Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PHACTR3 Gene

Aliases for PHACTR3 Gene

  • Phosphatase And Actin Regulator 3 2 3 5
  • Scaffold-Associated PP1-Inhibiting Protein 3 4
  • C20orf101 3 4
  • SCAPININ 3 4
  • SCAPIN1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 123 3
  • Chromosome 20 Open Reading Frame 101 2
  • Regulatory Subunit 123 2
  • Protein Phosphatase 1 2
  • PPP1R123 3
  • H17739 3

External Ids for PHACTR3 Gene

Previous HGNC Symbols for PHACTR3 Gene

  • C20orf101

Previous GeneCards Identifiers for PHACTR3 Gene

  • GC20P058866
  • GC20P057585
  • GC20P058152
  • GC20P054968

Summaries for PHACTR3 Gene

Entrez Gene Summary for PHACTR3 Gene

  • This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PHACTR3 Gene

PHACTR3 (Phosphatase And Actin Regulator 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and protein phosphatase 1 binding. An important paralog of this gene is PHACTR4.

Gene Wiki entry for PHACTR3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHACTR3 Gene

Genomics for PHACTR3 Gene

Regulatory Elements for PHACTR3 Gene

Enhancers for PHACTR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PHACTR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PHACTR3 Gene

59,577,509 bp from pter
59,847,711 bp from pter
270,203 bases
Plus strand

Genomic View for PHACTR3 Gene

Genes around PHACTR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PHACTR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PHACTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHACTR3 Gene

Proteins for PHACTR3 Gene

  • Protein details for PHACTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatase and actin regulator 3
    Protein Accession:
    Secondary Accessions:
    • B1AKX0
    • B1AN68
    • B1AN69
    • B2RB46
    • Q32P33
    • Q707P6
    • Q9H4T4

    Protein attributes for PHACTR3 Gene

    559 amino acids
    Molecular mass:
    62552 Da
    Quaternary structure:
    • Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity.
    • Sequence=CAC67489.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PHACTR3 Gene


neXtProt entry for PHACTR3 Gene

Proteomics data for PHACTR3 Gene at MOPED

Post-translational modifications for PHACTR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PHACTR3 Gene

Domains & Families for PHACTR3 Gene

Protein Domains for PHACTR3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphatase and actin regulator family.
  • Contains 4 RPEL repeats.
  • Belongs to the phosphatase and actin regulator family.
  • Contains 4 RPEL repeats.
genes like me logo Genes that share domains with PHACTR3: view

Function for PHACTR3 Gene

Molecular function for PHACTR3 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide.

Gene Ontology (GO) - Molecular Function for PHACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008157 protein phosphatase 1 binding IEA --
GO:0008599 protein phosphatase type 1 regulator activity IEA --
genes like me logo Genes that share ontologies with PHACTR3: view
genes like me logo Genes that share phenotypes with PHACTR3: view

Animal Model Products

CRISPR Products

miRNA for PHACTR3 Gene

miRTarBase miRNAs that target PHACTR3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PHACTR3 Gene

Localization for PHACTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHACTR3 Gene

Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.

Subcellular locations from

Jensen Localization Image for PHACTR3 Gene COMPARTMENTS Subcellular localization image for PHACTR3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PHACTR3 Gene

Pathways & Interactions for PHACTR3 Gene

SuperPathways for PHACTR3 Gene

No Data Available

Interacting Proteins for PHACTR3 Gene

Gene Ontology (GO) - Biological Process for PHACTR3 Gene


No data available for Pathways by source and SIGNOR curated interactions for PHACTR3 Gene

Drugs & Compounds for PHACTR3 Gene

No Compound Related Data Available

Transcripts for PHACTR3 Gene

Unigene Clusters for PHACTR3 Gene

Phosphatase and actin regulator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHACTR3 Gene

No ASD Table

Relevant External Links for PHACTR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PHACTR3 Gene

mRNA expression in normal human tissues for PHACTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHACTR3 Gene

This gene is overexpressed in Brain - Amygdala (x5.7), Brain - Hippocampus (x5.1), Brain - Spinal cord (cervical c-1) (x4.4), Brain - Substantia nigra (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for PHACTR3 Gene

