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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PGM3 Gene

protein-coding GIFtS: 56
GCID: GC06M083876

phosphoglucomutase 3

Explore 5 diseases affiliated with
PGM3 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphoglucomutase 3¹ ²		DKFZP434B187¹
AGM1¹ ² ³ ⁵		N-Acetylglucosamine-Phosphate Mutase 1²
PAGM¹ ² ³		Phosphoacetylglucosamine Mutase²
Acetylglucosamine Phosphomutase² ³		Phosphoglucomutase-3³
PGM 3² ³		N-Acetylglucosamine-Phosphate Mutase³
EC 5.4.2.3³ ⁸		EC 5.4.2⁸

External Ids:	HGNC: 8907¹	Entrez Gene: 5238²	Ensembl: ENSG00000013375⁷	OMIM: 172100⁵	UniProtKB: O95394³

Export aliases for PGM3 gene to outside databases

Previous GC identifers: GC06U990094 GC06M083841 GC06M083874 GC06M083935 GC06M081106

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PGM3:

This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and

utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single

nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy.

Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by

RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: AGM1_HUMAN, O95394

Function: Interconverts GlcNAc-6-P and GlcNAc-1-P

Gene Wiki entry for PGM3 (Phosphoglucomutase 3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PGM3 gene promoter:
MyoD Pax-2 Pax-2a POU3F2 Evi-1 RORalpha1 Sox9 Msx-1 ATF6 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PGM3 promoter sequence

Search SABiosciences Chromatin IP Primers for PGM3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PGM3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.1-q15 Ensembl cytogenetic band: 6q14.2 HGNC cytogenetic band: 6q14.1-q15

PGM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PGM3 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M083876: view genomic region (about GC identifiers)

Start:	83,870,869 bp from pter	End:	83,903,655 bp from pter
Size:	32,787 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AGM1_HUMAN, O95394 (See protein sequence)

Recommended Name: Phosphoacetylglucosamine mutase

Size: 542 amino acids; 59852 Da

Cofactor: Binds 1 magnesium ion per subunit (By similarity)

Sequence caution: Sequence=BAB14652.1; Type=Erroneous initiation; Sequence=CAI22635.1; Type=Erroneous gene model

prediction; Sequence=CAI42427.1; Type=Erroneous gene model prediction;

Secondary accessions: B2RB65 E1P547 Q5JWR4 Q96J46 Q9H8G5 Q9NS94 Q9NTT6 Q9UFV5 Q9UIY2

Explore the universe of human proteins at neXtProt for PGM3: NX_O95394

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95394

4/5 DME Specific Peptides for PGM3 (O95394) (see all 5)

TGVKHLH

QTAYANG

FDGDADR

FEANGHGT

PGM3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001186846.1 NP_001186847.1 NP_001186848.1 NP_056414.1

ENSEMBL proteins:

ENSP00000421154 ENSP00000424874 ENSP00000421565 ENSP00000283977 ENSP00000425809

ENSP00000423389 ENSP00000427420 ENSP00000423769 ENSP00000425558 ENSP00000424865

ENSP00000422362

Reactome Protein details: O95394
Human Recombinant Protein Products for PGM3:

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	Uscn Proteins for PGM3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005829	cytosol	TAS	--

PGM3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PGM3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PGM3 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR005843 A-D-PHexomutase_C

IPR016066 A-D-PHexomutase_CS

IPR016055 A-D-PHexomutase_a/b/a-I/II/III

IPR016657 PAGM

IPR005844 A-D-PHexomutase_a/b/a-I

Graphical View of Domain Structure for InterPro Entry O95394

ProtoNet protein and cluster: O95394

UniProtKB/Swiss-Prot: AGM1_HUMAN, O95394

Similarity: Belongs to the phosphohexose mutase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AGM1_HUMAN, O95394

Function: Interconverts GlcNAc-6-P and GlcNAc-1-P

Catalytic activity: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

Genatlas biochemistry entry for PGM3:

phosphoglucomutase 3

Enzyme Numbers (IUBMB): EC 5.4.2.3¹ ² EC 5.4.2²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004610	phosphoacetylglucosamine mutase activity	IDA	11004509
GO:0004614	phosphoglucomutase activity	--	--

PGM3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for PGM3:

Increased gamma-H2AX phosphory

Wnt reporter downregulated

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Pgm3):

cellular	digestive/alimentary	endocrine/exocrine gland	hematopoietic system	immune system
mortality/aging	renal/urinary system	reproductive system

PGM3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PGM3

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		hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-379* hsa-miR-3653 hsa-miR-30d hsa-miR-192 hsa-miR-550a*

		SwitchGear 3'UTR luciferase reporter plasmid: PGM3 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGM3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Metabolism of proteins	0.15
	Post-translational protein modification	0.44

