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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGR Gene

protein-coding   GIFtS: 75
GCID: GC11M100943

Progesterone Receptor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Progesterone Receptor1 2
Nuclear Receptor Subfamily 3 Group C Member 32 3
NR3C32 3
PR2 3

External Ids:    HGNC: 89101   Entrez Gene: 52412   Ensembl: ENSG000000821757   OMIM: 6073115   UniProtKB: P064013   

Export aliases for PGR gene to outside databases

Previous GC identifers: GC11M103103 GC11M102266 GC11M100446 GC11M100414 GC11M096837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGR Gene:
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological
effects of progesterone, which plays a central role in reproductive events associated with the establishment and
maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to
produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in
the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.
(provided by RefSeq, Jan 2011)

GeneCards Summary for PGR Gene: 
PGR (progesterone receptor) is a protein-coding gene. Diseases associated with PGR include progesterone resistance, and glassy cell carcinoma of the cervix, and among its related super-pathways are Nuclear Receptors and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is ESRRB.

UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401
Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression
and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is
involved activation of c-SRC/MAPK signaling on hormone stimulation
Function: Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation
Function: Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by
progesterone

summary for PGR Gene:
Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes
mineralocorticoid, glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB
proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via
direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other
proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are
found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is
induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation,
mammary gland development and maintenance of pregnancy. In addition, progesterone, signaling through the
progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and
decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The
human gene encoding the progesterone receptor has been localized to 11q22.

Gene Wiki entry for PGR (Progesterone receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGR gene promoter:
         TBP   NF-1   Spz1   LUN-1   Meis-1b   PPAR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PGR promoter sequence
   Search SABiosciences Chromatin IP Primers for PGR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.1   HGNC cytogenetic band: 11q22-q23

PGR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGR gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M100943:  view genomic region     (about GC identifiers)

Start:
100,900,355 bp from pter      End:
101,001,255 bp from pter
Size:
100,901 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401 (See protein sequence)
Recommended Name: Progesterone receptor  
Size: 933 amino acids; 98981 Da
Subunit: Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination,
decreases sumoylation, and repesses transcriptional activity. Interacts with PIAS3; the interaction promotes
sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with
SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2
Subcellular location: Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent.
On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases
Subcellular location: Isoform A: Nucleus. Cytoplasm. Note=Mainly nuclear
Subcellular location: Isoform 4: Mitochondrion outer membrane
6/18 PDB 3D structures from and Proteopedia for PGR (see all 18):
1A28 (3D)        1E3K (3D)        1SQN (3D)        1SR7 (3D)        1ZUC (3D)        2C7A (3D)    
Secondary accessions: A7LQ08 A7X8B0 B4E3T0 Q9UPF7
Alternative splicing: 4 isoforms:  P06401-1   P06401-2   P06401-3   P06401-4   

Explore the universe of human proteins at neXtProt for PGR: NX_P06401

Explore proteomics data for PGR at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294
    occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on
    Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on
    Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro
    by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin,
    IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation
    and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the
    G(2)/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1
  • UniProtKB: Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is
    enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by
    ubiquitination on the same site, and modulated by phosphorylation at Ser-294
  • UniProtKB: Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated
    phosphorylation on Ser-294
  • UniProtKB: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid
    intracellular signaling via ERK and AKT kinases and cAMP generation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06401

  • PGR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGR Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000917.3  NP_001189403.1  NP_001258090.1  NP_001258091.1  

    ENSEMBL proteins: 
     ENSP00000325120   ENSP00000436561   ENSP00000432914   ENSP00000432352   ENSP00000436803  
     ENSP00000263463  
    Reactome Protein details: P06401
    Human Recombinant Protein Products for PGR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PGR
    OriGene Protein Over-expression Lysate for PGR
    OriGene MassSpec for PGR 
    OriGene Custom Protein Services for PGR
    GenScript Custom Purified and Recombinant Proteins Services for PGR
    Novus Biologicals PGR Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PGR
    Cloud-Clone Corp. Proteins for PGR 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005741mitochondrial outer membrane IEA--

