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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGRMC1 Gene

protein-coding   GIFtS: 64
GCID: GC0XP118370

Progesterone Receptor Membrane Component 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Progesterone Receptor Membrane Component 11 2     Progesterone Binding Protein2
HPR6.62 3     PGRMC3
MPR2     mPR3
Membrane-Associated Progesterone Receptor Component 12     

External Ids:    HGNC: 160901   Entrez Gene: 108572   Ensembl: ENSG000001018567   OMIM: 3004355   UniProtKB: O002643   

Export aliases for PGRMC1 gene to outside databases

Previous GC identifers: GC0XP113188 GC0XP115355 GC0XP116345 GC0XP117124 GC0XP118152 GC0XP118254 GC0XP107864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGRMC1 Gene:
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed
predominantly in the liver and kidney. (provided by RefSeq, Mar 2010)

GeneCards Summary for PGRMC1 Gene: 
PGRMC1 (progesterone receptor membrane component 1) is a protein-coding gene. Diseases associated with PGRMC1 include placental choriocarcinoma, and sphenoid sinusitis. GO annotations related to this gene include steroid binding and heme binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
Function: Receptor for progesterone (By similarity)

Gene Wiki entry for PGRMC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGRMC1 gene promoter:
         C/EBPbeta   USF1   AP-1   ATF-2   HNF-4alpha2   HNF-4alpha1   HEN1   USF-1   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGRMC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PGRMC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGRMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22-q24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq22-q24

PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGRMC1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP118370:  view genomic region     (about GC identifiers)

Start:
118,370,211 bp from pter      End:
118,378,429 bp from pter
Size:
8,219 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264 (See protein sequence)
Recommended Name: Membrane-associated progesterone receptor component 1  
Size: 195 amino acids; 21671 Da
Subcellular location: Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum
membrane; Single-pass membrane protein (By similarity)
Secondary accessions: Q9UGJ9

Explore the universe of human proteins at neXtProt for PGRMC1: NX_O00264

Explore proteomics data for PGRMC1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00264

  • PGRMC1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGRMC1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001269550.1  NP_006658.1  

    ENSEMBL proteins: 
     ENSP00000217971   ENSP00000442821  

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    Cloud-Clone Corp. Proteins for PGRMC1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0009986cell surface IDA12493773

    PGRMC1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001199 Cyt_B5-like_heme/steroid-bd

    Graphical View of Domain Structure for InterPro Entry O00264

    ProtoNet protein and cluster: O00264

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Domain: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and
    131 (By similarity)
    Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    PGRMC1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGRC1_HUMAN, O00264
    Function: Receptor for progesterone (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005496steroid binding IEA--
    GO:0005515protein binding IPI--
    GO:0020037heme binding IEA--
         
    PGRMC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PGRMC1:
     Decreased Salmonella enterica  

    Animal Models:
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    hsa-let-7d hsa-miR-4305 hsa-miR-200a hsa-miR-4275 hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPGRMC1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGRMC1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptosis and Autophagy
    Apoptosis and Autophagy
    2Glucose / Energy Metabolism
    Glucose / Energy Metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PGRMC1
        Apoptosis and Autophagy
    Glucose / Energy Metabolism




    PGRMC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PGRMC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/43 Interacting proteins for PGRMC1 (O002641, 2, 3 ENSP000002179714) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLF1IPQ71F232, 3, ENSP000002814534MINT-8263225 I2D: score=2 STRING: ENSP00000281453
    PAM16Q9Y3D72, 3, ENSP000003156934MINT-8259423 I2D: score=2 STRING: ENSP00000315693
    ABCD3P282883, ENSP000003592334I2D: score=2 STRING: ENSP00000359233
    DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
    EFHD1Q9BUP03, ENSP000002640594I2D: score=2 STRING: ENSP00000264059
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance IEA--

    PGRMC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PGRMC1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGRMC1 (PGRC1)

    3 HMDB Compounds for PGRMC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--
    Progesterone17a-Progesterone (see all 114)57-83-0--

