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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PHB Gene

protein-coding   GIFtS: 68
GCID: GC17M047481

Prohibitin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
prohibitin1 2
PHB12

External Ids:    HGNC: 89121   Entrez Gene: 52452   Ensembl: ENSG000001670857   OMIM: 1767055   UniProtKB: P352323   

Export aliases for PHB gene to outside databases

Previous GC identifers: GC17M047192 GC17M049961 GC17M047823 GC17M047956 GC17M044836 GC17M042846


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PHB Gene:
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and
tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to
function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for PHB Gene: 
PHB (prohibitin) is a protein-coding gene. Diseases associated with PHB include sporadic breast cancer, and breast cancer susceptibility, and among its related super-pathways are DNA Damage. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: PHB_HUMAN, P35232
Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if
the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity
and in aging

Gene Wiki entry for PHB (Prohibitin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PHB gene promoter:
         AML1a   GATA-3   MyoD   CUTL1   STAT5A   POU3F2   RORalpha1   SRY   STAT3   CP1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHB promoter sequence
   Search SABiosciences Chromatin IP Primers for PHB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21

PHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M047481:  view genomic region     (about GC identifiers)

Start:
47,481,414 bp from pter      End:
47,492,246 bp from pter
Size:
10,833 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PHB_HUMAN, P35232 (See protein sequence)
Recommended Name: Prohibitin  
Size: 272 amino acids; 29804 Da
Subunit: Interacts with PHB2. Interacts with STOML2
Subcellular location: Mitochondrion inner membrane (By similarity)
Developmental stage: Levels of expression in fibroblasts decrease heterogeneously during cellular aging
1 PDB 3D structure from and Proteopedia for PHB:
1LU7 (3D)    
Secondary accessions: Q4VBQ0

Explore the universe of human proteins at neXtProt for PHB: NX_P35232

Explore proteomics data for PHB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35232

  • PHB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PHB Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001268425.1  NP_001268426.1  NP_001268644.1  NP_002625.1  

    ENSEMBL proteins: 
     ENSP00000300408   ENSP00000393320   ENSP00000426433   ENSP00000422182   ENSP00000407828  
     ENSP00000410680   ENSP00000425035  

    Human Recombinant Protein Products for PHB: 
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    Novus Biologicals PHB Proteins
    Novus Biologicals PHB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHB 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005654nucleoplasm IDA12466959
    GO:0005737cytoplasm IDA16964284
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS14500729

    PHB for ontologies           About GeneDecksing



    PHB Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for PHB 

    Assay Products for PHB: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHB 
    Cloud-Clone Corp. CLIAs for PHB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000163 Prohibitin
     IPR001107 Band_7

    Graphical View of Domain Structure for InterPro Entry P35232

    ProtoNet protein and cluster: P35232

    1 Blocks protein domain: IPB000163 Prohibitin signature

    UniProtKB/Swiss-Prot: PHB_HUMAN, P35232
    Similarity: Belongs to the prohibitin family


    PHB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHB_HUMAN, P35232
    Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if
    the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity
    and in aging
    Induction: Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the
    cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol

         Genatlas biochemistry entry for PHB:
    prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI11302691
    GO:0042826histone deacetylase binding IPI16964284
    GO:0044212transcription regulatory region DNA binding IDA18487222
         
    PHB for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for PHB:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased focal adhesion (FA)  
     Decreased viability  Decreased viability of wild-ty  Decreased viability with pacli  G0/1 arrest 
     Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Phb):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  integument  mortality/aging 
     reproductive system 

    PHB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phbtm1.2Bwo for PHB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PHB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PHB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHB 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHB:
    hsa-mir-27a (MIRT001210)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHB
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PHB (see all 19):
    hsa-miR-362-3p hsa-miR-1224-3p hsa-miR-3616-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-609 hsa-miR-500a hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidPHB 3' UTR sequence
    Inhib. RNA
    Products:
        
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                         Customized lentivirus expression plasmids for stable overexpression of PHB 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PHB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    Cell Cycle / Checkpoint Control0.32
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PHB
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for PHB
        Integrated Breast Cancer Pathway




    PHB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/534 Interacting proteins for PHB (P352321, 2, 3 ENSP000003004084) via UniProtKB, MINT, STRING, and/or I2D (see all 534)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16964284
    GO:0006260DNA replication IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA14500729
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007165signal transduction TAS16130169

    PHB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PHB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PHB

    10/20 Novoseek inferred chemical compound relationships for PHB gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1alpha-hydroxyvitamin d5 80.5 2 17207617 (1), 16849588 (1)
    leptomycin b 39.3 2 16319068 (1), 16506698 (1)
    glyceraldehyde 3-phosphate 28.2 6 15986332 (1), 16947118 (1), 18310271 (1), 17459200 (1)
    camptothecin 27.6 6 16319068 (4), 14500729 (1), 17030995 (1)
    pyruvate 25.3 5 19212829 (1), 16420480 (1), 15337753 (1), 18398875 (1)
    isocitrate 24.5 1 15986332 (1)
    phenylalanine 23.6 5 19238206 (1)
    lipid 21 7 16796804 (1), 15337753 (1), 16835267 (1), 18558096 (1)
    atp 18.1 12 17284347 (5), 17085086 (1), 19628287 (1), 15337753 (1) (see all 5)
    gdp 7.39 2 17459200 (1), 9548300 (1)

