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PGRMC1 Gene

protein-coding   GIFtS: 64
GCID: GC0XP118370

Progesterone Receptor Membrane Component 1

  See PGRMC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Progesterone Receptor Membrane Component 11 2     Progesterone Binding Protein2
HPR6.62 3     PGRMC3
MPR2     mPR3
Membrane-Associated Progesterone Receptor Component 12     

External Ids:    HGNC: 160901   Entrez Gene: 108572   Ensembl: ENSG000001018567   OMIM: 3004355   UniProtKB: O002643   

Export aliases for PGRMC1 gene to outside databases

Previous GC identifers: GC0XP113188 GC0XP115355 GC0XP116345 GC0XP117124 GC0XP118152 GC0XP118254 GC0XP107864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PGRMC1 Gene:
This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed
predominantly in the liver and kidney. (provided by RefSeq, Mar 2010)

GeneCards Summary for PGRMC1 Gene:
PGRMC1 (progesterone receptor membrane component 1) is a protein-coding gene. Diseases associated with PGRMC1 include patulous eustachian tube, and discrete subaortic stenosis. GO annotations related to this gene include steroid binding and heme binding. An important paralog of this gene is PGRMC2.

UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
Function: Receptor for progesterone (By similarity)

Gene Wiki entry for PGRMC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PGRMC1 gene promoter:
         C/EBPbeta   USF1   AP-1   ATF-2   HNF-4alpha2   HNF-4alpha1   HEN1   USF-1   c-Myb   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGRMC1 promoter sequence
   Search Chromatin IP Primers for PGRMC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PGRMC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22-q24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq22-q24

PGRMC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGRMC1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP118370:  view genomic region     (about GC identifiers)

Start:
118,370,211 bp from pter      End:
118,378,429 bp from pter
Size:
8,219 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264 (See protein sequence)
Recommended Name: Membrane-associated progesterone receptor component 1  
Size: 195 amino acids; 21671 Da
Secondary accessions: Q9UGJ9

Explore the universe of human proteins at neXtProt for PGRMC1: NX_O00264

Explore proteomics data for PGRMC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys96, Lys102, Lys105, Lys132
  • Modification sites at PhosphoSitePlus

  • See PGRMC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269550.1  NP_006658.1  

    ENSEMBL proteins: 
     ENSP00000217971   ENSP00000442821  

    PGRMC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for PGRMC1

     
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    antibodies-online proteins for PGRMC1 (9 products) 

     
    antibodies-online peptides for PGRMC1

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    antibodies-online antibodies for PGRMC1 (14 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001199 Cyt_B5-like_heme/steroid-bd

    Graphical View of Domain Structure for InterPro Entry O00264

    ProtoNet protein and cluster: O00264

    1 Blocks protein domain: IPB001199 Cytochrome b5

    UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Domain: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 107 and
    131 (By similarity)
    Similarity: Belongs to the cytochrome b5 family. MAPR subfamily
    Similarity: Contains 1 cytochrome b5 heme-binding domain


    Find genes that share domains with PGRMC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGRC1_HUMAN, O00264
    Function: Receptor for progesterone (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005496steroid binding IEA--
    GO:0005515protein binding IPI--
    GO:0020037heme binding IEA--
         
    Find genes that share ontologies with PGRMC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PGRMC1:
     Decreased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PGRMC1

    miRNA
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    miRTarBase miRNAs that target PGRMC1:
    hsa-mir-130b-3p (MIRT044164), hsa-mir-98-5p (MIRT027601), hsa-let-7b-5p (MIRT001609), hsa-mir-25-3p (MIRT050203), hsa-mir-455-3p (MIRT037888)

    Block miRNA regulation of human, mouse, rat PGRMC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PGRMC1 (see all 38):
    hsa-let-7d hsa-miR-4305 hsa-miR-200a hsa-miR-4275 hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPGRMC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PGRMC1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGRMC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGRC1_HUMAN, O00264: Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum
    membrane; Single-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    endosome2
    golgi apparatus2
    lysosome2
    plasma membrane2
    vacuole2
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PGRMC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PGRMC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    2Apoptosis and Autophagy
    Apoptosis and Autophagy


    Find genes that share SuperPaths with PGRMC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PGRMC1
        Apoptosis and Autophagy
    Glucose / Energy Metabolism



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PGRMC1
    Interactions:

