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Aliases for PHB Gene

Aliases for PHB Gene

  • Prohibitin 2 3 3 5
  • Epididymis Secretory Sperm Binding Protein Li 54e 3
  • Epididymis Luminal Protein 215 3
  • HEL-S-54e 3
  • HEL-215 3
  • PHB1 3

External Ids for PHB Gene

Previous GeneCards Identifiers for PHB Gene

  • GC17M047192
  • GC17M049961
  • GC17M047823
  • GC17M047956
  • GC17M044836
  • GC17M047481
  • GC17M042846

Summaries for PHB Gene

Entrez Gene Summary for PHB Gene

  • This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PHB Gene

PHB (Prohibitin) is a Protein Coding gene. Diseases associated with PHB include Breast Cancer and Igg4-Related Disease. Among its related pathways are RET signaling and MAPK Signaling: Mitogen Stimulation Pathway. GO annotations related to this gene include enzyme binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for PHB Gene

  • Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

Gene Wiki entry for PHB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHB Gene

Genomics for PHB Gene

Regulatory Elements for PHB Gene

Enhancers for PHB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G049387 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +25.3 25290 4.5 PKNOX1 ATF1 ZNF133 FEZF1 DMAP1 TCF12 GTF3C2 GATA2 FOS ZNF592 ZNF652 ENSG00000262837 LOC102724596 PHB ENSG00000207127 FLJ45513 ABI3 SNF8 PHOSPHO1 GNGT2
GH17G049687 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -273.4 -273377 2.5 ELF3 FOXA2 MLX ARID4B DMAP1 DNMT3B ZSCAN9 RARA SLC30A9 GATA2 LOC100288866 NXPH3 SLC35B1 PHB RPL21P124 ENSG00000250186 FAM117A SPOP PHOSPHO1 SAMD14
GH17G049507 1.5 FANTOM5 Ensembl ENCODE 11.2 -93.8 -93758 2.0 PKNOX1 FOXA2 FEZF1 BRCA1 ZBTB7B ETS1 ELK1 FOS SP3 YY2 SUMO2P17 ENSG00000207127 PHB ENSG00000250186 RPL21P124 ENSG00000230532 ATP5G1 HOXB3 MIR6165 ENSG00000279036
GH17G049259 1.5 FANTOM5 Ensembl ENCODE 10.9 +154.4 154416 1.9 CREB3L1 ZFP64 SIN3A ZNF2 FOS ZNF263 YY2 ZNF518A ZNF592 ZNF585B PHOSPHO1 RPL21P124 ENSG00000250186 PHB ZNF652 UBE2Z CALCOCO2 GC17P049267 FLJ40194
GH17G049340 1.4 Ensembl ENCODE dbSUPER 11.4 +72.6 72615 3.5 TBL1XR1 BMI1 YBX1 ZNF366 RELB IKZF2 CREM ZNF362 CBFB CEBPB ZNF652 RPL21P124 ENSG00000250186 PHB ABI3 GNGT2 FLJ40194 GC17M049339 PIR41840
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PHB on UCSC Golden Path with GeneCards custom track

Promoters for PHB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095474 -95 1601 HDGF CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for PHB Gene

Chromosome:
17
Start:
49,404,048 bp from pter
End:
49,414,905 bp from pter
Size:
10,858 bases
Orientation:
Minus strand

Genomic View for PHB Gene

Genes around PHB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHB Gene

Proteins for PHB Gene

  • Protein details for PHB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35232-PHB_HUMAN
    Recommended name:
    Prohibitin
    Protein Accession:
    P35232
    Secondary Accessions:
    • B4DY47
    • Q4VBQ0

    Protein attributes for PHB Gene

    Size:
    272 amino acids
    Molecular mass:
    29804 Da
    Quaternary structure:
    • Interacts with PHB2. Interacts with STOML2.

