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Aliases for PGRMC1 Gene

Aliases for PGRMC1 Gene

  • Progesterone Receptor Membrane Component 1 2 3 5
  • HPR6.6 3 4
  • MPR 3 4
  • Membrane-Associated Progesterone Receptor Component 1 3
  • Progesterone Binding Protein 3
  • PGRMC 4

External Ids for PGRMC1 Gene

Previous GeneCards Identifiers for PGRMC1 Gene

  • GC0XP113188
  • GC0XP115355
  • GC0XP116345
  • GC0XP117124
  • GC0XP118152
  • GC0XP118254
  • GC0XP118370
  • GC0XP107864

Summaries for PGRMC1 Gene

Entrez Gene Summary for PGRMC1 Gene

  • This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

GeneCards Summary for PGRMC1 Gene

PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include Supraglottis Cancer and Eustachian Tube Disease. Among its related pathways are Glucose / Energy Metabolism and Innate Immune System. GO annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot for PGRMC1 Gene

  • Receptor for progesterone.

Gene Wiki entry for PGRMC1 Gene

Additional gene information for PGRMC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC1 Gene

Genomics for PGRMC1 Gene

Regulatory Elements for PGRMC1 Gene

Enhancers for PGRMC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH119239 0.5 ENCODE 5.9 +4.3 4296 1.8 PKNOX1 HNF1A YY1 PGRMC1 AKAP17BP
GH0XH119240 0.4 ENCODE 0.7 +3.0 3013 0 YY1 PGRMC1 AKAP17BP
GH0XH119228 0.2 ENCODE 0.4 -7.5 -7533 0.2 NUDT19P1 PGRMC1 GC0XM119222
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PGRMC1 on UCSC Golden Path with GeneCards custom track

Promoters for PGRMC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248320 1055 3001 HDGF PKNOX1 ZNF493 ZFP64 ARID4B SIN3A DMAP1 GLI4 ZNF2 YY1

Genomic Locations for PGRMC1 Gene

Genomic Locations for PGRMC1 Gene
8,222 bases
Plus strand

Genomic View for PGRMC1 Gene

Genes around PGRMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGRMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC1 Gene

Proteins for PGRMC1 Gene

  • Protein details for PGRMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-associated progesterone receptor component 1
    Protein Accession:
    Secondary Accessions:
    • B7Z1L3
    • Q9UGJ9

    Protein attributes for PGRMC1 Gene

    195 amino acids
    Molecular mass:
    21671 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PGRMC1 Gene

    Alternative splice isoforms for PGRMC1 Gene


neXtProt entry for PGRMC1 Gene

Post-translational modifications for PGRMC1 Gene

  • Ubiquitination at Lys96, Lys102, Lys105, and Lys132
  • Modification sites at PhosphoSitePlus

Other Protein References for PGRMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PGRMC1 Gene

Domains & Families for PGRMC1 Gene

Gene Families for PGRMC1 Gene

Protein Domains for PGRMC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC1: view

Function for PGRMC1 Gene

Molecular function for PGRMC1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for progesterone.

Gene Ontology (GO) - Molecular Function for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 21081644
GO:0008289 lipid binding IEA --
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with PGRMC1: view
genes like me logo Genes that share phenotypes with PGRMC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC1 Gene

Localization for PGRMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC1 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGRMC1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
nucleus 3
cytosol 2
lysosome 2
golgi apparatus 2
endosome 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 25390692
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 25390692
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with PGRMC1: view

Pathways & Interactions for PGRMC1 Gene

genes like me logo Genes that share pathways with PGRMC1: view

Pathways by source for PGRMC1 Gene

1 Cell Signaling Technology pathway for PGRMC1 Gene
3 Reactome pathways for PGRMC1 Gene

Gene Ontology (GO) - Biological Process for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with PGRMC1: view

No data available for SIGNOR curated interactions for PGRMC1 Gene

Drugs & Compounds for PGRMC1 Gene

(10) Drugs for PGRMC1 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved, Vet_approved Pharma Full agonist, Activator 578
Dextromethorphan Approved Pharma Target, binder 135
Nortriptyline Approved Pharma Antagonist, Pore Blocker, Target, binder 50
OPC-14523 Investigational Pharma agonist, inhibitor 0
heme Pharma Agonist 0

(2) Additional Compounds for PGRMC1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with PGRMC1: view

Transcripts for PGRMC1 Gene

mRNA/cDNA for PGRMC1 Gene

Unigene Clusters for PGRMC1 Gene

Progesterone receptor membrane component 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for PGRMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGRMC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGRMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC1 Gene

This gene is overexpressed in Nasal epithelium (13.6), Bone (8.7), and Fetal testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGRMC1 Gene

Protein tissue co-expression partners for PGRMC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PGRMC1 Gene:


SOURCE GeneReport for Unigene cluster for PGRMC1 Gene:


mRNA Expression by UniProt/SwissProt for PGRMC1 Gene:

Tissue specificity: Widely expressed, with highest expression in liver and kidney.

