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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGRMC1 Gene

protein-coding   GIFtS: 63
GCID: GC0XP118370

progesterone receptor membrane component 1
 Explore 25 diseases affiliated with
PGRMC1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PGRMC1    

Aliases
for PGRMC1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Progesterone Receptor Membrane Component 11 2     Progesterone Binding Protein2
HPR6.61 2 3     PGRMC3
MPR2     MPR2
Membrane-Associated Progesterone Receptor Component 12     

External Ids:    HGNC: 160901   Entrez Gene: 108572   Ensembl: ENSG000001018567   OMIM: 3004355   UniProtKB: O002643   

Export aliases for PGRMC1 gene to outside databases

Previous GC identifers: GC0XP113188 GC0XP115355 GC0XP116345 GC0XP117124 GC0XP118152 GC0XP118254 GC0XP107864


Summaries
for PGRMC1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PGRMC1:
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly
in the liver and kidney. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
Function: Receptor for progesterone (By similarity)

Gene Wiki entry for PGRMC1


Genomic Views
for PGRMC1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGRMC1 gene promoter:
         C/EBPbeta   USF1   AP-1   ATF-2   HNF-4alpha2   HNF-4alpha1   HEN1   USF-1   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PGRMC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PGRMC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGRMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22-q24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq22-q24

PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGRMC1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP118370:  view genomic region     (about GC identifiers)

Start:
 118,370,211 bp from pter      End:
 118,378,429 bp from pter
Size:
 8,219 bases      Orientation:
 plus strand

Proteins
for PGRMC1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264 (See protein sequence)
Recommended Name: Membrane-associated progesterone receptor component 1  
Size: 195 amino acids; 21671 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum membrane;
Single-pass membrane protein (By similarity)
Secondary accessions: Q9UGJ9

Explore the universe of human proteins at neXtProt for PGRMC1: NX_O00264

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00264

    • PGRMC1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006658.1  
    ENSEMBL proteins: 
     ENSP00000217971   ENSP00000442821  

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    Novus Biologicals PGRMC1 Proteins
    Novus Biologicals PGRMC1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PGRMC1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005792microsome ----


    PGRMC1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PGRMC1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PGRMC1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001199 Cyt_B5-like_heme/steroid-bd

    Graphical View of Domain Structure for InterPro Entry O00264

    ProtoNet protein and cluster: O00264

    1 Blocks protein family: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Domain: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and 131
    (By similarity)
    Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    Function
    for PGRMC1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Function: Receptor for progesterone (By similarity)

    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PGRMC1 (see all 38):
    hsa-let-7d hsa-miR-4305 hsa-miR-200a hsa-miR-4275 hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: PGRMC1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for PGRMC1

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005496steroid binding IEA--
    GO:0005515protein binding IPI--
    GO:0020037heme binding IEA--


    PGRMC1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PGRMC1:
     Decreased Salmonella enterica  


    Pathways & Interactions
    for PGRMC1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PGRMC1
        Apoptosis and Autophagy
    Glucose / Energy Metabolism



    PGRMC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PGRMC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/44 Interacting proteins for PGRMC1 (O002641, 2, 3 ENSP000002179714) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLF1IPQ71F232, 3, ENSP000002814534MINT-8263225 I2D: score=2 STRING: ENSP00000281453
    PAM16Q9Y3D72, 3, ENSP000003156934MINT-8259423 I2D: score=2 STRING: ENSP00000315693
    ABCD3P282883, ENSP000003592334I2D: score=2 STRING: ENSP00000359233
    DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
    EFHD1Q9BUP03, ENSP000002640594I2D: score=2 STRING: ENSP00000264059
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance IEA--


    PGRMC1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PGRMC1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PGRMC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGRMC1

    3 HMDB Compounds for PGRMC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--
    Progesterone17a-Progesterone (see all 114)57-83-0--
    7 Novoseek chemical compound relationships for PGRMC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progestin 81.4 9 16452458 (1), 17082257 (1), 16959873 (1), 17157338 (1) (see all 9)
    progesterone 81.2 108 17583495 (3), 20164297 (3), 2113367 (3), 10579369 (2) (see all 49)
    progestins 73.2 2 15242342 (1), 17154304 (1)
    steroid 66.5 6 10579369 (1), 17583495 (1), 14735466 (1), 18992768 (1) (see all 6)
    estrogen 45.1 4 12030612 (1), 17932349 (1), 8905348 (1), 16763010 (1)
    testosterone 12.9 1 8905348 (1)
    calcium 0 1 10579369 (1)