        GeneGlobe Interaction Network for PGRMC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PGRMC1 (O002641, 2, 3 ENSP000002179714) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPUQ71F232, 3, ENSP000002814534MINT-8263225 I2D: score=2 STRING: ENSP00000281453
    PAM16Q9Y3D72, 3, ENSP000003156934MINT-8259423 I2D: score=2 STRING: ENSP00000315693
    ABCD3P282883, ENSP000003592334I2D: score=2 STRING: ENSP00000359233
    DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
    EFHD1Q9BUP03, ENSP000002640594I2D: score=2 STRING: ENSP00000264059
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance IEA--

    Find genes that share ontologies with PGRMC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PGRMC1 (PGRC1)

    3 HMDB Compounds for PGRMC1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    IronArmco iron (see all 19)7439-89-6--
    Progesterone17a-Progesterone (see all 114)57-83-0--

    7 Novoseek inferred chemical compound relationships for PGRMC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progestin 81.4 9 16452458 (1), 17082257 (1), 16959873 (1), 17157338 (1) (see all 9)
    progesterone 81.2 108 17583495 (3), 20164297 (3), 2113367 (3), 10579369 (2) (see all 49)
    progestins 73.2 2 15242342 (1), 17154304 (1)
    steroid 66.5 6 10579369 (1), 17583495 (1), 14735466 (1), 18992768 (1) (see all 6)
    estrogen 45.1 4 12030612 (1), 17932349 (1), 8905348 (1), 16763010 (1)
    testosterone 12.9 1 8905348 (1)
    calcium 0 1 10579369 (1)



    Find genes that share compounds with PGRMC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PGRMC1 gene (2 alternative transcripts): 
    NM_001282621.1  NM_006667.4  

    Unigene Cluster for PGRMC1:

    Progesterone receptor membrane component 1
    Hs.90061  [show with all ESTs]
    Unigene Representative Sequence: NM_006667
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217971(uc004erb.3 uc011mts.2) ENST00000535419
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PGRMC1 (see all 38):
    hsa-let-7d hsa-miR-4305 hsa-miR-200a hsa-miR-4275 hsa-miR-141 hsa-let-7g hsa-let-7a hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidPGRMC1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PGRMC1
      QuantiFast Probe-based Assays in human, mouse, rat PGRMC1

    Additional mRNA sequence: 

    AK293618.1 AK313956.1 BC034238.1 CR456993.1 Y12711.2 

    11 DOTS entries:

    DT.99938179  DT.219641  DT.121280826  DT.100888111  DT.100888101  DT.95161851  DT.121280828  DT.100888100 
    DT.101970132  DT.95161849  DT.95161869 

    Selected AceView cDNA sequences (see all 593):

    CR600631 AI868530 BQ717747 BM903988 AA828843 CA313543 AL546846 BG695964 
    AA970835 AI188490 BU153811 BM673142 BU190011 AI581161 BE893549 AI289805 
    CA395967 CR607904 AA040456 AL553437 AL535050 CR604189 CR623275 AA425689 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for PGRMC1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
    SP1:                          -                           
    SP2:                    -     -                           
    SP3:                    -                                 


    ECgene alternative splicing isoforms for PGRMC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PGRMC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACCCCTG
    PGRMC1 Expression
    About this image


    PGRMC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Lung (Respiratory System)
             Trachea
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    PGRMC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PGRMC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.90061

    UniProtKB/Swiss-Prot: PGRC1_HUMAN, O00264
    Tissue specificity: Widely expressed, with highest expression in liver and kidney

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    QuantiFast Probe-based Assays in human, mouse, rat PGRMC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGRMC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PGRMC1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgrmc11 , 5 progesterone receptor membrane component 11, 5 91.79(n)1
    95.38(a)1
      X (21.00 cM)5
    533281  NM_016783.31  NP_058063.21 
     365982065 
    chicken
    (Gallus gallus)
    Aves PGRMC11 progesterone receptor membrane component 1 75.39(n)
    72.25(a)
      772196  NM_001271939.1  NP_001258868.1 
    lizard
    (Anolis carolinensis)
    Reptilia PGRMC16
    progesterone receptor membrane component 1
    83(a)
    1 ↔ 1
    GL344275.1(498-2561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.53752 Xenopus laevis transcribed sequence with weak similarity more 75.15(n)    BU901285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.267892 Transcribed sequence with weak similarity to protein more 72.46(n)    57042095 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG90663
    MSBP1
    membrane steroid binding protein1 54(a)3
    54.41(n)1
    55.75(a)1
      13F173
    325481  NM_001169294.11  NP_001162765.11 
    worm
    (Caenorhabditis elegans)
    Secernentea vem-11 vem-1 51.24(n)
    43.28(a)
      181066  NM_001029598.2  NP_001024769.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAP1(YPL170W)4
    DAP11
    Heme-binding protein involved in regulation of cytochrome more4
    DAP11
    48.39(n)1
    43.55(a)1
      16(228314-228772)4
    8559331, 4  NP_015155.11, 4 