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

1.00

Synthesis of substrates in N-glycan biosythesis

0.53

Glucuronidation

Glucuronidation

1.00

Amino sugar and nucleotide sugar metabolism

Amino sugar and nucleotide sugar metabolism

1.00

UDP-N-acetyl-D-glucosamine biosynthesis II

Synthesis of UDP-N-acetyl-glucosamine

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for PGM3

Glucuronidation

5/6 Reactome Pathways for PGM3 (see all 6)

	Synthesis of substrates in N-glycan biosythesis
	Asparagine N-linked glycosylation
	Metabolism of proteins
	Post-translational protein modification
	Synthesis of UDP-N-acetyl-glucosamine

1 Kegg Pathway (Kegg details for PGM3):

Amino sugar and nucleotide sugar metabolism

UniProtKB/Swiss-Prot: AGM1_HUMAN, O95394

Pathway: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine

1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2

PGM3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PGM3

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/26 Interacting proteins for PGM3 (O95394³ ENSP00000283977⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
WRNIP1	Q96S55³, ENSP00000370150⁴	I2D: score=4 STRING: ENSP00000370150
PDHB	P11177³, ENSP00000307241⁴	I2D: score=2 STRING: ENSP00000307241
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
PICK1	Q9NRD5³, ENSP00000349465⁴	I2D: score=2 STRING: ENSP00000349465
EIF4A2	Q14240³	I2D: score=5

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	--	--
GO:0006041	glucosamine metabolic process	NAS	11004509
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	TAS	--
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	--
GO:0007283	spermatogenesis	--	--

PGM3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PGM3

4 HMDB Compounds for PGM3 About this table

Compound	Synonyms	CAS #	PubMed Ids
D-Ribose 5-phosphate	D-Ribose 5-phosphate (see all 11)	3615-55-2	--
D-Ribulose 5-phosphate	D-Ribulose 5-phosphate (see all 5)	4151-19-3	--
Glucose 1-phosphate	Cori ester (see all 22)	59-56-3	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about PGM3 / AGM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PGM3 gene (4 alternative transcripts):

NM_001199917.1 NM_001199918.1 NM_001199919.1 NM_015599.2

Unigene Cluster for PGM3:

Phosphoglucomutase 3

Hs.661665 [show with all ESTs]

Unigene Representative Sequence: NM_001199917

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000504780 ENST00000513973(uc003pju.2 uc003pjw.3 uc011dyz.2 uc021zcd.1)

ENST00000512866 ENST00000283977 ENST00000506587 ENST00000509219 ENST00000503356

ENST00000507404 ENST00000510258 ENST00000505470 ENST00000507554 ENST00000508748

ENST00000503094 ENST00000515333

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PGM3
		8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate PGM3 (see all 51):
		hsa-miR-411* hsa-miR-579 hsa-miR-361-5p hsa-miR-379* hsa-miR-3653 hsa-miR-30d hsa-miR-192 hsa-miR-550a*

		SwitchGear 3'UTR luciferase reporter plasmid: PGM3 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PGM3

Additional cDNA sequence:

AB032081.1 AF102265.1 AF180371.1 AK001365.1 AK021676.1 AK023432.1 AK023685.1 AK023709.1

AK225363.1 AK301867.1 AK314512.1 AL117443.1 BC001258.1

21 DOTS entries:

DT.214469 DT.100834022 DT.97794023 DT.100824253 DT.121328750 DT.99979335 DT.95178678 DT.95178650

DT.75131298 DT.91899906 DT.121328735 DT.101967083 DT.121328689 DT.121328701 DT.121328714 DT.121328747

DT.121328755 DT.40129874 DT.97778253 DT.99933860 DT.99951655

24/221 AceView cDNA sequences (see all 221):

AA001870 CB161161 CA448381 BM819315 AI219213 AA496528 AK023685 AI810133

AA599539 BU507433 AK001365 BM542575 NM_015599 CN479404 CA446414 CA943055

AI379721 BU622418 BQ014102 BX483923 BP376850 AI638190 AI190938 BM477301

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for PGM3 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b
SP1:							-
SP2:							-		-
SP3:									-
SP4:			-		-		-
SP5:							-

ECgene alternative splicing isoforms for PGM3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PGM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See PGM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PGM3

SOURCE GeneReport for Unigene cluster: Hs.661665

UniProtKB/Swiss-Prot: AGM1_HUMAN, O95394

Tissue specificity: Found in many tissues except lung. Relatively high expression in pancreas, heart, liver, and

placenta, and relatively low expression in brain, skeletal muscle and kidney

SABiosciences Expression via Pathway-Focused PCR Array including PGM3:

