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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHC1 Gene

protein-coding   GIFtS: 49
GCID: GC12P009067

Polyhomeotic Homolog 1 (Drosophila)

(Previous names: early development regulator 1 (homolog of polyhomeotic 1),...)
(Previous symbol: EDR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polyhomeotic Homolog 1 (Drosophila)1 2     MCPH112
EDR11 2 3     RAE282
Early Development Regulator 1 (Homolog Of Polyhomeotic 1)1 2     Polyhomeotic-Like 12
Early Development Regulatory Protein 12 3     Polyhomeotic-Like Protein 12
Polyhomeotic-Like 1 (Drosophila)1     PH13
HPH12     hPH13

External Ids:    HGNC: 31821   Entrez Gene: 19112   Ensembl: ENSG000001117527   OMIM: 6029785   UniProtKB: P783643   

Export aliases for PHC1 gene to outside databases

Previous GC identifers: GC12P009215 GC12P008967 GC12P008958 GC12P008847


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PHC1 Gene:
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The
gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb
protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly
conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions
and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. (provided by RefSeq,
Jul 2008)

GeneCards Summary for PHC1 Gene: 
PHC1 (polyhomeotic homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with PHC1 include hodgkin's lymphoma, and prostate cancer. GO annotations related to this gene include chromatin binding and DNA binding. An important paralog of this gene is PHC3.

UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
'Lys-119', rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PHC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHC1 gene promoter:
         Oct-B1   oct-B2   MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

PHC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P009067:  view genomic region     (about GC identifiers)

Start:
9,066,492 bp from pter      End:
9,094,063 bp from pter
Size:
27,572 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364 (See protein sequence)
Recommended Name: Polyhomeotic-like protein 1  
Size: 1004 amino acids; 105534 Da
Subunit: Homodimer. Component of a PRC1-like complex
Subcellular location: Nucleus
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of
different PRC1-like complexes
Sequence caution: Sequence=AAH17748.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PHC1:
2L8E (3D)    
Secondary accessions: D3DUV4 Q8WVM3 Q9BU63

Explore the universe of human proteins at neXtProt for PHC1: NX_P78364

Explore proteomics data for PHC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78364

  • PHC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PHC1 Protein Expression
    REFSEQ proteins: NP_004417.2  
    ENSEMBL proteins: 
     ENSP00000437654   ENSP00000440674   ENSP00000399194   ENSP00000437659   ENSP00000437645  
     ENSP00000437459   ENSP00000444308   ENSP00000445939   ENSP00000446388   ENSP00000443676  
     ENSP00000445307   ENSP00000440488  

    Human Recombinant Protein Products for PHC1: 
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    OriGene Protein Over-expression Lysate for PHC1
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    Novus Biologicals PHC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHC1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016604nuclear body IEA--
    GO:0031519PcG protein complex IDA--

    PHC1 for ontologies           About GeneDecksing



    PHC1 Antibody Products: 
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    Novus Biologicals PHC1 Antibodies
    Abcam antibodies for PHC1
    Cloud-Clone Corp. Antibodies for PHC1 
    Search ThermoFisher Antibodies for PHC1
    Search LSBio for Antibodies for PHC1 

    Assay Products for PHC1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for PHC1 
    Cloud-Clone Corp. CLIAs for PHC1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SAMD: Sterile alpha motif (SAM) domain containing

    5 InterPro protein domains:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR012313 Znf_FCS
     IPR010507 Znf_MYM

    Graphical View of Domain Structure for InterPro Entry P78364

    ProtoNet protein and cluster: P78364

    1 Blocks protein domain: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364
    Similarity: Contains 1 FCS-type zinc finger
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    PHC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHC1_HUMAN, P78364
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain
    the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1
    complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A
    'Lys-119', rendering chromatin heritably changed in its expressibility

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    PHC1 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Phc1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging  skeleton  vision/eye 

    PHC1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phc1tm1Os for PHC1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PHC1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PHC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHC1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHC1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHC1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PHC1 (see all 39):
    hsa-miR-1224-3p hsa-miR-29a hsa-let-7a-2* hsa-miR-3167 hsa-miR-1184 hsa-miR-149 hsa-miR-1243 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidPHC1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHC1
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                         Customized lentivirus expression plasmids for stable overexpression of PHC1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PHC1
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PHC1

    5/51 Interacting proteins for PHC1 (P783642, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206287Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    ENSG00000226788Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    ENSG00000228520Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    ENSG00000231115Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    ENSG00000235107Q065872, 3MINT-8010325 MINT-8010390 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0071300cellular response to retinoic acid IEA--

    PHC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHC1

    Search CenterWatch for drugs/clinical trials and news about PHC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHC1 gene: 
    NM_004426.2  

    Unigene Cluster for PHC1:

    Polyhomeotic homolog 1 (Drosophila)
    Hs.744902  [show with all ESTs]
    Unigene Representative Sequence: NM_004426
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538657 ENST00000543824(uc010sgn.1) ENST00000433847(uc001qvc.1)
    ENST00000433083 ENST00000544916 ENST00000544539 ENST00000539063 ENST00000540574
    ENST00000541181 ENST00000542346 ENST00000539928 ENST00000537610 ENST00000535510
    ENST00000540809 ENST00000536844
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHC1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PHC1 (see all 39):
    hsa-miR-1224-3p hsa-miR-29a hsa-let-7a-2* hsa-miR-3167 hsa-miR-1184 hsa-miR-149 hsa-miR-1243 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidPHC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PHC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHC1
    Clone
    Products:
         
