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Aliases for PGRMC2 Gene

Aliases for PGRMC2 Gene

  • Progesterone Receptor Membrane Component 2 2 3
  • Steroid Receptor Protein DG6 3 4
  • PMBP 3 4
  • DG6 3 4
  • Progesterone Membrane Binding Protein 3
  • Progesterone Membrane-Binding Protein 4

External Ids for PGRMC2 Gene

Previous GeneCards Identifiers for PGRMC2 Gene

  • GC04M130123
  • GC04M129484
  • GC04M129650
  • GC04M129548
  • GC04M129190
  • GC04M124921

Summaries for PGRMC2 Gene

GeneCards Summary for PGRMC2 Gene

PGRMC2 (Progesterone Receptor Membrane Component 2) is a Protein Coding gene. GO annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC1.

UniProtKB/Swiss-Prot for PGRMC2 Gene

  • Receptor for steroids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC2 Gene

Genomics for PGRMC2 Gene

Regulatory Elements for PGRMC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PGRMC2 Gene

Chromosome:
4
Start:
128,269,237 bp from pter
End:
128,288,829 bp from pter
Size:
19,593 bases
Orientation:
Minus strand

Genomic View for PGRMC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGRMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC2 Gene

Proteins for PGRMC2 Gene

  • Protein details for PGRMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15173-PGRC2_HUMAN
    Recommended name:
    Membrane-associated progesterone receptor component 2
    Protein Accession:
    O15173
    Secondary Accessions:
    • Q569H1

    Protein attributes for PGRMC2 Gene

    Size:
    223 amino acids
    Molecular mass:
    23818 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PGRMC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGRMC2 Gene

Proteomics data for PGRMC2 Gene at MOPED

Post-translational modifications for PGRMC2 Gene

  • Ubiquitination at Lys 126, Lys 135, Lys 191, and Lys 193
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PGRMC2 Gene

Domains & Families for PGRMC2 Gene

Protein Domains for PGRMC2 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O15173

UniProtKB/Swiss-Prot:

PGRC2_HUMAN :
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
Domain:
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC2: view

No data available for Gene Families for PGRMC2 Gene

Function for PGRMC2 Gene

Molecular function for PGRMC2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for steroids.

Gene Ontology (GO) - Molecular Function for PGRMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity TAS 9705155
GO:0005496 steroid binding IEA --
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with PGRMC2: view
genes like me logo Genes that share phenotypes with PGRMC2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGRMC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC2 Gene

Localization for PGRMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGRMC2 Gene COMPARTMENTS Subcellular localization image for PGRMC2 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PGRMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PGRMC2: view

Pathways & Interactions for PGRMC2 Gene

SuperPathways for PGRMC2 Gene

No Data Available

Interacting Proteins for PGRMC2 Gene

Gene Ontology (GO) - Biological Process for PGRMC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043401 steroid hormone mediated signaling pathway TAS 9705155
genes like me logo Genes that share ontologies with PGRMC2: view

No data available for Pathways by source and SIGNOR curated interactions for PGRMC2 Gene

Drugs & Compounds for PGRMC2 Gene

(2) Drugs for PGRMC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
heme Pharma Agonist 0

(1) Additional Compounds for PGRMC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with PGRMC2: view

Transcripts for PGRMC2 Gene

Unigene Clusters for PGRMC2 Gene

Progesterone receptor membrane component 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGRMC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for PGRMC2 Gene

GeneLoc Exon Structure for
PGRMC2
ECgene alternative splicing isoforms for
PGRMC2

Expression for PGRMC2 Gene

mRNA expression in normal human tissues for PGRMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC2 Gene

This gene is overexpressed in Nasal epithelium (12.5), Bone (12.3), and Adipocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGRMC2 Gene



SOURCE GeneReport for Unigene cluster for PGRMC2 Gene Hs.507910

genes like me logo Genes that share expression patterns with PGRMC2: view

Protein tissue co-expression partners for PGRMC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGRMC2 Gene

Orthologs for PGRMC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PGRMC2 35
  • 94.47 (n)
  • 95.52 (a)
PGRMC2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGRMC2 35
  • 95.67 (n)
  • 95.96 (a)
PGRMC2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgrmc2 35
  • 87.25 (n)
  • 89.4 (a)
Pgrmc2 16
Pgrmc2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PGRMC2 35
  • 99.33 (n)
  • 98.38 (a)
PGRMC2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgrmc2 35
  • 86.02 (n)
  • 88.94 (a)
oppossum
(Monodelphis domestica)
Mammalia PGRMC2 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGRMC2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGRMC2 35
  • 83.13 (n)
  • 85.12 (a)
PGRMC2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGRMC2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394928 35
pgrmc2 35
  • 75.31 (n)
  • 80.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33468 35
zebrafish
(Danio rerio)
Actinopterygii pgrmc2 35
  • 69.46 (n)
  • 74.25 (a)
wufb25g12 35
pgrmc2 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9066 37
  • 53 (a)
MSBP 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vem-1 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4516 35
Species with no ortholog for PGRMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC2 Gene

ENSEMBL:
Gene Tree for PGRMC2 (if available)
TreeFam:
Gene Tree for PGRMC2 (if available)

Paralogs for PGRMC2 Gene

Paralogs for PGRMC2 Gene

(1) SIMAP similar genes for PGRMC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGRMC2: view

Variants for PGRMC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for PGRMC2 Gene

Variant ID Type Subtype PubMed ID
esv274485 CNV Insertion 20981092
esv271720 CNV Insertion 20981092
nsv292512 CNV Insertion 16902084

Variation tolerance for PGRMC2 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGRMC2 Gene

HapMap Linkage Disequilibrium report
PGRMC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PGRMC2 Gene

Disorders for PGRMC2 Gene

Relevant External Links for PGRMC2

Genetic Association Database (GAD)
PGRMC2
Human Genome Epidemiology (HuGE) Navigator
PGRMC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGRMC2
genes like me logo Genes that share disorders with PGRMC2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGRMC2 Gene

Publications for PGRMC2 Gene

  1. Molecular markers of preterm labor in the choriodecidua. (PMID: 20009011) Shankar R. … Brennecke S.P. (Reprod Sci 2010) 23 67
  2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PMID: 11697142) Bernauer S. … Falkenstein E. (DNA Seq. 2001) 23 67
  3. Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm. (PMID: 10579369) Falkenstein E. … Wehling M. (Endocrinology 1999) 23 67
  4. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D. … Falkenstein E. (Biol. Chem. 1998) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for PGRMC2 Gene

Sources for PGRMC2 Gene

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