    Search CenterWatch for drugs/clinical trials and news about PGRMC1 / PGRC1 

    Transcripts
    for PGRMC1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PGRMC1 gene: 
    NM_006667.3  

    Unigene Cluster for PGRMC1:

    Progesterone receptor membrane component 1
    Hs.90061  [show with all ESTs]
    Unigene Representative Sequence: NM_006667
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217971(uc004erb.3 uc011mts.2) ENST00000535419

    miRNA
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate PGRMC1 (see all 38):
    hsa-let-7d hsa-miR-4305 hsa-miR-200a hsa-miR-4275 hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmid: PGRMC1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PGRMC1 (see all 7)
    OriGene shRNA RFP: PGRMC1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGRMC1
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGRMC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGRMC1

    Additional cDNA sequence: 

    AK293618.1 AK313956.1 BC034238.1 CR456993.1 Y12711.2 

    11 DOTS entries:

    DT.99938179  DT.219641  DT.121280826  DT.100888111  DT.100888101  DT.95161851  DT.100888100  DT.121280828 
    DT.101970132  DT.95161849  DT.95161869 

    24/593 AceView cDNA sequences (see all 593):

    CR600631 AI868530 CA313543 BM903988 BQ717747 AA828843 BG695964 AL546846 
    AA970835 AI188490 BU153811 BM673142 BU190011 BE893549 AI289805 AI581161 
    CA395967 CR607904 AA040456 AL553437 AL535050 CR623275 CR604189 AA425689 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:                          -                           
    SP2:                    -     -                           
    SP3:                    -                                 


    ECgene alternative splicing isoforms for PGRMC1

    Expression
    for PGRMC1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGRMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACACCCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PGRMC1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PGRMC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGRMC1

    SOURCE GeneReport for Unigene cluster: Hs.90061

    UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Tissue specificity: Widely expressed, with highest expression in liver and kidney

        SABiosciences Custom PCR Arrays for PGRMC1
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for PGRMC1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PGRMC1 gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PGRMC11 progesterone receptor membrane component 1 75.22(n)
    72.25(a)    		   772196  XM_001234321.2  XP_001234322.2 
    lizard
    (Anolis carolinensis)    		 Reptilia PGRMC16
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL344275.1(498-2561)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.53752 Xenopus laevis transcribed sequence with weak similarity more 75.15(n)    BU901285.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.267892 Transcribed sequence with weak similarity to protein more 72.46(n)    57042095 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG90663
    MSBP1    		 membrane steroid binding protein1 54(a)3
    54.41(n)1
    55.75(a)1    		   13F173
    325481  NM_132859.31  NP_573087.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea vem-11 Protein VEM-1 51.58(n)
    43.07(a)    		   181066  NM_001029598.1  NP_001024769.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DAP1(YPL170W)4
    DAP11    		 Heme-binding protein involved in regulation of cytochrome more4
    Dap1p1    		 51.63(n)1
    49.02(a)1    		   16(228314-228772)4
    8559331, 4  NP_015155.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MAPR31 membrane steroid-binding protein 2 49.17(n)
    38.75(a)    		   824050  NM_114748.2  NP_190458.1 
    rice
    (Oryza sativa)    		 Liliopsida Os10g05026001 hypothetical protein 56.61(n)
    44.44(a)    		   4349046  NM_001071528.1  NP_001064993.1 


    ENSEMBL Gene Tree for PGRMC1 (if available)
    TreeFam Gene Tree for PGRMC1 (if available) 

    Paralogs
    for PGRMC1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGRMC1 gene
    PGRMC22  CYB5D22  NENF2  
    2 SIMAP similar genes for PGRMC1 using alignment to 3 protein entries:     PGRC1_HUMAN (see all proteins):
    PGRMC2    NENF

    PGRMC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PGRMC1
    PGOHUM00000237030