    7 Novoseek inferred chemical compound relationships for PGRMC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progestin 81.4 9 16452458 (1), 17082257 (1), 16959873 (1), 17157338 (1) (see all 9)
    progesterone 81.2 108 17583495 (3), 20164297 (3), 2113367 (3), 10579369 (2) (see all 49)
    progestins 73.2 2 15242342 (1), 17154304 (1)
    steroid 66.5 6 10579369 (1), 17583495 (1), 14735466 (1), 18992768 (1) (see all 6)
    estrogen 45.1 4 12030612 (1), 17932349 (1), 8905348 (1), 16763010 (1)
    testosterone 12.9 1 8905348 (1)
    calcium 0 1 10579369 (1)

    Search CenterWatch for drugs/clinical trials and news about PGRMC1 / PGRC1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGRMC1 gene (2 alternative transcripts): 
    NM_001282621.1  NM_006667.4  

    Unigene Cluster for PGRMC1:

    Progesterone receptor membrane component 1
    Hs.90061  [show with all ESTs]
    Unigene Representative Sequence: NM_006667
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217971(uc004erb.3 uc011mts.2) ENST00000535419
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGRMC1
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    Additional mRNA sequence: 

    AK293618.1 AK313956.1 BC034238.1 CR456993.1 Y12711.2 

    11 DOTS entries:

    DT.99938179  DT.219641  DT.121280826  DT.100888111  DT.100888101  DT.95161851  DT.121280828  DT.100888100 
    DT.101970132  DT.95161849  DT.95161869 

    24/593 AceView cDNA sequences (see all 593):

    CR600631 AI868530 BQ717747 BM903988 AA828843 CA313543 AL546846 BG695964 
    AA970835 AI188490 BU153811 BM673142 BU190011 AI581161 BE893549 AI289805 
    CA395967 CR607904 AA040456 AL553437 AL535050 CR604189 CR623275 AA425689 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:                          -                           
    SP2:                    -     -                           
    SP3:                    -                                 


    ECgene alternative splicing isoforms for PGRMC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGRMC1 expression in normal human tissues (normalized intensities)      PGRMC1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACCCCTG
    PGRMC1 Expression
    About this image


    PGRMC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Substantia Nigra   
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Dorsal Horn   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             PERIPHERAL NERVOUS SYSTEM   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose   

    See PGRMC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGRMC1

    SOURCE GeneReport for Unigene cluster: Hs.90061

    UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Tissue specificity: Widely expressed, with highest expression in liver and kidney

        SABiosciences Custom PCR Arrays for PGRMC1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGRMC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PGRMC1 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgrmc11 , 5 progesterone receptor membrane component 11, 5 91.79(n)1
    95.38(a)1
      X (21.00 cM)5
    533281  NM_016783.31  NP_058063.21 
     365982065 
    chicken
    (Gallus gallus)
    Aves PGRMC11 progesterone receptor membrane component 1 75.22(n)
    72.25(a)
      772196  XM_001234321.2  XP_001234322.2 
    lizard
    (Anolis carolinensis)
    Reptilia PGRMC16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL344275.1(498-2561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53752 Xenopus laevis transcribed sequence with weak similarity more 75.15(n)    BU901285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.267892 Transcribed sequence with weak similarity to protein more 72.46(n)    57042095 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90663
    MSBP1
    membrane steroid binding protein1 54(a)3
    54.41(n)1
    55.75(a)1
      13F173
    325481  NM_132859.31  NP_573087.11 
    worm
    (Caenorhabditis elegans)
    Secernentea vem-11 Protein VEM-1 51.58(n)
    43.07(a)
      181066  NM_001029598.1  NP_001024769.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAP1(YPL170W)4
    DAP11
    Heme-binding protein involved in regulation of cytochrome more4
    Dap1p1
    51.63(n)1
    49.02(a)1
      16(228314-228772)4
    8559331, 4  NP_015155.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MAPR31 membrane steroid-binding protein 2 49.17(n)
    38.75(a)
      824050  NM_114748.2  NP_190458.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g05026001 hypothetical protein 56.61(n)
    44.44(a)
      4349046  NM_001071528.1  NP_001064993.1 


    ENSEMBL Gene Tree for PGRMC1 (if available)
    TreeFam Gene Tree for PGRMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGRMC1 gene
    PGRMC22  
    2 SIMAP similar genes for PGRMC1 using alignment to 3 protein entries:     PGRC1_HUMAN (see all proteins):
    PGRMC2    NENF

