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Aliases for PGR Gene

Aliases for PGR Gene

  • Progesterone Receptor 2 3
  • Nuclear Receptor Subfamily 3 Group C Member 3 3 4
  • NR3C3 3 4
  • PR 3 4

External Ids for PGR Gene

Summaries for PGR Gene

Entrez Gene Summary for PGR Gene

  • This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]

GeneCards Summary for PGR Gene

PGR (Progesterone Receptor) is a Protein Coding gene. Diseases associated with PGR include progesterone resistance and endometrial stromal nodule. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is AR.

UniProtKB/Swiss-Prot for PGR Gene

  • The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation

  • Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation

  • Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone

Tocris Summary for PGR Gene

  • Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition, progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

Gene Wiki entry for PGR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGR Gene

Genomics for PGR Gene

Genomic Location for PGR Gene

Start:
101,029,624 bp from pter
End:
101,130,524 bp from pter
Size:
100,901 bases
Orientation:
Minus strand

Genomic View for PGR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGR Gene

Regulatory Elements for PGR Gene

Proteins for PGR Gene

  • Protein details for PGR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06401-PRGR_HUMAN
    Recommended name:
    Progesterone receptor
    Protein Accession:
    P06401
    Secondary Accessions:
    • A7LQ08
    • A7X8B0
    • B4E3T0
    • Q8TDS3
    • Q9UPF7

    Protein attributes for PGR Gene

    Size:
    933 amino acids
    Molecular mass:
    98981 Da
    Quaternary structure:
    • Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2.

    Three dimensional structures from OCA and Proteopedia for PGR Gene

    Alternative splice isoforms for PGR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGR Gene

Proteomics data for PGR Gene at MOPED

Post-translational modifications for PGR Gene

  • Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.
  • Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.
  • Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.
  • Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PGR Gene

Domains for PGR Gene

Gene Families for PGR Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

Suggested Antigen Peptide Sequences for PGR Gene

Graphical View of Domain Structure for InterPro Entry

P06401

UniProtKB/Swiss-Prot:

PRGR_HUMAN
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain:
    • P06401
  • Contains 1 nuclear receptor DNA-binding domain.:
    • P06401
Family:
  • Belongs to the nuclear hormone receptor family. NR3 subfamily.:
    • P06401
genes like me logo Genes that share domains with PGR: view

Function for PGR Gene

Molecular function for PGR Gene

GENATLAS Biochemistry: progesterone receptor with two distinct forms PR-A (94kDa),PR-B (114kDa) transcribed from distinct promoters of PRG,with PR-A acting as a transcriptional repressor and PR-B as an activator,steroid/thyroid hormone receptor superfamily,required for normal mammary development in the puberty
UniProtKB/Swiss-Prot Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation
UniProtKB/Swiss-Prot Function: Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation
UniProtKB/Swiss-Prot Function: Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone

Gene Ontology (GO) - Molecular Function for PGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17785366
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 17785366
GO:0003677 DNA binding TAS 3551956
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with PGR: view
genes like me logo Genes that share phenotypes with PGR: view

Animal Models for PGR Gene

MGI Knock Outs for PGR:

miRNA for PGR Gene

miRTarBase miRNAs that target PGR
Targeting motifs for PGR Gene
HOMER Transcription Factor Regulatory Elements motif PGR
  • Consensus sequence: VAGRACAKNCTGTBC Submotif: canonical Cell Type: T47D GeoId: GSE31130

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for PGR Gene

Localization for PGR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGR Gene

Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.
Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear.
Isoform 4: Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PGR Gene COMPARTMENTS Subcellular localization image for PGR gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
extracellular 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with PGR: view

Pathways for PGR Gene

genes like me logo Genes that share pathways with PGR: view

Pathways by source for PGR Gene

Gene Ontology (GO) - Biological Process for PGR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001542 ovulation from ovarian follicle IEA --
GO:0002070 epithelial cell maturation IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with PGR: view

Compounds for PGR Gene

(3) Tocris Compounds for PGR Gene

Compound Action Cas Number
Levonorgestrel Synthetic progesterone analog [797-63-7]
Mifepristone Progesterone and glucocorticoid antagonist [84371-65-3]
Progesterone Endogenous progesterone receptor agonist [57-83-0]

(2) HMDB Compounds for PGR Gene

Compound Synonyms Cas Number PubMed IDs
Medroxyprogesterone
  • 17-Hydroxy-6a-methylprogesterone
520-85-4
Progesterone
  • 17a-Progesterone
57-83-0

(18) Drugbank Compounds for PGR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Allylestrenol
432-60-0 target agonist
Danazol
17230-88-5 target agonist
Desogestrel
54024-22-5 target agonist
Drospirenone
  • 6β,7β,15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17 carbolactone
67392-87-4 target agonist
Dydrogesterone
  • 10alpha-Isopregnenone
152-62-5 target agonist

