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Aliases for PGM2 Gene

Aliases for PGM2 Gene

  • Phosphoglucomutase 2 2 3 5
  • Glucose Phosphomutase 2 3 4
  • Phosphodeoxyribomutase 3 4
  • Phosphopentomutase 2 4
  • EC 5.4.2.2 4 61
  • PGM 2 3 4
  • Phosphoglucomutase-2 3
  • EC 5.4.2.7 4
  • EC 5.4.2 61
  • MSTP006 3

External Ids for PGM2 Gene

Previous GeneCards Identifiers for PGM2 Gene

  • GC04U990041
  • GC04P037725
  • GC04P037650
  • GC04P037504
  • GC04P037152

Summaries for PGM2 Gene

GeneCards Summary for PGM2 Gene

PGM2 (Phosphoglucomutase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include magnesium ion binding and phosphoglucomutase activity. An important paralog of this gene is PGM2L1.

UniProtKB/Swiss-Prot for PGM2 Gene

  • Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.

Gene Wiki entry for PGM2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PGM2 Gene

Genomics for PGM2 Gene

Regulatory Elements for PGM2 Gene

Enhancers for PGM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F037825 1.1 ENCODE 78.4 +0.1 93 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 PGM2 ENSG00000279386
GH04F037802 0.8 ENCODE 83 -24.4 -24380 0.2 ELF3 CTCF WRNIP1 ZFP64 ARID4B RAD21 RFX5 TEAD3 FOXK2 SMC3 PGM2 TBC1D1 ENSG00000248936 RELL1 GC04P037820 LOC105374406
GH04F037815 0.7 Ensembl ENCODE 77.8 -10.4 -10433 1.2 REST EGR2 PGM2 GC04P037820 LOC105374406
GH04F037810 0.6 ENCODE 72.7 -15.8 -15814 1.4 ARID1B JUND RNF2 NCOR1 TAL1 KDM1A PGM2 GC04P037820 LOC105374406
GH04F037812 0.5 ENCODE 72.5 -13.7 -13684 1.1 JUND JUN CEBPB EP300 PGM2 GC04P037820 LOC105374406
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PGM2 on UCSC Golden Path with GeneCards custom track

Promoters for PGM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001430641 -33 2401 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5

Genomic Location for PGM2 Gene

Chromosome:
4
Start:
37,826,633 bp from pter
End:
37,862,938 bp from pter
Size:
36,306 bases
Orientation:
Plus strand

Genomic View for PGM2 Gene

Genes around PGM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PGM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PGM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PGM2 Gene

Proteins for PGM2 Gene

  • Protein details for PGM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G03-PGM2_HUMAN
    Recommended name:
    Phosphoglucomutase-2
    Protein Accession:
    Q96G03
    Secondary Accessions:
    • B4E0G8
    • Q53FP5
    • Q5QTR0
    • Q9H0P9
    • Q9NV22

    Protein attributes for PGM2 Gene

    Size:
    612 amino acids
    Molecular mass:
    68283 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PGM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PGM2 Gene

Selected DME Specific Peptides for PGM2 Gene

Q96G03:
  • GIMITASHNP
  • RDLTTGY
  • FEEAIGYM
  • LANDPDADRLAVAEK

Post-translational modifications for PGM2 Gene

  • Ubiquitination at Lys 27, Lys 91, and Lys 292
  • Modification sites at PhosphoSitePlus

Other Protein References for PGM2 Gene

Domains & Families for PGM2 Gene

Suggested Antigen Peptide Sequences for PGM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96G03

UniProtKB/Swiss-Prot:

PGM2_HUMAN :
  • Belongs to the phosphohexose mutase family.
Family:
  • Belongs to the phosphohexose mutase family.
genes like me logo Genes that share domains with PGM2: view

No data available for Gene Families for PGM2 Gene

Function for PGM2 Gene

Molecular function for PGM2 Gene

GENATLAS Biochemistry:
phosphoglucomutase 2
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=45.7 uM for alpha-D-ribose 1-phosphate {ECO:0000269 PubMed:17804405}; KM=4.1 uM for 2-deoxy-alpha-D-ribose 1-phosphate {ECO:0000269 PubMed:17804405}; KM=114 uM for alpha-D-glucose 1-phosphate {ECO:0000269 PubMed:17804405}; Vmax=104.3 umol/min/mg enzyme with alpha-D-ribose 1-phosphate as substrate {ECO:0000269 PubMed:17804405}; Vmax=20.8 umol/min/mg enzyme with 2-deoxy-alpha-D-ribose 1- phosphate as substrate {ECO:0000269 PubMed:17804405}; Vmax=22.8 umol/min/mg enzyme with alpha-D-glucose 1-phosphate as substrate {ECO:0000269 PubMed:17804405};
UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-alpha-D-ribose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.

Enzyme Numbers (IUBMB) for PGM2 Gene

Gene Ontology (GO) - Molecular Function for PGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004614 phosphoglucomutase activity EXP 1840235
GO:0005515 protein binding IPI 21044950
GO:0008973 phosphopentomutase activity TAS --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PGM2: view
genes like me logo Genes that share phenotypes with PGM2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PGM2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PGM2 Gene

Localization for PGM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PGM2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PGM2 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2
mitochondrion 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PGM2: view

Pathways & Interactions for PGM2 Gene

genes like me logo Genes that share pathways with PGM2: view

UniProtKB/Swiss-Prot Q96G03-PGM2_HUMAN

  • Pathway: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 1/2.

