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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHC1 Gene

protein-coding   GIFtS: 50
GCID: GC12P009067

polyhomeotic homolog 1 (Drosophila)

(Previous names: early development regulator 1 (homolog of polyhomeotic...)
(Previous symbol: EDR1)
 Explore 5 diseases affiliated with
PHC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PHC1    

Aliases
for PHC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Polyhomeotic Homolog 1 (Drosophila)1 2     Polyhomeotic-Like 1 (Drosophila)1
EDR11 2 3     Polyhomeotic-Like 12
HPH11 2     Polyhomeotic-Like Protein 12
RAE281 2     PH13
Early Development Regulator 1 (Homolog Of Polyhomeotic 1)1 2     HPH11 2
Early Development Regulatory Protein 12 3     

External Ids:    HGNC: 31821   Entrez Gene: 19112   Ensembl: ENSG000001117527   OMIM: 6029785   UniProtKB: P783643   

Export aliases for PHC1 gene to outside databases

Previous GC identifers: GC12P009215 GC12P008967 GC12P008958 GC12P008847


Summaries
for PHC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PHC1:
This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene
product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1.
The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named
homology domains I and II. These domains are involved in protein-protein interactions and may mediate
heterodimerization of the protein encoded by this gene and the EDR2 protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364
Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the
transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts
via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',
rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PHC1


Genomic Views
for PHC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHC1 gene promoter:
         Oct-B1   oct-B2   MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PHC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PHC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

PHC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHC1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P009067:  view genomic region     (about GC identifiers)

Start:
 9,066,492 bp from pter      End:
 9,094,063 bp from pter
Size:
 27,572 bases      Orientation:
 plus strand

Proteins
for PHC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364 (See protein sequence)
Recommended Name: Polyhomeotic-like protein 1  
Size: 1004 amino acids; 105534 Da
Subunit: Homodimer. Component of a PRC1-like complex
Subcellular location: Nucleus
Miscellaneous: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different
PRC1-like complexes
Sequence caution: Sequence=AAH17748.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PHC1:
2L8E (3D)    
Secondary accessions: D3DUV4 Q8WVM3 Q9BU63

Explore the universe of human proteins at neXtProt for PHC1: NX_P78364

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78364

    • PHC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004417.2  
    ENSEMBL proteins: 
     ENSP00000437654   ENSP00000440674   ENSP00000399194   ENSP00000437659   ENSP00000437645  
     ENSP00000437459   ENSP00000444308   ENSP00000445939   ENSP00000446388   ENSP00000443676  
     ENSP00000445307   ENSP00000251757   ENSP00000440488  

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    OriGene Protein Over-expression Lysate: PHC1
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PHC1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001739sex chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016604nuclear body IEA--
    GO:0031519PcG protein complex IDA--


    PHC1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PHC1

    Protein Domains /
    Families
    for PHC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PHC1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR021129 SAM_type1
     IPR013761 SAM/pointed
     IPR001660 SAM
     IPR012313 Znf_FCS
     IPR010507 Znf_MYM

    Graphical View of Domain Structure for InterPro Entry P78364

    ProtoNet protein and cluster: P78364

    1 Blocks protein family: IPB001660 Sterile alpha motif SAM

    UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364
    Similarity: Contains 1 FCS-type zinc finger
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    Function
    for PHC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PHC1_HUMAN, P78364
    Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the
    transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts
    via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',
    rendering chromatin heritably changed in its expressibility

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHC1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PHC1 (see all 39):
    hsa-miR-1224-3p hsa-miR-29a hsa-let-7a-2* hsa-miR-3167 hsa-miR-1184 hsa-miR-149 hsa-miR-1243 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: PHC1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHC1 (see all 7)
    OriGene shRNA RFP: PHC1
    OriGene siRNA: PHC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHC1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PHC1

    Clone
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    GenScript: all cDNA clones in your preferred vector: PHC1 (NM_004426)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHC1 

    Cell Line
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    Search LifeMap BioReagents cell lines for PHC1

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0008270zinc ion binding IEA--