This gene is overexpressed in Frontal cortex (35.7) and Fetal Brain (29.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PHACTR3 Gene

SOURCE GeneReport for Unigene cluster for PHACTR3 Gene Hs.473218

mRNA Expression by UniProt/SwissProt for PHACTR3 Gene

Tissue specificity: Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells.
genes like me logo Genes that share expression patterns with PHACTR3: view

Protein tissue co-expression partners for PHACTR3 Gene

- Elite partner

Primer Products

Orthologs for PHACTR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHACTR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PHACTR3 35
  • 87.6 (n)
  • 91.06 (a)
  • 91 (a)
(Mus musculus)
Mammalia Phactr3 35
  • 87.04 (n)
  • 88.89 (a)
Phactr3 16
Phactr3 36
  • 84 (a)
(Pan troglodytes)
Mammalia PHACTR3 35
  • 99.58 (n)
  • 99.46 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Phactr3 35
  • 86.63 (n)
  • 89.34 (a)
(Bos Taurus)
Mammalia PHACTR3 36
  • 90 (a)
(Monodelphis domestica)
Mammalia PHACTR3 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia PHACTR3 36
  • 78 (a)
(Gallus gallus)
Aves PHACTR3 35
  • 73.39 (n)
  • 76.36 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia PHACTR3 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia phactr3 35
  • 67.85 (n)
  • 68.97 (a)
Str.15737 35
(Danio rerio)
Actinopterygii phactr3b 35
  • 63.74 (n)
  • 62.5 (a)
phactr3a 36
  • 53 (a)
phactr3b 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32264 36
  • 18 (a)
(Caenorhabditis elegans)
Secernentea F26H9.2 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1850 36
  • 17 (a)
CSA.9409 36
  • 45 (a)
Species with no ortholog for PHACTR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHACTR3 Gene

Gene Tree for PHACTR3 (if available)
Gene Tree for PHACTR3 (if available)

Paralogs for PHACTR3 Gene

Paralogs for PHACTR3 Gene

(2) SIMAP similar genes for PHACTR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PHACTR3: view

Variants for PHACTR3 Gene

Sequence variations from dbSNP and Humsavar for PHACTR3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2277759 - 59,755,284(+) CCAGC(C/T)CGGAA reference, missense
rs707563 -- 59,705,187(+) CCTGA(A/G)CAAAA intron-variant
rs707564 -- 59,759,128(+) TAGCA(C/T)GTGTG intron-variant
rs1040797 -- 59,694,973(+) CTTCA(A/G)AACAA intron-variant
rs1045844 -- 59,847,606(+) TATTA(A/T)ACTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PHACTR3 Gene

Variant ID Type Subtype PubMed ID
nsv3434 CNV Insertion 18451855
nsv3435 CNV Insertion 18451855
esv2722636 CNV Deletion 23290073
esv2676757 CNV Deletion 23128226
esv2722637 CNV Deletion 23290073
esv2722638 CNV Deletion 23290073
esv2722640 CNV Deletion 23290073
esv2338184 CNV Deletion 18987734
esv2666676 CNV Deletion 23128226
esv2722641 CNV Deletion 23290073
dgv703e201 CNV Deletion 23290073
esv22391 CNV Loss 19812545
esv2663243 CNV Deletion 23128226
nsv459033 CNV Loss 19166990
nsv520022 CNV Loss 19592680
nsv912966 CNV Loss 21882294
esv992120 CNV Deletion 20482838

Variation tolerance for PHACTR3 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.78% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PHACTR3 Gene

Disorders for PHACTR3 Gene

Relevant External Links for PHACTR3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PHACTR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PHACTR3 Gene

Publications for PHACTR3 Gene

  1. Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. (PMID: 12925532) Sagara J. … Taniguchi S. (J. Biol. Chem. 2003) 3 4 23 67
  2. Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton. (PMID: 19158953) Sagara J. … Taniguchi S. (PLoS ONE 2009) 3 23
  3. Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. (PMID: 16974080) Worch S. … Schlote D. (Cytogenet. Genome Res. 2006) 3 23
  4. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. (PMID: 15107502) Allen P.B. … Greengard P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for PHACTR3 Gene

Sources for PHACTR3 Gene