    OriGene clones in human, mouse for PHC1 (see all 7)
    OriGene ORF clones in mouse, rat for PHC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHC1 (NM_004426)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC1
    Sirion Biotech Customized lentivirus for stable overexpression of PHC1 
                         Customized lentivirus expression plasmids for stable overexpression of PHC1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for PHC1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHC1

    Additional mRNA sequence: 

    AB209063.1 AK293893.1 BC002871.2 BC017748.1 BC073964.1 BC157850.1 BX640639.1 U89277.1 

    24/31 DOTS entries (see all 31):

    DT.99952542  DT.92461710  DT.91823927  DT.454306  DT.75194392  DT.95140600  DT.121164325  DT.99955641 
    DT.121125309  DT.95140538  DT.91968065  DT.92461707  DT.75189472  DT.100641691  DT.92390918  DT.121125325 
    DT.91661450  DT.100798776  DT.102838172  DT.100798769  DT.102838175  DT.102838176  DT.102838177  DT.121125255 

    24/291 AceView cDNA sequences (see all 291):

    AI458376 F03237 AI871465 AI635343 AI016230 AI278242 BU732811 BM315003 
    CA314583 AI701124 BQ070998 BC002871 AI078738 CD106879 BQ688768 BM544928 
    BQ217056 AA182596 AA582265 AV702165 AA429451 BM702653 BM915439 AI571509 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHC1 expression in normal human tissues (normalized intensities)      PHC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCAATCA
    PHC1 Expression
    About this image


    PHC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             CyT49
             H1-GFP   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/midbrain   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See PHC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHC1

    SOURCE GeneReport for Unigene cluster: Hs.744902
        SABiosciences Expression via Pathway-Focused PCR Arrays including PHC1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for PHC1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phc11 , 5 polyhomeotic-like 1 (Drosophila)1, 5 88.84(n)1
    92.53(a)1
      6 (57.52 cM)5
    136191  NM_007905.21  NP_031931.21 
     1223177385 
    chicken
    (Gallus gallus)
    Aves PHC11 polyhomeotic homolog 1 (Drosophila) 74.11(n)
    79.82(a)
      418252  NM_001006249.1  NP_001006249.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHC16
    polyhomeotic homolog 1 (Drosophila)
    75(a)
    1 ↔ 1
    2(81549095-81590307)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162602 Xenopus laevis transcribed sequence with moderate similarity more 74.3(n)    BJ033642.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phc11 polyhomeotic homolog 1 47.26(n)
    39.46(a)
      403008  NM_205707.1  NP_991270.1 


    ENSEMBL Gene Tree for PHC1 (if available)
    TreeFam Gene Tree for PHC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHC1 gene
    PHC32  PHC22  SAMD72  SAMD112  
    6 SIMAP similar genes for PHC1 using alignment to 13 protein entries:     PHC1_HUMAN (see all proteins):
    HPH1    DKFZp686A1782    SAMD13    PHC3    SAMD1    HPH2

    PHC1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/553 SNPs in PHC1 are shown (see all 553)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866270681,2
    --9065321(+) TGTACC/TCTCTT 1 -- us2k10--------
    rs18057821,2
    C,F--9065324(-) ACCAAG/AAGGGT 1 -- us2k16Minor allele frequency- A:0.12NA WA CSA 128
    rs1453873321,2
    --9065331(+) TGGTAC/TACAAG 1 -- us2k10--------
    rs18057431,2
    C,F,H--9065342(-) AGCCTA/GTGGAA 1 -- us2k112Minor allele frequency- G:0.26NA EA CSA WA 616
    rs1492135541,2
    --9065380(+) TATCTA/GCATTC 1 -- us2k10--------
    rs1179123661,2
    F--9065538(+) GGTGCT/CAGAAA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1433557211,2
    --9065761(+) CGTGTC/TTTCGC 1 -- us2k10--------
    rs18057421,2
    C,F,A,H--9065846(-) GAGAAC/GAATTT 1 -- us2k128Minor allele frequency- G:0.24NS EA NA CSA WA 2022
    rs18057811,2
    C,F,H--9065888(-) GGACTC/TCAAGG 1 -- us2k123Minor allele frequency- T:0.03NS MN EA NA 2474
    rs1914311661,2
    --9065920(+) AAATCG/TAAATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHC1 (9066492 - 9094063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PHC1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv52793CNV Loss16902084
    nsv832327CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602978    OMIM disorders: --

    3 diseases for PHC1:    About MalaCards
    hodgkin's lymphoma    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for PHC1:
    Embryonal carcinoma

    PHC1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for PHC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 50.6 1 15470680 (1)
    tumors 1.51 2 16528373 (1)

    Genetic Association Database (GAD): PHC1

    Export disorders for PHC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHC1 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with PHC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PubMed id 9121482)1, 2, 3, 9 Gunster M.J.... Otte A.P. (1997)
    2. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PubMed id 9199346)1, 2, 9 Satijn D.P.E.... Otte A.P. (1997)
    3. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (2002)
    6. Structure and chromosomal localization of the RAE28/HPH1 gene, a human homologue of the polyhomeotic gene. (PubMed id 10902910)1, 9 Ohta H.... Takihara Y. (2000)
    7. Structure of the polycomb group protein PCGF1 in compl ex with BCOR reveals basis for binding selectivity of PCGF homologs. (PubMed id 23523425)1 Junco S.E....Kim C.A. (2013)
    8. Protein phosphatase 1g isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (2013)
    9. Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcri ptional repression of Hoxa9 and Hoxb4. (PubMed id 23207902)1 Yasunaga S....Takihara Y. (2013)
    10. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1911 HGNC: 3182 AceView: PHC1 Ensembl:ENSG00000111752 euGenes: HUgn1911
    ECgene: PHC1 H-InvDB: PHC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHC1 gene:
    Search GeneIP for patents involving PHC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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