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PHB2 Gene

protein-coding   GIFtS: 60
GCID: GC12M007074

Prohibitin 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Prohibitin 21 2     BCAP372
REA2 3 5     Bap372
Repressor Of Estrogen Receptor Activity2 3     PNAS-1412
BAP2 3     B-Cell Associated Protein2
D-prohibitin2 3     p222
B-Cell Receptor-Associated Protein BAP372 3     prohibitin-22

External Ids:    HGNC: 303061   Entrez Gene: 113312   Ensembl: ENSG000002150217   OMIM: 6107045   UniProtKB: Q996233   
ORGUL members:         

Export aliases for PHB2 gene to outside databases

Previous GC identifer: GC12M006945


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PHB2 Gene:
PHB2 (prohibitin 2) is a protein-coding gene. Diseases associated with PHB2 include enthesopathy, and dysentery. GO annotations related to this gene include estrogen receptor binding.

UniProtKB/Swiss-Prot: PHB2_HUMAN, Q99623
Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone
deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the
inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for
modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and
in aging

Gene Wiki entry for PHB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHB2 gene promoter:
         SRF   Sp1   HFH-1   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHB2 promoter sequence
   Search Chromatin IP Primers for PHB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

PHB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M007074:  view genomic region     (about GC identifiers)

Start:
7,074,490 bp from pter      End:
7,079,988 bp from pter
Size:
5,499 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PHB2_HUMAN, Q99623 (See protein sequence)
Recommended Name: Prohibitin-2  
Size: 299 amino acids; 33296 Da
Subunit: Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). Interacts with ZNF703. Interacts with STOML2
Developmental stage: Levels of expression in fibroblasts decrease heterogeneously during cellular aging
Secondary accessions: B4DP75 Q2YDA4 Q7KYU3 Q92978
Alternative splicing: 2 isoforms:  Q99623-1   Q99623-2   

Explore the universe of human proteins at neXtProt for PHB2: NX_Q99623

Explore proteomics data for PHB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6, Lys97, Lys147, Lys224, Lys244
  • Modification sites at PhosphoSitePlus

  • See PHB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138303.1  NP_001254629.1  

    ENSEMBL proteins: 
     ENSP00000438634   ENSP00000441875   ENSP00000440317   ENSP00000475382   ENSP00000441662  
     ENSP00000438068   ENSP00000439029   ENSP00000382362   ENSP00000412856  

    PHB2 Human Recombinant Protein Products:

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    OriGene Purified Protein for PHB2
    OriGene Protein Over-expression Lysate for PHB2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHB2
    GenScript Custom Purified and Recombinant Proteins Services for PHB2
    Novus Biologicals PHB2 Proteins
    Novus Biologicals PHB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PHB2
    Cloud-Clone Corp. Proteins for PHB2

    PHB2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PHB2
    R&D Systems Antibodies for PHB2 (Prohibitin 2)
    Cell Signaling Technology (CST) Antibodies for PHB2  (BAP37)
    OriGene Antibodies for PHB2
    OriGene Custom Antibody Services for PHB2
    Novus Biologicals PHB2 Antibodies
    Abcam antibodies for PHB2
    Cloud-Clone Corp. Antibodies for PHB2
    ThermoFisher Antibody for PHB2
    LSBio Antibodies in human, mouse, rat for PHB2

    PHB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHB2
    Cloud-Clone Corp. CLIAs for PHB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000163 Prohibitin
     IPR001107 Band_7

    Graphical View of Domain Structure for InterPro Entry Q99623

    ProtoNet protein and cluster: Q99623

    1 Blocks protein domain: IPB000163 Prohibitin signature

    UniProtKB/Swiss-Prot: PHB2_HUMAN, Q99623
    Similarity: Belongs to the prohibitin family


    PHB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHB2_HUMAN, Q99623
    Function: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone
    deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the
    inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for
    modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and
    in aging
    Induction: Expression increases approximately 3-fold upon entry into G1 phase compared to other phases of the cell
    cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10359819
    GO:0030331estrogen receptor binding NAS10359819
         
    PHB2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for PHB2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Phb2):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  integument 
     mortality/aging  reproductive system 

    PHB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PHB2: Phb2tm1Katz Phb2tm1.1Tlan

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHB2:
    hsa-mir-193b-3p (MIRT041559), hsa-mir-25-3p (MIRT050313), hsa-mir-10a-5p (MIRT047600), hsa-mir-30a-5p (MIRT028641)

    Block miRNA regulation of human, mouse, rat PHB2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PHB2:
    hsa-miR-4251 hsa-miR-539 hsa-miR-34b hsa-miR-580 hsa-miR-548c-3p hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidPHB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHB2
    Predesigned siRNA for gene silencing in human, mouse, rat PHB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHB2

