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Aliases for PHACTR3 Gene

Aliases for PHACTR3 Gene

  • Phosphatase And Actin Regulator 3 2 3
  • SCAPININ 3 4 6
  • Scaffold-Associated PP1-Inhibiting Protein 3 4
  • C20orf101 3 4
  • SCAPIN1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 123 3
  • Chromosome 20 Open Reading Frame 101 2
  • Regulatory Subunit 123 2
  • Protein Phosphatase 1 2
  • PPP1R123 3
  • H17739 3

External Ids for PHACTR3 Gene

Previous Symbols for PHACTR3 Gene

  • C20orf101

Summaries for PHACTR3 Gene

Entrez Gene Summary for PHACTR3 Gene

  • This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for PHACTR3 Gene

PHACTR3 (Phosphatase And Actin Regulator 3) is a Protein Coding gene. GO annotations related to this gene include actin binding and protein phosphatase inhibitor activity. An important paralog of this gene is PHACTR4.

Gene Wiki entry for PHACTR3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHACTR3 Gene

Genomics for PHACTR3 Gene

Genomic Location for PHACTR3 Gene

Start:
59,577,509 bp from pter
End:
59,847,711 bp from pter
Size:
270,203 bases
Orientation:
Plus strand

Genomic View for PHACTR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHACTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHACTR3 Gene

Regulatory Elements for PHACTR3 Gene

Proteins for PHACTR3 Gene

  • Protein details for PHACTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KR7-PHAR3_HUMAN
    Recommended name:
    Phosphatase and actin regulator 3
    Protein Accession:
    Q96KR7
    Secondary Accessions:
    • B1AKX0
    • B1AN68
    • B1AN69
    • B2RB46
    • Q32P33
    • Q707P6
    • Q9H4T4

    Protein attributes for PHACTR3 Gene

    Size:
    559 amino acids
    Molecular mass:
    62552 Da
    Quaternary structure:
    • Binds actin and PPP1CA; thus inhibiting the protein phosphatase 1 (PP1) activity
    SequenceCaution:
    • Sequence=CAC67489.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PHACTR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHACTR3 Gene

Proteomics data for PHACTR3 Gene at MOPED

Post-translational modifications for PHACTR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PHACTR3 Gene

Domains for PHACTR3 Gene

Gene Families for PHACTR3 Gene

HGNC:
  • PHACTR :Phosphatase and actin regulators

Protein Domains for PHACTR3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

PHAR3_HUMAN
Family:
  • Belongs to the phosphatase and actin regulator family.:
    • Q96KR7
Similarity:
  • Contains 4 RPEL repeats.:
    • Q96KR7
genes like me logo Genes that share domains with PHACTR3: view

Function for PHACTR3 Gene

Molecular function for PHACTR3 Gene

UniProtKB/Swiss-Prot Induction: Down-regulated in HL-60 leukemia cells by RA, PMA and dimethyl sulfoxide

Gene Ontology (GO) - Molecular Function for PHACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0008157 protein phosphatase 1 binding IEA --
GO:0008599 protein phosphatase type 1 regulator activity IEA --
genes like me logo Genes that share ontologies with PHACTR3: view

Phenotypes for PHACTR3 Gene

genes like me logo Genes that share phenotypes with PHACTR3: view

miRNA for PHACTR3 Gene

miRTarBase miRNAs that target PHACTR3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHACTR3 Gene

Localization for PHACTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PHACTR3 Gene

Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHACTR3 Gene COMPARTMENTS Subcellular localization image for PHACTR3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PHACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with PHACTR3: view

Pathways for PHACTR3 Gene

SuperPathways for PHACTR3 Gene

No Data Available

Interacting Proteins for PHACTR3 Gene

Gene Ontology (GO) - Biological Process for PHACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PHACTR3: view

No data available for Pathways by source for PHACTR3 Gene

Transcripts for PHACTR3 Gene

Unigene Clusters for PHACTR3 Gene

Phosphatase and actin regulator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHACTR3 Gene

No ASD Table

Relevant External Links for PHACTR3 Gene

GeneLoc Exon Structure for
PHACTR3
ECgene alternative splicing isoforms for
PHACTR3

Expression for PHACTR3 Gene

mRNA expression in normal human tissues for PHACTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PHACTR3 Gene

This gene is overexpressed in Brain - Amygdala (5.7), Brain - Hippocampus (5.1), Brain - Spinal cord (cervical c-1) (4.4), Brain - Substantia nigra (4.2), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PHACTR3 Gene