    Genomic Variants
    for PGRMC1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/131 NCBI SNPs in PGRMC1 are shown (see all 131)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs412948741,2
    		C,F,--107862228(+) GACTAG/AAATCT 1 -- us2k15Minor allele frequency- A:0.01NS 344
    rs412948781,2
    		C,F,--107862825(+) TGGAGG/ATCTGC 1 -- us2k15Minor allele frequency- A:0.01NS 332
    rs412948801,2
    		C,--107862826(+) GGAGGT/CCTGCT 1 -- us2k15Minor allele frequency- C:0.00NS 336
    rs412948841,2
    		C,F,--107863053(+) ACGTTG/TCTTGT 1 -- us2k16Minor allele frequency- T:0.09NS CSA 351
    rs735995521,2
    		C,--107863335(+) TAAGAC/AAGCTT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs412948881,2
    		F--107864637(+) GCGGGTAGGC   
       GGG    /-    CAGGC     		1 -- int15Minor allele frequency- -:0.00NS 362
    rs412948901,2
    		C,F--107864639(+) CGGGCAG/-GCGGA 1 -- int16Minor allele frequency- -:0.12NS CSA 362
    rs24990451,2
    		C,--107866074(-) GAGACC/AAGCCT 1 -- int12Minor allele frequency- A:0.25NA WA 4
    rs24990441,2
    		--107866151(-) ccggtA/Gcagtg 1 -- int10--------
    rs558159421,2
    		C,--107867450(+) TTTTAA/GTATTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for PGRMC1 (118370211 - 118378429 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PGRMC1
         3 CNVs: 83704 96922 96921
    Human Gene Mutation Database (HGMD): PGRMC1

    Locus Specific Mutation Databases (LSDB): PGRMC1

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for PGRMC1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PGRMC1 for disorders           About GeneDecksing

    OMIM gene information: 300435    OMIM disorders: --

    20/25 diseases for PGRMC1 (see all 25):    About MalaCards
    patulous eustachian tube    discrete subaortic stenosis    trigeminal neuralgia    sphenoid sinusitis
    abdominal aortic aneurysm    tracheal stenosis    premature ovarian failure    carotid stenosis
    placental choriocarcinoma    polycystic ovary syndrome    spondylolysis    parotitis
    spondylolisthesis    aortic aneurysm    choriocarcinoma    breast cancer
    sinusitis    hepatocellular carcinoma    ovarian cancer    prostate cancer

    8 diseases from the University of Copenhagen DISEASES database for PGRMC1:
    Patulous eustachian tube     Carotid stenosis     Parotitis     Tracheal stenosis
    Trigeminal neuralgia     Cancer     Discrete subaortic stenosis     Spondylolisthesis

    4 Novoseek disease relationships for PGRMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 42.8 8 14523988 (3), 20164297 (2), 17157338 (1), 19340614 (1)
    tumors 16 8 19797399 (2), 1868457 (1), 20164297 (1), 19090968 (1) (see all 6)
    cancer 11.3 1 20164297 (1)
    cysts 0 2 2113367 (1), 2244881 (1)

    Human Genome Epidemiology (HuGE) Navigator: PGRMC1 (4 documents)

    Export disorders for PGRMC1 gene to outside databases

    Publications
    for PGRMC1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGRMC1 gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with PGRMC1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue expression of two putative steroid membrane receptors. (PubMed id 9705155)1, 2, 3, 9 Gerdes D.... Falkenstein E. (1998)
    2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PubMed id 11697142)1, 2, 9 Bernauer S.... Falkenstein E. (2001)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. (PubMed id 20164297)1, 9 Ahmed I.S....Craven R.J. (2010)
    6. Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells. (PubMed id 14523988)1, 9 Hand R.A. and Craven R.J. (2003)
    7. Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. (PubMed id 18440126)1, 9 Zhang L....Pru J.K. (2008)
    8. Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nu de mice. (PubMed id 19797399)1, 9 Peluso J.J....Pru J.K. (2009)
    9. Progesterone activates a progesterone receptor membra ne component 1-dependent mechanism that promotes human granulosa/luteal cell su rvival but not progesterone secretion. (PubMed id 19417032)1, 9 Peluso J.J....Johnston-MacAnanny E. (2009)
    10. Alterations in the expression, structure and function of progesterone receptor membrane component-1 (PGRMC1) in premature ovarian failure. (PubMed id 18782852)1, 9 Mansouri M.R....Dahl N. (2008)

    External Searches for PGRMC1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PGRMC1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10857 HGNC: 16090 AceView: PGRMC1 Ensembl:ENSG00000101856 euGenes: HUgn10857
    ECgene: PGRMC1 H-InvDB: PGRMC1

    Other Databases showing PGRMC1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PGRMC1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGRMC1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PGRMC1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PGRMC1 gene:
    Search GeneIP for patents involving PGRMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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