Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PGM5 Gene

protein-coding   GIFtS: 58
GCID: GC09P070971

Phosphoglucomutase 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphoglucomutase 51 2     aciculin2
Phosphoglucomutase-Related Protein1 2 3     Phosphoglucomutase-Like Protein 52
PGM-RP2 3     Aciculin3
PGMRP2 3     EC 5.4.2.28

External Ids:    HGNC: 89081   Entrez Gene: 52392   Ensembl: ENSG000001543307   OMIM: 6009815   UniProtKB: Q151243   

Export aliases for PGM5 gene to outside databases

Previous GC identifers: GC09P062016 GC09P062828 GC09P064541 GC09P066429 GC09P066428 GC09P068201 GC09P070161 GC09P040808


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGM5 Gene:
Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of
glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from
glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995
(PubMed 8586438)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PGM5 Gene: 
PGM5 (phosphoglucomutase 5) is a protein-coding gene. Diseases associated with PGM5 include tuberculosis, and among its related super-pathways are Glucuronidation. GO annotations related to this gene include structural molecule activity and phosphoglucomutase activity. An important paralog of this gene is PGM1.

UniProtKB/Swiss-Prot: PGM5_HUMAN, Q15124
Function: Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity

Gene Wiki entry for PGM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PGM5 gene promoter:
         RP58   AML1a   GATA-3   NF-kappaB   CREB   HFH-1   deltaCREB   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPGM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for PGM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13   Ensembl cytogenetic band:  9q21.11   HGNC cytogenetic band: 9q13

PGM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGM5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P070971:  view genomic region     (about GC identifiers)

Start:
70,943,224 bp from pter      End:
71,145,977 bp from pter
Size:
202,754 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PGM5_HUMAN, Q15124 (See protein sequence)
Recommended Name: Phosphoglucomutase-like protein 5  
Size: 567 amino acids; 62225 Da
Cofactor: Binds 1 magnesium ion per subunit (Potential)
Subunit: Interacts with cytoskeletal proteins dystrophin and utrophin
Subcellular location: Cell junction, adherens junction. Cytoplasm, cytoskeleton. Note=Adherens-type cellular
junctions. Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments
Developmental stage: In the developing aorta, expressed at low levels in 10-12 week old fetuses. Levels increase
progressively in 24 week fetus, 6 month old child and 1.5 year old child aortic smooth muscle, reaching a maximum
at maturity
Sequence caution: Sequence=AAC41948.1; Type=Erroneous initiation; Sequence=AAH33073.1; Type=Erroneous initiation;
Sequence=CAA73882.1; Type=Erroneous initiation;
Secondary accessions: B1AM46 B4DLQ6 Q5VYV3 Q8N527 Q9UDH4
Alternative splicing: 2 isoforms:  Q15124-1   Q15124-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PGM5: NX_Q15124

Explore proteomics data for PGM5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15124

  • 4 DME Specific Peptides for PGM5 (Q15124)
     LSTPAVS  GILSTPA  HPDPNLTYA  CGEESFGTG 

    PGM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PGM5 Protein Expression
    REFSEQ proteins: NP_068800.2  
    ENSEMBL proteins: 
     ENSP00000379674   ENSP00000379678   ENSP00000394864  

    Human Recombinant Protein Products for PGM5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for PGM5
    GenScript Custom Purified and Recombinant Proteins Services for PGM5
    Novus Biologicals PGM5 Protein
    Novus Biologicals PGM5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PGM5 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA8175905
    GO:0005829NOT cytosol IBA--
    GO:0005913cell-cell adherens junction IDA8175905
    GO:0005914spot adherens junction IDA8175905
    GO:0005925focal adhesion IDA8175905

    PGM5 for ontologies           About GeneDecksing



    PGM5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PGM5
    GenScript Custom Superior Antibodies Services for PGM5
    Novus Biologicals PGM5 Antibodies
    Abcam antibodies for PGM5
    Cloud-Clone Corp. Antibodies for PGM5 
    Search ThermoFisher Antibodies for PGM5
    LSBio Antibodies in human, mouse, rat for PGM5 