Gene Ontology (GO) - Biological Process for PGM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005978 glycogen biosynthetic process TAS --
GO:0005980 glycogen catabolic process TAS --
GO:0006006 glucose metabolic process IEA --
GO:0006098 pentose-phosphate shunt TAS --
genes like me logo Genes that share ontologies with PGM2: view

No data available for SIGNOR curated interactions for PGM2 Gene

Drugs & Compounds for PGM2 Gene

(5) Drugs for PGM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-D-Glucose 1,6-bisphosphate Experimental Pharma 0
D-Mannose 1-phosphate Experimental Pharma 0
Glucose 1-phosphate Experimental Pharma 0
Glucose 6-phosphate Experimental Pharma 0
Magnesium Nutra 0

(8) Additional Compounds for PGM2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Deoxyribose 1-phosphate
  • 2-Deoxy-alpha-D-ribose 1-phosphate
  • 2-Deoxy-alpha-delta-ribose 1-phosphate
  • 2-Deoxy-D-erythro-pentofuranose 1-phosphate
  • 2-Deoxy-D-ribose 1-phosphate
  • 2-Deoxy-D-ribose-1-phosphate
17210-42-3
Deoxyribose 5-monophosphate
Deoxyribose 5-phosphate
  • 2-Deoxy-alpha-D-ribose 5-phosphate
  • 2-Deoxy-alpha-delta-ribose 5-phosphate
  • 2-Deoxy-D-ribose 5-phosphate
  • 2-Deoxy-D-ribose-5-phosphate
  • 2-Deoxyribose 5-phosphate
102916-66-5
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
Mannose 6-phosphate
  • alpha-D-Mannose-6-P
  • alpha-D-Mannose-6-phosphate
  • alpha-delta-Mannose-6-P
  • alpha-delta-Mannose-6-phosphate
  • D-Mannose 6-phosphate
3672-15-9
genes like me logo Genes that share compounds with PGM2: view

Transcripts for PGM2 Gene

Unigene Clusters for PGM2 Gene

Phosphoglucomutase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PGM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PGM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3:

Relevant External Links for PGM2 Gene

GeneLoc Exon Structure for
PGM2
ECgene alternative splicing isoforms for
PGM2

Expression for PGM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PGM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PGM2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for PGM2 Gene

This gene is overexpressed in Retina (10.8), Lymph node (9.1), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PGM2 Gene



Protein tissue co-expression partners for PGM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PGM2 Gene:

PGM2

SOURCE GeneReport for Unigene cluster for PGM2 Gene:

Hs.23363
genes like me logo Genes that share expression patterns with PGM2: view

No data available for mRNA Expression by UniProt/SwissProt for PGM2 Gene

Orthologs for PGM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PGM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PGM2 34 35
  • 96.51 (n)
dog
(Canis familiaris)
Mammalia PGM2 34 35
  • 90.52 (n)
cow
(Bos Taurus)
Mammalia PGM2 34 35
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Pgm1 34 16 35
  • 85.25 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PGM2 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves PGM2 34 35
  • 76.74 (n)
lizard
(Anolis carolinensis)
Reptilia PGM2 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pgm2 34
  • 72.71 (n)
Str.2180 34
zebrafish
(Danio rerio)
Actinopterygii pgm2 34 35
  • 67.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008305 34
  • 57.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pmm45A 34 35
  • 53.46 (n)
CG10202 35
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y43F4B.5 34 35
  • 53.96 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL126W 34
  • 49.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PGM3 34 35
  • 49.8 (n)
PRM15 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01573g 34
  • 49.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6664 35
  • 56 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1840.05c 34
  • 51.88 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3456 34
Species where no ortholog for PGM2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PGM2 Gene

ENSEMBL:
Gene Tree for PGM2 (if available)
TreeFam:
Gene Tree for PGM2 (if available)

Paralogs for PGM2 Gene

Paralogs for PGM2 Gene

(2) SIMAP similar genes for PGM2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PGM2: view

Variants for PGM2 Gene

Sequence variations from dbSNP and Humsavar for PGM2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000528 -- 37,843,257(+) TTACT(A/G)TAGGT intron-variant
rs10000814 -- 37,843,632(+) GAGAC(A/G)GAGTT intron-variant
rs10001580 -- 37,850,235(+) CAAGA(A/C)ACCAT reference, missense
rs10003112 -- 37,854,647(+) gccac(C/T)gcgcc intron-variant
rs10010767 -- 37,830,245(+) GACAC(A/T)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PGM2 Gene

Variant ID Type Subtype PubMed ID
nsv526455 CNV loss 19592680

Variation tolerance for PGM2 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PGM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PGM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PGM2 Gene

Disorders for PGM2 Gene

Relevant External Links for PGM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PGM2

No disorders were found for PGM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PGM2 Gene

Publications for PGM2 Gene

  1. Molecular identification of mammalian phosphopentomutase and glucose- 1,6-bisphosphate synthase, two members of the alpha-D- phosphohexomutase family. (PMID: 17804405) Maliekal P. … Van Schaftingen E. (J. Biol. Chem. 2007) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for PGM2 Gene

Sources for PGM2 Gene

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