    Three dimensional structures from OCA and Proteopedia for PHB Gene

    Alternative splice isoforms for PHB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHB Gene

Post-translational modifications for PHB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PHB (PHB)

No data available for DME Specific Peptides for PHB Gene

Domains & Families for PHB Gene

Protein Domains for PHB Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P35232

UniProtKB/Swiss-Prot:

PHB_HUMAN :
  • Belongs to the prohibitin family.
Family:
  • Belongs to the prohibitin family.
genes like me logo Genes that share domains with PHB: view

No data available for Gene Families for PHB Gene

Function for PHB Gene

Molecular function for PHB Gene

GENATLAS Biochemistry:
prohibitin (antiproliferative protein) potential tumor suppressor regulating E2F1 function
UniProtKB/Swiss-Prot Function:
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.

Gene Ontology (GO) - Molecular Function for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA --
GO:0001850 complement component C3a binding IDA 17070910
GO:0001851 complement component C3b binding IDA 17070910
GO:0005515 protein binding IPI 11302691
GO:0008022 protein C-terminus binding IPI 19906925
genes like me logo Genes that share ontologies with PHB: view
genes like me logo Genes that share phenotypes with PHB: view

Animal Models for PHB Gene

MGI Knock Outs for PHB:

Animal Model Products

  • Taconic Biosciences Mouse Models for PHB

CRISPR Products

miRNA for PHB Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PHB Gene

Localization for PHB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHB Gene

Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PHB gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 5
endosome 5
cytosol 3
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005654 nucleoplasm IDA 12466959
GO:0005737 cytoplasm IDA 16964284
GO:0005739 mitochondrion IEA,IDA 20833797
GO:0005743 mitochondrial inner membrane TAS 14500729
genes like me logo Genes that share ontologies with PHB: view

Pathways & Interactions for PHB Gene

SuperPathway Contained pathways
1 RET signaling
2 Signaling by moderate kinase activity BRAF mutants
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with PHB: view

Pathways by source for PHB Gene

1 Cell Signaling Technology pathway for PHB Gene
1 BioSystems pathway for PHB Gene

Gene Ontology (GO) - Biological Process for PHB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 16964284
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006355 regulation of transcription, DNA-templated IDA 14500729
GO:0006851 mitochondrial calcium ion transport TAS --
GO:0007005 mitochondrion organization IMP 17008324
genes like me logo Genes that share ontologies with PHB: view

No data available for SIGNOR curated interactions for PHB Gene

Drugs & Compounds for PHB Gene

(10) Drugs for PHB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for PHB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PHB: view

Transcripts for PHB Gene

Unigene Clusters for PHB Gene

Prohibitin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PHB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for PHB Gene

GeneLoc Exon Structure for
PHB
ECgene alternative splicing isoforms for
PHB

Expression for PHB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PHB Gene

Protein differential expression in normal tissues from HIPED for PHB Gene

This gene is overexpressed in Nasal epithelium (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PHB Gene



Protein tissue co-expression partners for PHB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PHB Gene:

PHB

SOURCE GeneReport for Unigene cluster for PHB Gene:

Hs.514303

mRNA Expression by UniProt/SwissProt for PHB Gene:

P35232-PHB_HUMAN
Tissue specificity: Widely expressed in different tissues.

Evidence on tissue expression from TISSUES for PHB Gene

  • Liver(4.9)
  • Nervous system(4.9)
  • Lung(4.8)
  • Muscle(4.7)
  • Intestine(4.1)
  • Skin(4.1)
  • Kidney(3.4)
  • Eye(3.3)
  • Pancreas(3.3)
  • Heart(2.9)
  • Stomach(2.5)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with PHB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PHB Gene