    PGR for ontologies           About GeneDecksing



    PGR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PGR
    R&D Systems Antibodies for PGR (Progesterone R/NR3C3, Progesterone R B/NR3C3)
    Cell Signaling Technology (CST) Antibodies for PGR  (PR)
    OriGene Antibodies for PGR
    OriGene Custom Antibody Services for PGR
    GenScript Superior Antibodies for PGR
    Novus Biologicals PGR Antibodies
    Abcam antibodies for PGR
    Cloud-Clone Corp. Antibodies for PGR 
    ThermoFisher Antibody for PGR
    LSBio Antibodies in human, mouse, rat for PGR 

    Assay Products for PGR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PGR
    R&D Systems ELISAs for PGR (Progesterone R/NR3C3)
    GenScript Custom Assay Services for PGR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PGR 
    Cloud-Clone Corp. CLIAs for PGR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Progesterone receptor 
    3C. 3-Ketosteroid receptors

    5/6 InterPro protein domains (see all 6):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000128 Progest_rcpt
     IPR001723 Str_hrmn_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core

    Graphical View of Domain Structure for InterPro Entry P06401

    ProtoNet protein and cluster: P06401

    2 Blocks protein domains:
    IPB000128 Progesterone receptor signature
    IPB001723 Steroid hormone receptor signature


    UniProtKB/Swiss-Prot: PRGR_HUMAN, P06401
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR3 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    PGR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PRGR_HUMAN, P06401
    Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression
    and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is
    involved activation of c-SRC/MAPK signaling on hormone stimulation
    Function: Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation
    Function: Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by
    progesterone

         Genatlas biochemistry entry for PGR:
    progesterone receptor with two distinct forms PR-A (94kDa),PR-B (114kDa) transcribed from distinct promoters of
    PRG,with PR-A acting as a transcriptional repressor and PR-B as an activator,steroid/thyroid hormone receptor
    superfamily,required for normal mammary development in the puberty

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS3551956
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003707steroid hormone receptor activity IEA--
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0005102receptor binding IPI12771131
         
    PGR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PGR:
     Increased HPV18 LCR reporter a  Increased cell death HMECs cel 

         15/17 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Pgr) (see all 17):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  muscle  no phenotypic analysis  normal  reproductive system 

    PGR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PGR: Pgrtm2Omc Pgrtm1Omc Pgrtm1.2Mlia Pgrtm1Bwo Pgrtm4.2Lyd

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PGR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PGR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PGR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGR
    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate PGR (see all 71):
    hsa-miR-548j hsa-miR-607 hsa-miR-578 hsa-miR-138-2* hsa-miR-4274 hsa-miR-149 hsa-miR-548a-5p hsa-miR-559
    SwitchGear 3'UTR luciferase reporter plasmidPGR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PGR
    Sirion Biotech Customized adenovirus for overexpression of PGR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PGR (see all 7)
    OriGene ORF clones in mouse, rat for PGR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PGR (NM_000926)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGR
    Sirion Biotech Customized lentivirus for stable overexpression of PGR 
                         Customized lentivirus expression plasmids for stable overexpression of PGR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PGR
    Search LifeMap BioReagents cell lines for PGR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGR About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.68
    Nuclear Receptors0.68
    2Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    3Oocyte meiosis
    Progesterone-mediated oocyte maturation0.35
    Oocyte meiosis0.35
    4PIP3 activates AKT signaling
    Signaling by ERBB40.67
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PGR
        Immune response MIF-JAB1 signaling


    1 GeneGo (Thomson Reuters) Pathway for PGR
        Immune response MIF-JAB1 signaling

    3 BioSystems Pathways for PGR
        Nuclear Receptors
    Ovarian Infertility Genes
    Cellular roles of Anthrax toxin