    Clone
    Products:
         
    OriGene clones in human, mouse for PHB2 (see all 11)
    OriGene ORF clones in mouse, rat for PHB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PHB2 (NM_004442)
    Sino Biological Human cDNA Clone for PHB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHB2_HUMAN, Q99623: Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By
    similarity). Note=Also cytoplasmic and nuclear (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    nucleus4
    cytosol2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane ISS--
    GO:0016020membrane ----
    GO:0016363nuclear matrix IDA--

    PHB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PHB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PHB2
        Estrogen Pathway

    1 Cell Signaling Technology (CST) Pathway for PHB2
        Protein Stability




    PHB2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including PHB2: 
              Estrogen Receptor Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PHB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PHB2 (Q996231, 2, 3 ENSP000003823624) via UniProtKB, MINT, STRING, and/or I2D (see all 615)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0033147negative regulation of intracellular estrogen receptor signaling pathway IEA--
    GO:0033600negative regulation of mammary gland epithelial cell proliferation IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA10359819
    GO:0060744mammary gland branching involved in thelarche IEA--

    PHB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHB2

    2 Novoseek inferred chemical compound relationships for PHB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 37.8 5 17008324 (2), 16309230 (1), 18835980 (1)
    estradiol 16.6 1 17008324 (1)



    PHB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHB2 gene (2 alternative transcripts): 
    NM_001144831.1  NM_001267700.1  

    Unigene Cluster for PHB2:

    Prohibitin 2
    Hs.504620  [show with all ESTs]
    Unigene Representative Sequence: BF204697
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537646 ENST00000543465(uc010sfu.1) ENST00000546111 ENST00000535923(uc021quf.1 uc021qug.1)
    ENST00000542912 ENST00000545555 ENST00000545167 ENST00000544888 ENST00000536316
    ENST00000544134 ENST00000546217 ENST00000542294 ENST00000399433(uc010sft.1)
    ENST00000440277

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHB2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate PHB2:
    hsa-miR-4251 hsa-miR-539 hsa-miR-34b hsa-miR-580 hsa-miR-548c-3p hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidPHB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHB2
    Predesigned siRNA for gene silencing in human, mouse, rat PHB2
    Clone
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    OriGene clones in human, mouse for PHB2 (see all 11)
    OriGene ORF clones in mouse, rat for PHB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PHB2 (NM_004442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PHB2
    OriGene qSTAR qPCR primer pairs in human, mouse for PHB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHB2
      QuantiTect SYBR Green Assays in human, mouse, rat PHB2
      QuantiFast Probe-based Assays in human, mouse, rat PHB2

    Additional mRNA sequence: 

    AF126021.1 AF150962.1 AF178980.1 AF279895.1 AK298217.1 BC013228.1 BC014766.1 BC110322.1 
    U72511.1 U72512.1 

    Selected DOTS entries (see all 43):

    DT.87001100  DT.121157357  DT.100879763  DT.100879760  DT.97795310  DT.121157466  DT.95308054  DT.121157247 
    DT.121157547  DT.121157914  DT.100879762  DT.121157622  DT.121157880  DT.121157529  DT.100879744  DT.95308210 
    DT.100879746  DT.121157495  DT.121157261  DT.40107282  DT.121158016  DT.121157820  DT.121157251  DT.121157301 

    Selected AceView cDNA sequences (see all 1074):

    BQ420268 BI834029 BX457530 BE259278 BI496838 BI907923 BQ063920 BF475859 
    BU160910 BM668155 BE782976 BU752120 BE746015 BU166751 BU162925 BU178613 
    BX425974 BI094454 AA314106 BG676660 BI837154 AL528469 CR595625 AA298033 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGATGGTCCC
    PHB2 Expression
    About this image


