

Residual Variation Intolerance Score: 14.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHC2 Gene

Human Gene Mutation Database (HGMD)
PHC2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHC2 Gene

Disorders for PHC2 Gene

Relevant External Links for PHC2

Genetic Association Database (GAD)
PHC2
Human Genome Epidemiology (HuGE) Navigator
PHC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHC2

No disorders were found for PHC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHC2 Gene

Publications for PHC2 Gene

  1. Identification and characterisation of novel mammalian homologues of Drosophila polyhomeotic permits new insights into relationships between members of the polyhomeotic family. (PMID: 12384788) Tonkin E. … Strachan T. (Hum. Genet. 2002) 2 3 4 22 64
  2. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PMID: 9121482) Gunster M.J. … Otte A.P. (Mol. Cell. Biol. 1997) 2 3 4 22 64
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens G.N. … Peters G. (PLoS ONE 2009) 3 4 64

Products for PHC2 Gene

Sources for PHC2 Gene

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