Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PGRMC1 Gene

Aliases for PGRMC1 Gene

  • Progesterone Receptor Membrane Component 1 2 3 5
  • HPR6.6 3 4
  • MPR 3 4
  • Membrane-Associated Progesterone Receptor Component 1 3
  • Progesterone Binding Protein 3
  • PGRMC 4

External Ids for PGRMC1 Gene

Previous GeneCards Identifiers for PGRMC1 Gene

  • GC0XP113188
  • GC0XP115355
  • GC0XP116345
  • GC0XP117124
  • GC0XP118152
  • GC0XP118254
  • GC0XP118370
  • GC0XP107864

Summaries for PGRMC1 Gene

Entrez Gene Summary for PGRMC1 Gene

  • This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

GeneCards Summary for PGRMC1 Gene

PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include Supraglottis Cancer and Patulous Eustachian Tube. Among its related pathways are Immune System and Glucose / Energy Metabolism. GO annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot for PGRMC1 Gene

  • Receptor for progesterone.

Gene Wiki entry for PGRMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC1 Gene

Genomics for PGRMC1 Gene

Regulatory Elements for PGRMC1 Gene

Enhancers for PGRMC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF119322 0.2 Ensembl 11.2 +86.3 86256 0.2 PGRMC1 ENSG00000226661 SLC25A43 PIR32271 PIR43826
GH0XF119239 0.9 ENCODE 5.9 +4.3 4296 1.8 SOX5 SOX13 PKNOX1 ATF2 NFIL3 HNF1A NR2F6 NFE2L2 PGRMC1 AKAP17BP
GH0XF119234 0.2 ENCODE 5.8 +0.8 762 4.2 HDGF PKNOX1 ZNF493 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 NKAP UPF3B PGRMC1 AKAP17BP
GH0XF119674 1.3 FANTOM5 ENCODE 5.4 +448.5 448459 20.2 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 YY1 NKAPP1 EEF1A1P30 NKAP SEPT6 NKRF UPF3B MIR766 CXorf56 PGRMC1 TMEM255A
GH0XF119240 0.6 ENCODE 0.8 +3.0 3013 0.0 PATZ1 PGRMC1 AKAP17BP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PGRMC1 on UCSC Golden Path with GeneCards custom track

Promoters for PGRMC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000481548 1155 3601 HDGF PKNOX1 ZNF493 ZFP64 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2

Genomic Location for PGRMC1 Gene

Chromosome:
X
Start:
119,236,245 bp from pter
End:
119,244,466 bp from pter
Size:
8,222 bases
Orientation:
Plus strand

Genomic View for PGRMC1 Gene

Genes around PGRMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGRMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC1 Gene

Proteins for PGRMC1 Gene

  • Protein details for PGRMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00264-PGRC1_HUMAN
    Recommended name:
    Membrane-associated progesterone receptor component 1
    Protein Accession:
    O00264
    Secondary Accessions:
    • B7Z1L3
    • Q9UGJ9

    Protein attributes for PGRMC1 Gene

    Size:
    195 amino acids
    Molecular mass:
    21671 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PGRMC1 Gene

    Alternative splice isoforms for PGRMC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGRMC1 Gene

Post-translational modifications for PGRMC1 Gene

  • Ubiquitination at Lys 96, Lys 102, Lys 105, and Lys 132
  • Modification sites at PhosphoSitePlus

Other Protein References for PGRMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PGRMC1 (PGRMC1)

No data available for DME Specific Peptides for PGRMC1 Gene

Domains & Families for PGRMC1 Gene

Gene Families for PGRMC1 Gene

Protein Domains for PGRMC1 Gene

Graphical View of Domain Structure for InterPro Entry

O00264

UniProtKB/Swiss-Prot:

PGRC1_HUMAN :
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
Domain:
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Contains 1 cytochrome b5 heme-binding domain.
Family:
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC1: view

Function for PGRMC1 Gene

Molecular function for PGRMC1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for progesterone.

Gene Ontology (GO) - Molecular Function for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 21081644
GO:0008289 lipid binding IEA --
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with PGRMC1: view
genes like me logo Genes that share phenotypes with PGRMC1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC1 Gene

Localization for PGRMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC1 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGRMC1 Gene COMPARTMENTS Subcellular localization image for PGRMC1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
nucleus 5
lysosome 3
cytosol 2
endosome 2
golgi apparatus 2
plasma membrane 2
vacuole 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IDA,IBA 19946888
genes like me logo Genes that share ontologies with PGRMC1: view

Pathways & Interactions for PGRMC1 Gene

genes like me logo Genes that share pathways with PGRMC1: view

Pathways by source for PGRMC1 Gene

1 Cell Signaling Technology pathway for PGRMC1 Gene
2 Reactome pathways for PGRMC1 Gene

Gene Ontology (GO) - Biological Process for PGRMC1 Gene

None

No data available for SIGNOR curated interactions for PGRMC1 Gene

Drugs & Compounds for PGRMC1 Gene

(10) Drugs for PGRMC1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator Endogenous progesterone receptor agonist 537
Dextromethorphan Approved Pharma Target, binder 129
Nortriptyline Approved Pharma Antagonist, Pore Blocker, Target, binder 50
OPC-14523 Investigational Pharma agonist, inhibitor 0
heme Pharma Agonist 0

