Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PGPEP1 Gene

Aliases for PGPEP1 Gene

  • Pyroglutamyl-Peptidase I 2 3 4 5
  • Pyrrolidone-Carboxylate Peptidase 3 4
  • Pyroglutamyl Aminopeptidase I 3 4
  • 5-Oxoprolyl-Peptidase 3 4
  • PAP-I 3 4
  • PGP-I 3 4
  • PGPI 3 4
  • Pyroglutamyl Aminopeptidase 2
  • Pyroglutamyl-Peptidase 1 3
  • PGlu-Peptidase I 3
  • EC 4
  • PGI 3
  • PCP 3
  • PGP 3

External Ids for PGPEP1 Gene

Previous GeneCards Identifiers for PGPEP1 Gene

  • GC00U990891
  • GC19P018296
  • GC19P018312
  • GC19P018451
  • GC19P018015
  • GC19P018342
  • GC19P018519
  • GC19P018522
  • GC19P018719

Summaries for PGPEP1 Gene

Entrez Gene Summary for PGPEP1 Gene

  • The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]

GeneCards Summary for PGPEP1 Gene

PGPEP1 (Pyroglutamyl-Peptidase I) is a Protein Coding gene. Diseases associated with PGPEP1 include Liver Cirrhosis and Endocervicitis. GO annotations related to this gene include cysteine-type peptidase activity and pyroglutamyl-peptidase activity. An important paralog of this gene is PGPEP1L.

UniProtKB/Swiss-Prot for PGPEP1 Gene

  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Gene Wiki entry for PGPEP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGPEP1 Gene

Genomics for PGPEP1 Gene

Regulatory Elements for PGPEP1 Gene

Enhancers for PGPEP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G018337 1.4 Ensembl ENCODE 43.3 -0.3 -335 5.1 HDGF PKNOX1 CREB3L1 ARNT SIN3A ARID4B DMAP1 ZNF2 SLC30A9 ZNF766 PGPEP1 RN7SL513P
GH19G018346 0.7 ENCODE 42.9 +5.9 5871 0.9 KLF1 RFX1 KLF4 ZIC2 SMARCA4 BCL11A POLR2A SCRT2 GLIS1 PRDM10 PGPEP1 GDF15
GH19G018328 1.7 FANTOM5 Ensembl ENCODE 16 -11.7 -11713 1.7 HDGF PKNOX1 ARNT AGO1 ZFP64 SIN3A FEZF1 ZNF2 ZBTB7B YY1 PGPEP1 LSM4 LRRC25 MPV17L2 RN7SL513P
GH19G018300 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -36.1 -36077 8.2 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC JUND LSM4 ENSG00000268030 COLGALT1 UPF1 PGPEP1 IL12RB1 ARRDC2 SSBP4 JAK3
GH19G018315 1.8 FANTOM5 ENCODE dbSUPER 10.3 -20.6 -20581 9.4 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LSM4 UPF1 ENSG00000268030 ENSG00000268938 PGPEP1 MVB12A SSBP4 LRRC25 IFI30 JUND
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PGPEP1 on UCSC Golden Path with GeneCards custom track

Promoters for PGPEP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PGPEP1 Gene

18,340,582 bp from pter
18,369,953 bp from pter
29,372 bases
Plus strand

Genomic View for PGPEP1 Gene

Genes around PGPEP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGPEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGPEP1 Gene

Proteins for PGPEP1 Gene

  • Protein details for PGPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyroglutamyl-peptidase 1
    Protein Accession:
    Secondary Accessions:
    • A8K1Q3
    • Q8IVT1

    Protein attributes for PGPEP1 Gene

    209 amino acids
    Molecular mass:
    23138 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for PGPEP1 Gene


neXtProt entry for PGPEP1 Gene

Post-translational modifications for PGPEP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PGPEP1 Gene

Domains & Families for PGPEP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C15 family.
  • Belongs to the peptidase C15 family.
genes like me logo Genes that share domains with PGPEP1: view

No data available for Gene Families for PGPEP1 Gene

Function for PGPEP1 Gene

Molecular function for PGPEP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by transition metal ions including Ni(2+), Zn(2+), and Cu(2+) and by sulfhydryl-blocking agents.
UniProtKB/Swiss-Prot Function:
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Enzyme Numbers (IUBMB) for PGPEP1 Gene

