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Aliases for PGRMC2 Gene

Aliases for PGRMC2 Gene

  • Progesterone Receptor Membrane Component 2 2 3 5
  • Steroid Receptor Protein DG6 3 4
  • PMBP 3 4
  • DG6 3 4
  • Progesterone Membrane Binding Protein 3
  • Progesterone Membrane-Binding Protein 4

External Ids for PGRMC2 Gene

Previous GeneCards Identifiers for PGRMC2 Gene

  • GC04M130123
  • GC04M129484
  • GC04M129650
  • GC04M129548
  • GC04M129190
  • GC04M124921

Summaries for PGRMC2 Gene

GeneCards Summary for PGRMC2 Gene

PGRMC2 (Progesterone Receptor Membrane Component 2) is a Protein Coding gene. GO annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC1.

UniProtKB/Swiss-Prot for PGRMC2 Gene

  • Receptor for steroids.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC2 Gene

Genomics for PGRMC2 Gene

Regulatory Elements for PGRMC2 Gene

Enhancers for PGRMC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGRMC2 on UCSC Golden Path with GeneCards custom track

Promoters for PGRMC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGRMC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PGRMC2 Gene

128,269,237 bp from pter
128,288,829 bp from pter
19,593 bases
Minus strand

Genomic View for PGRMC2 Gene

Genes around PGRMC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGRMC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGRMC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC2 Gene

Proteins for PGRMC2 Gene

  • Protein details for PGRMC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-associated progesterone receptor component 2
    Protein Accession:
    Secondary Accessions:
    • Q569H1

    Protein attributes for PGRMC2 Gene

    223 amino acids
    Molecular mass:
    23818 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PGRMC2 Gene


neXtProt entry for PGRMC2 Gene

Proteomics data for PGRMC2 Gene at MOPED

Post-translational modifications for PGRMC2 Gene

  • Ubiquitination at Lys 126, Lys 135, Lys 191, and Lys 193
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PGRMC2 Gene

Domains & Families for PGRMC2 Gene

Protein Domains for PGRMC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161.
  • Contains 1 cytochrome b5 heme-binding domain.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC2: view

No data available for Gene Families for PGRMC2 Gene

Function for PGRMC2 Gene

Molecular function for PGRMC2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for steroids.
genes like me logo Genes that share phenotypes with PGRMC2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC2 Gene

Localization for PGRMC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PGRMC2 Gene COMPARTMENTS Subcellular localization image for PGRMC2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PGRMC2 Gene

Pathways & Interactions for PGRMC2 Gene

SuperPathways for PGRMC2 Gene

No Data Available

Interacting Proteins for PGRMC2 Gene

Gene Ontology (GO) - Biological Process for PGRMC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for PGRMC2 Gene

Drugs & Compounds for PGRMC2 Gene

(2) Drugs for PGRMC2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Full agonist, Activator Endogenous progesterone receptor agonist 511
heme Pharma Agonist 0

(1) Additional Compounds for PGRMC2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with PGRMC2: view

Transcripts for PGRMC2 Gene

Unigene Clusters for PGRMC2 Gene

Progesterone receptor membrane component 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for PGRMC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGRMC2 Gene

mRNA expression in normal human tissues for PGRMC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC2 Gene

This gene is overexpressed in Nasal epithelium (12.5), Bone (12.3), and Adipocyte (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGRMC2 Gene

SOURCE GeneReport for Unigene cluster for PGRMC2 Gene Hs.507910

genes like me logo Genes that share expression patterns with PGRMC2: view

Protein tissue co-expression partners for PGRMC2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PGRMC2 Gene

Orthologs for PGRMC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGRMC2 35
  • 94.47 (n)
  • 95.52 (a)
  • 96 (a)
(Canis familiaris)
Mammalia PGRMC2 35
  • 95.67 (n)
  • 95.96 (a)
  • 96 (a)
(Mus musculus)
Mammalia Pgrmc2 35
  • 87.25 (n)
  • 89.4 (a)
Pgrmc2 16
Pgrmc2 36
  • 89 (a)
(Pan troglodytes)
Mammalia PGRMC2 35
  • 99.33 (n)
  • 98.38 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Pgrmc2 35
  • 86.02 (n)
  • 88.94 (a)
(Monodelphis domestica)
Mammalia PGRMC2 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia PGRMC2 36
  • 89 (a)
(Gallus gallus)
Aves PGRMC2 35
  • 83.13 (n)
  • 85.12 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia PGRMC2 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394928 35
pgrmc2 35
  • 75.31 (n)
  • 80.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33468 35
(Danio rerio)
Actinopterygii pgrmc2 35
  • 69.46 (n)
  • 74.25 (a)
wufb25g12 35
pgrmc2 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9066 37
  • 53 (a)
  • 35 (a)
(Caenorhabditis elegans)
Secernentea vem-1 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 36
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4516 35
Species with no ortholog for PGRMC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC2 Gene

Gene Tree for PGRMC2 (if available)
Gene Tree for PGRMC2 (if available)

Paralogs for PGRMC2 Gene

Paralogs for PGRMC2 Gene

(1) SIMAP similar genes for PGRMC2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PGRMC2: view

Variants for PGRMC2 Gene

Sequence variations from dbSNP and Humsavar for PGRMC2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs4016 -- 128,269,325(+) TTTTT(A/T)CTGCA utr-variant-3-prime
rs4022 -- 128,269,448(+) TTTTT(G/T)TTTAG utr-variant-3-prime
rs15388 -- 128,270,228(+) ATTCA(G/T)ACACA utr-variant-3-prime
rs172343 -- 128,272,741(-) AAGAT(C/T)TAAGT intron-variant
rs172344 -- 128,272,850(-) GGCTT(C/T)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGRMC2 Gene

Variant ID Type Subtype PubMed ID
esv274485 CNV Insertion 20981092
esv271720 CNV Insertion 20981092
nsv292512 CNV Insertion 16902084

Variation tolerance for PGRMC2 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PGRMC2 Gene

Disorders for PGRMC2 Gene

Relevant External Links for PGRMC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PGRMC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGRMC2 Gene

Publications for PGRMC2 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D. … Falkenstein E. (Biol. Chem. 1998) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Expression patterns of progesterone receptor membrane components 1 and 2 in endometria from women with and without endometriosis. (PMID: 23793472) Bunch K. … Stallings J.D. (Reprod Sci 2014) 3

Products for PGRMC2 Gene

Sources for PGRMC2 Gene