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Aliases for PHACTR4 Gene

Aliases for PHACTR4 Gene

  • Phosphatase And Actin Regulator 4 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 124 3
  • Regulatory Subunit 124 2
  • Protein Phosphatase 1 2
  • PPP1R124 3

External Ids for PHACTR4 Gene

Previous GeneCards Identifiers for PHACTR4 Gene

  • GC01P028504
  • GC01P028627
  • GC01P028696
  • GC01P026949

Summaries for PHACTR4 Gene

Entrez Gene Summary for PHACTR4 Gene

  • This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PHACTR4 Gene

PHACTR4 (Phosphatase And Actin Regulator 4) is a Protein Coding gene. GO annotations related to this gene include actin binding and protein phosphatase type 1 activator activity. An important paralog of this gene is PHACTR2.

UniProtKB/Swiss-Prot for PHACTR4 Gene

  • Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at Thr-320. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHACTR4 Gene

Genomics for PHACTR4 Gene

Regulatory Elements for PHACTR4 Gene

Promoters for PHACTR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PHACTR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHACTR4 Gene

Chromosome:
1
Start:
28,369,582 bp from pter
End:
28,500,369 bp from pter
Size:
130,788 bases
Orientation:
Plus strand

Genomic View for PHACTR4 Gene

Genes around PHACTR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHACTR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHACTR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHACTR4 Gene

Proteins for PHACTR4 Gene

  • Protein details for PHACTR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ21-PHAR4_HUMAN
    Recommended name:
    Phosphatase and actin regulator 4
    Protein Accession:
    Q8IZ21
    Secondary Accessions:
    • A2APK6
    • B9ZVW0
    • D3DPM3
    • Q68DD4
    • Q6NUN6
    • Q8N384
    • Q9H395
    • Q9H6X0
    • Q9H8W6

    Protein attributes for PHACTR4 Gene

    Size:
    702 amino acids
    Molecular mass:
    78211 Da
    Quaternary structure:
    • Binds PPP1CA and actin.
    SequenceCaution:
    • Sequence=AAG35507.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH68508.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB14483.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15130.1; Type=Frameshift; Positions=51; Evidence={ECO:0000305}; Sequence=CAH18286.1; Type=Frameshift; Positions=53; Evidence={ECO:0000305};

    Alternative splice isoforms for PHACTR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHACTR4 Gene

Proteomics data for PHACTR4 Gene at MOPED

Post-translational modifications for PHACTR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PHACTR4 Gene

Antibody Products

No data available for DME Specific Peptides for PHACTR4 Gene

Domains & Families for PHACTR4 Gene

Protein Domains for PHACTR4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PHACTR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZ21

UniProtKB/Swiss-Prot:

PHAR4_HUMAN :
  • Belongs to the phosphatase and actin regulator family.
  • Contains 3 RPEL repeats.
Family:
  • Belongs to the phosphatase and actin regulator family.
Similarity:
  • Contains 3 RPEL repeats.
genes like me logo Genes that share domains with PHACTR4: view

Function for PHACTR4 Gene

Molecular function for PHACTR4 Gene

UniProtKB/Swiss-Prot Function:
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at Thr-320. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).

Gene Ontology (GO) - Molecular Function for PHACTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008157 protein phosphatase 1 binding IEA,ISS --
genes like me logo Genes that share ontologies with PHACTR4: view
genes like me logo Genes that share phenotypes with PHACTR4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHACTR4 Gene

Localization for PHACTR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHACTR4 Gene

Cytoplasm. Cell projection, lamellipodium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHACTR4 Gene COMPARTMENTS Subcellular localization image for PHACTR4 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for PHACTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with PHACTR4: view

Pathways & Interactions for PHACTR4 Gene

SuperPathways for PHACTR4 Gene

No Data Available

Interacting Proteins for PHACTR4 Gene

Gene Ontology (GO) - Biological Process for PHACTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001755 neural crest cell migration ISS --
GO:0007266 Rho protein signal transduction IEA,ISS --
GO:0048484 enteric nervous system development IEA,ISS --
GO:0061386 closure of optic fissure IEA,ISS --
GO:2001045 negative regulation of integrin-mediated signaling pathway IEA,ISS --
genes like me logo Genes that share ontologies with PHACTR4: view