Gene Ontology (GO) - Molecular Function for PGPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016920 pyroglutamyl-peptidase activity IEA --
genes like me logo Genes that share ontologies with PGPEP1: view
genes like me logo Genes that share phenotypes with PGPEP1: view

Animal Model Products

CRISPR Products

miRNA for PGPEP1 Gene

miRTarBase miRNAs that target PGPEP1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGPEP1 Gene

Localization for PGPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGPEP1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGPEP1 gene
Compartment Confidence
cytosol 5
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PGPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA,IEA --
genes like me logo Genes that share ontologies with PGPEP1: view

Pathways & Interactions for PGPEP1 Gene

SuperPathways for PGPEP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PGPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA,IEA --
genes like me logo Genes that share ontologies with PGPEP1: view

No data available for Pathways by source and SIGNOR curated interactions for PGPEP1 Gene

Drugs & Compounds for PGPEP1 Gene

No Compound Related Data Available

Transcripts for PGPEP1 Gene

Unigene Clusters for PGPEP1 Gene

Pyroglutamyl-peptidase I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGPEP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for PGPEP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGPEP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PGPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGPEP1 Gene

This gene is overexpressed in Testis (11.9), Islet of Langerhans (9.2), Spinal cord (8.5), and Kidney (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGPEP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PGPEP1 Gene:


SOURCE GeneReport for Unigene cluster for PGPEP1 Gene:


Evidence on tissue expression from TISSUES for PGPEP1 Gene

  • Nervous system(4.7)
  • Intestine(4.4)
  • Blood(4.3)
  • Kidney(2.5)
  • Pancreas(2.3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with PGPEP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PGPEP1 Gene

Orthologs for PGPEP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PGPEP1 34 35
  • 99.68 (n)
(Canis familiaris)
Mammalia PGPEP1 35
  • 97 (a)
(Monodelphis domestica)
Mammalia PGPEP1 35
  • 92 (a)
(Bos Taurus)
Mammalia PGPEP1 34 35
  • 88.68 (n)
(Rattus norvegicus)
Mammalia Pgpep1 34
  • 82.37 (n)
(Mus musculus)
Mammalia Pgpep1 34 16 35
  • 82.21 (n)
(Ornithorhynchus anatinus)
Mammalia PGPEP1 35
  • 80 (a)
(Gallus gallus)
Aves PGPEP1 34 35
  • 77.5 (n)
(Anolis carolinensis)
Reptilia PGPEP1 35
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgpep1 34
  • 71.34 (n)
(Danio rerio)
Actinopterygii pgpep1 34 35
  • 70.05 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7142 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006964 34
  • 46.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32147 34 35
  • 44.68 (n)
(Caenorhabditis elegans)
Secernentea M04C9.3 34
  • 46.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
Species where no ortholog for PGPEP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGPEP1 Gene

Gene Tree for PGPEP1 (if available)
Gene Tree for PGPEP1 (if available)

Paralogs for PGPEP1 Gene

Paralogs for PGPEP1 Gene

(1) SIMAP similar genes for PGPEP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PGPEP1: view

Variants for PGPEP1 Gene

Sequence variations from dbSNP and Humsavar for PGPEP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs193921074 Uncertain significance 18,357,612(+) TGCCG(A/G)CAGGT intron-variant, nc-transcript-variant, reference, missense
rs1000047599 -- 18,364,601(+) AGAGC(A/G)AGACT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000080992 -- 18,366,474(+) ATTTT(C/T)TATTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000119138 -- 18,352,144(+) GTGGG(C/T)GCCTG intron-variant
rs1000152514 -- 18,370,385(+) CACTG(C/T)ACTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PGPEP1 Gene

Variant ID Type Subtype PubMed ID
esv3643837 CNV loss 21293372
nsv952420 CNV deletion 24416366

Variation tolerance for PGPEP1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGPEP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGPEP1 Gene

Disorders for PGPEP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PGPEP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
liver cirrhosis
  • cirrhosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PGPEP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PGPEP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PGPEP1 Gene

Publications for PGPEP1 Gene

  1. Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme. (PMID: 12651114) Dando P.M. … Barrett A.J. (Protein Expr. Purif. 2003) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. (PMID: 15380924) Valdivia A. … Casis L. (Regul. Pept. 2004) 3 22 64

Products for PGPEP1 Gene

Sources for PGPEP1 Gene

Loading form....