(2) Additional Compounds for PGRMC1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with PGRMC1: view

Transcripts for PGRMC1 Gene

mRNA/cDNA for PGRMC1 Gene

Unigene Clusters for PGRMC1 Gene

Progesterone receptor membrane component 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for PGRMC1 Gene

GeneLoc Exon Structure for
PGRMC1
ECgene alternative splicing isoforms for
PGRMC1

Expression for PGRMC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGRMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC1 Gene

This gene is overexpressed in Nasal epithelium (13.6), Bone (8.7), and Fetal testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGRMC1 Gene



Protein tissue co-expression partners for PGRMC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PGRMC1 Gene:

PGRMC1

SOURCE GeneReport for Unigene cluster for PGRMC1 Gene:

Hs.90061

mRNA Expression by UniProt/SwissProt for PGRMC1 Gene:

O00264-PGRC1_HUMAN
Tissue specificity: Widely expressed, with highest expression in liver and kidney.
genes like me logo Genes that share expression patterns with PGRMC1: view

Primer Products

No data available for mRNA differential expression in normal tissues for PGRMC1 Gene

Orthologs for PGRMC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGRMC1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGRMC1 34 35
  • 95.38 (n)
cow
(Bos Taurus)
Mammalia PGRMC1 34 35
  • 92.78 (n)
mouse
(Mus musculus)
Mammalia Pgrmc1 34 16 35
  • 91.79 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PGRMC1 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgrmc1 34
  • 87.7 (n)
oppossum
(Monodelphis domestica)
Mammalia PGRMC1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGRMC1 34 35
  • 75.39 (n)
lizard
(Anolis carolinensis)
Reptilia PGRMC1 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pgrmc1 34
  • 69.41 (n)
Str.1525 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5375 34
zebrafish
(Danio rerio)
Actinopterygii pgrmc1 34 35
  • 65.48 (n)
Dr.26789 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.28 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000767 34
  • 62.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta MSBP 34 35
  • 54.41 (n)
CG9066 36
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea vem-1 34 35
  • 51.24 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL106W 34
  • 52.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09757g 34
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 34 35 37
  • 48.39 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07286 34
  • 54.34 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dap1 34
  • 50.68 (n)
Species where no ortholog for PGRMC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC1 Gene

ENSEMBL:
Gene Tree for PGRMC1 (if available)
TreeFam:
Gene Tree for PGRMC1 (if available)

Paralogs for PGRMC1 Gene

Paralogs for PGRMC1 Gene

(2) SIMAP similar genes for PGRMC1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PGRMC1 Gene

genes like me logo Genes that share paralogs with PGRMC1: view

Variants for PGRMC1 Gene

Sequence variations from dbSNP and Humsavar for PGRMC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1051759 -- 119,244,221(+) TACCC(A/C)CTGCA utr-variant-3-prime
rs1063649 -- 119,244,328(+) TGAAC(A/C)CCTAG downstream-variant-500B, utr-variant-3-prime
rs111298006 -- 119,239,759(+) CCACC(A/G)ATACT intron-variant
rs111814644 -- 119,242,998(+) GCAAG(C/G)ACGGT intron-variant
rs112057907 -- 119,239,907(+) ATCAG(C/T)GCTTA intron-variant

Variation tolerance for PGRMC1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGRMC1 Gene

Human Gene Mutation Database (HGMD)
PGRMC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGRMC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGRMC1 Gene

Disorders for PGRMC1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for PGRMC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
supraglottis cancer
  • ca larynx - supraglottis
patulous eustachian tube
  • pet
eustachian tube disease
  • eustachian tube disorder
trachea adenoid cystic carcinoma
  • adenoid cystic carcinoma of trachea
petrous apex meningioma
  • meningioma of the petrous ridge
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PGRMC1

Genetic Association Database (GAD)
PGRMC1
Human Genome Epidemiology (HuGE) Navigator
PGRMC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGRMC1
genes like me logo Genes that share disorders with PGRMC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGRMC1 Gene

Publications for PGRMC1 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D. … Falkenstein E. (Biol. Chem. 1998) 2 3 4 22 64
  2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PMID: 11697142) Bernauer S. … Falkenstein E. (DNA Seq. 2001) 3 4 22 64
  3. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman K.K. … Jacobsson B. (PLoS ONE 2010) 3 46 64
  4. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. (PMID: 20164297) Ahmed I.S. … Craven R.J. (J. Pharmacol. Exp. Ther. 2010) 3 22 64
  5. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez D.R. … Menon R. (Am. J. Obstet. Gynecol. 2009) 3 46 64

Products for PGRMC1 Gene

Sources for PGRMC1 Gene

Content
Loading form....