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PHACTR1 Gene

protein-coding   GIFtS: 51
GCID: GC06P012717

Phosphatase And Actin Regulator 1

(Previous name: RPEL repeat containing 1)
(Previous symbol: RPEL1)
  See related diseases
at
MalaCards
 

Aliases
for PHACTR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatase And Actin Regulator 11 2
RPEL11 2 3
RPEL Repeat Containing 11 2
KIAA17333 5
RPEL2
dJ257A7.22

External Ids:    HGNC: 209901   Entrez Gene: 2216922   Ensembl: ENSG000001121377   OMIM: 6087235   UniProtKB: Q9C0D03   

Export aliases for PHACTR1 gene to outside databases

Previous GC identifers: GC06P012826 GC06P012827


Summaries
for PHACTR1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PHACTR1 Gene:
PHACTR1 (phosphatase and actin regulator 1) is a protein-coding gene. Diseases associated with PHACTR1 include migraine without aura, and migraine. GO annotations related to this gene include actin binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot: PHAR1_HUMAN, Q9C0D0
Function: Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in
formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by
endothelial cells. Regulates PPP1CA activity. Required for normal cell survival




Genomic Views
for PHACTR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PHACTR1 gene promoter:
         HOXA9   HOXA9B   Gfi-1   Meis-1b   MEF-2A   FOXJ2 (long isoform)   FOXJ2   aMEF-2   FOXO1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PHACTR1 promoter sequence
   Search Chromatin IP Primers for PHACTR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PHACTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.1   Ensembl cytogenetic band:  6p24.1   HGNC cytogenetic band: 6p23

PHACTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHACTR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P012717:  view genomic region     (about GC identifiers)

Start:
 12,717,037 bp from pter      End:
 13,288,645 bp from pter
Size:
 571,609 bases      Orientation:
 plus strand

Proteins
for PHACTR1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PHAR1_HUMAN, Q9C0D0 (See protein sequence)
Recommended Name: Phosphatase and actin regulator 1  
Size: 580 amino acids; 66308 Da
Subunit: Interacts (via RPEL repeats) with ACTA1 and PPP1CA; ACTA1 and PPP1CA compete for the same binding site
Sequence caution: Sequence=BAB21824.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K1V2 Q3MJ93 Q5JSJ2
Alternative splicing: 2 isoforms:  Q9C0D0-1   Q9C0D0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PHACTR1: NX_Q9C0D0

Explore proteomics data for PHACTR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See PHACTR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229577.1  NP_112210.1  

    ENSEMBL proteins: 
     ENSP00000368655   ENSP00000368653   ENSP00000384760   ENSP00000412573   ENSP00000395948  
     ENSP00000368639   ENSP00000368633   ENSP00000329880   ENSP00000397669   ENSP00000368650  

    PHACTR1 Human Recombinant Protein Products:

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    Novus Biologicals PHACTR1 Protein
    Novus Biologicals PHACTR1 Lysate
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    Cloud-Clone Corp. Proteins for PHACTR1

    PHACTR1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for PHACTR1

    PHACTR1 Assay Products:

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    Domains /
    Families
    for PHACTR1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    PHACTR: Phosphatase and actin regulators

    1 InterPro protein domain:
     IPR004018 RPEL_repeat

    Graphical View of Domain Structure for InterPro Entry Q9C0D0

    ProtoNet protein and cluster: Q9C0D0

    UniProtKB/Swiss-Prot: PHAR1_HUMAN, Q9C0D0
    Domain: Binds three actin monomers via the three C-terminal RPEL repeats (By similarity)
    Similarity: Belongs to the phosphatase and actin regulator family
    Similarity: Contains 4 RPEL repeats


    PHACTR1 for domains           About GeneDecksing


    Function
    for PHACTR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PHAR1_HUMAN, Q9C0D0
    Function: Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in
    formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by
    endothelial cells. Regulates PPP1CA activity. Required for normal cell survival
    Induction: Up-regulated by VEGFA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0004864protein phosphatase inhibitor activity IEA--
         
    PHACTR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PHACTR1:
     High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PHACTR1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PHACTR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PHACTR1

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat PHACTR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHACTR1 (see all 11):
    hsa-miR-2052 hsa-miR-34b* hsa-miR-4271 hsa-miR-4307 hsa-miR-634 hsa-miR-218-2* hsa-miR-182* hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmid: PHACTR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PHACTR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PHACTR1

    Clone
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    OriGene ORF clones in mouse, rat for PHACTR1
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    GenScript: all cDNA clones in your preferred vector: PHACTR1 (NM_030948)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHACTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHACTR1