Evidence on tissue expression from TISSUES for PGRMC1 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.4)
  • Intestine(2.9)
  • Kidney(2.9)
  • Lung(2.7)
  • Eye(2.6)
  • Skin(2.6)
  • Heart(2.5)
  • Muscle(2.2)
  • Lymph node(2.1)
  • Stomach(2.1)
  • Adrenal gland(2)
  • Bone(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with PGRMC1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGRMC1 Gene

Orthologs for PGRMC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGRMC1 34
  • 99 (a)
(Canis familiaris)
Mammalia PGRMC1 33 34
  • 95.38 (n)
(Bos Taurus)
Mammalia PGRMC1 33 34
  • 92.78 (n)
(Mus musculus)
Mammalia Pgrmc1 33 16 34
  • 91.79 (n)
(Ornithorhynchus anatinus)
Mammalia PGRMC1 34
  • 88 (a)
(Rattus norvegicus)
Mammalia Pgrmc1 33
  • 87.7 (n)
(Monodelphis domestica)
Mammalia PGRMC1 34
  • 79 (a)
(Gallus gallus)
Aves PGRMC1 33 34
  • 75.39 (n)
(Anolis carolinensis)
Reptilia PGRMC1 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgrmc1 33
  • 69.41 (n)
Str.1525 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5375 33
(Danio rerio)
Actinopterygii pgrmc1 33 34
  • 65.48 (n)
Dr.26789 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.28 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000767 33
  • 62.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta MSBP 33 34
  • 54.41 (n)
CG9066 35
  • 54 (a)
(Caenorhabditis elegans)
Secernentea vem-1 33 34
  • 51.24 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL106W 33
  • 52.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09757g 33
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 33 34 36
  • 48.39 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07286 33
  • 54.34 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dap1 33
  • 50.68 (n)
Species where no ortholog for PGRMC1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC1 Gene

Gene Tree for PGRMC1 (if available)
Gene Tree for PGRMC1 (if available)

Paralogs for PGRMC1 Gene

Paralogs for PGRMC1 Gene

(2) SIMAP similar genes for PGRMC1 Gene using alignment to 3 proteins: Pseudogenes for PGRMC1 Gene

genes like me logo Genes that share paralogs with PGRMC1: view

Variants for PGRMC1 Gene

Sequence variations from dbSNP and Humsavar for PGRMC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000130913 -- 119,244,690(+) TTGTC(A/G)AAGTT downstream-variant-500B
rs1001402611 -- 119,236,565(+) CCCGC(C/T)TCAAG reference, missense
rs1001656160 -- 119,242,011(+) TGTGC(C/T)GGGAA intron-variant
rs1001706050 -- 119,241,313(+) GCTGA(C/G)TTCAG intron-variant
rs1002008841 -- 119,234,295(+) GGACA(A/T)TTAGG upstream-variant-2KB

Variation tolerance for PGRMC1 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGRMC1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGRMC1 Gene

Disorders for PGRMC1 Gene

MalaCards: The human disease database

(30) MalaCards diseases for PGRMC1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
supraglottis cancer
  • ca larynx - supraglottis
eustachian tube disease
  • eustachian tube disorder
patulous eustachian tube
  • pet
herpetic whitlow
  • herpetic felon
trachea adenoid cystic carcinoma
  • adenoid cystic carcinoma of trachea
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PGRMC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PGRMC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGRMC1 Gene

Publications for PGRMC1 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D … Falkenstein E (Biological chemistry 1998) 2 3 4 22 60
  2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PMID: 11697142) Bernauer S … Falkenstein E (DNA sequence : the journal of DNA sequencing and mapping 2001) 3 4 22 60
  3. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 45 60
  4. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. (PMID: 20164297) Ahmed IS … Craven RJ (The Journal of pharmacology and experimental therapeutics 2010) 3 22 60
  5. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez DR … Menon R (American journal of obstetrics and gynecology 2009) 3 45 60

Products for PGRMC1 Gene

Sources for PGRMC1 Gene

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