    Assay Products for PGM5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PGM5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PGM5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PGM5 
    Cloud-Clone Corp. CLIAs for PGM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR016066 A-D-PHexomutase_CS
     IPR016055 A-D-PHexomutase_a/b/a-I/II/III
     IPR005841 Alpha-D-phosphohexomutase_SF
     IPR005844 A-D-PHexomutase_a/b/a-I
     IPR005846 A-D-PHexomutase_a/b/a-III

    Graphical View of Domain Structure for InterPro Entry Q15124

    ProtoNet protein and cluster: Q15124

    1 Blocks protein domain: IPB001254 Serine protease

    UniProtKB/Swiss-Prot: PGM5_HUMAN, Q15124
    Similarity: Belongs to the phosphohexose mutase family


    PGM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGM5_HUMAN, Q15124
    Function: Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity

         Genatlas biochemistry entry for PGM5:
    phosphoglucomutase 5,with homology to PGM1 but unknown function,widely expressed in fetal and adult tissues

         Enzyme Number (IUBMB): EC 5.4.2.22

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004614NOT phosphoglucomutase activity IDA8175905
    GO:0005198structural molecule activity NAS8631316
    GO:0005515protein binding ----
    GO:0016868intramolecular transferase activity, phosphotransferases ----
         
    PGM5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PGM5:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PGM5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PGM5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PGM5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGM5
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PGM5 (see all 11):
    hsa-miR-3910 hsa-miR-548p hsa-miR-328 hsa-miR-3660 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1260 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidPGM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PGM5
    Sirion Biotech Customized adenovirus for overexpression of PGM5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PGM5 (see all 4)
    OriGene ORF clones in mouse, rat for PGM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PGM5 (NM_021965)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGM5
    Sirion Biotech Customized lentivirus for stable overexpression of PGM5 
                         Customized lentivirus expression plasmids for stable overexpression of PGM5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PGM5
    Search LifeMap BioReagents cell lines for PGM5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGM5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PGM5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Glucuronidation0.67


    1 BioSystems Pathway for PGM5
        Glucuronidation


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PGM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for PGM5 (Q151243 ENSP000003796784) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UTRNP469393, ENSP000003565154I2D: score=2 STRING: ENSP00000356515
    DMDP115323, ENSP000003549234I2D: score=3 STRING: ENSP00000354923
    CAV3ENSP000003419404STRING: ENSP00000341940
    DAG1ENSP000003124354STRING: ENSP00000312435
    SGCAENSP000002620184STRING: ENSP00000262018
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0005978NOT glycogen biosynthetic process IBA--
    GO:0005992NOT trehalose biosynthetic process IBA--
    GO:0006006glucose metabolic process IEA--
    GO:0007155cell adhesion IEA--

    PGM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PGM5

    1 HMDB Compound for PGM5    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about PGM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PGM5 gene: 
    NM_021965.3  

    Unigene Cluster for PGM5:

    Phosphoglucomutase 5
    Hs.307835  [show with all ESTs]
    Unigene Representative Sequence: AL137698
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604870 ENST00000396392 ENST00000396396(uc004agr.3) ENST00000431583
    ENST00000587852 ENST00000472639 ENST00000496758
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGM5
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate PGM5 (see all 11):
    hsa-miR-3910 hsa-miR-548p hsa-miR-328 hsa-miR-3660 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-1260 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidPGM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PGM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGM5
    Clone
    Products:
         
    OriGene clones in human, mouse for PGM5 (see all 4)
    OriGene ORF clones in mouse, rat for PGM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PGM5 (NM_021965)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PGM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGM5
    Sirion Biotech Customized lentivirus for stable overexpression of PGM5 
                         Customized lentivirus expression plasmids for stable overexpression of PGM5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for PGM5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PGM5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGM5

    Additional mRNA sequence: 

    AK297108.1 AL137698.1 BC033073.1 

    6 DOTS entries:

    DT.414970  DT.95311414  DT.100025722  DT.121153071  DT.75127860  DT.97817207 

    24/94 AceView cDNA sequences (see all 94):

