Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PHACTR2 Gene

protein-coding   GIFtS: 52
GCID: GC06P143858

Phosphatase And Actin Regulator 2

(Previous name: chromosome 6 open reading frame 56)
(Previous symbol: C6orf56)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phosphatase And Actin Regulator 21 2
C6orf561 2 3
KIAA06803 5
Chromosome 6 Open Reading Frame 561

External Ids:    HGNC: 209561   Entrez Gene: 97492   Ensembl: ENSG000001124197   OMIM: 6087245   UniProtKB: O751673   

Export aliases for PHACTR2 gene to outside databases

Previous GC identifers: GC06P143979 GC06P143971 GC06P141493


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for PHACTR2 Gene:
PHACTR2 (phosphatase and actin regulator 2) is a protein-coding gene. Diseases associated with PHACTR2 include type 1 diabetes, and parkinson's disease. GO annotations related to this gene include actin binding and protein phosphatase inhibitor activity. An important paralog of this gene is PHACTR4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHACTR2 gene promoter:
         SREBP-1c   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   MEF-2A   PPAR-gamma1   SREBP-1a   STAT3   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PHACTR2 promoter sequence
   Search Chromatin IP Primers for PHACTR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHACTR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.2   Ensembl cytogenetic band:  6q24.2   HGNC cytogenetic band: 6q24.1

PHACTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHACTR2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P143858:  view genomic region     (about GC identifiers)

Start:
143,857,982 bp from pter      End:
144,152,322 bp from pter
Size:
294,341 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PHAR2_HUMAN, O75167 (See protein sequence)
Recommended Name: Phosphatase and actin regulator 2  
Size: 634 amino acids; 69700 Da
Subunit: Binds PPP1CA and actin (By similarity)
Sequence caution: Sequence=BAA31655.2; Type=Erroneous initiation; Sequence=BAG60527.1; Type=Erroneous termination;
Positions=46; Note=Translated as Trp; Sequence=CAI14133.1; Type=Erroneous gene model prediction;
Sequence=CAI19814.1; Type=Erroneous gene model prediction; Sequence=CAI21446.1; Type=Erroneous gene model
prediction;
Secondary accessions: A6NKP5 A7MCZ5 A8MZC0 B2RWP7 B4DN76 B4DPB5 B4DTH7 Q5TFA0 Q68DM2
Alternative splicing: 4 isoforms:  O75167-1   O75167-2   O75167-4   O75167-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHACTR2: NX_O75167

Explore proteomics data for PHACTR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PHACTR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001093634.1  NP_001093635.1  NP_001093636.1  NP_055536.2  

    ENSEMBL proteins: 
     ENSP00000356556   ENSP00000391763   ENSP00000305530   ENSP00000417038   ENSP00000356554  
     ENSP00000402449   ENSP00000442153   ENSP00000381067  

    PHACTR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PHACTR2
    OriGene Protein Over-expression Lysate for PHACTR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for PHACTR2
    GenScript Custom Purified and Recombinant Proteins Services for PHACTR2
    Novus Biologicals PHACTR2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PHACTR2

    PHACTR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PHACTR2
    OriGene Custom Antibody Services for PHACTR2
    Novus Biologicals PHACTR2 Antibodies
    Abcam antibodies for PHACTR2
    Cloud-Clone Corp. Antibodies for PHACTR2
    ThermoFisher Antibodies for PHACTR2
    LSBio Antibodies in human, mouse, rat for PHACTR2

    PHACTR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PHACTR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PHACTR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PHACTR2
    Cloud-Clone Corp. CLIAs for PHACTR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PHACTR: Phosphatase and actin regulators

    1 InterPro protein domain:
     IPR004018 RPEL_repeat

    Graphical View of Domain Structure for InterPro Entry O75167

    ProtoNet protein and cluster: O75167

    UniProtKB/Swiss-Prot: PHAR2_HUMAN, O75167
    Similarity: Belongs to the phosphatase and actin regulator family
    Similarity: Contains 4 RPEL repeats


    PHACTR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0004864protein phosphatase inhibitor activity IEA--
    GO:0005515protein binding IPI17474147
         
    PHACTR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PHACTR2:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHACTR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHACTR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHACTR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHACTR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target PHACTR2:
    hsa-mir-124-3p (MIRT023052), hsa-mir-21-5p (MIRT030971), hsa-mir-378a-3p (MIRT043915), hsa-mir-185-5p (MIRT045328)

    Block miRNA regulation of human, mouse, rat PHACTR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHACTR2 (see all 126):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-300 hsa-miR-631 hsa-miR-15a hsa-miR-374a hsa-miR-30d hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PHACTR2
    Predesigned siRNA for gene silencing in human, mouse, rat PHACTR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PHACTR2

    Clone
    Products:
         
