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PHB Gene

protein-coding   GIFtS: 69
GCID: GC17M047481

Prohibitin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
prohibitin1 2
HEL-2152
HEL-S-54e2
PHB12
Epididymis Luminal Protein 2152
Epididymis Secretory Sperm Binding Protein Li 54e2

External Ids:    HGNC: 89121   Entrez Gene: 52452   Ensembl: ENSG000001670857   OMIM: 1767055   UniProtKB: P352323   

Export aliases for PHB gene to outside databases

Previous GC identifers: GC17M047192 GC17M049961 GC17M047823 GC17M047956 GC17M044836 GC17M042846


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PHB Gene:
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and
tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to
function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for PHB Gene:
PHB (prohibitin) is a protein-coding gene. Diseases associated with PHB include brca1 and brca2 hereditary breast and ovarian cancer, and chikungunya. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: PHB_HUMAN, P35232
Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if
the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity
and in aging

Gene Wiki entry for PHB (Prohibitin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHB gene promoter:
         AML1a   GATA-3   MyoD   CUTL1   STAT5A   POU3F2   RORalpha1   SRY   STAT3   CP1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPHB promoter sequence
   Search Chromatin IP Primers for PHB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21

PHB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M047481:  view genomic region     (about GC identifiers)

Start:
47,481,414 bp from pter      End:
47,492,246 bp from pter
Size:
10,833 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PHB_HUMAN, P35232 (See protein sequence)
Recommended Name: Prohibitin  
Size: 272 amino acids; 29804 Da
Subunit: Interacts with PHB2. Interacts with STOML2
Developmental stage: Levels of expression in fibroblasts decrease heterogeneously during cellular aging
1 PDB 3D structure from and Proteopedia for PHB:
1LU7 (3D)    
Secondary accessions: Q4VBQ0

Explore the universe of human proteins at neXtProt for PHB: NX_P35232

Explore proteomics data for PHB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys128
  • Modification sites at PhosphoSitePlus

  • See PHB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001268425.1  NP_001268426.1  NP_001268644.1  NP_002625.1  

    ENSEMBL proteins: 
     ENSP00000300408   ENSP00000393320   ENSP00000426433   ENSP00000422182   ENSP00000407828  
     ENSP00000410680   ENSP00000425035  

    PHB Human Recombinant Protein Products:

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    Novus Biologicals PHB Proteins
    Novus Biologicals PHB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PHB
    Cloud-Clone Corp. Proteins for PHB

    PHB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of PHB
    R&D Systems Antibodies for PHB (Prohibitin)
    Cell Signaling Technology (CST) Antibodies for PHB 
    OriGene Antibodies for PHB
    OriGene Custom Antibody Services for PHB
    Novus Biologicals PHB Antibodies
    Abcam antibodies for PHB
    Cloud-Clone Corp. Antibodies for PHB
    ThermoFisher Antibody for PHB
    LSBio Antibodies in human, mouse, rat for PHB

    PHB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHB
    Cloud-Clone Corp. CLIAs for PHB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000163 Prohibitin
     IPR001107 Band_7

    Graphical View of Domain Structure for InterPro Entry P35232

    ProtoNet protein and cluster: P35232

    1 Blocks protein domain: IPB000163 Prohibitin signature

    UniProtKB/Swiss-Prot: PHB_HUMAN, P35232
    Similarity: Belongs to the prohibitin family


    PHB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHB_HUMAN, P35232
    Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if
    the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity
    and in aging
    Induction: Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the
    cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol

         Genatlas biochemistry entry for PHB:
    prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005515protein binding IPI11302691
    GO:0042826histone deacetylase binding IPI16964284
    GO:0044212transcription regulatory region DNA binding IDA18487222
         
    PHB for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for PHB:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased focal adhesion (FA)  
     Decreased viability  Decreased viability of wild-ty  Decreased viability with pacli  G0/1 arrest 
     Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Phb):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  integument  mortality/aging 
     reproductive system 

    PHB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Phbtm1.2Bwo for PHB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHB

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHB:
    hsa-mir-484 (MIRT041678), hsa-mir-27a-3p (MIRT001210)