(12) IUPHAR Ligand for PGR Gene

Ligand Type Action Affinity Pubmed IDs
mifepristone Antagonist Antagonist 9.4
progesterone Pore Blocker Inhibition 5.3
norethisterone Agonist Agonist
dydrogesterone Agonist Agonist
promegestone Agonist Agonist
asoprisnil Antagonist Antagonist
[3H]ORG2058 Agonist Agonist
onapristone Antagonist Antagonist
ORG2058 Agonist Agonist
levonorgestrel Agonist Agonist
ZK112993 Antagonist Antagonist
medroxyprogesterone Agonist Agonist

(120) Novoseek inferred chemical compound relationships for PGR Gene

Compound -log(P) Hits PubMed IDs
progesterone 98.9 576
estrogen 97.3 470
progestins 89.2 116
steroid 89 125
mifepristone 87 161

(2) PharmGKB related drug/compound annotations for PGR Gene

Drug/compound Annotation
anastrozole
letrozole
genes like me logo Genes that share compounds with PGR: view

Transcripts for PGR Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PGR Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6:
SP7: -

Relevant External Links for PGR Gene

GeneLoc Exon Structure for
PGR
ECgene alternative splicing isoforms for
PGR

Expression for PGR Gene

mRNA expression in normal human tissues for PGR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGR Gene

This gene is overexpressed in Uterus (10.5), Cervix - Endocervix (8.6), Cervix - Ectocervix (7.6), and Fallopian Tube (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGR Gene

SOURCE GeneReport for Unigene cluster for PGR Gene Hs.32405

genes like me logo Genes that share expressions with PGR: view

No data available for mRNA Expression by UniProt/SwissProt for PGR Gene

Orthologs for PGR Gene

This gene was present in the common ancestor of chordates.

Orthologs for PGR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGR 35
  • 99.57 (n)
  • 98.93 (a)
PGR 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PGR 35
  • 84.63 (n)
  • 81.23 (a)
PGR 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PGR 35
  • 81.73 (n)
  • 76.27 (a)
PGR 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pgr 35
  • 79.93 (n)
  • 80.65 (a)
Pgr 16
Pgr 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PGR 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PGR 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pgr 35
  • 80.01 (n)
  • 81.02 (a)
chicken
(Gallus gallus)
Aves PGR 35
  • 76.49 (n)
  • 77.44 (a)
PGR 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PGR 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia pgr-A 35
zebrafish
(Danio rerio)
Actinopterygii pgr 36
  • 48 (a)
OneToOne
Species with no ortholog for PGR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PGR Gene

ENSEMBL:
Gene Tree for PGR (if available)
TreeFam:
Gene Tree for PGR (if available)

Paralogs for PGR Gene

Paralogs for PGR Gene

Selected SIMAP similar genes for PGR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PGR: view

Variants for PGR Gene

Sequence variations from dbSNP and Humsavar for PGR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471305 -- 101,087,728(+) aacag(C/T)tgaac intron-variant
rs471715 -- 101,115,866(+) CATAG(C/T)CTATA intron-variant
rs471767 -- 101,034,566(+) AAACT(A/G)TTCTT utr-variant-3-prime, nc-transcript-variant
rs472290 -- 101,087,860(+) tatgc(A/C)aatca intron-variant
rs472800 -- 101,115,686(+) GAATC(A/G)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGR Gene

Variant ID Type Subtype PubMed ID
nsv826058 CNV Loss 20364138
esv272143 CNV Insertion 20981092
nsv826059 CNV Loss 20364138
nsv898328 CNV Loss 21882294

Relevant External Links for PGR Gene

HapMap Linkage Disequilibrium report
PGR
Human Gene Mutation Database (HGMD)
PGR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGR Gene

Disorders for PGR Gene

(1) OMIM Diseases for PGR Gene (607311)

(93) Novoseek inferred disease relationships for PGR Gene

Disease -log(P) Hits PubMed IDs
breast cancer 93.9 291
breast carcinoma 91.5 148
carcinoma ductal 88.3 76
tumors 85 285
endometrial carcinoma 85 156

Relevant External Links for PGR

Genetic Association Database (GAD)
PGR
Human Genome Epidemiology (HuGE) Navigator
PGR
Tumor Gene Database (TGDB):
PGR
genes like me logo Genes that share disorders with PGR: view

No data available for UniProtKB/Swiss-Prot for PGR Gene

Publications for PGR Gene

  1. No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer. (PMID: 11323389) Spurdle A.B. … Chenevix-Trench G. (Carcinogenesis 2001) 3 23 48
  2. Atomic structure of progesterone complexed with its receptor. (PMID: 9620806) Williams S.P. … Sigler P.B. (Nature 1998) 3 4 23
  3. Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives. (PMID: 11668223) Runnebaum I.B. … Narod S.A. (Pharmacogenetics 2001) 3 23 48
  4. Analysis of the human progesterone receptor gene polymorphism progins in Austrian ovarian carcinoma patients. (PMID: 11668524) Tong D. … Zeillinger R. (Int. J. Cancer 2001) 3 23 48
  5. PROGINS receptor gene polymorphism is associated with endometriosis. (PMID: 11821088) Wieser F. … Wenzl R. (Fertil. Steril. 2002) 3 23 48

Products for PGR Gene

  • Addgene plasmids for PGR

Sources for PGR Gene

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