    OriGene clones in human, mouse for PHACTR2 (see all 25)
    OriGene ORF clones in mouse, rat for PHACTR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PHACTR2 (NM_001100164)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHACTR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHACTR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PHACTR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for PHACTR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHACTR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    golgi apparatus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHACTR2
    Interactions:

        Search GeneGlobe Interaction Network for PHACTR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for PHACTR2 (O751671, 3 ENSP000004170384) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1754409,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    PIK3R1P279863, ENSP000002743354I2D: score=1 STRING: ENSP00000274335
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHACTR2 (PHAR2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for PHACTR2 gene (4 alternative transcripts): 
    NM_001100164.1  NM_001100165.1  NM_001100166.1  NM_014721.2  

    Unigene Cluster for PHACTR2:

    Phosphatase and actin regulator 2
    Hs.102471  [show with all ESTs]
    Unigene Representative Sequence: NM_001100164
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367584 ENST00000427704(uc003qjq.4 uc010khh.3 uc010khi.3 uc003qjr.4)
    ENST00000305766 ENST00000440869 ENST00000367582 ENST00000402863 ENST00000451827
    ENST00000542769 ENST00000397980 ENST00000545919 ENST00000420771 ENST00000536245

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PHACTR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHACTR2 (see all 126):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-300 hsa-miR-631 hsa-miR-15a hsa-miR-374a hsa-miR-30d hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PHACTR2
    Predesigned siRNA for gene silencing in human, mouse, rat PHACTR2
    Clone
    Products:
         
    OriGene clones in human, mouse for PHACTR2 (see all 25)
    OriGene ORF clones in mouse, rat for PHACTR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PHACTR2 (NM_001100164)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHACTR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHACTR2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PHACTR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHACTR2
      QuantiTect SYBR Green Assays in human, mouse, rat PHACTR2
      QuantiFast Probe-based Assays in human, mouse, rat PHACTR2

    Additional mRNA sequence: 

    AB014580.1 AK297799.1 AK298263.1 AK300221.1 BC150630.1 BC152416.1 CR749345.1 

    17 DOTS entries:

    DT.97837231  DT.452905  DT.213315  DT.95147847  DT.75111170  DT.100729950  DT.91700581  DT.121333614 
    DT.306970  DT.97810072  DT.121333707  DT.91990460  DT.95258546  DT.100688736  DT.91700578  DT.99937260 
    DT.91659706 

    Selected AceView cDNA sequences (see all 313):

    BU625028 D62600 BQ632528 BM471611 AA453940 AI472209 BG169580 AI925440 
    H12758 AA827111 NM_032860 BX484050 AA359093 CR749345 AA046612 BQ182440 
    BQ434819 AW664913 AK027815 BU145747 AA456845 BC009855 AI096332 BF515101 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PHACTR2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:              -                                                                             -               
    SP2:              -                 -                                                                           
    SP3:                                                                                                            
    SP4:                                -                                                                           


    ECgene alternative splicing isoforms for PHACTR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    PHACTR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PHACTR2 Expression
    About this image

    PHACTR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PHACTR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102471
        Custom PCR Arrays for PHACTR2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PHACTR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHACTR2
    QuantiTect SYBR Green Assays in human, mouse, rat PHACTR2
    QuantiFast Probe-based Assays in human, mouse, rat PHACTR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHACTR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for PHACTR2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Phactr21 , 5 phosphatase and actin regulator 21, 5 83.98(n)1
    82.81(a)1
      10 (4.72 cM)5
    2157891  NM_001195096.11  NP_001182025.11 
     132133955 
    chicken
    (Gallus gallus)
    Aves PHACTR21 phosphatase and actin regulator 2 68.21(n)
    64.26(a)
      421667  XM_003640962.2  XP_003641010.2 
    lizard
    (Anolis carolinensis)
    Reptilia PHACTR26
    phosphatase and actin regulator 2
    63(a)
    1 ↔ 1
    GL343710.1(81404-151014)
    zebrafish
    (Danio rerio)
    Actinopterygii phactr26
    phosphatase and actin regulator 2
    48(a)
    1 ↔ 1
    13(24143357-24180068) ENSDARG00000027172
    fruit fly
    (Drosophila melanogaster)
    Insecta CG322646
    --
    19(a)
    1 → many
    3L(3714826-3806459)
    worm
    (Caenorhabditis elegans)
    Secernentea F26H9.26
    Protein F26H9.2 (F26H9.2) mRNA, complete cds
    29(a)
    1 → many
    I(9289744-9294007) WBGene00009174


    ENSEMBL Gene Tree for PHACTR2 (if available)
    TreeFam Gene Tree for PHACTR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for PHACTR2 gene
    PHACTR42  PHACTR32  
    2 SIMAP similar genes for PHACTR2 using alignment to 5 protein entries:     PHAR2_HUMAN (see all proteins):
    PHACTR1    PHACTR3