    Block miRNA regulation of human, mouse, rat PHB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHB (see all 19):
    hsa-miR-362-3p hsa-miR-1224-3p hsa-miR-3616-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-609 hsa-miR-500a hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidPHB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHB
    Predesigned siRNA for gene silencing in human, mouse, rat PHB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHB

    Clone
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    OriGene clones in human, mouse for PHB (see all 7)
    OriGene ORF clones in mouse, rat for PHB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHB (NM_004441)
    Sino Biological Human cDNA Clone for PHB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHB

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for PHB
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHB_HUMAN, P35232: Mitochondrion inner membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    plasma membrane4
    cytoskeleton2
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005654nucleoplasm IDA12466959
    GO:0005737cytoplasm IDA16964284
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS14500729

    PHB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PHB About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PHB
        Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for PHB
        Integrated Breast Cancer Pathway




    PHB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHB
    Interactions:

        GeneGlobe Interaction Network for PHB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PHB (P352321, 2, 3 ENSP000003004084) via UniProtKB, MINT, STRING, and/or I2D (see all 553)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16964284
    GO:0006260DNA replication IEA--
    GO:0006355regulation of transcription, DNA-templated IDA14500729
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007165signal transduction TAS16130169

    PHB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHB

    Selected Novoseek inferred chemical compound relationships for PHB gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1alpha-hydroxyvitamin d5 80.5 2 17207617 (1), 16849588 (1)
    leptomycin b 39.3 2 16319068 (1), 16506698 (1)
    glyceraldehyde 3-phosphate 28.2 6 15986332 (1), 16947118 (1), 18310271 (1), 17459200 (1)
    camptothecin 27.6 6 16319068 (4), 14500729 (1), 17030995 (1)
    pyruvate 25.3 5 19212829 (1), 16420480 (1), 15337753 (1), 18398875 (1)
    isocitrate 24.5 1 15986332 (1)
    phenylalanine 23.6 5 19238206 (1)
    lipid 21 7 16796804 (1), 15337753 (1), 16835267 (1), 18558096 (1)
    atp 18.1 12 17284347 (5), 17085086 (1), 19628287 (1), 15337753 (1) (see all 5)
    gdp 7.39 2 17459200 (1), 9548300 (1)



    PHB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHB gene (4 alternative transcripts): 
    NM_001281496.1  NM_001281497.1  NM_001281715.1  NM_002634.3  

    Unigene Cluster for PHB:

    Prohibitin
    Hs.514303  [show with all ESTs]
    Unigene Representative Sequence: BF676086
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300408(uc002iox.1) ENST00000511933 ENST00000419140 ENST00000504124
    ENST00000508009 ENST00000512041 ENST00000446735 ENST00000393345 ENST00000506273
    ENST00000434917 ENST00000507748 ENST00000513412 ENST00000511832
    miRNA
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    Block miRNA regulation of human, mouse, rat PHB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHB (see all 19):
    hsa-miR-362-3p hsa-miR-1224-3p hsa-miR-3616-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-609 hsa-miR-500a hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidPHB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PHB
    Clone
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    OriGene clones in human, mouse for PHB (see all 7)
    OriGene ORF clones in mouse, rat for PHB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PHB (NM_004441)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHB
    Primer
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    OriGene qPCR primer pairs and template standards for PHB
    OriGene qSTAR qPCR primer pairs in human, mouse for PHB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHB
      QuantiTect SYBR Green Assays in human, mouse, rat PHB
      QuantiFast Probe-based Assays in human, mouse, rat PHB

    Additional mRNA sequence: 

    AK223181.1 AK290766.1 AK302258.1 AK307767.1 AK312649.1 AY577780.1 BC013401.2 BC095460.1 
    BT007411.1 CR541706.1 S85655.1 

    Selected DOTS entries (see all 42):

    DT.99926453  DT.95365342  DT.91773892  DT.120988859  DT.95365360  DT.120988824  DT.95145943  DT.100685731 
    DT.100693956  DT.95365338  DT.120988857  DT.95365368  DT.121294986  DT.97864576  DT.120988860  DT.95306898 
    DT.95365352  DT.100685733  DT.100842943  DT.120988844  DT.120988849  DT.100685729  DT.100685745  DT.100710137 

