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Aliases for PGM5 Gene

Aliases for PGM5 Gene

  • Phosphoglucomutase 5 2 3
  • Phosphoglucomutase-Related Protein 2 3 4
  • Aciculin 3 4
  • PGM-RP 3 4
  • PGMRP 3 4
  • Phosphoglucomutase-Like Protein 5 3
  • EC 63

External Ids for PGM5 Gene

Previous GeneCards Identifiers for PGM5 Gene

  • GC09P062016
  • GC09P062828
  • GC09P064541
  • GC09P066429
  • GC09P066428
  • GC09P068201
  • GC09P070161
  • GC09P070971
  • GC09P040808

Summaries for PGM5 Gene

Entrez Gene Summary for PGM5 Gene

  • Phosphoglucomutases (EC, such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PGM5 Gene

PGM5 (Phosphoglucomutase 5) is a Protein Coding gene. Among its related pathways are Glucuronidation. GO annotations related to this gene include structural molecule activity and phosphoglucomutase activity. An important paralog of this gene is PGM1.

UniProtKB/Swiss-Prot for PGM5 Gene

  • Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity

Gene Wiki entry for PGM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGM5 Gene

Genomics for PGM5 Gene

Regulatory Elements for PGM5 Gene

Genomic Location for PGM5 Gene

68,328,308 bp from pter
68,531,061 bp from pter
202,754 bases
Plus strand

Genomic View for PGM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PGM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGM5 Gene

Proteins for PGM5 Gene

  • Protein details for PGM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphoglucomutase-like protein 5
    Protein Accession:
    Secondary Accessions:
    • B1AM46
    • B4DLQ6
    • Q5VYV3
    • Q8N527
    • Q9UDH4

    Protein attributes for PGM5 Gene

    567 amino acids
    Molecular mass:
    62225 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    • Interacts with cytoskeletal proteins dystrophin and utrophin
    • Sequence=AAC41948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH33073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA73882.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PGM5 Gene


neXtProt entry for PGM5 Gene

Proteomics data for PGM5 Gene at MOPED

Selected DME Specific Peptides for PGM5 Gene

Post-translational modifications for PGM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PGM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PGM5 Gene

Suggested Antigen Peptide Sequences for PGM5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q15124
  • Belongs to the phosphohexose mutase family.
genes like me logo Genes that share domains with PGM5: view

No data available for Gene Families for PGM5 Gene

Function for PGM5 Gene

Molecular function for PGM5 Gene

GENATLAS Biochemistry:
phosphoglucomutase 5,with homology to PGM1 but unknown function,widely expressed in fetal and adult tissues
UniProtKB/Swiss-Prot Function:
Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity

Enzyme Numbers (IUBMB) for PGM5 Gene

Gene Ontology (GO) - Molecular Function for PGM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004614 NOT phosphoglucomutase activity IDA 8175905
GO:0005198 structural molecule activity NAS 8631316
GO:0005515 protein binding --
GO:0016868 intramolecular transferase activity, phosphotransferases --
genes like me logo Genes that share ontologies with PGM5: view

Phenotypes for PGM5 Gene

GenomeRNAi human phenotypes for PGM5:
genes like me logo Genes that share phenotypes with PGM5: view

miRNA for PGM5 Gene

miRTarBase miRNAs that target PGM5

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PGM5 Gene

Localization for PGM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGM5 Gene

Cell junction, adherens junction. Cytoplasm, cytoskeleton. Note=Adherens-type cellular junctions. Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments.

Subcellular locations from

Jensen Localization Image for PGM5 Gene COMPARTMENTS Subcellular localization image for PGM5 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PGM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 8175905
GO:0005829 NOT cytosol IBA --
GO:0005913 cell-cell adherens junction IDA 8175905
GO:0005914 spot adherens junction IDA 8175905
GO:0005925 focal adhesion IDA 8175905
genes like me logo Genes that share ontologies with PGM5: view

Pathways for PGM5 Gene

SuperPathways for PGM5 Gene

Superpath Contained pathways
1 Glucuronidation
genes like me logo Genes that share pathways with PGM5: view

Pathways by source for PGM5 Gene

1 BioSystems pathway for PGM5 Gene

Gene Ontology (GO) - Biological Process for PGM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0005978 NOT glycogen biosynthetic process IBA --
GO:0006006 NOT glucose metabolic process IBA --
GO:0007155 cell adhesion IEA --
GO:0019388 NOT galactose catabolic process IBA --
genes like me logo Genes that share ontologies with PGM5: view

Compounds for PGM5 Gene

(1) HMDB Compounds for PGM5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium
genes like me logo Genes that share compounds with PGM5: view

Transcripts for PGM5 Gene

Unigene Clusters for PGM5 Gene

Phosphoglucomutase 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PGM5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGM5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: - -

Relevant External Links for PGM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PGM5 Gene

mRNA expression in normal human tissues for PGM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGM5 Gene

This gene is overexpressed in Colon - Sigmoid (6.2), Esophagus - Muscularis (5.5), Esophagus - Gastroesophageal Junction (4.9), and Bladder (4.7).