    ENSEMBL Gene Tree for PGRMC1 (if available)
    TreeFam Gene Tree for PGRMC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PGRMC1 gene
    PGRMC22  
    2 SIMAP similar genes for PGRMC1 using alignment to 3 protein entries:     PGRC1_HUMAN (see all proteins):
    PGRMC2    NENF

    Find genes that share paralogs with PGRMC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PGRMC1
    PGOHUM00000237030


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PGRMC1 (see all 152)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs412948881,2
    F--107864630(+) GCGGGTAGGC   
       GGG
    /-
    CAGGC
    1 -- int15Minor allele frequency- -:0.00NS 362
    rs412948901,2
    C,F--107864639(+) CGGGCAG/-GCGGA 1 -- int16Minor allele frequency- -:0.12NS CSA 362
    rs1904915781,2
    --118363601(+) AATTAA/GTTCGC 1 -- us2k10--------
    rs1381697201,2
    --118363702(+) GTCTGC/TGTTTC 1 -- us2k10--------
    rs1830312031,2
    --118363703(+) TCTGCA/GTTTCT 1 -- us2k10--------
    rs1869562141,2
    --118363857(+) CAATAA/GTGTGT 1 -- us2k10--------
    rs412948741,2
    C,F--118364038(+) GACTAG/AAATCT 1 -- us2k15Minor allele frequency- A:0.01NS 344
    rs412948761,2
    C,F--118364138(+) ATTAGC/TTTTCT 1 -- us2k18Minor allele frequency- T:0.14NS NA CSA 371
    rs1917941971,2
    --118364581(+) TCCCCC/GCGCCA 1 -- us2k10--------
    rs412948781,2
    C,F--118364635(+) TGGAGG/ATCTGC 1 -- us2k15Minor allele frequency- A:0.01NS 332

    HapMap Linkage Disequilibrium report for PGRMC1 (118370211 - 118378429 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PGRMC1: --
    Human Gene Mutation Database (HGMD): PGRMC1
    Locus Specific Mutation Databases (LSDB): PGRMC1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PGRMC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PGRMC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300435    OMIM disorders: --

    7 diseases for PGRMC1:    
    About MalaCards
    patulous eustachian tube    discrete subaortic stenosis    placental choriocarcinoma    parotitis
    tracheal stenosis    trigeminal neuralgia    spondylolisthesis

    8 diseases from the University of Copenhagen DISEASES database for PGRMC1:
    Patulous eustachian tube     Discrete subaortic stenosis     Carotid stenosis     Tracheal stenosis
    Trigeminal neuralgia     Parotitis     Cancer     Spondylolisthesis

    Find genes that share disorders with PGRMC1           About GenesLikeMe

    4 Novoseek inferred disease relationships for PGRMC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 42.8 8 14523988 (3), 20164297 (2), 17157338 (1), 19340614 (1)
    tumors 16 8 19797399 (2), 1868457 (1), 20164297 (1), 19090968 (1) (see all 6)
    cancer 11.3 1 20164297 (1)
    cysts 0 2 2113367 (1), 2244881 (1)

    Genetic Association Database (GAD): PGRMC1
    Human Genome Epidemiology (HuGE) Navigator: PGRMC1 (4 documents)

    Export disorders for PGRMC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PGRMC1 gene, integrated from 10 sources (see all 121):
    (articles sorted by number of sources associating them with PGRMC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue expression of two putative steroid membrane receptors. (PubMed id 9705155)1, 2, 3, 9 Gerdes D.... Falkenstein E. (Biol. Chem. 1998)
    2. The human membrane progesterone receptor gene: genomic structure and promoter analysis. (PubMed id 11697142)1, 2, 9 Bernauer S.... Falkenstein E. (DNA Seq. 2001)
    3. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    4. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    5. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    6. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule. (PubMed id 20164297)1, 9 Ahmed I.S....Craven R.J. (J. Pharmacol. Exp. Ther. 2010)
    10. Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells. (PubMed id 14523988)1, 9 Hand R.A. and Craven R.J. (J. Cell. Biochem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10857 HGNC: 16090 AceView: PGRMC1 Ensembl:ENSG00000101856 euGenes: HUgn10857
    ECgene: PGRMC1 H-InvDB: PGRMC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PGRMC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PGRMC1 gene:
    Search GeneIP for patents involving PGRMC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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