Orthologs for PHB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PHB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHB 34 35
  • 99.75 (n)
oppossum
(Monodelphis domestica)
Mammalia PHB 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHB 34 35 35
  • 93.5 (n)
-- 35
  • 93 (a)
OneToMany
cow
(Bos Taurus)
Mammalia PHB 34 35
  • 93.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PHB 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phb 34
  • 91.54 (n)
mouse
(Mus musculus)
Mammalia Phb 34 16 35
  • 91.18 (n)
chicken
(Gallus gallus)
Aves -- 35
  • 89 (a)
OneToMany
PHB 34 35
  • 82.84 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 92 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia phb 34
  • 78.8 (n)
MGC75944 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64447 34
zebrafish
(Danio rerio)
Actinopterygii phb 34 35
  • 77.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10205 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Cc 36 34 35
  • 68.51 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009323 34
  • 67.03 (n)
worm
(Caenorhabditis elegans)
Secernentea Y37E3.9 36
  • 68 (a)
phb-1 34 35
  • 62.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR313C 34
  • 60.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PHB1 34 35 37
  • 56.82 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16302g 34
  • 55.71 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PHB3 34
  • 56.63 (n)
soybean
(Glycine max)
eudicotyledons Gma.15151 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3157 34
rice
(Oryza sativa)
Liliopsida Os02g0580500 34
  • 57.95 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.24798 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6789 35
  • 71 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08946 34
  • 58.04 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes phb1 34
  • 56.58 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4549 34
Species where no ortholog for PHB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PHB Gene

ENSEMBL:
Gene Tree for PHB (if available)
TreeFam:
Gene Tree for PHB (if available)

Paralogs for PHB Gene

No data available for Paralogs for PHB Gene

Variants for PHB Gene

Sequence variations from dbSNP and Humsavar for PHB Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs121918372 A breast cancer sample 49,409,410(-) TCCTC(A/G)CATCT reference, missense
rs121918373 A breast cancer sample 49,409,461(-) GAATG(C/T)CAACA reference, missense
rs112294663 other 49,404,263(+) AAGGT(A/C/G/T)GGGGG utr-variant-3-prime
rs1001162524 -- 49,407,624(+) ATTTA(C/T)TTATT intron-variant
rs1001167734 -- 49,410,822(+) GAAAA(C/T)AGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHB Gene

Variant ID Type Subtype PubMed ID
nsv833473 CNV gain+loss 17160897
nsv960500 CNV duplication 23825009
nsv960501 CNV duplication 23825009
nsv960502 CNV duplication 23825009
nsv962338 CNV duplication 23825009
nsv978437 CNV duplication 23825009

Variation tolerance for PHB Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHB Gene

Human Gene Mutation Database (HGMD)
PHB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PHB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHB Gene

Disorders for PHB Gene

MalaCards: The human disease database

(7) MalaCards diseases for PHB Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
igg4-related disease
  • hyper-igg4 disease
chikungunya
  • chikungunya fever
brca1 and brca2 hereditary breast and ovarian cancer
  • hboc
ovarian epithelial cancer
  • eoc
- elite association - COSMIC cancer census association via MalaCards
Search PHB in MalaCards View complete list of genes associated with diseases

Relevant External Links for PHB

Genetic Association Database (GAD)
PHB
Human Genome Epidemiology (HuGE) Navigator
PHB
Tumor Gene Database (TGDB):
PHB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHB
genes like me logo Genes that share disorders with PHB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PHB Gene

Publications for PHB Gene

  1. The human prohibitin (PHB) gene family and its somatic mutations in human tumors. (PMID: 8244394) Sato T. … Nakamura Y. (Genomics 1993) 2 3 4 22 64
  2. The prohibitin 3' untranslated region polymorphism in patients with ovarian cancer. (PMID: 17544200) Grimm C. … Hefler L.A. (Eur. J. Obstet. Gynecol. Reprod. Biol. 2008) 3 22 46 64
  3. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PMID: 18397521) Jakubowska A. … Hamann U. (BMC Cancer 2008) 3 22 46 64
  4. Lack of association between prohibitin 3' untranslated region C-->T polymorphism and breast cancer in a Turkish population. (PMID: 18494604) Karakus N. … Ulusoy A.N. (DNA Cell Biol. 2008) 3 22 46 64
  5. The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation. (PMID: 17004108) Jakubowska A. … Hamann U. (Breast Cancer Res. Treat. 2007) 3 22 46 64

Products for PHB Gene

Sources for PHB Gene

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