Protein differential expression in normal tissues for PGM5 Gene

This gene is overexpressed in Urinary Bladder (15.9), Seminal vesicle (12.1), Prostate (10.0), and Uterus (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PGM5 Gene

SOURCE GeneReport for Unigene cluster for PGM5 Gene Hs.307835

mRNA Expression by UniProt/SwissProt for PGM5 Gene

Tissue specificity: Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level).
genes like me logo Genes that share expressions with PGM5: view

Expression partners for PGM5 Gene

In Situ Assay Products

Orthologs for PGM5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PGM5 35
  • 93.3 (n)
  • 98.06 (a)
PGM5 36
  • 98 (a)
(Canis familiaris)
Mammalia PGM5 35
  • 91.81 (n)
  • 97.29 (a)
PGM5 36
  • 97 (a)
(Mus musculus)
Mammalia Pgm5 35
  • 90.83 (n)
  • 97.53 (a)
Pgm5 16
Pgm5 36
  • 98 (a)
(Pan troglodytes)
Mammalia LOC472942 35
  • 99.12 (n)
  • 98.94 (a)
PGM5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pgm5 35
  • 90.36 (n)
  • 97.71 (a)
(Monodelphis domestica)
Mammalia PGM5 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia PGM5 36
  • 90 (a)
(Gallus gallus)
Aves PGM5 35
  • 80.6 (n)
  • 88.54 (a)
PGM5 36
  • 88 (a)
(Anolis carolinensis)
Reptilia PGM5 36
  • 87 (a)
(Danio rerio)
Actinopterygii pgm5 35
  • 72.73 (n)
  • 77.21 (a)
pgm5 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pgm 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea R05F9.6 37
  • 53 (a)
R05F9.6 36
  • 52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PGM1 36
  • 41 (a)
PGM2 36
  • 43 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G70730 35
  • 54.91 (n)
  • 54.07 (a)
(Oryza sativa)
Liliopsida Os03g0712700 35
  • 56.02 (n)
  • 52.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6075 36
  • 54 (a)
Species with no ortholog for PGM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PGM5 Gene

Gene Tree for PGM5 (if available)
Gene Tree for PGM5 (if available)

Paralogs for PGM5 Gene

Paralogs for PGM5 Gene

Selected SIMAP similar genes for PGM5 Gene using alignment to 2 proteins: Pseudogenes for PGM5 Gene

genes like me logo Genes that share paralogs with PGM5: view

Variants for PGM5 Gene

Sequence variations from dbSNP and Humsavar for PGM5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs97981 -- 68,370,129(+) GCTGT(A/G)TGGTC intron-variant
rs166422 -- 68,385,903(+) ATCGT(C/T)TGGGA intron-variant
rs183807 -- 68,382,524(+) tcaaa(C/T)taaaa intron-variant
rs187844 -- 68,487,813(+) TGCCA(C/T)TGTAA intron-variant
rs196723 -- 68,384,789(+) TTATG(A/G)TTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGM5 Gene

Variant ID Type Subtype PubMed ID
essv2899 CNV CNV 17122850
dgv2383e1 CNV Complex 17122850
dgv8238n71 CNV Gain 21882294
dgv2384e1 CNV Complex 17122850
dgv2385e1 CNV Complex 17122850
nsv428218 CNV Loss 18775914
dgv8240n71 CNV Gain 21882294
nsv831609 CNV Gain 17160897
nsv8519 CNV Gain 18304495
nsv8520 CNV Gain 18304495
nsv8521 CNV Loss 18304495
dgv8241n71 CNV Gain 21882294
dgv8242n71 CNV Gain 21882294
nsv893414 CNV Gain 21882294

Relevant External Links for PGM5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGM5 Gene

Disorders for PGM5 Gene

No disorders were found for PGM5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PGM5 Gene

Publications for PGM5 Gene

  1. A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily. (PMID: 8631316) Moiseeva E.P. … Critchley D.R. (Eur. J. Biochem. 1996) 2 3 4 23
  2. A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9. (PMID: 8586438) Edwards Y.H. … Ives J.H. (Genomics 1995) 2 3 23
  3. Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle. (PMID: 9342213) Moiseeva E.P. … Critchley D.R. (Eur. J. Biochem. 1997) 3 4 23
  4. Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles. (PMID: 10867799) Wakayama Y. … Oniki H. (Acta Neuropathol. 2000) 3 23
  5. A novel phosphoglucomutase-related protein is concentrated in adherens junctions of muscle and nonmuscle cells. (PMID: 8175905) Belkin A.M. … Koteliansky V.E. (J. Cell Sci. 1994) 3 4

Products for PGM5 Gene

Sources for PGM5 Gene

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