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Aliases for PGPEP1 Gene

Aliases for PGPEP1 Gene

  • Pyroglutamyl-Peptidase I 2 3 4 5
  • Pyrrolidone-Carboxylate Peptidase 3 4
  • Pyroglutamyl Aminopeptidase I 3 4
  • 5-Oxoprolyl-Peptidase 3 4
  • PAP-I 3 4
  • PGP-I 3 4
  • PGPI 3 4
  • Pyroglutamyl Aminopeptidase 2
  • EC 4
  • PCP 3
  • PGP 3

External Ids for PGPEP1 Gene

Previous GeneCards Identifiers for PGPEP1 Gene

  • GC00U990891
  • GC19P018296
  • GC19P018312
  • GC19P018451
  • GC19P018015
  • GC19P018342

Summaries for PGPEP1 Gene

Entrez Gene Summary for PGPEP1 Gene

  • Pyroglutamyl peptidase I (EC catalyzes the hydrolysis of N-terminal pyroglutamyl residues from oligopeptides and proteins.[supplied by OMIM, Mar 2008]

GeneCards Summary for PGPEP1 Gene

PGPEP1 (Pyroglutamyl-Peptidase I) is a Protein Coding gene. GO annotations related to this gene include cysteine-type peptidase activity and pyroglutamyl-peptidase activity. An important paralog of this gene is PGPEP1L.

UniProtKB/Swiss-Prot for PGPEP1 Gene

  • Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Gene Wiki entry for PGPEP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGPEP1 Gene

Genomics for PGPEP1 Gene

Regulatory Elements for PGPEP1 Gene

Enhancers for PGPEP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PGPEP1 on UCSC Golden Path with GeneCards custom track

Promoters for PGPEP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PGPEP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PGPEP1 Gene

18,340,582 bp from pter
18,369,953 bp from pter
29,372 bases
Plus strand

Genomic View for PGPEP1 Gene

Genes around PGPEP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGPEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGPEP1 Gene

Proteins for PGPEP1 Gene

  • Protein details for PGPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pyroglutamyl-peptidase 1
    Protein Accession:
    Secondary Accessions:
    • A8K1Q3
    • Q8IVT1

    Protein attributes for PGPEP1 Gene

    209 amino acids
    Molecular mass:
    23138 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for PGPEP1 Gene


neXtProt entry for PGPEP1 Gene

Proteomics data for PGPEP1 Gene at MOPED

Post-translational modifications for PGPEP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PGPEP1 Gene

Domains & Families for PGPEP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C15 family.
  • Belongs to the peptidase C15 family.
genes like me logo Genes that share domains with PGPEP1: view

No data available for Gene Families for PGPEP1 Gene

Function for PGPEP1 Gene

Molecular function for PGPEP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by transition metal ions including Ni(2+), Zn(2+), and Cu(2+) and by sulfhydryl-blocking agents.
UniProtKB/Swiss-Prot Function:
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Enzyme Numbers (IUBMB) for PGPEP1 Gene

genes like me logo Genes that share phenotypes with PGPEP1: view

Animal Model Products

CRISPR Products

miRNA for PGPEP1 Gene

miRTarBase miRNAs that target PGPEP1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGPEP1 Gene

Localization for PGPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGPEP1 Gene


Subcellular locations from

Jensen Localization Image for PGPEP1 Gene COMPARTMENTS Subcellular localization image for PGPEP1 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PGPEP1 Gene

Pathways & Interactions for PGPEP1 Gene

SuperPathways for PGPEP1 Gene

No Data Available

Interacting Proteins for PGPEP1 Gene

Gene Ontology (GO) - Biological Process for PGPEP1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PGPEP1 Gene

Drugs & Compounds for PGPEP1 Gene

No Compound Related Data Available

Transcripts for PGPEP1 Gene

Unigene Clusters for PGPEP1 Gene

Pyroglutamyl-peptidase I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PGPEP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6: - - -

Relevant External Links for PGPEP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGPEP1 Gene

mRNA expression in normal human tissues for PGPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PGPEP1 Gene

This gene is overexpressed in Testis (11.9), Islet of Langerhans (9.2), Spinal cord (8.5), and Kidney (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PGPEP1 Gene

SOURCE GeneReport for Unigene cluster for PGPEP1 Gene Hs.131776

genes like me logo Genes that share expression patterns with PGPEP1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for PGPEP1 Gene

Orthologs for PGPEP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PGPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGPEP1 35
  • 88.68 (n)
  • 98.56 (a)
  • 99 (a)
(Mus musculus)
Mammalia Pgpep1 35
  • 82.21 (n)
  • 95.19 (a)
Pgpep1 16
Pgpep1 36
  • 95 (a)
(Pan troglodytes)
Mammalia PGPEP1 35
  • 99.68 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pgpep1 35
  • 82.37 (n)
  • 94.71 (a)
(Canis familiaris)
Mammalia PGPEP1 36
  • 97 (a)
(Monodelphis domestica)
Mammalia PGPEP1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia PGPEP1 36
  • 80 (a)
(Gallus gallus)
Aves PGPEP1 35
  • 77.5 (n)
  • 87.5 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia PGPEP1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pgpep1 35
  • 71.34 (n)
  • 74.4 (a)
(Danio rerio)
Actinopterygii pgpep1 35
  • 70.05 (n)
  • 69.57 (a)
pgpep1 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7142 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006964 35
  • 46.87 (n)
  • 36.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32147 35
  • 44.68 (n)
  • 36.7 (a)
CG32147 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea M04C9.3 35
  • 46.88 (n)
  • 36.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for PGPEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGPEP1 Gene

Gene Tree for PGPEP1 (if available)
Gene Tree for PGPEP1 (if available)

Paralogs for PGPEP1 Gene

Paralogs for PGPEP1 Gene

(1) SIMAP similar genes for PGPEP1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PGPEP1: view

Variants for PGPEP1 Gene

Sequence variations from dbSNP and Humsavar for PGPEP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12976357 -- 18,356,787(+) TAATC(C/T)GAGCA intron-variant
rs12977553 -- 18,351,220(+) agatc(A/G)cgcca intron-variant
rs12977748 -- 18,359,783(+) gctgg(A/G)attat intron-variant
rs12978101 -- 18,343,554(+) GCCAG(A/C)GGCTA intron-variant
rs8100332 -- 18,352,087(+) taaca(C/T)gatga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGPEP1 Gene

Variant ID Type Subtype PubMed ID
nsv911271 CNV Loss 21882294
dgv3781n71 CNV Loss 21882294
nsv911274 CNV Loss 21882294

Variation tolerance for PGPEP1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PGPEP1 Gene

Disorders for PGPEP1 Gene

Relevant External Links for PGPEP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PGPEP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGPEP1 Gene

Publications for PGPEP1 Gene

  1. Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme. (PMID: 12651114) Dando P.M. … Barrett A.J. (Protein Expr. Purif. 2003) 3 4 23 67
  2. Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. (PMID: 15380924) Valdivia A. … Casis L. (Regul. Pept. 2004) 3 23
  3. Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study. (PMID: 12030812) Gil J. … Casis L. (Neuropeptides 2001) 3 23
  4. Serum pyroglutamyl aminopeptidase activity: aA promising novel biomarker candidate for liver cirrhosis. (PMID: 25687677) Megias M.J. … Ramirez-Sanchez M. (Endocr Regul 2015) 3
  5. Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer. (PMID: 26078706) Perez I. … Larrinaga G. (Int J Med Sci 2015) 3

Products for PGPEP1 Gene

Sources for PGPEP1 Gene