    Search CenterWatch for drugs/clinical trials and news about PHB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PHB gene (4 alternative transcripts): 
    NM_001281496.1  NM_001281497.1  NM_001281715.1  NM_002634.3  

    Unigene Cluster for PHB:

    Prohibitin
    Hs.514303  [show with all ESTs]
    Unigene Representative Sequence: BF676086
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300408(uc002iox.1) ENST00000511933 ENST00000419140 ENST00000504124
    ENST00000508009 ENST00000512041 ENST00000446735 ENST00000393345 ENST00000506273
    ENST00000434917 ENST00000507748 ENST00000513412 ENST00000511832

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHB
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate PHB (see all 19):
    hsa-miR-362-3p hsa-miR-1224-3p hsa-miR-3616-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-609 hsa-miR-500a hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidPHB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PHB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHB
    Clone
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    GenScript: all cDNA clones in your preferred vector: PHB (NM_004441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHB
    Sirion Biotech Customized lentivirus for stable overexpression of PHB 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHB

    Additional mRNA sequence: 

    AK223181.1 AK290766.1 AK302258.1 AK307767.1 AK312649.1 AY577780.1 BC013401.2 BC095460.1 
    BT007411.1 CR541706.1 S85655.1 

    24/42 DOTS entries (see all 42):

    DT.99926453  DT.95365342  DT.91773892  DT.120988859  DT.95365360  DT.120988824  DT.95145943  DT.100685731 
    DT.100693956  DT.95365338  DT.120988857  DT.95365368  DT.121294986  DT.97864576  DT.120988860  DT.95306898 
    DT.95365352  DT.100685733  DT.100842943  DT.120988844  DT.120988849  DT.100685729  DT.100685745  DT.100710137 

    24/1004 AceView cDNA sequences (see all 1004):

    BQ278642 AL531031 BQ427983 CA423073 BU173812 BQ948000 BP338844 BX417878 
    CR601626 BX377964 CA454876 BQ020569 BX360093 BM015798 BG029858 BM695199 
    BX362626 BC013401 AA357152 BU781606 BM313820 BE905776 BX417956 CD675486 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PHB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                    -     -     -                                                   
    SP2:                                -                                                   
    SP3:                    -     -                                                         
    SP4:                                -                                                   
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for PHB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PHB expression in normal human tissues (normalized intensities)      PHB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGGCTTAA
    PHB Expression
    About this image


    PHB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See PHB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PHB

    SOURCE GeneReport for Unigene cluster: Hs.514303

    UniProtKB/Swiss-Prot: PHB_HUMAN, P35232
    Tissue specificity: Widely expressed in different tissues

        SABiosciences Custom PCR Arrays for PHB
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHB
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PHB gene from 10/29 species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phb1 , 5 prohibitin1, 5 91.18(n)1
    99.63(a)1
      11 (59.01 cM)5
    186731  NM_008831.41  NP_032857.11 
     956669575 
    chicken
    (Gallus gallus)
    Aves PHB1 prohibitin 82.84(n)
    95.96(a)
      419980  NM_001177735.1  NP_001171206.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    92(a)
    82(a)
    possible ortholog
    possible ortholog
    6(76297413-76304897)
    GL343756.1(204845-205663)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644472 hypothetical protein MGC64447 79.07(n)    BC045121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phb2 prohibitin 78.78(n)   321346  BC055384.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)37Cc1 , 3 larval/pupal development (sensu
    Insecta)3
    lethal (2) 37Cc1
    57(a)3
    68.51(n)1
    75.28(a)1
      2 37C13
    491681  NM_057259.51  NP_476607.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E3.93
    phb-11
    Protein PHB-11 68(a)3
    62.21(n)1
    66.17(a)1
      I(2071355-2072300)3
    1717681  NM_058528.31  NP_490929.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHB1(YGR132C)4
    PHB11
    Subunit of the prohibitin complex (Phb1p-Phb2p), a more4
    Phb1p1
    56.82(n)1
    54.17(a)1
      7(756452-755589)4
    8530331, 4  NP_011648.31  NP_011648.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PHB31 prohibitin 3 56.63(n)
    55.76(a)
      834077  NM_123442.4  NP_198893.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05805001 hypothetical protein 57.95(n)
    55.68(a)
      4329777  NM_001053771.1  NP_001047236.1 


    ENSEMBL Gene Tree for PHB (if available)
    TreeFam Gene Tree for PHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PHB gene
    2 SIMAP similar genes for PHB using alignment to 9 protein entries:     PHB_HUMAN (see all proteins):
    ZNF607    PHB2