    5/6        Reactome Pathways for PGR (see all 6)
        Generic Transcription Pathway
    Nuclear Receptor transcription pathway
    Signal Transduction
    Gene Expression
    Signaling by ERBB4


    2         Kegg Pathways  (Kegg details for PGR):
        Oocyte meiosis
    Progesterone-mediated oocyte maturation


    PGR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PGR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/83 Interacting proteins for PGR (P064011, 2, 3 ENSP000003251204) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUEDC2Q9H4671, 2, 3, ENSP000003589534EBI-78539,EBI-1248228 MINT-4787932 MINT-4787991 MINT-4787971 MINT-4788009 MINT-4787894 MINT-4787873 MINT-4787953 I2D: score=4 STRING: ENSP00000358953
    JDP2Q8WYK22, 3, ENSP000002675694MINT-4788079 I2D: score=3 STRING: ENSP00000267569
    NCOR2Q9Y6182, 3, ENSP000003485514MINT-4788120 I2D: score=3 STRING: ENSP00000348551
    BCAS2O759343, ENSP000003585544I2D: score=2 STRING: ENSP00000358554
    RBM39Q144983, ENSP000002533634I2D: score=2 STRING: ENSP00000253363
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001542ovulation from ovarian follicle IEA--
    GO:0002070epithelial cell maturation IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    PGR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PGR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for PGR

    Compounds for PGR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MifepristoneProgesterone and glucocorticoid antagonist[84371-65-3]
    LevonorgestrelSynthetic progesterone analog[797-63-7]
    ProgesteroneEndogenous progesterone receptor agonist[57-83-0]

    2 HMDB Compounds for PGR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Medroxyprogesterone17-Hydroxy-6a-methylprogesterone (see all 13)520-85-4--
    Progesterone17a-Progesterone (see all 114)57-83-0--

    10/18 DrugBank Compounds for PGR (see all 18)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    MegestrolMegestrol Acetate (see all 5)3562-63-8targetagonist16343217 15086241 19731987 9744490 14687437 11752352 19434889 2982481 15595341
    Allylestrenol-- 432-60-0targetagonist17015480 17169175 3928974 17013809 17109827 17138644
    Desogestrel-- 54024-22-5targetagonist11041225 7750284 11752352 10601100 6645495 3139361
    Drospirenone6β,7β,15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17 carbolactone (see all 4)67392-87-4targetagonist16291771 17000933 16157482 15493951 8922878 11024226
    Dydrogesterone10alpha-Isopregnenone (see all 7)152-62-5targetagonist16045524 8486204 11752352 6827166 436795 15128769
    Levonorgestrel18-Methylnorethisterone (see all 3)797-63-7targetbinder17077229 16157482 16084894 11752352 17531625 17484506
    MedroxyprogesteroneCBP-1011 (see all 9)520-85-4targetagonist17015480 17013809 17109827 11752352 16985038 17138644
    MifepristoneMifepriston (see all 2)84371-65-3targetantagonist10682471 11783365 11752352 10806733 10699595 10374120
    Norethindrone-- 68-22-4targetagonist10494488 15261304 16084894 11752352 7711211 15189034
    ProgesteroneCorpus Luteum Hormone (see all 4)57-83-0targetagonist17015480 17169175 17013809 17109827 9506743 17138644

    10/12 IUPHAR Ligands for PGR (Progesterone receptor) (see all 12)    About this table 
    LigandTypeActionAffinityPubmed IDs
    norethisterone
    AgonistAgonist14670641
    dydrogesterone
    AgonistAgonist14670641
    progesterone
    AgonistAgonist14670641
    promegestone
    AgonistAgonist14670641
    mifepristone
    AntagonistMixed14670641
    asoprisnil
    AntagonistAntagonist14670641
    [3H]ORG2058
    AgonistAgonist--
    onapristone
    AntagonistInverse agonist14670641
    ORG2058
    AgonistAgonist--
    levonorgestrel
    AgonistAgonist14670641