SOURCE GeneReport for Unigene cluster for PHACTR3 Gene Hs.473218

mRNA Expression by UniProt/SwissProt for PHACTR3 Gene

Q96KR7-PHAR3_HUMAN
Tissue specificity: Abundantly expressed in brain. Also found in several tumors such as lung carcinomas, nervous tumors and HL-60 leukemia cells. Isoform 3 is the major form in U-937, GOTO and HL-60 leukemia cells
genes like me logo Genes that share expressions with PHACTR3: view

Orthologs for PHACTR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHACTR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHACTR3 36
  • 99.58 (n)
  • 99.46 (a)
PHACTR3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHACTR3 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHACTR3 36
  • 87.6 (n)
  • 91.06 (a)
PHACTR3 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phactr3 36
  • 87.04 (n)
  • 88.89 (a)
Phactr3 16
Phactr3 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHACTR3 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHACTR3 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phactr3 36
  • 86.63 (n)
  • 89.34 (a)
chicken
(Gallus gallus)
Aves PHACTR3 36
  • 73.39 (n)
  • 76.36 (a)
PHACTR3 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHACTR3 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia phactr3 36
  • 67.85 (n)
  • 68.97 (a)
Str.15737 36
zebrafish
(Danio rerio)
Actinopterygii phactr3a 37
  • 53 (a)
OneToMany
phactr3b 36
  • 63.74 (n)
  • 62.5 (a)
phactr3b 37
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32264 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26H9.2 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1850 37
  • 17 (a)
ManyToMany
CSA.9409 37
  • 45 (a)
ManyToMany
Species with no ortholog for PHACTR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PHACTR3 Gene

ENSEMBL:
Gene Tree for PHACTR3 (if available)
TreeFam:
Gene Tree for PHACTR3 (if available)

Paralogs for PHACTR3 Gene

Paralogs for PHACTR3 Gene

Selected SIMAP similar genes for PHACTR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PHACTR3: view

Variants for PHACTR3 Gene

Sequence variations from dbSNP and Humsavar for PHACTR3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs707563 -- 59,705,187(+) CCTGA(A/G)CAAAA intron-variant
rs707564 -- 59,759,128(+) TAGCA(C/T)GTGTG intron-variant
rs721574 -- 59,589,954(-) ACGGC(A/G)GCTGT intron-variant
rs730273 -- 59,678,883(+) cctgt(A/C)tcaga intron-variant
rs730274 -- 59,678,916(+) aaggc(A/G)attgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHACTR3 Gene

Variant ID Type Subtype PubMed ID
nsv3434 CNV Insertion 18451855
nsv3435 CNV Insertion 18451855
esv2722636 CNV Deletion 23290073
esv2676757 CNV Deletion 23128226
esv2722637 CNV Deletion 23290073
esv2722638 CNV Deletion 23290073
esv2722640 CNV Deletion 23290073
esv2338184 CNV Deletion 18987734
esv2666676 CNV Deletion 23128226
esv2722641 CNV Deletion 23290073
dgv703e201 CNV Deletion 23290073
esv22391 CNV Loss 19812545
esv2663243 CNV Deletion 23128226
nsv459033 CNV Loss 19166990
nsv520022 CNV Loss 19592680
nsv912966 CNV Loss 21882294
esv992120 CNV Deletion 20482838

Relevant External Links for PHACTR3 Gene

HapMap Linkage Disequilibrium report
PHACTR3

Disorders for PHACTR3 Gene

Relevant External Links for PHACTR3

Genetic Association Database (GAD)
PHACTR3
Human Genome Epidemiology (HuGE) Navigator
PHACTR3
genes like me logo Genes that share disorders with PHACTR3: view

No data available for UniProtKB/Swiss-Prot for PHACTR3 Gene

Publications for PHACTR3 Gene

  1. Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. (PMID: 12925532) Sagara J. … Taniguchi S. (J. Biol. Chem. 2003) 3 4 23
  2. Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human. (PMID: 16974080) Worch S. … Schlote D. (Cytogenet. Genome Res. 2006) 3 23
  3. Scapinin, the protein phosphatase 1 binding protein, enhances cell spreading and motility by interacting with the actin cytoskeleton. (PMID: 19158953) Sagara J. … Taniguchi S. (PLoS ONE 2009) 3 23
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PHACTR3 Gene

Sources for PHACTR3 Gene

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