    Cell Line
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    In Situ Assay
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    Localization
    for PHACTR1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PHAR1_HUMAN, Q9C0D0: Cytoplasm (By similarity). Cell junction, synapse (By similarity). Nucleus (By similarity).
    Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon
    serum stimulation. Interaction with actin prevents nuclear import (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol ISS--
    GO:0030054cell junction IEA--
    GO:0045202synapse IEA--

    PHACTR1 for ontologies           About GeneDecksing


    Pathways & Interactions
    for PHACTR1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PHACTR1
    Interactions:

        Search GeneGlobe Interaction Network for PHACTR1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for PHACTR1 (Q9C0D02, 3 ENSP000003976694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTA1P681333, ENSP000003556454I2D: score=2 STRING: ENSP00000355645
    PPP1CAP621363, ENSP000003260314I2D: score=2 STRING: ENSP00000326031
    GRB2P629933I2D: score=1 
    --P310162MINT-8109062
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031032actomyosin structure organization IMP--
    GO:0031532actin cytoskeleton reorganization ISS--
    GO:0043149stress fiber assembly IMP--
    GO:0048870cell motility IMP--

    PHACTR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PHACTR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PHACTR1 (PHAR1)



    Transcripts
    for PHACTR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PHACTR1 gene (2 alternative transcripts): 
    NM_001242648.1  NM_030948.2  

    Unigene Cluster for PHACTR1:

    Phosphatase and actin regulator 1
    Hs.436996  [show with all ESTs]
    Unigene Representative Sequence: NM_030948
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379350(uc003nag.2) ENST00000379348(uc003nai.3) ENST00000406205
    ENST00000482982 ENST00000434977 ENST00000415087(uc003nah.2 uc010jpc.3)
    ENST00000489548 ENST00000379335 ENST00000379329 ENST00000481706 ENST00000332995
    ENST00000457702 ENST00000379345
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat PHACTR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PHACTR1 (see all 11):
    hsa-miR-2052 hsa-miR-34b* hsa-miR-4271 hsa-miR-4307 hsa-miR-634 hsa-miR-218-2* hsa-miR-182* hsa-miR-2116
    SwitchGear 3'UTR luciferase reporter plasmid: PHACTR1 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for PHACTR1
    Predesigned siRNA for gene silencing in human, mouse, rat PHACTR1
    Clone
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    OriGene ORF clones in mouse, rat for PHACTR1
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    GenScript: all cDNA clones in your preferred vector: PHACTR1 (NM_030948)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PHACTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PHACTR1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PHACTR1
      QuantiTect SYBR Green Assays in human, mouse, rat PHACTR1
      QuantiFast Probe-based Assays in human, mouse, rat PHACTR1

    Additional mRNA sequence: 

    AK090769.1 AK290017.1 AK295263.1 BC047159.1 BC101526.1 BC101528.1 

    11 DOTS entries:

    DT.92418000  DT.313401  DT.75199379  DT.100691753  DT.121367811  DT.121367839  DT.40188426  DT.95076613 
    DT.100698616  DT.408950  DT.95333051 

    Selected AceView cDNA sequences (see all 74):

    AA364675 BQ434462 BQ879198 BC067280 AA809685 BU729910 AI654726 BQ224051 
    AK090769 BG150259 AX746608 BF593405 BM704008 AW025250 CA444621 BM675260 
    AA713488 CD639878 AL598323 H98750 BF026507 AI498529 AB051520 AW054711 

    GeneLoc Exon Structure


    Expression
    for PHACTR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PHACTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTGAGTAG
    PHACTR1 Expression
    About this image


    PHACTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Melanocytes (Integumentary System)    fully expand to see all 4 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     NULL (Integumentary System)
             skin 1 ; melanocytes   
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
    PHACTR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    PHACTR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436996

    UniProtKB/Swiss-Prot: PHAR1_HUMAN, Q9C0D0
    Tissue specificity: Detected in umbilical vein endothelial cells

        Custom PCR Arrays for PHACTR1
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    In Situ
    Assay Products:     
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    Orthologs
    for PHACTR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PHACTR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Phactr11 , 5 phosphatase and actin regulator 11, 5 88.85(n)1
    96.21(a)1    		   13 (21.05 cM)5
    2181941  NM_198419.31  NP_940811.21 
     426806235 
    chicken
    (Gallus gallus)    		 Aves PHACTR11 phosphatase and actin regulator 1 79.46(n)
    85.78(a)    		   395093  NM_204446.1  NP_989777.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia phactr11 phosphatase and actin regulator 1 74.67(n)
    81.05(a)    		   100216198  NM_001142167.1  NP_001135639.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003347761 phosphatase and actin regulator 1-like 59.83(n)
    59.75(a)    		   100334776  XM_005173828.1  XP_005173885.1 