    PHC1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Phc1tm1Os for PHC1
         14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Phc1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging  skeleton  vision/eye 

    PHC1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PHC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PHC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/65 Interacting proteins for PHC1 (P783642, 3 ENSP000002517574) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF2Q994962, 3, ENSP000003564804MINT-8010325 MINT-8010390 I2D: score=5 STRING: ENSP00000356480
    CBX2Q147812, 3, ENSP000003087504MINT-8010325 MINT-8010390 I2D: score=1 STRING: ENSP00000308750
    CBX4O002572, 3, ENSP000002693974MINT-8010325 MINT-8010390 I2D: score=1 STRING: ENSP00000269397
    BMI1P352262, 3, ENSP000003658514MINT-8010325 I2D: score=4 STRING: ENSP00000365851
    PCGF2P352272, 3, ENSP000003540334MINT-8010390 I2D: score=2 STRING: ENSP00000354033
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0071300cellular response to retinoic acid IEA--


    PHC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PHC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHC1
    Search CenterWatch for drugs/clinical trials and news about PHC1 

    Transcripts
    for PHC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PHC1 gene: 
    NM_004426.2  

    Unigene Cluster for PHC1:

    Polyhomeotic homolog 1 (Drosophila)
    Hs.305985  [show with all ESTs]
    Unigene Representative Sequence: NM_004426
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538657 ENST00000543824(uc010sgn.1) ENST00000433847(uc001qvc.1)
    ENST00000433083 ENST00000544916 ENST00000544539 ENST00000539063 ENST00000540574
    ENST00000541181 ENST00000542346 ENST00000539928 ENST00000537610 ENST00000535510
    ENST00000540809 ENST00000251757(uc001qvd.3 uc001qve.3) ENST00000536844


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHC1
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate PHC1 (see all 39):
    hsa-miR-1224-3p hsa-miR-29a hsa-let-7a-2* hsa-miR-3167 hsa-miR-1184 hsa-miR-149 hsa-miR-1243 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmid: PHC1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHC1 (see all 7)
    OriGene shRNA RFP: PHC1
    OriGene siRNA: PHC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHC1
    Clone
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    GenScript: all cDNA clones in your preferred vector: PHC1 (NM_004426)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHC1

    Additional cDNA sequence: 

    AB209063.1 AK293893.1 BC002871.2 BC017748.1 BC073964.1 BC157850.1 BX640639.1 U89277.1 

    24/31 DOTS entries (see all 31):

    DT.99952542  DT.92461710  DT.91823927  DT.454306  DT.75194392  DT.95140600  DT.99955641  DT.121164325 
    DT.121125309  DT.95140538  DT.91968065  DT.75189472  DT.92461707  DT.100641691  DT.92390918  DT.121125325 
    DT.91661450  DT.100798776  DT.102838172  DT.100798769  DT.102838175  DT.102838176  DT.102838177  DT.121125255 

    24/291 AceView cDNA sequences (see all 291):

    AI278242 AI093186 T31592 BQ688768 BM702653 AI078497 CA314583 BQ217056 
    F03237 AW612766 AA338510 AA582265 AI078738 AI458376 BM544928 BM315003 
    BC002871 BM543280 BI752280 AA091502 CD106879 AI802189 BQ070998 AI571509 

    GeneLoc Exon Structure


    Expression
    for PHC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGCAATCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PHC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PHC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHC1

    SOURCE GeneReport for Unigene cluster: Hs.305985
        SABiosciences Expression via Pathway-Focused PCR Arrays including PHC1: 
              Polycomb & Trithorax Complexes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PHC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for PHC1 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Phc11 , 5 polyhomeotic-like 1 (Drosophila)1, 5 88.84(n)1
    92.53(a)1    		   6 (57.52 cM)5
    136191  NM_007905.21  NP_031931.21 
     1223177385 
    chicken
    (Gallus gallus)    		 Aves PHC11 polyhomeotic homolog 1 (Drosophila) 74.11(n)
    79.82(a)    		   418252  NM_001006249.1  NP_001006249.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PHC16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 2(81571721-81590307)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.162602 Xenopus laevis transcribed sequence with moderate similarity more 74.3(n)    BJ033642.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii phc11 polyhomeotic homolog 1 47.26(n)
    39.46(a)    		   403008  NM_205707.1  NP_991270.1 