    PHACTR2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PHACTR2
    PGOHUM00000258506


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for PHACTR2 (see all 4616)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429408221,2
    C--143927328(+) ATAAGC/TAAAGA 2 -- us2k10--------
    rs743874461,2
    C--143927360(+) TTCAAG/TTTATG 2 -- us2k14Minor allele frequency- T:0.09CSA WA NA EA 359
    rs2003699281,2
    C--143927395(+) ACTTAA/CAAAAA 2 -- us2k10--------
    rs106804721,2
    C--143927399(+) CAAAA-/AACAACAA 2 -- cds1 tfbs30--------
    rs754579591,2
    --143927399(+) ACAAAA/CAACAA 2 -- us2k10--------
    rs339611571,2
    C--143927400(+) AAAAA-/AACACAAT 2 -- cds10--------
    rs737786071,2
    C,F--143927464(+) AAATCG/ACATTG 2 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1924422521,2
    --143927511(+) CCAGTA/CAGTAT 2 -- us2k10--------
    rs1832780191,2
    --143927522(+) TTATGA/GAAAAA 2 -- us2k10--------
    rs1408828541,2
    C--143927777(+) TCCTC-/TTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for PHACTR2 (143857982 - 144107982 bp, first 250kb of PHACTR2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PHACTR2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2355696CNV Deletion18987734
    esv2732822CNV Deletion23290073
    esv2676201CNV Deletion23128226
    esv2732821CNV Deletion23290073
    esv2249743CNV Deletion18987734
    nsv5512CNV Insertion18451855
    nsv5514CNV Insertion18451855
    esv273892CNV Insertion20981092
    esv268521CNV Insertion20981092
    nsv5513CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHACTR2
    DNA2.0 Custom Variant and Variant Library Synthesis for PHACTR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608724    OMIM disorders: --

    6 diseases for PHACTR2:    
    About MalaCards
    type 1 diabetes    parkinson's disease    inflammatory bowel disease    obesity
    alzheimer's disease    lung cancer


    PHACTR2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PHACTR2
    Human Genome Epidemiology (HuGE) Navigator: PHACTR2 (7 documents)

    Export disorders for PHACTR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for PHACTR2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with PHACTR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. An application of Random Forests to a genome-wide association dataset: methodological considerations &amp; new findings. (PubMed id 20546594)1, 4 Goldstein B.A....Barcellos L.F. (BMC Genet. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Phactr2 and Parkinson's disease. (PubMed id 19429005)1, 4 Wider C....Ross O.A. (Neurosci. Lett. 2009)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. (PubMed id 15107502)1, 3 Allen P.B....Greengard P. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer. (PubMed id 23108145)1 Wang L.E....Wei Q. (Cancer Res. 2013)
    9. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    10. Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort. (PubMed id 22704111)1 Hotaling J.M....Wessells H. (J. Urol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9749 HGNC: 20956 AceView: C6orf93andPHACTR2 Ensembl:ENSG00000112419 euGenes: HUgn9749
    ECgene: PHACTR2 H-InvDB: PHACTR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0680

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for PHACTR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for PHACTR2 gene:
    Search GeneIP for patents involving PHACTR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PHACTR2   OriGene RNAi products in human, mouse, rat for PHACTR2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for PHACTR2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PHACTR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for PHACTR2   OriGene Purified Protein for PHACTR2  
     OriGene ORF clones in mouse, rat for PHACTR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PHACTR2   OriGene Custom Protein Services for PHACTR2  

     
     
     Block miRNA regulation of human, mouse, rat PHACTR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PHACTR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHACTR2 Predesigned siRNA for gene silencing in human, mouse, rat PHACTR2
     QuantiFast Probe-based Assays in human, mouse, rat PHACTR2 QuantiTect SYBR Green Assays in human, mouse, rat PHACTR2
     Custom PCR Arrays for PHACTR2 Search Chromatin IP Primers for PHACTR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHACTR2  Search GeneGlobe Interaction Network for PHACTR2
     Regulatory tfbs in PHACTR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for PHACTR2 GenScript cDNA clones with any tag delivered in your preferred vector for PHACTR2
     GenScript Custom Assay Services for PHACTR2 GenScript Custom overexpressing Cell Line Services for PHACTR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for PHACTR2 (PHAR2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     PHACTR2 antibodies
     PHACTR2 proteins
     Antibodies for PHACTR2
     See all of Abcam's Antibodies, Kits and Proteins for PHACTR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for PHACTR2
     Antibodies for PHACTR2
     ELISAs for PHACTR2
     CLIAs for PHACTR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for PHACTR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHACTR2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PHACTR2
     SwitchGear Promoter luciferase reporter plasmids for PHACTR2
     ThermoFisher Antibodies for PHACTR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHACTR2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHACTR2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PHACTR2
     LSBio Antibodies in human, mouse, rat for PHACTR2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PHACTR2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4