    10/120 Novoseek inferred chemical compound relationships for PGR gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 98.9 13625 16236516 (10), 11389093 (9), 14595509 (8), 12416559 (8) (see all 99)
    estrogen 97.3 7222 11918216 (9), 2404751 (9), 1567780 (8), 17535263 (8) (see all 99)
    progestins 89.2 175 8049131 (2), 18467956 (2), 8398308 (2), 2373707 (2) (see all 99)
    steroid 89 480 10499535 (3), 15072922 (3), 11355082 (3), 18566116 (3) (see all 99)
    mifepristone 87 306 19372222 (5), 11326932 (5), 1420166 (5), 9528977 (5) (see all 99)
    tamoxifen 86.9 372 1634918 (6), 8251648 (5), 1936925 (5), 11056315 (5) (see all 99)
    onapristone 85.3 68 9528977 (5), 7854344 (4), 8499339 (4), 7626494 (3) (see all 28)
    progestin 84.6 186 9408241 (6), 18321550 (5), 2385853 (3), 15657363 (3) (see all 99)
    asoprisnil 81.5 16 18765509 (2), 20414849 (2), 17652152 (2), 18281245 (2) (see all 10)
    estradiol 81.4 292 11165037 (5), 2004610 (5), 1351839 (4), 8486312 (4) (see all 99)

    1 PharmGKB related drug/compound annotation for PGR gene    About this table
    Drug/compound PharmGKB Annotation
    letrozole

    Search CenterWatch for drugs/clinical trials and news about PGR / PRGR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGR gene (4 alternative transcripts): 
    NM_000926.4  NM_001202474.3  NM_001271161.2  NM_001271162.1  

    Unigene Clusters for PGR:

    Progesterone receptor
    Hs.32405  [show with all ESTs], Hs.742403
    Unigene Representative Sequences: NM_000926, FJ515871
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325455(uc001pgg.2 uc001pgh.2 uc001pgi.2 uc009yww.1 uc001pgj.2 uc009ywx.1)
    ENST00000534013 ENST00000533207 ENST00000528960 ENST00000534780 ENST00000526300
    ENST00000263463 ENST00000530764
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AY382152.1 FJ515871.1 FJ515872.1 FJ515873.1 

    9 DOTS entries:

    DT.403831  DT.302605  DT.437770  DT.433385  DT.100019113  DT.120729880  DT.97824326  DT.95364504 
    DT.100019112 

    20 AceView cDNA sequences:

    AB085844 AF016381 AB084248 AL709143 AB085845 AB085843 AY382152 M15716 
    AB085683 BI461125 BV173553 AY212933 AL708996 BU570792 AY382151 X51730 
    NM_000926 BI827058 BI832037 AI498426 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for PGR (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:                          -     -                                                         
    SP2:                          -     -                       -                                 
    SP3:                          -     -     -                                                   
    SP4:                    -     -     -                       -                                 
    SP5:                          -     -     -                 -     -                           


    ECgene alternative splicing isoforms for PGR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGR expression in normal human tissues (normalized intensities)      PGR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCACGCCC
    PGR Expression
    About this image


    PGR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Uterus
             uterus, post-menopause ; glandular cells   
             uterine fibroid tissue   
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Decidua-derived mesenchymal cells
             placenta ; decidual cells   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See PGR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGR

    SOURCE GeneReport for Unigene clusters: Hs.32405 Hs.742403
        SABiosciences Expression via Pathway-Focused PCR Arrays including PGR: 
              Estrogen Receptor Signaling in human mouse rat
              Cancer Drug Targets in human mouse rat
              Breast Cancer in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PGR gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgr1 , 5 progesterone receptor1, 5 80.11(n)1
    80.97(a)1
      9 (2.46 cM)5
    186671  NM_008829.21  NP_032855.21 
     89004195 
    chicken
    (Gallus gallus)
    Aves PGR1 progesterone receptor 69.47(n)
    67.31(a)
      396198  NM_205262.1  NP_990593.1 
    lizard
    (Anolis carolinensis)
    Reptilia PGR6
    Uncharacterized protein
    86(a)
    1 ↔ 1
    3(192841818-192983342)
    African clawed frog
    (Xenopus laevis)
    Amphibia pgr-A2 progesterone receptor 75.16(n)    AF279335.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pgr6
    progesterone receptor
    43(a)
    1 ↔ 1
    18(40219884-40238456)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hr836
    Hr786
    Hormone-receptor-like in 78
    22(a)
    12(a)
    possible ortholog
    possible ortholog
    3R(2174965-2176234)
    3L(21487119-21490594)
    worm
    (Caenorhabditis elegans)
    Secernentea nhr-2396
    nhr-2366
    (see all 6)
    Protein NHR-236
    (see all 6)
    24(a)
    20(a)
    (see all 6)
    many ↔ many
    possible ortholog
    (see all 6)
    III(2561710-2566589)
    IV(2327126-2329640)


    ENSEMBL Gene Tree for PGR (if available)
    TreeFam Gene Tree for PGR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGR gene
    ESRRB2  ESRRA2  NR3C22  ESR12  ESR22  ESRRG2  NR3C12  AR2  
    5 SIMAP similar genes for PGR using alignment to 1 protein entry:     PRGR_HUMAN:
    PR    NR3C4    NR3C1    NR3C2    AR

    PGR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2197 SNPs in PGR are shown (see all 2197)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340601131,2
    C,F--96837324(-) CAATTT/-GTACA 7 -- ds50016Minor allele frequency- -:0.34MN CSA 382
    rs1489877251,2
    C--96864057(+) AAAAA-/AA    
       C
    /ACA
    CACTT
    11 -- cds1 int10--------
    rs6024811,2
    C,F--96867674(+) aaaaaA/Gaaaaa 7 -- int16Minor allele frequency- G:0.02NA MN 118
    rs680472031,2
    C--96870682(+) ATCGA-/A/AATGA/
    ATGA
    /GA/TGA
    ATGAA
    11 -- int1 cds10--------
    rs1447912061,2
    C--96879895(+) GAAAG-/C/GTCGGG 7 -- int10--------
    rs1457662911,2
    C--96890391(+) ACTGG-/AGTAAA 7 -- int10--------
    rs1476648321,2
    C--96892420(+) GAGCT-/GAGATTGCGC
    CACTGCACTCCA
    GCCTG
    7 -- int10--------
    rs563550971,2
    C--96915693(+) AAAAA-/A/GGAAAG 7 -- int10--------
    rs106778811,2
    C--96921253(+) ttttt-/T/TT  
            
    gtatt
    7 -- int11NA 2
    rs4951891,2
    C,F,O,A,H--96928860(+) GAACCC/ATAATG 7 -- int124Minor allele frequency- A:0.45NS NA EA WA CSA 2653

    HapMap Linkage Disequilibrium report for PGR (100900355 - 101001255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PGR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272143CNV Insertion20981092
    nsv826059CNV Loss20364138
    nsv898328CNV Loss21882294
    nsv826058CNV Loss20364138


    Human Gene Mutation Database (HGMD): PGR
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607311   
    OMIM disorders: 264080  
    20/198 diseases for PGR (see all 198):    About MalaCards
    progesterone resistance    glassy cell carcinoma of the cervix    trigonitis    optic nerve sheath meningioma
    vulvar dystrophy    pleomorphic lipoma    apocrine adenosis of breast    radiation induced meningioma
    vulvar syringoma    leiomyoma    cerebral meningioma    endometrial stromal nodule
    synchronous bilateral breast carcinoma    papillary serous adenocarcinoma    catamenial pneumothorax    cribriform carcinoma
    breast disease    progesterone-receptor positive breast cancer    endometrial adenocarcinoma    benign metastasizing leiomyoma

    12 diseases from the University of Copenhagen DISEASES database for PGR:
    Breast cancer     Endometrial cancer     Carcinoma     Ductal carcinoma in situ
    Endometriosis     Leiomyoma     Uterine fibroid     Meningioma
    Breast disease     Ovarian cancer     Breast fibroadenoma     Myoma