Glucose Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PGM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PGM3 gene from 10/35 species (see all 35) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pgm3^{1 , 5}	phosphoglucomutase 3^{1, 5}	83.58(n)¹ 87.64(a)¹		9 (46.58 cM)⁵ 109785¹ NM_028352.4¹ NP_082628.3¹ 86552476⁵
chicken (Gallus gallus)	Aves	PGM3¹	phosphoglucomutase 3	73.83(n) 74.44(a)		421841 XM_419862.3 XP_419862.2
lizard (Anolis carolinensis)	Reptilia	PGM3⁶	--	76(a)	1 ↔ 1	1(197744857-197763869)
African clawed frog (Xenopus laevis)	Amphibia	pgm3-prov²	phosphoglucomutase 3	75.57(n)		BC056094.1
zebrafish (Danio rerio)	Actinopterygii	pgm3¹	phosphoglucomutase 3	65.55(n) 68.97(a)		474321 NM_001007053.1 NP_001007054.1
fruit fly (Drosophila melanogaster)	Insecta	CG10627¹	CG10627	54.89(n) 55.21(a)		39434 NM_140331.2 NP_648588.1
worm (Caenorhabditis elegans)	Secernentea	F21D5.1¹	Protein F21D5.1	50.77(n) 44.21(a)		177678 NM_069099.4 NP_501500.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	PCM1(YEL058W)⁴ PCM1¹	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors less⁴ Pcm1p¹	52.16(n)¹ 47.5(a)¹		5(43252-44925)⁴ 856652^{1, 4} NP_010856.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	DRT101¹	phosphoacetylglucosamine mutase	52.71(n) 47.16(a)		831926 NM_121812.2 NP_568359.2
rice (Oryza sativa)	Liliopsida	Os.5949²	Oryza sativa (japonica cultivar-group) cDNA cloneJ023034C14, full insert sequence less	72.64(n)		AK069901.1

ENSEMBL Gene Tree for PGM3 (if available)
TreeFam Gene Tree for PGM3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62419258^1,2	C,F	other	83892687(+)	`GTTAAA/C/TAAGCC`	12	L F	syn¹ mis¹		1		EU	971
rs80051168^1,2	C,F	--	83874133(+)	`TATGAC/TCCCAG`	5	--	int¹ ds500¹		1		WA	118
rs184437272^1,2		--	83874180(+)	`GTAATA/GAGAAT`	5	--	ds500¹ int¹		0	--	--	--	--
rs13212413^1,2	H	--	83874234(+)	`GTCTTT/ATGCCC`	5	--	int¹ ds500¹		4		NS EA	418
rs149272904^1,2	C	--	83874326(+)	`GGCCAA/GGCATA`	5	--	int¹ ds500¹		0	--	--	--	--
rs147397834^1,2	C	--	83874472(+)	`TGGCA-/GGCAAA`	5	--	ds500¹ int¹		0	--	--	--	--
rs117358021^1,2	C,F	--	83874490(+)	`AAATAT/CTGAGA`	5	--	ds500¹ int¹		1		NA	120
rs187233787^1,2		--	83874508(+)	`CCAGGC/TCTGAA`	5	--	ds500¹ int¹		0	--	--	--	--
rs144429027^1,2		--	83874512(+)	`GTCTGA/GATGTC`	5	--	ds500¹ int¹		0	--	--	--	--
rs191644765^1,2		--	83874783(+)	`AGTTAC/GCTATA`	5	--	ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PGM3 (83870869 - 83903655 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PGM3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PGM3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PGM3 for disorders           About GeneDecksing

OMIM gene information: 172100    OMIM disorders: --

5 diseases for PGM3:    About MalaCards

nephropathy neuropathy prostate cancer prostatitis

malaria

Human Genome Epidemiology (HuGE) Navigator: PGM3 (3 documents)

Export disorders for PGM3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PGM3 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with PGM3)

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Identification of human phosphoglucomutase 3 (PGM3) as N- acetylglucosamine-phosphate mutase (AGM1). (PubMed id 12174217)^{1, 2, 3, 9} Pang H.... Kimura H. (2002)
Cloning and characterization of complementary DNA encoding human N- acetylglucosamine-phosphate mutase protein. (PubMed id 10721701)^{1, 2, 3, 9} Li C.... Banerjee D. (2000)
Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. (PubMed id 11004509)^{1, 2, 9} Mio T.... Yamada-Okabe H. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
N-acetylglucosamine-phosphate mutase genotype and diabetic microvascular complications. (PubMed id 12752494)^{1, 9} Pang H....Yamagishi S.I. (2003)
Polymorphic analysis of the human phosphoglucomutase- 3 gene based on mismatched PCR-RFLP technique. (PubMed id 20221814)^{1, 9} Pang H....Ding M. (2010)
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. (PubMed id 23042605)¹ Mosbech A.... Mailand N. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5238	HGNC: 8907	AceView: PGM3	Ensembl:ENSG00000013375	euGenes: HUgn5238
ECgene: PGM3	Kegg: 5238	H-InvDB: PGM3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PGM3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PGM3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PGM3 gene:
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GeneCards and IP:
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