    AI361547 AL710966 BP379938 AA715132 AL046941 AI078570 AA070085 AI095018 
    BX094630 CA437740 BQ001679 CB269083 BM699018 BQ890368 AA688336 AA709405 
    NM_021965 BF793292 W95363 BX484521 N68909 AA701613 BF058433 CA406687 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PGM5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                              
    SP2:                                            -     -                           
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for PGM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PGM5 expression in normal human tissues (normalized intensities)      PGM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGAGAGCT
    PGM5 Expression
    About this image


    PGM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             smooth muscle ; smooth muscle cells   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
             heart muscle ; myocytes   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Fibroblast (Respiratory System)    fully expand to see all 2 entries
             X-gene Foreskin Fibroblasts   

    See PGM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PGM5

    SOURCE GeneReport for Unigene cluster: Hs.307835

    UniProtKB/Swiss-Prot: PGM5_HUMAN, Q15124
    Tissue specificity: Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level.
    Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver,
    kidney, skin and brain (at protein level)

        SABiosciences Custom PCR Arrays for PGM5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for PGM5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PGM5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGM5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PGM5 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pgm51 , 5 phosphoglucomutase 51, 5 90.83(n)1
    97.53(a)1
      19 (19.78 cM)5
    2260411  NM_175013.21  NP_778178.31 
     246830165 
    chicken
    (Gallus gallus)
    Aves PGM51 phosphoglucomutase 5 80.6(n)
    88.54(a)
      427215  XM_424802.3  XP_424802.3 
    lizard
    (Anolis carolinensis)
    Reptilia PGM56
    Uncharacterized protein
    87(a)
    1 ↔ 1
    2(49911652-49971753)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5602971 novel protein similar to vertebrate phosphoglucomutase more 72.73(n)
    77.21(a)
      560297  NM_001126396.1  NP_001119868.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pgm6
    Phosphogluconate mutase
    49(a)
    1 → many
    3L(16119118-16121631)
    worm
    (Caenorhabditis elegans)
    Secernentea R05F9.63 phosphoglucomutase 53(a)   II(4889433-4891290)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PGM26
    PGM16
    Phosphoglucomutase, catalyzes the conversion from ...
    Phosphoglucomutase, minor isoform; catalyzes the c...
    43(a)
    41(a)
    many ↔ many
    many ↔ many
    XIII(475897-477606)
    XI(203541-205253)


    ENSEMBL Gene Tree for PGM5 (if available)
    TreeFam Gene Tree for PGM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PGM5 gene
    PGM12  
    1 SIMAP similar gene for PGM5 using alignment to 2 protein entries:     PGM5_HUMAN (see all proteins):
    PGM1

    PGM5 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for PGM5
    PGOHUM00000240872 PGOHUM00000235941 PGOHUM00000263221 PGOHUM00000263222


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3233 SNPs in PGM5 are shown (see all 3233)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3725811,2
    F,H--70975096(-) GCAATT/CACATA 1 -- int18Minor allele frequency- C:0.02NS EA NA 1224
    rs1923612701,2
    --70975282(+) AAACAC/TTATAA 1 -- int10--------
    rs1828899461,2
    --70975628(+) TTCCTA/GTATTT 1 -- int10--------
    rs1875285451,2
    --70975747(+) AGTTAC/TGAAAT 1 -- int10--------
    rs1479525611,2
    C--70975751(+) ACGAA-/ATCATCTT 1 -- int10--------
    rs31196521,2
    C,F--70975778(-) AAAACC/TATTTT 1 -- int11Minor allele frequency- T:0.12NA 120
    rs1923115071,2
    --70975869(+) TTGCTC/TTTTCA 1 -- int10--------
    rs27771611,2
    --70975923(-) caggaA/Gtttga 1 -- int10--------
    rs74705981,2
    C,F--70976000(+) cagctA/Cattta 1 -- int11Minor allele frequency- C:0.00NA 2
    rs1383481831,2
    C--70976020(+) TAGAGA/GTGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for PGM5 (70943224 - 71145977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for PGM5 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv8521CNV Loss18304495
    nsv428218CNV Loss18775914
    dgv8241n71CNV Gain21882294
    nsv8520CNV Gain18304495
    nsv831609CNV Gain17160897
    dgv8238n71CNV Gain21882294
    nsv8519CNV Gain18304495
    dgv8240n71CNV Gain21882294
    nsv893414CNV Gain21882294
    dgv8242n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PGM5
    DNA2.0 Custom Variant and Variant Library Synthesis for PGM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600981    OMIM disorders: --