    Selected AceView cDNA sequences (see all 1004):

    BX422430 BQ677058 CB120569 BQ958592 BM925628 BP342096 CA398031 BU176849 
    AW130141 AL531031 BC013401 BM795027 BM918494 CB139022 CA418453 AI342089 
    AA345571 CD364515 BM760782 CB124291 BU944001 BP376532 CB132483 BM781873 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PHB    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                    -     -     -                                                   
    SP2:                                -                                                   
    SP3:                    -     -                                                         
    SP4:                                -                                                   
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for PHB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGGCTTAA
    PHB Expression
    About this image


    PHB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PHB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514303

    UniProtKB/Swiss-Prot: PHB_HUMAN, P35232
    Tissue specificity: Widely expressed in different tissues

        Custom PCR Arrays for PHB
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    QuantiFast Probe-based Assays in human, mouse, rat PHB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PHB gene from Selected species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phb1 , 5 prohibitin1, 5 91.18(n)1
    99.63(a)1
      11 (59.01 cM)5
    186731  NM_008831.41  NP_032857.11 
     956669575 
    chicken
    (Gallus gallus)
    Aves PHB1 prohibitin 82.84(n)
    95.96(a)
      419980  NM_001177735.1  NP_001171206.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    92(a)
    82(a)
    many → 1
    many → 1
    6(76297413-76304897)
    GL343756.1(204845-205663)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644472 hypothetical protein MGC64447 79.07(n)    BC045121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii phb2 prohibitin 78.78(n)   321346  BC055384.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)37Cc1 , 3 larval/pupal development (sensu
    Insecta)3
    lethal (2) 37Cc1
    57(a)3
    68.51(n)1
    75.28(a)1
      2 37C13
    491681  NM_165281.11  NP_724165.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y37E3.93
    phb-11
    phb-11 68(a)3
    62.21(n)1
    66.17(a)1
      I(2071355-2072300)3
    1717681  NM_058528.41  NP_490929.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PHB1(YGR132C)4
    PHB11
    Subunit of the prohibitin complex (Phb1p-Phb2p), a more4
    PHB11
    56.82(n)1
    54.17(a)1
      7(756452-755589)4
    8530331, 4  NP_011648.31  NP_011648.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PHB31 PHB3 56.63(n)
    55.76(a)
      834077  NM_123442.4  NP_198893.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05805001 Os02g0580500 57.95(n)
    55.68(a)
      4329777  NM_001053771.1  NP_001047236.1 


    ENSEMBL Gene Tree for PHB (if available)
    TreeFam Gene Tree for PHB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHB gene
    3 SIMAP similar genes for PHB using alignment to 9 protein entries:     PHB_HUMAN (see all proteins):
    HEL-S-54e    ZNF607    PHB2

    PHB for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for PHB (see all 24)
    PGOHUM00000238905 PGOHUM00000250388 PGOHUM00000242517 PGOHUM00000242654 PGOHUM00000239440


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHB (see all 275)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0064804
    A breast cancer sample4--see VAR_0064802 R H mis40--------
    VAR_0064794
    A breast cancer sample4--see VAR_0064792 V A mis40--------
    rs1126640361,2
    C--47480927(+) AAGTGG/TGACCC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs2009172051,2
    C--47480999(-) CTCTTG/TTTTTC 1 -- ds50010--------
    rs1817195101,2
    --47481034(+) GCCCCA/GAGCCA 1 -- ds50010--------
    rs1860592241,2
    --47481152(+) TGGCAC/TCAAAA 1 -- ds50010--------
    rs1492351901,2
    --47481243(+) CCTTCA/GGGTTG 1 -- ds50010--------
    rs49870821,2
    C,F,H--47481374(-) GGATCA/GGAACA 1 -- ds500139Minor allele frequency- G:0.21MN EA NA NS 3602
    rs1904332271,2
    --47481419(+) TGAGCC/TGGAAG 1 -- ds50010--------
    rs1473277271,2
    --47481473(+) CCTTCC/TCAGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PHB (47481414 - 47492246 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PHB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833473CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): PHB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHB
    DNA2.0 Custom Variant and Variant Library Synthesis for PHB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176705   
    OMIM disorders: 114480  
    Selected diseases for PHB (see all 50):    
    About MalaCards
    brca1 and brca2 hereditary breast and ovarian cancer    chikungunya    brca2 hereditary breast and ovarian cancer    breast cancer
    hereditary breast ovarian cancer    cervical adenocarcinoma    severe acute respiratory syndrome    gastric adenocarcinoma
    sporadic breast cancer    endocarditis    adrenocortical carcinoma    papillary thyroid carcinoma
    ovarian cancer    bladder carcinoma    esophageal squamous cell carcinoma    retinoblastoma
    lung cancer susceptibility    inflammatory bowel disease    endometriosis    ulcerative colitis