    PGRMC1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PGRMC1
    PGOHUM00000237030


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/152 SNPs in PGRMC1 are shown (see all 152)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs412948881,2
    F--107864630(+) GCGGGTAGGC   
       GGG
    /-
    CAGGC
    1 -- int15Minor allele frequency- -:0.00NS 362
    rs412948901,2
    C,F--107864639(+) CGGGCAG/-GCGGA 1 -- int16Minor allele frequency- -:0.12NS CSA 362
    rs1904915781,2
    --118363601(+) AATTAA/GTTCGC 1 -- us2k10--------
    rs1381697201,2
    --118363702(+) GTCTGC/TGTTTC 1 -- us2k10--------
    rs1830312031,2
    --118363703(+) TCTGCA/GTTTCT 1 -- us2k10--------
    rs1869562141,2
    --118363857(+) CAATAA/GTGTGT 1 -- us2k10--------
    rs412948741,2
    C,F--118364038(+) GACTAG/AAATCT 1 -- us2k15Minor allele frequency- A:0.01NS 344
    rs412948761,2
    C,F--118364138(+) ATTAGC/TTTTCT 1 -- us2k18Minor allele frequency- T:0.14NS NA CSA 371
    rs1917941971,2
    --118364581(+) TCCCCC/GCGCCA 1 -- us2k10--------
    rs412948781,2
    C,F--118364635(+) TGGAGG/ATCTGC 1 -- us2k15Minor allele frequency- A:0.01NS 332

    HapMap Linkage Disequilibrium report for PGRMC1 (118370211 - 118378429 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PGRMC1: --

    Human Gene Mutation Database (HGMD): PGRMC1

    Locus Specific Mutation Databases (LSDB): PGRMC1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PGRMC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PGRMC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300435    OMIM disorders: --

    20/25 diseases for PGRMC1 (see all 25):    About MalaCards
    placental choriocarcinoma    sphenoid sinusitis    discrete subaortic stenosis    patulous eustachian tube
    spondylolysis    trigeminal neuralgia    tracheal stenosis    parotitis
    spondylolisthesis    carotid stenosis    premature ovarian failure    choriocarcinoma
    sinusitis    abdominal aortic aneurysm    aortic aneurysm    polycystic ovary syndrome
    cytochrome p450    breast cancer    retinitis    ovarian cancer

    8 diseases from the University of Copenhagen DISEASES database for PGRMC1:
    Patulous eustachian tube     Discrete subaortic stenosis     Carotid stenosis     Tracheal stenosis
    Trigeminal neuralgia     Parotitis     Cancer     Spondylolisthesis

    PGRMC1 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PGRMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 42.8 8 14523988 (3), 20164297 (2), 17157338 (1), 19340614 (1)
    tumors 16 8 19797399 (2), 1868457 (1), 20164297 (1), 19090968 (1) (see all 6)
    cancer 11.3 1 20164297 (1)
    cysts 0 2 2113367 (1), 2244881 (1)

    Genetic Association Database (GAD): PGRMC1
    Human Genome Epidemiology (HuGE) Navigator: PGRMC1 (4 documents)

    Export disorders for PGRMC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGRMC1 gene, integrated from 9 sources (see all 120):
    (articles sorted by number of sources associating them with PGRMC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue expression of two putative steroid membrane receptors. (PubMed id 9705155)1, 2, 3, 9 Gerdes D.... Falkenstein E. (1998)
    2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PubMed id 11697142)1, 2, 9 Bernauer S.... Falkenstein E. (2001)
    3. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (2010)
    4. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    5. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    6. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. (PubMed id 20164297)1, 9 Ahmed I.S....Craven R.J. (2010)
    10. Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells. (PubMed id 14523988)1, 9 Hand R.A. and Craven R.J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10857 HGNC: 16090 AceView: PGRMC1 Ensembl:ENSG00000101856 euGenes: HUgn10857
    ECgene: PGRMC1 H-InvDB: PGRMC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGRMC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGRMC1 gene:
    Search GeneIP for patents involving PGRMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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