    PHB for paralogs           About GeneDecksing


    5/24 Pseudogenes.org Pseudogenes for PHB (see all 24)
    PGOHUM00000238905 PGOHUM00000250388 PGOHUM00000242517 PGOHUM00000242654 PGOHUM00000239440


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/275 SNPs in PHB are shown (see all 275)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0064804
    A breast cancer sample4--see VAR_0064802 R H mis40--------
    VAR_0064794
    A breast cancer sample4--see VAR_0064792 V A mis40--------
    rs1126640361,2
    C--47480927(+) AAGTGG/TGACCC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs2009172051,2
    C--47480999(-) CTCTTG/TTTTTC 1 -- ds50010--------
    rs1817195101,2
    --47481034(+) GCCCCA/GAGCCA 1 -- ds50010--------
    rs1860592241,2
    --47481152(+) TGGCAC/TCAAAA 1 -- ds50010--------
    rs1492351901,2
    --47481243(+) CCTTCA/GGGTTG 1 -- ds50010--------
    rs49870821,2
    C,F,H--47481374(-) GGATCA/GGAACA 1 -- ds500139Minor allele frequency- G:0.21MN EA NA NS 3602
    rs1904332271,2
    --47481419(+) TGAGCC/TGGAAG 1 -- ds50010--------
    rs1473277271,2
    --47481473(+) CCTTCC/TCAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHB (47481414 - 47492246 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PHB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833473CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): PHB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PHB
    DNA2.0 Custom Variant and Variant Library Synthesis for PHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176705   
    OMIM disorders: 114480  
    20/40 diseases for PHB (see all 40):    About MalaCards
    sporadic breast cancer    breast cancer susceptibility    chikungunya    cervical adenocarcinoma
    severe acute respiratory syndrome    breast cancer    gastric adenocarcinoma    endocarditis
    papillary thyroid carcinoma    bladder carcinoma    esophageal squamous cell carcinoma    gastric cancer
    endometriosis    ulcerative colitis    obesity    ovarian cancer
    osteosarcoma    retinoblastoma    adenocarcinoma    thyroiditis


    PHB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/15 Novoseek inferred disease relationships for PHB gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 45.7 21 12923326 (1), 17196136 (1), 17085086 (1), 20448348 (1) (see all 16)
    breast cancer 36.3 29 8809404 (3), 16849588 (3), 17004108 (2), 11377649 (2) (see all 15)
    tumors 34.4 39 10376528 (2), 8244394 (2), 8809404 (2), 8591812 (2) (see all 30)
    retinoblastoma 26.4 5 8198603 (1), 10523633 (1), 16964284 (1), 20205716 (1)
    gastric cancer 25.9 16 18709484 (9), 18789835 (2), 12923326 (1), 20440860 (1)
    cancer 23.6 6 15759318 (1), 17704829 (1), 15823758 (1), 16861898 (1) (see all 5)
    ovarian cancer 22.9 11 17544200 (4), 12821355 (3), 8349162 (1), 18397521 (1) (see all 5)
    prostate cancer 16.2 14 19725029 (3), 16733518 (2), 16964284 (1), 18384941 (1) (see all 6)
    colitis 8.65 9 19327358 (4)
    somatic mutations 5.33 2 8244394 (2)

    Genetic Association Database (GAD): PHB
    Human Genome Epidemiology (HuGE) Navigator: PHB (13 documents)
    Tumor Gene Database (TGDB): PHB

    Export disorders for PHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PHB gene, integrated from 9 sources (see all 296):
    (articles sorted by number of sources associating them with PHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PubMed id 8244394)1, 2, 3, 9 Sato T....Nakamura Y. (1993)
    2. The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PubMed id 17544200)1, 4, 9 Grimm C....Hefler L.A. (2008)
    3. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. (PubMed id 10376528)1, 3, 9 Wang S....Chellappan S. (1999)
    4. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PubMed id 18397521)1, 4, 9 Jakubowska A....Hamann U. (2008)
    5. The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. (PubMed id 17004108)1, 4, 9 Jakubowska A....Hamann U. (2007)
    6. The prohibitin 3' untranslated region polymorphism is not associated with risk of ovarian cancer. (PubMed id 12821355)1, 4, 9 Spurdle A.B....Chenevix-Trench G. (2003)
    7. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PubMed id 11302691)1, 2, 9 Coates P.J.... Wright E.G. (2001)
    8. Lack of Association between Prohibitin 3' Untranslated Region C-->T Polymorphism and Breast Cancer in a Turkish Population. (PubMed id 18494604)1, 4, 9 Karakus N....Ulusoy A.N. (2008)
    9. Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women. (PubMed id 12354477)1, 4, 9 Spurdle A.B....Chenevix-Trench G. (2002)
    10. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. (PubMed id 11377649)1, 4, 9 Jupe E.R....Thompson L.F. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5245 HGNC: 8912 AceView: PHB Ensembl:ENSG00000167085 euGenes: HUgn5245
    ECgene: PHB H-InvDB: PHB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PHB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PHB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PHB gene:
    Search GeneIP for patents involving PHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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