    PHB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PHB gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 45.7 21 12923326 (1), 17196136 (1), 17085086 (1), 20448348 (1) (see all 16)
    breast cancer 36.3 29 8809404 (3), 16849588 (3), 17004108 (2), 11377649 (2) (see all 15)
    tumors 34.4 39 10376528 (2), 8244394 (2), 8809404 (2), 8591812 (2) (see all 30)
    retinoblastoma 26.4 5 8198603 (1), 10523633 (1), 16964284 (1), 20205716 (1)
    gastric cancer 25.9 16 18709484 (9), 18789835 (2), 12923326 (1), 20440860 (1)
    cancer 23.6 6 15759318 (1), 17704829 (1), 15823758 (1), 16861898 (1) (see all 5)
    ovarian cancer 22.9 11 17544200 (4), 12821355 (3), 8349162 (1), 18397521 (1) (see all 5)
    prostate cancer 16.2 14 19725029 (3), 16733518 (2), 16964284 (1), 18384941 (1) (see all 6)
    colitis 8.65 9 19327358 (4)
    somatic mutations 5.33 2 8244394 (2)

    Genetic Association Database (GAD): PHB
    Human Genome Epidemiology (HuGE) Navigator: PHB (13 documents)
    Tumor Gene Database (TGDB): PHB

    Export disorders for PHB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHB gene, integrated from 10 sources (see all 300):
    (articles sorted by number of sources associating them with PHB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PubMed id 8244394)1, 2, 3, 9 Sato T.... Nakamura Y. (Genomics 1993)
    2. The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PubMed id 17544200)1, 4, 9 Grimm C....Hefler L.A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2008)
    3. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. (PubMed id 10376528)1, 3, 9 Wang S....Chellappan S. (Oncogene 1999)
    4. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PubMed id 18397521)1, 4, 9 Jakubowska A....Hamann U. (BMC Cancer 2008)
    5. The 3' untranslated region C &gt; T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. (PubMed id 17004108)1, 4, 9 Jakubowska A....Hamann U. (Breast Cancer Res. Treat. 2007)
    6. The prohibitin 3' untranslated region polymorphism is not associated with risk of ovarian cancer. (PubMed id 12821355)1, 4, 9 Spurdle A.B....Chenevix-Trench G. (Gynecol. Oncol. 2003)
    7. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. (PubMed id 11302691)1, 2, 9 Coates P.J.... Wright E.G. (Exp. Cell Res. 2001)
    8. Lack of association between prohibitin 3' untranslated region C--&gt;T polymorphism and breast cancer in a Turkish population. (PubMed id 18494604)1, 4, 9 Karakus N....Ulusoy A.N. (DNA Cell Biol. 2008)
    9. Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women. (PubMed id 12354477)1, 4, 9 Spurdle A.B....Chenevix-Trench G. (Lancet 2002)
    10. Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility. (PubMed id 11377649)1, 4, 9 Jupe E.R....Thompson L.F. (Lancet 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5245 HGNC: 8912 AceView: PHB Ensembl:ENSG00000167085 euGenes: HUgn5245
    ECgene: PHB H-InvDB: PHB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PHB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PHB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PHB gene:
    Search GeneIP for patents involving PHB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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