No data available for Pathways by source and SIGNOR curated interactions for PHACTR4 Gene

Drugs & Compounds for PHACTR4 Gene

No Compound Related Data Available

Transcripts for PHACTR4 Gene

Unigene Clusters for PHACTR4 Gene

Phosphatase and actin regulator 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHACTR4 Gene

No ASD Table

Relevant External Links for PHACTR4 Gene

GeneLoc Exon Structure for
PHACTR4
ECgene alternative splicing isoforms for
PHACTR4

Expression for PHACTR4 Gene

mRNA expression in normal human tissues for PHACTR4 Gene

Protein differential expression in normal tissues from HIPED for PHACTR4 Gene

This gene is overexpressed in Fetal Brain (15.6), Pancreas (12.0), Testis (8.6), and Fetal Liver (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PHACTR4 Gene



SOURCE GeneReport for Unigene cluster for PHACTR4 Gene Hs.225641

genes like me logo Genes that share expression patterns with PHACTR4: view

Protein tissue co-expression partners for PHACTR4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PHACTR4 Gene

Orthologs for PHACTR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHACTR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHACTR4 36
  • 99 (a)
OneToOne
PHACTR4 35
  • 99.43 (n)
  • 99 (a)
cow
(Bos Taurus)
Mammalia PHACTR4 36
  • 85 (a)
OneToOne
PHACTR4 35
  • 87.41 (n)
  • 85.15 (a)
dog
(Canis familiaris)
Mammalia PHACTR4 35
  • 90.06 (n)
  • 87.48 (a)
PHACTR4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phactr4 36
  • 81 (a)
OneToOne
Phactr4 16
Phactr4 35
  • 82.14 (n)
  • 80.53 (a)
oppossum
(Monodelphis domestica)
Mammalia PHACTR4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHACTR4 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phactr4 35
  • 81.33 (n)
  • 80.63 (a)
chicken
(Gallus gallus)
Aves PHACTR4 35
  • 66.96 (n)
  • 65.41 (a)
PHACTR4 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.28993 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6262 35
zebrafish
(Danio rerio)
Actinopterygii phactr4a 36
  • 30 (a)
OneToMany
phactr4b 36
  • 40 (a)
OneToMany
zgc63484 35
fruit fly
(Drosophila melanogaster)
Insecta CG32264 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26H9.2 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1850 36
  • 22 (a)
ManyToMany
CSA.9409 36
  • 53 (a)
ManyToMany
Species with no ortholog for PHACTR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHACTR4 Gene

ENSEMBL:
Gene Tree for PHACTR4 (if available)
TreeFam:
Gene Tree for PHACTR4 (if available)

Paralogs for PHACTR4 Gene

Paralogs for PHACTR4 Gene

genes like me logo Genes that share paralogs with PHACTR4: view

Variants for PHACTR4 Gene

Sequence variations from dbSNP and Humsavar for PHACTR4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs9502 -- 28,500,083(-) AACAT(A/G)AATGA utr-variant-3-prime
rs1138143 -- 28,409,239(+) caagc(A/G)gtctt intron-variant
rs4615861 -- 28,403,701(-) ttttt(G/T)ggggg intron-variant
rs4130543 -- 28,452,421(-) TCAAG(C/T)GATCC intron-variant
rs4323678 -- 28,492,763(-) ttttt(C/T)cctga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHACTR4 Gene

Variant ID Type Subtype PubMed ID
dgv208n71 CNV Gain 21882294
nsv870624 CNV Gain 21882294
nsv7568 CNV Insertion 18451855

Variation tolerance for PHACTR4 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.24; 81.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PHACTR4 Gene

HapMap Linkage Disequilibrium report
PHACTR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PHACTR4 Gene

Disorders for PHACTR4 Gene

Relevant External Links for PHACTR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PHACTR4

No disorders were found for PHACTR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHACTR4 Gene

Publications for PHACTR4 Gene

  1. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. (PMID: 15107502) Allen P.B. … Greengard P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 67
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. STOP gene Phactr4 is a tumor suppressor. (PMID: 23319639) Solimini N.L. … Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  5. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3

Products for PHACTR4 Gene

Sources for PHACTR4 Gene

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