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Aliases for PGRMC1 Gene

Aliases for PGRMC1 Gene

  • Progesterone Receptor Membrane Component 1 2 3
  • HPR6.6 3 4
  • MPR 3 4
  • Progesterone Binding Protein 3
  • PGRMC 4

External Ids for PGRMC1 Gene

Previous GeneCards Identifiers for PGRMC1 Gene

  • GC0XP113188
  • GC0XP115355
  • GC0XP116345
  • GC0XP117124
  • GC0XP118152
  • GC0XP118254
  • GC0XP118370
  • GC0XP107864

Summaries for PGRMC1 Gene

Entrez Gene Summary for PGRMC1 Gene

  • This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

GeneCards Summary for PGRMC1 Gene

PGRMC1 (Progesterone Receptor Membrane Component 1) is a Protein Coding gene. Diseases associated with PGRMC1 include petrous apex meningioma and cerebral falx meningioma. Among its related pathways are Glucose / Energy Metabolism. GO annotations related to this gene include heme binding and steroid binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot for PGRMC1 Gene

  • Receptor for progesterone.

Gene Wiki entry for PGRMC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGRMC1 Gene

Genomics for PGRMC1 Gene

Regulatory Elements for PGRMC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PGRMC1 Gene

119,236,245 bp from pter
119,244,466 bp from pter
8,222 bases
Plus strand

Genomic View for PGRMC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGRMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGRMC1 Gene

Proteins for PGRMC1 Gene

  • Protein details for PGRMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-associated progesterone receptor component 1
    Protein Accession:
    Secondary Accessions:
    • B7Z1L3
    • Q9UGJ9

    Protein attributes for PGRMC1 Gene

    195 amino acids
    Molecular mass:
    21671 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PGRMC1 Gene


neXtProt entry for PGRMC1 Gene

Proteomics data for PGRMC1 Gene at MOPED

Post-translational modifications for PGRMC1 Gene

  • Ubiquitination at Lys 96, Lys 102, Lys 105, and Lys 132
  • Modification sites at PhosphoSitePlus

Other Protein References for PGRMC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PGRMC1 (PGRMC1)

No data available for DME Specific Peptides for PGRMC1 Gene

Domains & Families for PGRMC1 Gene

Protein Domains for PGRMC1 Gene


Graphical View of Domain Structure for InterPro Entry



  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
  • The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131.
  • Contains 1 cytochrome b5 heme-binding domain.
  • Belongs to the cytochrome b5 family. MAPR subfamily.
genes like me logo Genes that share domains with PGRMC1: view

No data available for Gene Families for PGRMC1 Gene

Function for PGRMC1 Gene

Molecular function for PGRMC1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for progesterone.

Gene Ontology (GO) - Molecular Function for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005496 steroid binding IEA --
GO:0005515 protein binding IPI 21081644
GO:0020037 heme binding IBA --
genes like me logo Genes that share ontologies with PGRMC1: view
genes like me logo Genes that share phenotypes with PGRMC1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGRMC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PGRMC1 Gene

Localization for PGRMC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGRMC1 Gene

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PGRMC1 Gene COMPARTMENTS Subcellular localization image for PGRMC1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
nucleus 4
lysosome 3
vacuole 3
endosome 2
golgi apparatus 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with PGRMC1: view

Pathways & Interactions for PGRMC1 Gene

SuperPathways for PGRMC1 Gene

Superpath Contained pathways
1 Glucose / Energy Metabolism
genes like me logo Genes that share pathways with PGRMC1: view

Pathways by source for PGRMC1 Gene

1 Cell Signaling Technology pathway for PGRMC1 Gene

Gene Ontology (GO) - Biological Process for PGRMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance IEA --
genes like me logo Genes that share ontologies with PGRMC1: view

No data available for SIGNOR curated interactions for PGRMC1 Gene

Drugs & Compounds for PGRMC1 Gene

(10) Drugs for PGRMC1 Gene - From: NovoSeek, HMDB, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
Dextromethorphan Approved Pharma Target, binder 113
Nortriptyline Approved Pharma Antagonist, Pore Blocker, Target, binder 46
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
OPC-14523 Investigational Pharma agonist, inhibitor 0

(2) Additional Compounds for PGRMC1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with PGRMC1: view

Transcripts for PGRMC1 Gene

mRNA/cDNA for PGRMC1 Gene

Unigene Clusters for PGRMC1 Gene

Progesterone receptor membrane component 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGRMC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2: - -
SP3: -

Relevant External Links for PGRMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGRMC1 Gene

mRNA expression in normal human tissues for PGRMC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGRMC1 Gene

This gene is overexpressed in Nasal epithelium (13.6), Bone (8.7), and Fetal testis (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGRMC1 Gene