    2 diseases for PGM5:    About MalaCards
    tuberculosis    


    PGM5 for disorders           About GeneDecksing


    Export disorders for PGM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PGM5 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with PGM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily. (PubMed id 8631316)1, 2, 3, 9 Moiseeva E.P....Critchley D.R. (1996)
    2. Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle. (PubMed id 9342213)1, 2, 9 Moiseeva E.P. and Critchley D.R. (1997)
    3. A novel human phosphoglucomutase (PGM5) maps to the centromeric region of chromosome 9. (PubMed id 8586438)1, 3, 9 Edwards Y.H....Ives J.H. (1995)
    4. A novel phosphoglucomutase-related protein is concentrated in adherens junctions of muscle and nonmuscle cells. (PubMed id 8175905)1, 2 Belkin A.M.... Koteliansky V.E. (1994)
    5. Association of aciculin with dystrophin and utrophin. (PubMed id 7890770)1, 9 Belkin A.M. and Burridge K. (1995)
    6. Localization of utrophin and aciculin at sites of cell-matrix and cell-cell adhesion in cultured cells. (PubMed id 7589238)1, 9 Belkin A.M. and Burridge K. (1995)
    7. Aciculin and its relation to dystrophin: immunocytochemical studies in human normal and Duchenne dystrophy quadriceps muscles. (PubMed id 10867799)1, 9 Wakayama Y....Oniki H. (2000)
    8. A genome-wide association study of seasonal pattern ma nia identifies NF1A as a possible susceptibility gene for bipolar disorder. (PubMed id 22925353)1 Lee H.J....Kelsoe J.R. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5239 HGNC: 8908 AceView: PGM5 Ensembl:ENSG00000154330 euGenes: HUgn5239
    ECgene: PGM5 H-InvDB: PGM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PGM5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PGM5 gene:
    Search GeneIP for patents involving PGM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for PGM5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for PGM5  
     OriGene qSTAR qPCR primer pairs in human, mouse for PGM5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for PGM5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PGM5   OriGene Custom Protein Services for PGM5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PGM5
     QIAGEN SeqTarget long-range PCR primers for resequencing PGM5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGM5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PGM5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGM5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PGM5
     GenScript Custom Purified and Recombinant Proteins Services for PGM5 GenScript cDNA clones with any tag delivered in your preferred vector for PGM5
     GenScript Custom Assay Services for PGM5 GenScript Custom Superior Antibodies Services for PGM5
     GenScript Custom overexpressing Cell Line Services for PGM5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PGM5 promoter
     Search Chromatin IP Primers for PGM5
     RT2 qPCR Primer Assay in human, mouse, rat PGM5
     Search GNC Networks for PGM5
     SABiosciences Custom PCR Arrays for PGM5
     Search Tocris compounds for PGM5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PGM5 antibodies
     PGM5 proteins
     PGM5 lysates
     Antibodies for PGM5
     See all of Abcam's Antibodies, Kits and Proteins for PGM5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PGM5
     Antibodies for PGM5
     ELISAs for PGM5
     CLIAs for PGM5
     Search LifeMap BioReagents cell lines for PGM5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGM5
     SwitchGear 3'UTR luciferase reporter plasmids for PGM5
     SwitchGear Promoter luciferase reporter plasmids for PGM5
     Search ThermoFisher Antibodies for PGM5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PGM5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PGM5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PGM5
    Customized:
     lentivirus for stable overexpression of PGM5
     lentivirus expression plasmids for stable overexpression of PGM5
     adenovirus for overexpression of PGM5
     LSBio Antibodies in human, mouse, rat for PGM5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PGM5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4