    ENSEMBL Gene Tree for PHC1 (if available)
    TreeFam Gene Tree for PHC1 (if available) 

    Paralogs
    for PHC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHC1 gene
    PHC32  SAMD72  PHC22  SAMD112  
    6 SIMAP similar genes for PHC1 using alignment to 13 protein entries:     PHC1_HUMAN (see all proteins):
    HPH1    DKFZp686A1782    SAMD13    PHC3    SAMD1    HPH2

    PHC1 for paralogs           About GeneDecksing



    Genomic Variants
    for PHC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/469 NCBI SNPs in PHC1 are shown (see all 469)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1866270681,2
    		--9065321(+) TGTACC/TCTCTT 1 -- us2k10--------
    rs18057821,2
    		C,F,--9065324(-) ACCAAG/AAGGGT 1 -- us2k16Minor allele frequency- A:0.12NA WA CSA 128
    rs1453873321,2
    		--9065331(+) TGGTAC/TACAAG 1 -- us2k10--------
    rs18057431,2
    		C,F,H,--9065342(-) AGCCTA/GTGGAA 1 -- us2k112Minor allele frequency- G:0.26NA EA CSA WA 616
    rs1492135541,2
    		--9065380(+) TATCTA/GCATTC 1 -- us2k10--------
    rs1179123661,2
    		--9065538(+) GGTGCT/CAGAAA 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1433557211,2
    		--9065761(+) CGTGTC/TTTCGC 1 -- us2k10--------
    rs18057421,2
    		C,F,A,H,--9065846(-) GAGAAC/GAATTT 1 -- us2k128Minor allele frequency- G:0.24NS EA NA CSA WA 2022
    rs18057811,2
    		C,F,H,--9065888(-) GGACTC/TCAAGG 1 -- us2k123Minor allele frequency- T:0.03NS MN EA NA 2474
    rs1914311661,2
    		--9065920(+) AAATCG/TAAATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHC1 (9066492 - 9094063 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for PHC1
         3 CNVs: 4768 39098 5655
         1 Indel: 39876

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    Disorders / Diseases
    for PHC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PHC1 for disorders           About GeneDecksing

    OMIM gene information: 602978    OMIM disorders: --

    5 diseases for PHC1:    About MalaCards
    hodgkin's lymphoma    embryonal carcinoma    prostate cancer    prostatitis
    carcinoma

    1 disease from the University of Copenhagen DISEASES database for PHC1:
    Embryonal carcinoma

    2 Novoseek disease relationships for PHC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 50.6 1 15470680 (1)
    tumors 1.51 2 16528373 (1)


    Export disorders for PHC1 gene to outside databases

    Publications
    for PHC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHC1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with PHC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PubMed id 9121482)1, 2, 3, 9 Gunster M.J.... Otte A.P. (1997)
    2. RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor. (PubMed id 9199346)1, 2, 9 Satijn D.P.E.... Otte A.P. (1997)
    3. Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)1, 2 Maertens G.N....Peters G. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)1, 2 Levine S.S....Kingston R.E. (2002)
    6. Structure and chromosomal localization of the RAE28/HPH1 gene, a human homologue of the polyhomeotic gene. (PubMed id 10902910)1, 9 Ohta H.... Takihara Y. (2000)
    7. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    8. PCGF homologs, CBX proteins, and RYBP define functiona lly distinct PRC1 family complexes. (PubMed id 22325352)1 Gao Z....Reinberg D. (2012)
    9. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PubMed id 21282530)2 Vandamme J.... Angrand P.O. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    External Searches for PHC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PHC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1911 HGNC: 3182 AceView: PHC1 Ensembl:ENSG00000111752 euGenes: HUgn1911
    ECgene: PHC1 H-InvDB: PHC1

    Other Databases showing PHC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PHC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PHC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PHC1 gene:
    Search GeneIP for patents involving PHC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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