PHACTR1 Gene

Aliases
for PHACTR1 gene

Previous GC identifers: GC06P012826 GC06P012827

Summaries
for PHACTR1 gene

Genomic Views
for PHACTR1 gene

RefSeq DNA sequence:

NC_000006.11  NC_018917.1  NT_007592.15  

SwitchGear Promoter luciferase reporter plasmid: PHACTR1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PHACTR1

PHACTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P012717:  view genomic region     (about GC identifiers)

Proteins
for PHACTR1 gene

Explore the universe of human proteins at neXtProt for PHACTR1: NX_Q9C0D0

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PHACTR1 OriGene Custom Protein Services for PHACTR1
	GenScript Custom Purified and Recombinant Proteins Services for PHACTR1
	Novus Biologicals PHACTR1 Protein Novus Biologicals PHACTR1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PHACTR1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

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	Browse OriGene Antibodies OriGene Custom Antibody Services for PHACTR1
	GenScript Custom Superior Antibodies Services for PHACTR1
	Novus Biologicals PHACTR1 Antibodies
	Search for Antibodies for PHACTR1 at Abcam
	Uscn Antibodies for PHACTR1
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	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PHACTR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PHACTR1

Protein Domains /
Families
for PHACTR1 gene

ProtoNet protein and cluster: Q9C0D0

Function
for PHACTR1 gene

miRNA Products:		OriGene 3'-UTR Clone: PHACTR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PHACTR1
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PHACTR1 (see all 11):
		hsa-miR-2052 hsa-miR-34b* hsa-miR-4271 hsa-miR-4307 hsa-miR-634 hsa-miR-218-2* hsa-miR-182* hsa-miR-2116
		SwitchGear 3'UTR luciferase reporter plasmid: PHACTR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PHACTR1 (see all 7) OriGene shRNA RFP: PHACTR1 OriGene siRNA: PHACTR1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PHACTR1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for PHACTR1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PHACTR1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PHACTR1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: PHACTR1 (NM_030948)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHACTR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHACTR1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for PHACTR1
		Search LifeMap BioReagents cell lines for PHACTR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHACTR1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for PHACTR1 gene

Drugs & Compounds
for PHACTR1 gene

Transcripts
for PHACTR1 gene

Expression
for PHACTR1 gene

PHACTR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTGAGTAG

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneMaxillary Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PHACTR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PHACTR1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PHACTR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PHACTR1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PHACTR1

Orthologs
for PHACTR1 gene

Paralogs
for PHACTR1 gene

Genomic Variants
for PHACTR1 gene

10/10132 NCBI SNPs in PHACTR1 are shown (see all 10132)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1932585451,2		--	12715125(+)	AATCTA/GTTACA	2	--	us2k1		0	--	--	--	--
rs1479150971,2		--	12715344(+)	CAAGCA/GATTCT	2	--	us2k1		0	--	--	--	--
rs715532221,2	C,	--	12715521(+)	CAGACA/GTGAGC	2	--	us2k1		3		NA WA	240
rs1416365181,2		--	12715524(+)	ACATGA/GGCCTC	2	--	us2k1		0	--	--	--	--
rs1150447141,2	C,	--	12715536(+)	GTGCCC/TGGCCC	2	--	us2k1		0	--	--	--	--
rs715624541,2	C,F,	--	12715537(+)	TGCCCG/AGCCCC	2	--	us2k1		4		NA WA	242
rs168733011,2	C,F,H,	--	12715593(+)	AATTAC/TGACCC	2	--	us2k1		23		NA NS EA CSA WA	2849
rs1512702191,2	C,	--	12715618(+)	TTCAC-/TTTGTA	2	--	us2k1		0	--	--	--	--
rs1835300101,2		--	12715665(+)	AGAAAC/TGACTG	2	--	us2k1		0	--	--	--	--
rs1158097601,2		--	12715762(+)	ATTTGC/AACTCA	2	--	us2k1		1		WA	118

HapMap Linkage Disequilibrium report for PHACTR1 (12717833 - 12967833 bp, first 250kb of PHACTR1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for PHACTR1
     7 CNVs: 36457 39439 69331 69332 36456 99432 36459
     2 Indels: 42853 28096

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PHACTR1

DNA2.0 Custom Variant and Variant Library Synthesis for PHACTR1

Disorders / Diseases
for PHACTR1 gene

Publications
for PHACTR1 gene

PubMed articles for PHACTR1 gene, integrated from 9 sources (see all 24) (see top 10): (articles sorted by number of sources associating them with PHACTR1)

Utopia: connect your pdf to the dynamic world of online information

1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{1, 2, 3} Nagase T.... Ohara O. (2000)
2. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. (PubMed id 15107502)^{1, 3} Allen P.B....Greengard P. (2004)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
6. Genome-wide association study in a Lebanese cohort con firms PHACTR1 as a major determinant of coronary artery stenosis. (PubMed id 22745674)¹ Hager J....Zalloua P.A. (2012)
7. Genetic heritability of ischemic stroke and the contri bution of previously reported candidate gene and genomewide associations. (PubMed id 23042660)¹ Bevan S....Markus H.S. (2012)
8. Genome-wide linkage and association scans for pulse pressure in Chinese twins. (PubMed id 22763476)¹ Zhang D....Tan Q. (2012)
9. Neuropilin-1 regulates a new VEGF-induced gene, Phactr -1, which controls tubulogenesis and modulates lamellipodial dynamics in human e ndothelial cells. (PubMed id 21939755)¹ Allain B....Lepelletier Y. (2012)
10. Genome-wide association study in Han Chinese identifie s four new susceptibility loci for coronary artery disease. (PubMed id 22751097)¹ Lu X....Gu D. (2012)
11. Genome-wide association analysis identifies susceptibi lity loci for migraine without aura. (PubMed id 22683712)¹ Freilinger T....van den Maagdenberg A.M. (2012)
12. Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990)¹ Schunkert H....Samani N.J. (2011)
13. Genome-wide association study for coronary artery calc ification with follow-up in myocardial infarction. (PubMed id 22144573)¹ O'Donnell C.J....Witteman J.C. (2011)
14. Depletion of the novel protein PHACTR-1 from human en dothelial cells abolishes tube formation and induces cell death receptor apopto sis. (PubMed id 21798305)¹ Jarray R....Raynaud F. (2011)
15. A genome-wide association study in Europeans and Sout h Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)¹ (2011)
16. A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease. (PubMed id 21846871)¹ Mehta N.N. (2011)
17. A multilocus genetic risk score for coronary heart di sease: case-control and prospective cohort analyses. (PubMed id 20971364)¹ Ripatti S....Kathiresan S. (2010)
18. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
19. Additive effect of multiple genetic variants on the r isk of coronary artery disease. (PubMed id 20738937)¹ LluA-s-Ganella C....Elosua R. (2010)
20. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)¹  ....Altshuler D. (2009)
21. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
22. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)¹ Kiel D.P....Karasik D. (2007)

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for PHACTR1 gene