SOURCE GeneReport for Unigene cluster for PGRMC1 Gene Hs.90061

mRNA Expression by UniProt/SwissProt for PGRMC1 Gene

Tissue specificity: Widely expressed, with highest expression in liver and kidney
genes like me logo Genes that share expression patterns with PGRMC1: view

Protein tissue co-expression partners for PGRMC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PGRMC1 Gene

Orthologs for PGRMC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGRMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGRMC1 35
  • 92.78 (n)
  • 95.36 (a)
  • 96 (a)
(Canis familiaris)
Mammalia PGRMC1 35
  • 95.38 (n)
  • 94.87 (a)
  • 95 (a)
(Mus musculus)
Mammalia Pgrmc1 35
  • 91.79 (n)
  • 95.38 (a)
Pgrmc1 16
Pgrmc1 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Pgrmc1 35
  • 87.7 (n)
  • 87.7 (a)
(Monodelphis domestica)
Mammalia PGRMC1 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia PGRMC1 36
  • 88 (a)
(Pan troglodytes)
Mammalia PGRMC1 36
  • 99 (a)
(Gallus gallus)
Aves PGRMC1 35
  • 75.39 (n)
  • 72.25 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia PGRMC1 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgrmc1 35
  • 69.41 (n)
  • 76.47 (a)
Str.1525 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5375 35
(Danio rerio)
Actinopterygii Dr.26789 35
pgrmc1 35
  • 65.48 (n)
  • 71.01 (a)
pgrmc1 36
  • 70 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.28 35
fruit fly
(Drosophila melanogaster)
Insecta CG9066 37
  • 54 (a)
  • 54.41 (n)
  • 55.75 (a)
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000767 35
  • 62.71 (n)
  • 58.12 (a)
(Caenorhabditis elegans)
Secernentea vem-1 35
  • 51.24 (n)
  • 43.28 (a)
vem-1 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL106W 35
  • 52.71 (n)
  • 47.01 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09757g 35
  • 49.83 (n)
  • 44.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAP1 35
  • 48.39 (n)
  • 43.55 (a)
DAP1 36
  • 38 (a)
DAP1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07286 35
  • 54.34 (n)
  • 47.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dap1 35
  • 50.68 (n)
  • 47.15 (a)
Species with no ortholog for PGRMC1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGRMC1 Gene

Gene Tree for PGRMC1 (if available)
Gene Tree for PGRMC1 (if available)

Paralogs for PGRMC1 Gene

Paralogs for PGRMC1 Gene

(2) SIMAP similar genes for PGRMC1 Gene using alignment to 3 proteins: Pseudogenes for PGRMC1 Gene

genes like me logo Genes that share paralogs with PGRMC1: view

Variants for PGRMC1 Gene

Sequence variations from dbSNP and Humsavar for PGRMC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1051759 -- 119,244,221(+) TACCC(A/C)CTGCA utr-variant-3-prime
rs1063649 -- 119,244,328(+) TGAAC(A/C)CCTAG utr-variant-3-prime
rs2499040 -- 119,243,029(-) CTTCT(C/T)GAAGG intron-variant
rs2499041 -- 119,242,890(-) GTGTA(A/C)GGAAT intron-variant
rs2499042 -- 119,242,455(-) GGCAG(A/C)GTGCA intron-variant

Variation tolerance for PGRMC1 Gene

Residual Variation Intolerance Score: 71.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGRMC1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PGRMC1 Gene

Disorders for PGRMC1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for PGRMC1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
petrous apex meningioma
  • meningioma of the petrous ridge
cerebral falx meningioma
  • falcine meningioma
anterior cranial fossa meningioma
  • meningioma of the anterior fossa
eustachian tube disease
  • eustachian tube disorder
trachea adenoid cystic carcinoma
  • tracheal adenoid cystic carcinoma
- elite association

Relevant External Links for PGRMC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PGRMC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGRMC1 Gene

Publications for PGRMC1 Gene

  1. Cloning and tissue expression of two putative steroid membrane receptors. (PMID: 9705155) Gerdes D. … Falkenstein E. (Biol. Chem. 1998) 2 23 67
  2. Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression. (PMID: 20144686) Peluso J.J. … Wu C.A. (Mol. Cell. Endocrinol. 2010) 23 67
  3. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. (PMID: 20164297) Ahmed I.S. … Craven R.J. (J. Pharmacol. Exp. Ther. 2010) 23 67
  4. Non-genomic progesterone actions in female reproduction. (PMID: 18936037) Gellersen B. … Brosens J.J. (Hum. Reprod. Update 2009) 23 67
  5. PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. (PMID: 18992768) Rohe H.J. … Craven R.J. (Pharmacol. Ther. 2009) 23 67

Products for PGRMC1 Gene

Sources for PGRMC1 Gene

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