    PHB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Brain (Nervous System)
             Medulla Oblongata
    PHB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504620
        Pathway & Disease-focused RT2 Profiler PCR Array including PHB2: 
              Estrogen Receptor Signaling in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PHB2
    OriGene qSTAR qPCR primer pairs in human, mouse for PHB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHB2
    QuantiTect SYBR Green Assays in human, mouse, rat PHB2
    QuantiFast Probe-based Assays in human, mouse, rat PHB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PHB2 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phb21 , 5 prohibitin 21, 5 91.3(n)1
    100(a)1
      6 (59.17 cM)5
    120341  NM_007531.21  NP_031557.21 
     1247123365 
    chicken
    (Gallus gallus)
    Aves PHB21 prohibitin 2 81.16(n)
    94.98(a)
      771124  NM_001080885.1  NP_001074354.1 
    lizard
    (Anolis carolinensis)
    Reptilia PHB26
    prohibitin 2
    84(a)
    1 ↔ 1
    GL343453.1(666274-675680)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158342 Xenopus laevis transcribed sequence with moderate similarity more 76.16(n)    CD326385.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059510.12   -- 75.44(n)   324421  BC059510.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)037091 lethal (2) 03709 69.04(n)
    71.19(a)
      46038  NM_001103902.1  NP_001097372.1 
    worm
    (Caenorhabditis elegans)
    Secernentea phb-21 phb-2 60.24(n)
    66.55(a)
      174034  NM_062849.4  NP_495250.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHB21 PHB2 57.84(n)
    56.34(a)
      853146   NP_011747.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PHB11 PHB1 55.88(n)
    55.88(a)
      828969  NM_118993.3  NP_194580.1 
    rice
    (Oryza sativa)
    Liliopsida Os.320132 Oryza sativa (japonica cultivar-group) cDNA clone0 more 70.94(n)    AK058481.1 


    ENSEMBL Gene Tree for PHB2 (if available)
    TreeFam Gene Tree for PHB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHB2 gene
    3 SIMAP similar genes for PHB2 using alignment to 8 protein entries:     PHB2_HUMAN (see all proteins):
    HEL-S-54e    PHB    ZNF607

    PHB2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PHB2
    PGOHUM00000238914


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHB2 (see all 57)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379563481,2
    C--7074034(+) CCCACC/TTCCCC 2 -- int10--------
    rs1143605441,2
    C,F--7074117(+) GCCACG/ACGATC 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1177815631,2
    F--7074118(+) CCACGC/TGATCC 2 -- int11Minor allele frequency- T:0.03EA 120
    rs22693621,2
    C,F,H--7074128(+) CACTGG/AGCTTC 2 -- int15Minor allele frequency- A:0.04EA NS NA 1940
    rs1154083981,2
    F--7074131(+) TGGGCT/CTCTGG 2 -- int11Minor allele frequency- C:0.02WA 118
    rs740572371,2
    C--7074141(+) GGCACA/GGAAGT 2 -- int12Minor allele frequency- G:0.14WA 120
    rs2018620601,2
    C--7074169(+) CAGGCC/TCNNNN 2 -- int10--------
    rs1931117101,2
    C--7074187(+) AAGGAA/TCCCTG 2 -- int10--------
    rs22693631,2
    C,F--7074324(+) GGCCTC/GGAGAA 2 -- int12Minor allele frequency- G:0.07EA 1612
    rs1441503681,2
    --7074346(+) CCTTCC/TCAGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for PHB2 (7074490 - 7079988 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PHB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509453CNV Insertion20534489
    nsv898641CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHB2
    DNA2.0 Custom Variant and Variant Library Synthesis for PHB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610704    OMIM disorders: --

    Selected diseases for PHB2 (see all 25):    
    About MalaCards
    enthesopathy    dysentery    osteoporotic fracture    balanitis
    onchocerciasis    reactive arthritis    dyslexia    severe acute respiratory syndrome
    urethritis    schistosomiasis    gastroenteritis    arthropathy
    synovitis    psoriatic arthritis    spondylitis    ankylosing spondylitis
    diarrhea    arthritis    hiv-1    hypoxia

    8 diseases from the University of Copenhagen DISEASES database for PHB2:
    Arthritis     Ankylosing spondylitis     Urethritis     Arthropathy
    Psoriatic arthritis     Synovitis     Enthesopathy     Dysentery

    PHB2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): PHB2
    Human Genome Epidemiology (HuGE) Navigator: PHB2 (2 documents)

    Export disorders for PHB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHB2 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with PHB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PubMed id 11302691)1, 2, 3 Coates P.J.... Wright E.G. (Exp. Cell Res. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. (PubMed id 10359819)1, 2 Montano M.M....Katzenellenbogen B.S. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    8. The prohibitin family of mitochondrial proteins regulate replicative lifespan. (PubMed id 9259555)1, 3 Coates P.J....Hall P.A. (Curr. Biol. 1997)
    9. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)1, 2 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1997)
    10. PHB2 protects sister-chromatid cohesion in mitosis. (PubMed id 17656096)1, 9 Takata H....Fukui K. (Curr. Biol. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11331 HGNC: 30306 AceView: REA Ensembl:ENSG00000215021 euGenes: HUgn11331
    ECgene: PHB2 H-InvDB: PHB2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PHB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PHB2 gene:
    Search GeneIP for patents involving PHB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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