    ENSEMBL Gene Tree for PHACTR1 (if available)
    TreeFam Gene Tree for PHACTR1 (if available)

    Paralogs
    for PHACTR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PHACTR1 gene
    3 SIMAP similar genes for PHACTR1 using alignment to 10 protein entries:     PHAR1_HUMAN (see all proteins):
    PFKM    PHACTR2    PHACTR3

    PHACTR1 for paralogs           About GeneDecksing



    Genomic Variants
    for PHACTR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PHACTR1 (see all 11534)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1932585451,2
    		--12715125(+) AATCTA/GTTACA 2 -- us2k10--------
    rs1479150971,2
    		--12715344(+) CAAGCA/GATTCT 2 -- us2k10--------
    rs715532221,2
    		C,F--12715521(+) CAGACA/GTGAGC 2 -- us2k13Minor allele frequency- G:0.24NA WA 240
    rs1416365181,2
    		--12715524(+) ACATGA/GGCCTC 2 -- us2k10--------
    rs1150447141,2
    		C--12715536(+) GTGCCC/TGGCCC 2 -- us2k10--------
    rs715624541,2
    		C,F--12715537(+) TGCCCG/AGCCCC 2 -- us2k14Minor allele frequency- A:0.12NA WA 242
    rs168733011,2
    		C,F,H--12715593(+) AATTAC/TGACCC 2 -- us2k123Minor allele frequency- T:0.16NA NS EA CSA WA 2849
    rs1512702191,2
    		C--12715618(+) TTCAC-/TTTGTA 2 -- us2k10--------
    rs1835300101,2
    		--12715665(+) AGAAAC/TGACTG 2 -- us2k10--------
    rs1158097601,2
    		C,F--12715762(+) ATTTGC/AACTCA 2 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for PHACTR1 (12717037 - 12967037 bp, first 250kb of PHACTR1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PHACTR1 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666863CNV Deletion23128226
    esv2535563CNV Deletion19546169
    esv2731601CNV Deletion23290073
    esv4766CNV Deletion18987735
    esv2731603CNV Deletion23290073
    esv2731599CNV Deletion23290073
    esv2731602CNV Deletion23290073
    esv1092896CNV Deletion17803354
    esv1978352CNV Deletion18987734
    esv2731604CNV Deletion23290073

    Human Gene Mutation Database (HGMD): PHACTR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PHACTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for PHACTR1

    Disorders / Diseases
    for PHACTR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608723    OMIM disorders: --

    10 diseases for PHACTR1:    
    About MalaCards
    migraine without aura    migraine    gigantism    intellectual disability
    coronary heart disease    coronary artery disease    myocardial infarction    breast cancer
    cerebritis    endotheliitis


    PHACTR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PHACTR1
    Human Genome Epidemiology (HuGE) Navigator: PHACTR1 (6 documents)

    Export disorders for PHACTR1 gene to outside databases

    Publications
    for PHACTR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PHACTR1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with PHACTR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. (PubMed id 21939755)1, 2 Allain B.... Lepelletier Y. (Cell. Signal. 2012)
    3. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PubMed id 21378990)1, 4 Schunkert H....Samani N.J. (Nat. Genet. 2011)
    4. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. (PubMed id 22144573)1, 4 O'Donnell C.J....Witteman J.C. (Circulation 2011)
    5. Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis. (PubMed id 21798305)1, 2 Jarray R.... Raynaud F. (Biochimie 2011)
    6. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (Nat. Genet. 2011)
    7. A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease. (PubMed id 21846871)1, 4 Mehta N.N. (Circ Cardiovasc Genet 2011)
    8. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (Lancet 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (Rev Esp Cardiol 2010)

    External Searches for PHACTR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PHACTR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221692 HGNC: 20990 AceView: PHACTR1 Ensembl:ENSG00000112137 euGenes: HUgn221692
    ECgene: PHACTR1 H-InvDB: PHACTR1

    Other Databases showing PHACTR1 gene

    (According to HUGE)
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    HUGE: KIAA1733

    Specialized Databases showing PHACTR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PHACTR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PHACTR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for PHACTR1 gene:
    Search GeneIP for patents involving PHACTR1

    GeneCards and IP:
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