    PGR for disorders           About GeneDecksing

    10/93 Novoseek inferred disease relationships for PGR gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 93.9 1981 18466613 (6), 9591211 (6), 19419938 (5), 8722747 (4) (see all 99)
    breast carcinoma 91.5 370 15301464 (4), 7914767 (4), 8751328 (4), 1734234 (3) (see all 99)
    carcinoma ductal 88.3 97 17522367 (2), 18296077 (2), 12014222 (2), 15375487 (2) (see all 70)
    tumors 85 2673 9392336 (9), 8095853 (6), 8251648 (5), 1916439 (5) (see all 99)
    endometrial carcinoma 85 224 12501628 (5), 10053107 (4), 16831363 (4), 9639729 (4) (see all 99)
    carcinoma lobular 79.2 30 10672061 (5), 1916439 (2), 8328824 (1), 15329896 (1) (see all 20)
    endometrial cancer 79 153 8467457 (4), 17556066 (4), 15001645 (4), 14519645 (4) (see all 85)
    carcinoma 77.7 305 17591366 (6), 10338073 (5), 1661896 (4), 8834526 (4) (see all 99)
    progesterone resistance 77.2 12 10946900 (2), 20104427 (2), 20108182 (1), 16406281 (1) (see all 6)
    metastasis 76 292 10053107 (5), 15360050 (4), 10206068 (3), 10338073 (2) (see all 99)

    Genetic Association Database (GAD): PGR
    Human Genome Epidemiology (HuGE) Navigator: PGR (207 documents)
    Tumor Gene Database (TGDB): PGR

    Export disorders for PGR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGR gene, integrated from 9 sources (see all 3494):
    (articles sorted by number of sources associating them with PGR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. (PubMed id 15937332)1, 2, 9 Zhang Z.... Winneker R.C. (2005)
    2. Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. (PubMed id 10655479)1, 2, 9 Lange C.A.... Horwitz K.B. (2000)
    3. The human progesterone receptor shows evidence of adaptive evolution associated with its ability to act as a transcription factor. (PubMed id 18375150)1, 2, 9 Chen C.... Wildman D.E. (2008)
    4. Progesterone receptor polymorphism +331G/A is associated with a decreased risk of deep infiltrating endometriosis. (PubMed id 16920727)1, 4, 9 van Kaam K.J....Groothuis P.G. (2007)
    5. Progesterone receptor variation and risk of ovarian cancer is limited to the invasive endometrioid subtype: results from the Ovarian Cancer Association Consortium pooled analysis. (PubMed id 18219286)1, 4, 9 Pearce C.L....Berchuck A. (2008)
    6. Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women. (PubMed id 15272917)1, 4, 9 Westberg L....Eriksson E. (2004)
    7. Association of the progesterone receptor gene with endometrial cancer risk in a Chinese population. (PubMed id 19382201)1, 4, 9 Xu W.H....Shu X.O. (2009)
    8. Disrupted cell cycle control in cultured endometrial cells from patients with endometriosis harboring the progesterone receptor poly morphism PROGINS. (PubMed id 19497994)1, 4, 9 D'Amora P....Schor E. (2009)
    9. Association study of gender identity disorder and sex hormone-related genes. (PubMed id 19604497)1, 4, 9 Ujike H....Kuroda S. (2009)
    10. A prospective study of androgen levels, hormone-relat ed genes and risk of rheumatoid arthritis. (PubMed id 19555469)1, 4, 9 Karlson E.W....De Vivo I. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5241 HGNC: 8910 AceView: PGR Ensembl:ENSG00000082175 euGenes: HUgn5241
    ECgene: PGR Kegg: 5241 H-InvDB: PGR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PGR Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pgr/
    Wikipedia http://en.wikipedia.org/wiki/Progesterone_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGR gene:
    Search GeneIP for patents involving PGR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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